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Covid-19 Hastalarının Tedavisinde Moleküler Hidrojen İnhalasyonunun ‎Potansiyel Uygulaması

Year 2022, Volume: 3 Issue: 1, 58 - 66, 30.06.2022

Abstract

COVID-19 (Corona Virüs Hastalığı 2019), SARS-CoV-2 suşunun neden olduğu ciddi ve akut ‎solunum sendromu hastalığıdır. İlk COVID-19 vakası Aralık 2019'da ortaya çıkmış ve aylar ‎içinde tüm dünyada görülen salgın haline gelmiştir. Moleküler hidrojen (H2); reaktif oksijen ‎türlerini seçici olarak süpürmesi, inflamatuar sitokinlerin inaktivasyonu, antiapoptotik ‎özelliği sayesinde birçok hastalık üzerinde etkili bir tedavi yöntemi olarak kullanılmaktadır. ‎Özellikle inflamatuar akciğer yaralanmaları tedavisinde H2’nin terapötik etkileri, COVID-19 ‎hastalığını hafifletebileceği görüşünü desteklemektedir. Aynı zamanda, H2 erken aşamada ‎COVID-19 sırasında SARS-CoV-2'nin neden olduğu yıkıcı sitokin fırtınasını ve akciğer ‎hasarını azaltabilir. Bu nedenle moleküler hidrojen tedavisi, COVID-19 için yeni ve etkili bir ‎tedavi yöntemi olma potansiyeline sahiptir. Fakat bu hipotezin doğrulanması için daha fazla ‎klinik denemelere ihtiyaç vardır.‎

Thanks

Projeye katkılarından dolayı Epoch (Tayvan) firmasına teşekkür ederiz.‎

References

  • Alwazeer, D. Potential Cheap and effective Drug for COVID-19 ‎https://www.researchgate.net/post/Potential_Cheap_and_effective_Drug_for_COVID-19 ‎‎(accessed June 26, 2021).‎
  • Alwazeer, D. and Al, S. (2021). Moleküler Hidrojenin Sağlık Alanında Kullanımı. Karya ‎Journal of Health Science. (Yayın sürecinde)‎
  • Cabler, S., et al. (2020). "A Cytokine Circus with a Viral Ringleader: SARS-CoV-2-‎Associated Cytokine Storm Syndromes." Trends in Molecular Medicine.‎
  • Cejka, C., et al. (2020). "An Immunohistochemical Study of the Increase in Antioxidant ‎Capacity of Corneal Epithelial Cells by Molecular Hydrogen, Leading to the Suppression of ‎Alkali-Induced Oxidative Stress." Oxid Med Cell Longev 2020: 7435260.‎
  • Chen, N., et al. (2020). "Epidemiological and clinical characteristics of 99 cases of 2019 ‎novel coronavirus pneumonia in Wuhan, China: a descriptive study." The lancet 395(10223): ‎‎507-513.‎
  • Conti, P., et al. (2020). "Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung ‎inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies." ‎J Biol Regul Homeost Agents 34(2): 1.‎
  • Farooqi, F., et al. (2020). "Treatment of severe COVID-19 with tocilizumab mitigates ‎cytokine storm and averts mechanical ventilation during acute respiratory distress: a case ‎report and literature review." Trop Med Infect Dis 5(3): 112.‎
  • Guan, W.-J., et al. (2020). "Hydrogen/oxygen mixed gas inhalation improves disease severity ‎and dyspnea in patients with Coronavirus disease 2019 in a recent multicenter, open-label ‎clinical trial." J Thorac Dis 12(6): 3448.‎
  • Iketani, M. and I. Ohsawa (2017). "Molecular hydrogen as a neuroprotective agent." Current ‎neuropharmacology 15(2): 324-331.‎
  • LeBaron, T., et al. (2020). "A novel functional beverage for COVID-19 and other conditions: ‎hypothesis and preliminary data, increased blood flow, and wound healing." J Transl Sci 6: ‎‎1-6.‎
  • Liu, Y., et al. (2020). "The reproductive number of COVID-19 is higher compared to SARS ‎coronavirus." Journal of travel medicine.‎
  • Menshchikova, E., et al. (2013). "Oxidative stress and free-radical oxidation in bcg ‎granulomatosis development." Oxid Med Cell Longev 2013.‎
  • Ohsawa, I., et al. (2007). "Hydrogen acts as a therapeutic antioxidant by selectively reducing ‎cytotoxic oxygen radicals." Nat Med 13(6): 688-694.‎
  • Ohta, S. (2015). "Molecular hydrogen as a novel antioxidant: overview of the advantages of ‎hydrogen for medical applications." Methods Enzymol 555: 289-317.‎
  • Rothan, H. A. and S. N. Byrareddy (2020). "The epidemiology and pathogenesis of ‎coronavirus disease (COVID-19) outbreak." Journal of autoimmunity 109: 102433.‎
  • Russell, G., et al. "Oxy-hydrogen Gas: The Rationale Behind Its Use as a Novel and ‎Sustainable Treatment for COVID-19 and Other Respiratory Diseases."‎
  • Russell, G., et al. (2020). "An overview of SARS-CoV-2 (COVID-19) infection and the ‎importance of molecular hydrogen as an adjunctive therapy." Reactive Oxygen Species ‎‎10(28): 150–165-150–165.‎
  • Sawalha, A. H., et al. (2020). "Epigenetic dysregulation of ACE2 and interferon-regulated ‎genes might suggest increased COVID-19 susceptibility and severity in lupus patients." ‎Clinical Immunology 215: 108410.‎
  • Wang, M., et al. (2021). "Hydrogen therapy as an effective and novel adjuvant treatment ‎against COVID-19." QJM: An International Journal of Medicine 114(1): 74-75.‎
  • Wang, S.-T., et al. (2020). "Hydrogen gas (XEN) inhalation ameliorates airway ‎inflammation in asthma and COPD patients." QJM: An International Journal of Medicine ‎‎113(12): 870-875.‎
  • Xiao, M., et al. (2013). "Hydrogen-rich saline reduces airway remodeling via inactivation of ‎NF-kappaB in a murine model of asthma." Eur Rev Med Pharmacol Sci 17(8): 1033-1043.‎
  • Xu, K. (2020). Hydrogen-oxygen Inhalation For Treatment Of Covid-19, World Scientific.‎
  • Yang, F., et al. (2020). "Hydrogen: a potential new adjuvant therapy for COVID-19 patients." ‎Front Pharmacol 11: 1420.‎
  • Yang, Y., et al. (2012). "Hydrogen-rich saline protects immunocytes from radiation-induced ‎apoptosis." Medical science monitor: international medical journal of experimental and ‎clinical research 18(4): BR144.‎
  • