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Chronic mercury exposure: oxidative stress and neurotoxicity

Year 2017, Volume: 10 Issue: 3, 58 - 64, 15.04.2017

Ceyhan Hacıoğlu Fatih Kar

Abstract

Mercury Hg is a bioaccumulative toxic metal that poses a high risk for human and environmental health through natural and anthropogenic emissions. Hg is an environmental toxic substance that causes neurological and developmental problems in biological systems. Although the molecular mechanisms mediating Hg-induced neurotoxicity are not fully understood, studies have shown that the oxidative stress created by this toxic substance has a critical effect on neurotoxicity. The purpose of this review is to summarize and discuss experimental and epidemiological studies that are important in elucidating oxidative damage to Hg and molecular events mediating neurotoxicity

Keywords

mercury oxidative stress neurotoxicity amyloid plaques aquaporins

References

  • Amoli, J.S., Barin, A., Ebrahimi-Rad, M., Sadighara, P. (2011). Cell damage through pentose phosphate pathway in fetus fibroblast cells exposed to methyl mercury. J Appl Toxicol, 31, 685-689.
  • Aschner, M., Onishchenko, N., Ceccatelli, S. (2011). Toxicology of alkylmercury compounds. Met Ions Life Sci, 7, 403-434.
  • Aschner, M., Syversen, T., Souza, D.O., Rocha, J.B., Farina, M. (2007). Involvement of glutamate and reactive oxygen species in methylmercury neurotoxicity. Braz J Med Biol Res, 40(3), 285-91.
  • Ayton, S., Lei, P., Bush, A.I. (2015). Biometals and their therapeutic implications in Alzheimer’s disease. Neurotherapeutics, 12(1), 109-120.
  • Berglund, M., Lind, B., Björnberg, K.A., Palm, B., Einarsson, O., Vahter, M. (2005). Inter-individual variations of human mercury exposure biomarkers: a cross-sectional assessment. Environ Health, 3, 4-20.
  • Berlin, M., Zalups, R.K., Fowler, B.A. (2015). Mercury (fourth ed.). Amsterdam: Academic Press.
  • Bernard, S., Enayati, A., Redwood, L., Roger, H., Binstock, T. (2001). Autism: a novel form of mercury poisoning. Med Hypotheses, 56, 462-71.
  • Bjorklund, G., Aaseth, J., Ajsuvakova, O.P., Nikonorov, A.A., Anatoly, V., Skalny, A.V., Tinkov, A.A. (2017). Molecular interaction between mercury and selenium in neurotoxicity. Coord Chem Rev, 332, 30-37.
  • Branco, V., Caito, S., Farina, M., Teixeira da Rocha, J., Aschner, M., Carvalho, C. (2017). Biomarkers of mercury toxicity: Past, present, and future trends. J Toxicol Environ Health B Crit Rev, 20, 119-154.
  • Branco, V., Canario, J., Holmgren, A., Carvalho, C. (2011). Inhibition of the thioredoxin system in the brain and liver of zebra-seabreams exposed to waterborne methylmercury. Toxicol Appl Pharmacol, 251, 95-103.
  • Branco, V., Canario, J., Lu, J., Holmgren, A., Carvalho, C. (2012). Mercury and selenium interaction in vivo: effects on thioredoxin reductase and glutathione peroxidase. Free Radic Biol Med, 52,781-793.
  • Bridges, C.C., Zalups, R.K. (2010). Transport of inorganic mercury and methylmercury in target tissues and organs. J Toxicol Environ Health B Crit Rev, 13, 385-410.
  • Brookes, N., Kristt, D.A. (1989). Inhibition of amino acid transport and protein synthesis by HgCl2 and methylmercury in astrocytes: selectivity and reversibility. J Neurochem, 53, 1228-1237.
  • Bush, A.I., Tanzi, R.E. (2008). Therapeutics for Alzheimer’s disease based on the metal hypothesis. Neurotherapeutics, 5(3), 421-432.
  • Carneiro, M.F., Grotto, D., Barbosa, F.Jr. (2014). Inorganic and methylmercury levels in plasma are differentially associated with age, gender, and oxidative stress markers in a population exposed to mercury through fish consumption. J Toxicol Environ Health A, 77, 69-79.
  • Carvalho, C.M., Chew, E.H., Hashemy, S.I., Lu, J., Holmgren, A. (2008). Inhibition of the human thioredoxin system. A molecular mechanism of mercury toxicity. J Biol Chem, 283(18), 11913-23.
  • Carvalho, C.M., Lu, J., Zhang, X., Arner, E.S., Holmgren, A. (2011). Effects of selenite and chelating agents on mammalian thioredoxin reductase inhibited by mercury: implications for treatment of mercury poisoning. FASEB J, 25, 370-381.
  • Carvalho, M.C., Franco, J.L., Ghizoni, H., Kobus, K., Nazari, E.M., Rocha, J.B., Nogueira, C.W., Dafre, A.L., Müller, Y.M., Farina, M. (2007). Effects of 2,3-dimercapto-1-propanesulfonic acid (DMPS) on methylmercury-induced locomotor deficits and cerebellar toxicity in mice. Toxicology, 239, 195-203.
  • Cedrola, S., Guzzi, G., Ferrari, D., Gritti, A., Vescovi, A.L., Pendergrass, J.C., La Porta, C.A. (2003). Inorganic mercury changes the fate of murine CNS stem cells. FASEB J, 17, 869-871.
  • Cercy, S.P., Wankmuller, M.M. (2008). Cognitive dysfunction associated with elemental mercury ingestion and inhalation: a case study. Appl Neuropsychol, 15(1), 79-91.
  • Chin-Chan, M., Segovia, J., Quintanar, L., Arcos-Lopez, T., Hersh, L.B., Chow, K.M., Rodgers, D.W., Quintanilla- Vega, B. (2015). Mercury Reduces the Enzymatic Activity of Neprilysin in Differentiated SH-SY5Y Cells. Toxicol Sci, 145(1), 128-37.
  • Clarkson, T.W., Magos, L. (2006). The toxicology of mercury and its chemical compounds. Crit Rev Toxicol, 36, 609- 62.
  • Clarkson, T.W., Magos, L., Myers, G.J. (2003). Human exposure to mercury: The three modern dilemmas. J Trace Elem Exp Med, 16, 321-343.
  • Clarkson, T.W., Magos, L., Myers, G.J. (2003). The toxicology of mercury current exposures and clinical manifestations. N Engl J Med, 349, 1731-1737.
  • Clarkson, T.W., Vyas, J.B., Ballatori, N. (2007). Mechanisms of mercury disposition in the body. Am J Ind Med, 50(10), 757-64.
  • Compeau, G.C., Bartha, R. (1985). Sulfate-reducing bacteria: principal methylators of mercury in anoxic estuarine sediment. Appl Environ Microbiol, 50, 498-502.
  • Crowe, W., Allsopp, P.J., Watson, G.E., Magee, P.J., Strain, J.J., Armstrong, D.J., Ball, E., McSorley, E.M. (2017). Mercury as an environmental stimulus in the development of autoimmunity-a systematic review. Autoimmun Rev, 16, 72-80.
  • de Oliveira Souza, V.C., de Marco, K.C., Laure, H.J., Rosa, J.C., Barbosa, F.Jr. (2016). A brain proteome profile in rats exposed to methylmercury or thimerosal (ethylmercury). J Toxicol Environ Health A, 79, 502-512.
  • Dietrich, M.O., Mantese, C.E., Anjos, G.D., Souza, D.O., Farina, M. (2005). Motor impairment induced by oral exposure to methylmercury in adult mice. Environ Toxicol Pharmacol, 19, 169-75.
  • Dietrich, M.O., Mantese, C.E., Anjos, G.D., Souza, D.O., Farina, M. (2005). Motor impairment induced by oral exposure to methylmercury in adult mice. Environ Toxicol Pharmacol, 19(1), 169-75.
  • Dorea, J.G. (2017). Low-dose Thimerosal in pediatric vaccines: adverse effects in perspective. Environ Res, 152, 280- 293.
  • Duhr, E.F., Pendergrass, J.C., Slevin, J.T., Haley, B.E. (1993). HgEDTA complex inhibits GTP interactions with the E- site of brain beta-tubulin. Toxicol Appl Pharmacol, 122(2), 273-80.
  • Eto, K., Marumoto, M., Takeya, M. (2010). The pathology of methylmercury poisoning (Minamata disease): The 50th Anniversary of Japanese Society of Neuropathology Neuropathology, 30, 471-479.
  • Falconer, M.M., Vaillant, A., Reuhl, K.R., Laferriere, N., Brown, D.L. (1994). The molecular basis of microtubule stability in neurons. Neurotoxicology, 15(1), 109-22.
  • Farina, M., Aschner, M., Rocha, J.B. (2011). Oxidative stress in MeHg-induced neurotoxicity. Toxicol Appl Pharmacol, 256, 405-417.
  • Farina, M., Avila, D.S., da Rocha, J.B., Aschner, M. (2013). Metals, oxidative stress and neurodegeneration: A focus on iron, manganese and mercury. Neurochem Int, 62(5), 575-94.
  • Farina, M., Avila, D.S., da Rocha, J.B., Aschner, M. (2013). Metals, oxidative stress and neurodegeneration: A focus on iron, manganese and mercury. Neurochem Int, 62(5), 575-94.
  • Farina, M., Campos, F., Vendrell, I., Berenguer, J., Barzi, M., Pons, S., Sunol, C. (2009). Probucol increases glutathione peroxidase-1 activity and displays long-lasting protection against methylmercury toxicity in cerebellar granule cells. Toxicol Sci, 112, 416-26.
  • Farina, M., Rocha, J.B., Aschner, M. (2011). Mechanisms of methylmercury-induced neurotoxicity: evidence from experimental studies. Life Sci, 89, 555-63.

