Effects of boric acid on electrolyte balance and lipid profile against renal ischemia/reperfusion injury
Abstract
Renal ischemia/reperfusion injury may occur due to hypotension, hypovolemic shock, vascular occlusion and renal transplantation. The severity of the damage increases with the duration of ischemia. Renal ischemia/reperfusion injury can also cause distant tissue damage, especially in the kidney. Boric acid with antioxidant properties is suggested to be a protective agent against ischemia / reperfusion injury. The aim of this study was to investigate the effects of boric acid on serum lipid profile and electrolyte levels in renal ischemia/reperfusion injury. 35 rats were divided into five groups: sham, ischemia/reperfusion and ischemia/reperfusion+50 mg/kg boric acid, ischemia/reperfusion+100 mg/kg boric acid, ischemia/reperfusion+200 mg/kg boric acid. Sham group was only subjected to surgical stress procedure. In the ischemia/reperfusion group, left renal artery was isolated and ischemia was induced for 45 minutes with anti-traumatic vascular clamp, followed by 24-hour reperfusion. In ischemia/reperfusion+boric acid groups, boric acid was administered intraperitoneally 10 minutes before reperfusion. Serum sodium, potassium, triglyceride, cholesterol, LDL and HDL levels were determined. In the ischemia/reperfusion injury group, boric acid decreased increasing potassium, triglyceride, cholesterol and LDL levels, while increasing decreasing sodium and HDL levels p
References
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- Ayub, A., Mackness, M.I., Arrol, S., Mackness, B., Patel, J., Durrington, P.N. (1999). Serum paraoxonase after myocardial infarction. Arteriosclerosis, Thrombosis, and Vascular Biology, 19, 330-335.
- Baykara, B., Tekmen, I., Pekcetin, C., Ulukus, C., Tuncel, P., Sagol, O., Ormen, M., Ozogul, C. (2009). The protective effects of carnosine and melatonin in ischemia reperfusion injury in the rat liver. Acta Histochemica, 111, 42-51.
- Bazzano, T., Restel, T.I., Porfirio, L.C., Souza, A.S., Silva, I.S. (2015). Renal biomarkers of male and female Wistar rats (Rattus norvegicus) undergoing renal ischemia and reperfusion. Acta Cirurgica Brasileira, 30(4), 277-88.
- Benderdour, M., Bui-Van, T., Dicko, A., Belleville, F. (1998). In vivo and in vitro effects of boron and boronated compounds. Journal of Trace Elements in Medicine and Biology, 121, 2-7.
- Bhalodia, Y., Sheth, N., Vaghasiya, J., Jivani N. (2009). Cardiac Damage Induced by Renal Ischemia/Reperfusion Injury in Hyperlipidemic Rats: Role of PPAR-a Agonist. Hong Kong Journal of Nephrology, 11, 59-65.
- Chatterjee, P.K., Cuzzocrea, S., Brown, P.A., Zacharowski, K., Stewart, K.N., Mota-Filipe, H., Thiemermann, C. (2000). Tempol, a membranepermeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat. Kidney International, 58, 658-73.
- Chatterjee, P.K., Cuzzocrea, S., Thiemermann, C. (1999). Inhibitors of poly (ADPribose) synthetase protect rat proximal tubular cells against oxidant stress. Kidney International, 56, 973-84.
- Colak, S., Geyikoglu, F., Keles, O.N., Türkez, H., Topal, A., Unal, B. (2011). The neuroprotective role of boric acid on aluminum chloride-induced neurotoxicity. Toxicology and Industrial Health, 27(8), 700-710.
- de Groot, H., Rauen, U. (2007). Ischemia-reperfusion injury: processes in pathogenic networks: a review. Transplantation Proceedings, 39, 481-4.
- Dobashi, K., Singh, I., Orak, J.K., Asayama, K., Singh, A.K. (2002). Combination therapy of N-acetylcysteine, sodium nitroprusside and phosphoramidon attenuates ischemia-reperfusion injury in rat kidney. Molecular and Cellular Biochemistry, 240, 9-17.
- Feng, W., Tang, R., Ye, X., Xue, C., Liao, Y. (2016). Identification of Genes and Pathways Associated with Kidney Ischemia-Reperfusion Injury by Bioinformatics Analyses. Kidney and Blood Pressure Research, 41, 48-54.
- Forrest, H., Nielsen, F.H. (2008). Is boron nutritionally relevant? Nutrition Reviews, 66, 183-191.
