Review
Year 2020,
Volume: 29 Issue: 2, 129 - 137, 30.06.2020
Abstract
Hidrojeller
“Smart (akıllı)” yapılar olarak tanımlanan ilaç taşınım sistemleri, enjekte
edilebilen polimer sistemleri, doku mühendisliği ve hücre enkapsülasyonu gibi
tıpta yaygın olarak kullanılan polimerlerdir. Hidrojeller suyu yapılarında
tutabilme özellikleri, yumuşak ve esnek yapıda olmaları ile canlı dokulara
büyük benzerlik göstermektedirler. Toksisitesi olmayan, biyolojik olarak
parçalanan ve biyolojik uyum gösterebilen yapıları sebebiyle hidrojellerin
biyomalzeme olarak kullanılması giderek güvenli hale gelmektedir. Aynı zamanda
hidrojellerin kontrollü serbest bırakma mekanizması, ilacın salınım hızını
düzenleyen geleneksel dozaj yöntemleri karşısında birçok avantaj sağlamaktadır.
Bu derlemede genel olarak yara örtüsünde, yanık, anevrizma tedavilerinde, kemik
rejenerasyonunda, kardiyak doku onarım ve rejenerasyonunda, kontrollü ilaç
salınımında, kontakt lenslerde, glokom tedavisinde kullanılan ve biyolojik
araştırmaları devam etmekte olan hidrojellerden bahsedilmektedir.
Thanks
Hidrojeller konusuna yönlenmem sürecinde fikirlerini esirgemeyen ve yeni ufuklar açan Doç.Dr. Burcu Okutucu’ya sonsuz teşekkürlerimi sunarım.
References
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- Kabiri K, Zohuriaan J. Superabsorbent polymer materials: A review. Iran Polym J. 2008;17(6):451-477
- Lin CC, Metters AT. Hydrogels in controlled release formulations: Network design and mathematical modeling. Adv Drug Deliv Rev. 2006;58 (12-13):1379–1408
- Sop ES, Doku genişletme amaçlı hidrojel sentezi, karakterizasyonu ve şişme kinetiği( Yüksek Lisans Tezi). Ankara, Hacettepe Üniversitesi, 2013
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- Wichterle O, Lim D. Hydrophilic gels for biological use. Nature. 1960;185:117-8
- Sarsılmaz F, Sarsılmaz C. Ortopedide kullanılan polimer esaslı kompozit malzemeler. Dogu Anadolu Bolge Arastirmalari Derg. 2003;3:113-7
- Brahıma S. pH ve sıcaklığa duyarlı hidrojellerin sentezlenmesi ve ilaç salım davranışlarının modellenmesi(Yüksek Lisans Tezi). Malatya, İnönü Üniversitesi, 2016
- Hamidi M, Azadi A, Rafiei P. Hydrogel nanoparticles in drug delivery. Adv Drug Deliv Rev. 2008;60:1638-1649
- Ullah F, Othman MBH, Javed F, Ahmad Z, Akil HM. Classification, processing and application of hydrogel: A review. Mater Sci Eng C Mater Biol Appl. 2015;57:414-433
- Ahmad EM. Hydrogel: Preparation, characterization, and applications: A review. J Adv Res. 2015; 6:105-121
- Pescosolido L, Vermonden T, Malda J, Censi R, Dhert WJA, Alhaique , Hennink WE, Matricardi P. In situ forming IPN hydrogels of calcium alginate and dextran-HEMA for biomedical applications. Acta Biomater.2011;7:1627-1633
- Peppas NA, Bures P, Leobandung W, Ichikawa H. Hydrogels in pharmaceutical formulations. Eur J Pharm Biopharm.2000;50:27-46
- Chung HJ, Park TG. Self-assembled and nanostructured hydrogels for drug delivery and tissue engineering. Nano Today. 2009;4:429-437
- Varaprasad K, Raghavendra GM, Jayaramudu T, Yallapu MM, Sadiku R. A mini review on hydrogels classification and recent developments in miscellaneous applications. Mater Sci Eng C Mater Biol Appl. 2017;79:958-971