Kronik cıva maruziyeti: oksidatif stres ve nörotoksisite

Year 2017, Volume: 10 Issue: 3, 58 - 64, 15.04.2017

Ceyhan Hacıoğlu Fatih Kar

Abstract

Cıva Hg , doğal ve antropojenik yayılımlarıyla insan ve çevre sağlığı için yüksek risk oluşturan biyoakümülatif özellikte toksik bir metaldir. Hg, biyolojik sistemlerde nörolojik ve gelişimsel problemlere neden olan çevresel kirletici bir maddedir. Hg kaynaklı nörotoksisiteye aracılık eden moleküler mekanizmalar tamamen anlaşılmamış olmasına rağmen, bu toksik maddenin yarattığı oksidatif stresin nörotoksisite üzerinde kritik bir öneme sahip olduğu yapılan çalışmalar ile ortaya konmaktadır. Bu derlemenin amacı, Hg'ye bağlı oksidatif hasarın ve nörotoksisiteye aracılık eden moleküler olayların aydınlatılmasında önemli olan deneysel ve epidemiyolojik çalışmaları özetlemek ve tartışmaktır

Keywords

cıva oksidatif stres nörotoksisite amiloid plaklar akuaporinler

References

  • Amoli, J.S., Barin, A., Ebrahimi-Rad, M., Sadighara, P. (2011). Cell damage through pentose phosphate pathway in fetus fibroblast cells exposed to methyl mercury. J Appl Toxicol, 31, 685-689.
  • Aschner, M., Onishchenko, N., Ceccatelli, S. (2011). Toxicology of alkylmercury compounds. Met Ions Life Sci, 7, 403-434.
  • Aschner, M., Syversen, T., Souza, D.O., Rocha, J.B., Farina, M. (2007). Involvement of glutamate and reactive oxygen species in methylmercury neurotoxicity. Braz J Med Biol Res, 40(3), 285-91.
  • Ayton, S., Lei, P., Bush, A.I. (2015). Biometals and their therapeutic implications in Alzheimer’s disease. Neurotherapeutics, 12(1), 109-120.
  • Berglund, M., Lind, B., Björnberg, K.A., Palm, B., Einarsson, O., Vahter, M. (2005). Inter-individual variations of human mercury exposure biomarkers: a cross-sectional assessment. Environ Health, 3, 4-20.
  • Berlin, M., Zalups, R.K., Fowler, B.A. (2015). Mercury (fourth ed.). Amsterdam: Academic Press.
  • Bernard, S., Enayati, A., Redwood, L., Roger, H., Binstock, T. (2001). Autism: a novel form of mercury poisoning. Med Hypotheses, 56, 462-71.
  • Bjorklund, G., Aaseth, J., Ajsuvakova, O.P., Nikonorov, A.A., Anatoly, V., Skalny, A.V., Tinkov, A.A. (2017). Molecular interaction between mercury and selenium in neurotoxicity. Coord Chem Rev, 332, 30-37.
  • Branco, V., Caito, S., Farina, M., Teixeira da Rocha, J., Aschner, M., Carvalho, C. (2017). Biomarkers of mercury toxicity: Past, present, and future trends. J Toxicol Environ Health B Crit Rev, 20, 119-154.
  • Branco, V., Canario, J., Holmgren, A., Carvalho, C. (2011). Inhibition of the thioredoxin system in the brain and liver of zebra-seabreams exposed to waterborne methylmercury. Toxicol Appl Pharmacol, 251, 95-103.
  • Branco, V., Canario, J., Lu, J., Holmgren, A., Carvalho, C. (2012). Mercury and selenium interaction in vivo: effects on thioredoxin reductase and glutathione peroxidase. Free Radic Biol Med, 52,781-793.
  • Bridges, C.C., Zalups, R.K. (2010). Transport of inorganic mercury and methylmercury in target tissues and organs. J Toxicol Environ Health B Crit Rev, 13, 385-410.
  • Brookes, N., Kristt, D.A. (1989). Inhibition of amino acid transport and protein synthesis by HgCl2 and methylmercury in astrocytes: selectivity and reversibility. J Neurochem, 53, 1228-1237.
  • Bush, A.I., Tanzi, R.E. (2008). Therapeutics for Alzheimer’s disease based on the metal hypothesis. Neurotherapeutics, 5(3), 421-432.
  • Carneiro, M.F., Grotto, D., Barbosa, F.Jr. (2014). Inorganic and methylmercury levels in plasma are differentially associated with age, gender, and oxidative stress markers in a population exposed to mercury through fish consumption. J Toxicol Environ Health A, 77, 69-79.
  • Carvalho, C.M., Chew, E.H., Hashemy, S.I., Lu, J., Holmgren, A. (2008). Inhibition of the human thioredoxin system. A molecular mechanism of mercury toxicity. J Biol Chem, 283(18), 11913-23.
  • Carvalho, C.M., Lu, J., Zhang, X., Arner, E.S., Holmgren, A. (2011). Effects of selenite and chelating agents on mammalian thioredoxin reductase inhibited by mercury: implications for treatment of mercury poisoning. FASEB J, 25, 370-381.
  • Carvalho, M.C., Franco, J.L., Ghizoni, H., Kobus, K., Nazari, E.M., Rocha, J.B., Nogueira, C.W., Dafre, A.L., Müller, Y.M., Farina, M. (2007). Effects of 2,3-dimercapto-1-propanesulfonic acid (DMPS) on methylmercury-induced locomotor deficits and cerebellar toxicity in mice. Toxicology, 239, 195-203.
  • Cedrola, S., Guzzi, G., Ferrari, D., Gritti, A., Vescovi, A.L., Pendergrass, J.C., La Porta, C.A. (2003). Inorganic mercury changes the fate of murine CNS stem cells. FASEB J, 17, 869-871.
  • Cercy, S.P., Wankmuller, M.M. (2008). Cognitive dysfunction associated with elemental mercury ingestion and inhalation: a case study. Appl Neuropsychol, 15(1), 79-91.
  • Chin-Chan, M., Segovia, J., Quintanar, L., Arcos-Lopez, T., Hersh, L.B., Chow, K.M., Rodgers, D.W., Quintanilla- Vega, B. (2015). Mercury Reduces the Enzymatic Activity of Neprilysin in Differentiated SH-SY5Y Cells. Toxicol Sci, 145(1), 128-37.
  • Clarkson, T.W., Magos, L. (2006). The toxicology of mercury and its chemical compounds. Crit Rev Toxicol, 36, 609- 62.
  • Clarkson, T.W., Magos, L., Myers, G.J. (2003). Human exposure to mercury: The three modern dilemmas. J Trace Elem Exp Med, 16, 321-343.
  • Clarkson, T.W., Magos, L., Myers, G.J. (2003). The toxicology of mercury current exposures and clinical manifestations. N Engl J Med, 349, 1731-1737.
  • Clarkson, T.W., Vyas, J.B., Ballatori, N. (2007). Mechanisms of mercury disposition in the body. Am J Ind Med, 50(10), 757-64.
  • Compeau, G.C., Bartha, R. (1985). Sulfate-reducing bacteria: principal methylators of mercury in anoxic estuarine sediment. Appl Environ Microbiol, 50, 498-502.