- Greenwood, N.N., Earnshaw, A. (1984). Chemistry of the elements. UK: Pergamon Press.
- Guindon, K.A., Bedard, L.L., Massey, T.E. (2007). Elevation of 8-hydroxydeoxyguanosine in DNA from isolated mouse lung cells following in vivo treatment with aflatoxin B-1. Toxicological Sciences, 98, 57-62.
- Lee, P., Prasad, K. (2003). Effects of flaxseed oil on serum lipids and atherosclerosis in hypercholesterolemic rabbits. Journal of Cardiovascular Pharmacology and Therapeutics, 8(3), 227-235.
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- Montalvo-Jave, E.E., Escalante-Tattersfield, T., Ortega-Salgado, J.A., Pina, E., Geller, D.A. (2008). Factors in the pathophysiology of the liver ischemia-reperfusion injury. Journal of Surgical Research, 147, 153-159.
- Nounou, H.A., Deif, M.M., Shalaby, M.A. (2012). Effect of flaxseed supplementation and exercise training on lipid profile, oxidative stress and inflammation in rats with myocardial ischemia. Lipids in Health and Disease, 11, 129.
- Paller, M.S. (1998). Acute renal failure: Controversies, clinical trials, and future directions. Seminars in Nephrology, 18, 482-9.
- Paragh, G., Seres, I., Balogh, Z., Varga, Z., Karpati, I., Matyus, J., Ujhelyi, L., Kakuk, G. (1998). The serum paraoxonase activity in patients with chronic renal failure and hyperlipidemia. Nephron, 80, 166-170.
- Pektas, A., Gemalmaz, H., Balkaya, M., Ünsal, C., Yenisey, Ç., Kılıçarslan, N., Çulhacı, N. (2014). The short-term protective effects of lycopene on renal ischemia-reperfusion injury in rats. Turkish Journal of Urology, 40(1), 46- 51.
- Pincemail, J., Delfraigne, J.O., Franssen, C., Bonnet, P., Deby-Dupont, G., Pirenne, J., Deby, C., Lamy, M., Limet, M., Merisse, M. (1993). Evidence for free radical formation during human kidney transplantation. Free Radical Biology and Medicine, 15, 343-8.
- Riesen, W.F., Mordasini, R.C. (2008). Update of lipid lowering therapy. Praxis, 97, 1179-1184.
- Sagiroglu, T., Torun, N., Yagci, M., Yalta, T., Sagiroglu, G., Oguz, S. (2012). Effects of apelin and leptin on renal functions following renal ischemia/reperfusion: An experimental study. Experimental and Therapeutic Medicine, 3(5), 908-914.
- Sahin, T., Begeç, Z., Toprak, H.İ., Polat, A., Vardi, N., Yücel, A., Durmuş, M., Ersoy, M.Ö. (2013). The effects of dexmedetomidine on liver ischemia-reperfusion injury in rats. Journal of Surgical Research, 183, 385-90.
- Sharifkan, A., Marjani, A., Zaker, F. (2012). Serum lipid profiles in acute myocardial infarction patients in Gorgan. Biomedical Research, 23(1), 19-124.
- Singh, D., Chander, V., Chopra, K. (2004) The effect of quercetin: A bioflavonoid on ischemia/reperfusion induced renal injury in rats. Archives of Medical Research, 35, 484-94.
- Suzuki, C., Isaka, Y., Takabatake, Y., Tanaka, H., Koike, M., Shibata, M., Uchiyama, Y., Takahara, S., Imai, E. (2008). Participation of autophagy in renal ischemia/reperfusion injury. Biochemical and Biophysical Research Communications, 368, 100-106.
- Thurman, J.M. (2007). Triggers of inflammation after renal ischemia/reperfusion. Clinical Immunology, 123, 7-13.
- Troncoso, P., Dominguez, J., Martinez, L., Zambrano, N. (1995). Oxidative damage markers in a renal ischemic- reperfusion model: the protective effect of monoamine oxidase inhibition. Transplantation Proceedings, 27, 1836- 1838.