- Hennink WE, Nostrum CF. Novel crosslinking methods to design hydrogels. Adv Drug Deliv Rev. 2002;54:13-36
- Ullah F, Othman MBH, Javed F, Ahmad Z, Akil H. Classification, processing and application of hydrogels: A review. Mater Sci Eng C Mater Biol Appl. 2015;57:414-433
- Satish CS, Satish KP, Shivakumar HG. Hydrogels as controlled drug delivery systems: Synthesis, crosslinking, water and drug transport mechanism. Indian J Pharm Sci. 2006;68(2):133-140
- Ganji F, Farahani EV. Hydrogels in controlled drug delivery systems. Iran Polym J.2009;18(1):63-88
- Radhakrishnan J, Krishnan UM, Sethuraman S. Hydrogel based injectable scaffolds for cardiac tissue regeneration. Biotechnol Adv. 2014;32:449-461
- Javanbakht S, Shaabani A. Carboxymethyl cellulose-based oral delivery systems. Int J Biol Macromol. 2019;133:21-29
- Syed I, Garg S, Sarkar P. Entrapment of essential oils in hydrogels for biomedical applications. Polymeric Gels: Characterization, Properties and Biomedical Applications, 1st ed (Eds K. Pal, I Banerjee): 125-141. Woodhead Publishing, Cambridge, 2018
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- Burdick JA, Prestwich GD. Hyaluronic acid hydrogel for biomedical applications. Adv Mater. 2011;23(12):41-56
- Hamedi H, Moradi S, Hudson SM, Tonelli AE. Chitosan based hydrogels and their applications for drug delivery in wound dressings: A review. Carbohydr Polym. 2018;199: 445-460
- Ragothaman M, Palanisamy T, Kalirajan C. Collagen–poly(dialdehyde) guar gum based porous 3D scaffolds immobilized with growth factor for tissue engineering applications. Carbohydr Polym. 2014;114:399-406
- Caló E, Khutoryanskiy VV. Biomedical applications of hydrogels: A review of patents and commercial products. Eur Polym J. 2015;65:252-267
- White PM, Lewis S, Gholkar A, Sellar R, Nahser H, Cognard C, Forrester L, Wardlaw JM. Hydrogel-coated coils versus bare platinum coils for the endovascular treatment of intracranial aneurysms(HELPS): a randomised controlled trial. Lancet. 2011;377:1655-1662
- Serafin Z, Leo GD, Palys A, Nowaczewska M, Beuth W, Sardanelli F. Follow-up of cerebral aneurysm embolization with hydrogel embolic system: Systematic review and meta-analysis. Eur J Radiol. 2015;84:1954-1963
- Bai X, Gao M, Syed S, Zhuang J, Xu X, Zhang XQ. Bioactive hydrogels for bone regeneration. Bioact Mater. 2018;3:401-417
- Grigore ME Hydrogels for cardiac tissue repair and regeneration. J Cardiovasc Med (Hagerstown). 2017;4(3):49-57
- Mishra B, Upadhyay M, Reddy ASK, Vasant BG, Muthu MS. Hydrogels: An introduction to a controlled drug delivery device, synthesis and application in drug delivery and tissue engineering. Austin J Biomed Eng. 2017;4(1):1037-1049
- Peppas NA, Bures P, Leobandung W, Ichikawa H. Hydrogels in pharmaceutical formulations. Eur J Pharm Biopharm. 2000;50:27-46
- Lloyd A.W., Faragher R.G., Denyer S.P., Ocular biomaterials and implants. Biomaterials. 2001;22(8):769-785
- Loh XJ, Lee TC, Ito Y. Hydrogels for biomedical applications. Polymeric and Self Assembled Hydrogels: From Fundamental Understanding to Applications, 1st ed (Eds XJ Loh, OA Scherman) :167-209. Royal Society of Chemistry, San Diego, 2013
- Aranguez AG, Colligris B, Pintor J. Contact lenses: Promising devices for ocular drug delivery. J Ocul Pharmacol Ther. 2012; 29(2):189-99
Year 2020,
Volume: 29 Issue: 2, 129 - 137, 30.06.2020
Abstract
References
- Ferreira NN, Ferreira LMB, CardosoVMO, Boni FI, Souza AL. Gremião MPD. Recent advances in smart hydrogels for biomedical applications: From self-assembly to functional approaches. Eur Polym J. 2018;99:117-133
- Kabiri K, Zohuriaan J. Superabsorbent polymer materials: A review. Iran Polym J. 2008;17(6):451-477
- Lin CC, Metters AT. Hydrogels in controlled release formulations: Network design and mathematical modeling. Adv Drug Deliv Rev. 2006;58 (12-13):1379–1408
- Sop ES, Doku genişletme amaçlı hidrojel sentezi, karakterizasyonu ve şişme kinetiği( Yüksek Lisans Tezi). Ankara, Hacettepe Üniversitesi, 2013
- Kishida A, Ikada Y, Hydrogels for biomedical and pharmaceutical applications, Polymeric Biomaterials, Revised and Expanded. 2nd ed(Eds S. Dumitriu):133-145. Marcel Dekker, Newyork, 2002
- Wichterle O, Lim D. Hydrophilic gels for biological use. Nature. 1960;185:117-8
- Sarsılmaz F, Sarsılmaz C. Ortopedide kullanılan polimer esaslı kompozit malzemeler. Dogu Anadolu Bolge Arastirmalari Derg. 2003;3:113-7
- Brahıma S. pH ve sıcaklığa duyarlı hidrojellerin sentezlenmesi ve ilaç salım davranışlarının modellenmesi(Yüksek Lisans Tezi). Malatya, İnönü Üniversitesi, 2016
- Hamidi M, Azadi A, Rafiei P. Hydrogel nanoparticles in drug delivery. Adv Drug Deliv Rev. 2008;60:1638-1649
- Ullah F, Othman MBH, Javed F, Ahmad Z, Akil HM. Classification, processing and application of hydrogel: A review. Mater Sci Eng C Mater Biol Appl. 2015;57:414-433
- Ahmad EM. Hydrogel: Preparation, characterization, and applications: A review. J Adv Res. 2015; 6:105-121
- Pescosolido L, Vermonden T, Malda J, Censi R, Dhert WJA, Alhaique , Hennink WE, Matricardi P. In situ forming IPN hydrogels of calcium alginate and dextran-HEMA for biomedical applications. Acta Biomater.2011;7:1627-1633
- Peppas NA, Bures P, Leobandung W, Ichikawa H. Hydrogels in pharmaceutical formulations. Eur J Pharm Biopharm.2000;50:27-46
- Chung HJ, Park TG. Self-assembled and nanostructured hydrogels for drug delivery and tissue engineering. Nano Today. 2009;4:429-437
- Varaprasad K, Raghavendra GM, Jayaramudu T, Yallapu MM, Sadiku R. A mini review on hydrogels classification and recent developments in miscellaneous applications. Mater Sci Eng C Mater Biol Appl. 2017;79:958-971
- Hennink WE, Nostrum CF. Novel crosslinking methods to design hydrogels. Adv Drug Deliv Rev. 2002;54:13-36
- Ullah F, Othman MBH, Javed F, Ahmad Z, Akil H. Classification, processing and application of hydrogels: A review. Mater Sci Eng C Mater Biol Appl. 2015;57:414-433
- Satish CS, Satish KP, Shivakumar HG. Hydrogels as controlled drug delivery systems: Synthesis, crosslinking, water and drug transport mechanism. Indian J Pharm Sci. 2006;68(2):133-140
- Ganji F, Farahani EV. Hydrogels in controlled drug delivery systems. Iran Polym J.2009;18(1):63-88