  • Crowe, W., Allsopp, P.J., Watson, G.E., Magee, P.J., Strain, J.J., Armstrong, D.J., Ball, E., McSorley, E.M. (2017). Mercury as an environmental stimulus in the development of autoimmunity-a systematic review. Autoimmun Rev, 16, 72-80.
  • de Oliveira Souza, V.C., de Marco, K.C., Laure, H.J., Rosa, J.C., Barbosa, F.Jr. (2016). A brain proteome profile in rats exposed to methylmercury or thimerosal (ethylmercury). J Toxicol Environ Health A, 79, 502-512.
  • Dietrich, M.O., Mantese, C.E., Anjos, G.D., Souza, D.O., Farina, M. (2005). Motor impairment induced by oral exposure to methylmercury in adult mice. Environ Toxicol Pharmacol, 19, 169-75.
  • Dietrich, M.O., Mantese, C.E., Anjos, G.D., Souza, D.O., Farina, M. (2005). Motor impairment induced by oral exposure to methylmercury in adult mice. Environ Toxicol Pharmacol, 19(1), 169-75.
  • Dorea, J.G. (2017). Low-dose Thimerosal in pediatric vaccines: adverse effects in perspective. Environ Res, 152, 280- 293.
  • Duhr, E.F., Pendergrass, J.C., Slevin, J.T., Haley, B.E. (1993). HgEDTA complex inhibits GTP interactions with the E- site of brain beta-tubulin. Toxicol Appl Pharmacol, 122(2), 273-80.
  • Eto, K., Marumoto, M., Takeya, M. (2010). The pathology of methylmercury poisoning (Minamata disease): The 50th Anniversary of Japanese Society of Neuropathology Neuropathology, 30, 471-479.
  • Falconer, M.M., Vaillant, A., Reuhl, K.R., Laferriere, N., Brown, D.L. (1994). The molecular basis of microtubule stability in neurons. Neurotoxicology, 15(1), 109-22.
  • Farina, M., Aschner, M., Rocha, J.B. (2011). Oxidative stress in MeHg-induced neurotoxicity. Toxicol Appl Pharmacol, 256, 405-417.
  • Farina, M., Avila, D.S., da Rocha, J.B., Aschner, M. (2013). Metals, oxidative stress and neurodegeneration: A focus on iron, manganese and mercury. Neurochem Int, 62(5), 575-94.
  • Farina, M., Avila, D.S., da Rocha, J.B., Aschner, M. (2013). Metals, oxidative stress and neurodegeneration: A focus on iron, manganese and mercury. Neurochem Int, 62(5), 575-94.
  • Farina, M., Campos, F., Vendrell, I., Berenguer, J., Barzi, M., Pons, S., Sunol, C. (2009). Probucol increases glutathione peroxidase-1 activity and displays long-lasting protection against methylmercury toxicity in cerebellar granule cells. Toxicol Sci, 112, 416-26.
  • Farina, M., Rocha, J.B., Aschner, M. (2011). Mechanisms of methylmercury-induced neurotoxicity: evidence from experimental studies. Life Sci, 89, 555-63.
There are 39 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Ceyhan Hacıoğlu This is me

Fatih Kar

Publication Date April 15, 2017
Published in Issue Year 2017 Volume: 10 Issue: 3

Cite

APA Hacıoğlu, C., & Kar, F. (2017). Kronik cıva maruziyeti: oksidatif stres ve nörotoksisite. Biological Diversity and Conservation, 10(3), 58-64.
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