Renal iskemi/reperfüzyon hasarına karşı borik asidin elektrolit dengesi ve lipit profili üzerine etkileri
Abstract
Hipotansiyon, hipovolemik şok, damar tıkanıklığı ve böbrek transplantasyonu gibi nedenler ile renal iskemi/reperfüzyon hasarı oluşabilir. Hasarın şiddeti iskeminin süresi ile artmaktadır. Renal iskemi/reperfüzyon hasarı başta böbrek olmak üzere uzak doku hasarlarına da neden olabilmektedir. Antioksidan özelliklere sahip borik asit iskemi/reperfüzyon hasarlarına karşı koruyucu bir ajan olabileceği önerilmektedir. Bu çalışmanın amacı, renal iskemi/reperfüzyon hasarında borik asidin serum lipit profili ve elektrolit düzeyleri üzerindeki etkilerini araştırmaktır. 35 sıçan beş gruba ayrıldı: sham, iskemi/reperfüzyon ve iskemi/reperfüzyon+50 mg/kg borik asit, iskemi/reperfüzyon+100 mg/kg borik asit, iskemi/reperfüzyon+200 mg/kg borik asit. Sham grubuna sadece cerrahi stres prosedürü uygulandı. İskemi/reperfüzyon grubunda, sol renal arter izole edilerek, anti-travmatik vaskular klemp yardımıyla 45 dakika süreyle iskemi oluşturuldu, ardından 24 saat reperfüzyon uygulandı. İskemi/reperfüzyon+borik asit gruplarında, reperfüzyondan 10 dakika önce intraperitonal olarak borik asit uygulandı. Serum sodyum, potasyum, trigliserit, kolesterol, LDL ve HDL düzeyleri belirlendi. Borik asit, iskemi/reperfüzyon hasarı grubunda artan potasyum, trigliserit, kolesterol ve LDL seviyelerini düşürürken, azalan sodyum ve HDL seviyelerini arttırmıştır p
References
- Aksit, H., Bildik, A. (2014). Determination of DNA Damage in Experimental Liver Intoxication and Role of N-Acetyl Cysteine. Cell Biochemistry Biophysics, 70, 1119-1125.
- Ayub, A., Mackness, M.I., Arrol, S., Mackness, B., Patel, J., Durrington, P.N. (1999). Serum paraoxonase after myocardial infarction. Arteriosclerosis, Thrombosis, and Vascular Biology, 19, 330-335.
- Baykara, B., Tekmen, I., Pekcetin, C., Ulukus, C., Tuncel, P., Sagol, O., Ormen, M., Ozogul, C. (2009). The protective effects of carnosine and melatonin in ischemia reperfusion injury in the rat liver. Acta Histochemica, 111, 42-51.
- Bazzano, T., Restel, T.I., Porfirio, L.C., Souza, A.S., Silva, I.S. (2015). Renal biomarkers of male and female Wistar rats (Rattus norvegicus) undergoing renal ischemia and reperfusion. Acta Cirurgica Brasileira, 30(4), 277-88.
- Benderdour, M., Bui-Van, T., Dicko, A., Belleville, F. (1998). In vivo and in vitro effects of boron and boronated compounds. Journal of Trace Elements in Medicine and Biology, 121, 2-7.
- Bhalodia, Y., Sheth, N., Vaghasiya, J., Jivani N. (2009). Cardiac Damage Induced by Renal Ischemia/Reperfusion Injury in Hyperlipidemic Rats: Role of PPAR-a Agonist. Hong Kong Journal of Nephrology, 11, 59-65.
- Chatterjee, P.K., Cuzzocrea, S., Brown, P.A., Zacharowski, K., Stewart, K.N., Mota-Filipe, H., Thiemermann, C. (2000). Tempol, a membranepermeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat. Kidney International, 58, 658-73.
- Chatterjee, P.K., Cuzzocrea, S., Thiemermann, C. (1999). Inhibitors of poly (ADPribose) synthetase protect rat proximal tubular cells against oxidant stress. Kidney International, 56, 973-84.
- Colak, S., Geyikoglu, F., Keles, O.N., Türkez, H., Topal, A., Unal, B. (2011). The neuroprotective role of boric acid on aluminum chloride-induced neurotoxicity. Toxicology and Industrial Health, 27(8), 700-710.
- de Groot, H., Rauen, U. (2007). Ischemia-reperfusion injury: processes in pathogenic networks: a review. Transplantation Proceedings, 39, 481-4.
- Dobashi, K., Singh, I., Orak, J.K., Asayama, K., Singh, A.K. (2002). Combination therapy of N-acetylcysteine, sodium nitroprusside and phosphoramidon attenuates ischemia-reperfusion injury in rat kidney. Molecular and Cellular Biochemistry, 240, 9-17.
- Feng, W., Tang, R., Ye, X., Xue, C., Liao, Y. (2016). Identification of Genes and Pathways Associated with Kidney Ischemia-Reperfusion Injury by Bioinformatics Analyses. Kidney and Blood Pressure Research, 41, 48-54.