- Radhakrishnan J, Krishnan UM, Sethuraman S. Hydrogel based injectable scaffolds for cardiac tissue regeneration. Biotechnol Adv. 2014;32:449-461
- Javanbakht S, Shaabani A. Carboxymethyl cellulose-based oral delivery systems. Int J Biol Macromol. 2019;133:21-29
- Syed I, Garg S, Sarkar P. Entrapment of essential oils in hydrogels for biomedical applications. Polymeric Gels: Characterization, Properties and Biomedical Applications, 1st ed (Eds K. Pal, I Banerjee): 125-141. Woodhead Publishing, Cambridge, 2018
- Roy N, Saha N. PVP-based hydrogels: Synthesis, properties and applications. Hydrogel: Synthesis, Characterization and Applications, 1st ed (Eds FV. Camara, LJ. Ferreira ):227-252. Nova Science Publishers, Lancaster, 2012
- Burdick JA, Prestwich GD. Hyaluronic acid hydrogel for biomedical applications. Adv Mater. 2011;23(12):41-56
- Hamedi H, Moradi S, Hudson SM, Tonelli AE. Chitosan based hydrogels and their applications for drug delivery in wound dressings: A review. Carbohydr Polym. 2018;199: 445-460
- Ragothaman M, Palanisamy T, Kalirajan C. Collagen–poly(dialdehyde) guar gum based porous 3D scaffolds immobilized with growth factor for tissue engineering applications. Carbohydr Polym. 2014;114:399-406
- Caló E, Khutoryanskiy VV. Biomedical applications of hydrogels: A review of patents and commercial products. Eur Polym J. 2015;65:252-267
- White PM, Lewis S, Gholkar A, Sellar R, Nahser H, Cognard C, Forrester L, Wardlaw JM. Hydrogel-coated coils versus bare platinum coils for the endovascular treatment of intracranial aneurysms(HELPS): a randomised controlled trial. Lancet. 2011;377:1655-1662
- Serafin Z, Leo GD, Palys A, Nowaczewska M, Beuth W, Sardanelli F. Follow-up of cerebral aneurysm embolization with hydrogel embolic system: Systematic review and meta-analysis. Eur J Radiol. 2015;84:1954-1963
- Bai X, Gao M, Syed S, Zhuang J, Xu X, Zhang XQ. Bioactive hydrogels for bone regeneration. Bioact Mater. 2018;3:401-417
- Grigore ME Hydrogels for cardiac tissue repair and regeneration. J Cardiovasc Med (Hagerstown). 2017;4(3):49-57
- Mishra B, Upadhyay M, Reddy ASK, Vasant BG, Muthu MS. Hydrogels: An introduction to a controlled drug delivery device, synthesis and application in drug delivery and tissue engineering. Austin J Biomed Eng. 2017;4(1):1037-1049
- Peppas NA, Bures P, Leobandung W, Ichikawa H. Hydrogels in pharmaceutical formulations. Eur J Pharm Biopharm. 2000;50:27-46
- Lloyd A.W., Faragher R.G., Denyer S.P., Ocular biomaterials and implants. Biomaterials. 2001;22(8):769-785
- Loh XJ, Lee TC, Ito Y. Hydrogels for biomedical applications. Polymeric and Self Assembled Hydrogels: From Fundamental Understanding to Applications, 1st ed (Eds XJ Loh, OA Scherman) :167-209. Royal Society of Chemistry, San Diego, 2013
- Aranguez AG, Colligris B, Pintor J. Contact lenses: Promising devices for ocular drug delivery. J Ocul Pharmacol Ther. 2012; 29(2):189-99
There are 36 citations in total.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Review |
| Authors | |
| Publication Date | June 30, 2020 |
| Acceptance Date | October 7, 2019 |
| Published in Issue | Year 2020 Volume: 29 Issue: 2 |
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