- Forrest, H., Nielsen, F.H. (2008). Is boron nutritionally relevant? Nutrition Reviews, 66, 183-191.
- Greenwood, N.N., Earnshaw, A. (1984). Chemistry of the elements. UK: Pergamon Press.
- Guindon, K.A., Bedard, L.L., Massey, T.E. (2007). Elevation of 8-hydroxydeoxyguanosine in DNA from isolated mouse lung cells following in vivo treatment with aflatoxin B-1. Toxicological Sciences, 98, 57-62.
- Lee, P., Prasad, K. (2003). Effects of flaxseed oil on serum lipids and atherosclerosis in hypercholesterolemic rabbits. Journal of Cardiovascular Pharmacology and Therapeutics, 8(3), 227-235.
- Mackness, B., Durrington, P.N., Mackness, M.I. (1998). Human serum paraoxonase. General Pharmacology, 31, 329- 336.
- Montalvo-Jave, E.E., Escalante-Tattersfield, T., Ortega-Salgado, J.A., Pina, E., Geller, D.A. (2008). Factors in the pathophysiology of the liver ischemia-reperfusion injury. Journal of Surgical Research, 147, 153-159.
- Nounou, H.A., Deif, M.M., Shalaby, M.A. (2012). Effect of flaxseed supplementation and exercise training on lipid profile, oxidative stress and inflammation in rats with myocardial ischemia. Lipids in Health and Disease, 11, 129.
- Paller, M.S. (1998). Acute renal failure: Controversies, clinical trials, and future directions. Seminars in Nephrology, 18, 482-9.
- Paragh, G., Seres, I., Balogh, Z., Varga, Z., Karpati, I., Matyus, J., Ujhelyi, L., Kakuk, G. (1998). The serum paraoxonase activity in patients with chronic renal failure and hyperlipidemia. Nephron, 80, 166-170.
- Pektas, A., Gemalmaz, H., Balkaya, M., Ünsal, C., Yenisey, Ç., Kılıçarslan, N., Çulhacı, N. (2014). The short-term protective effects of lycopene on renal ischemia-reperfusion injury in rats. Turkish Journal of Urology, 40(1), 46- 51.
- Pincemail, J., Delfraigne, J.O., Franssen, C., Bonnet, P., Deby-Dupont, G., Pirenne, J., Deby, C., Lamy, M., Limet, M., Merisse, M. (1993). Evidence for free radical formation during human kidney transplantation. Free Radical Biology and Medicine, 15, 343-8.
- Riesen, W.F., Mordasini, R.C. (2008). Update of lipid lowering therapy. Praxis, 97, 1179-1184.
- Sagiroglu, T., Torun, N., Yagci, M., Yalta, T., Sagiroglu, G., Oguz, S. (2012). Effects of apelin and leptin on renal functions following renal ischemia/reperfusion: An experimental study. Experimental and Therapeutic Medicine, 3(5), 908-914.
- Sahin, T., Begeç, Z., Toprak, H.İ., Polat, A., Vardi, N., Yücel, A., Durmuş, M., Ersoy, M.Ö. (2013). The effects of dexmedetomidine on liver ischemia-reperfusion injury in rats. Journal of Surgical Research, 183, 385-90.
- Sharifkan, A., Marjani, A., Zaker, F. (2012). Serum lipid profiles in acute myocardial infarction patients in Gorgan. Biomedical Research, 23(1), 19-124.
- Singh, D., Chander, V., Chopra, K. (2004) The effect of quercetin: A bioflavonoid on ischemia/reperfusion induced renal injury in rats. Archives of Medical Research, 35, 484-94.
- Suzuki, C., Isaka, Y., Takabatake, Y., Tanaka, H., Koike, M., Shibata, M., Uchiyama, Y., Takahara, S., Imai, E. (2008). Participation of autophagy in renal ischemia/reperfusion injury. Biochemical and Biophysical Research Communications, 368, 100-106.
- Thurman, J.M. (2007). Triggers of inflammation after renal ischemia/reperfusion. Clinical Immunology, 123, 7-13.
- Troncoso, P., Dominguez, J., Martinez, L., Zambrano, N. (1995). Oxidative damage markers in a renal ischemic- reperfusion model: the protective effect of monoamine oxidase inhibition. Transplantation Proceedings, 27, 1836- 1838.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Research Article |
| Authors | |
| Publication Date | August 15, 2018 |
| Published in Issue | Year 2018 Volume: 11 Issue: 2 |
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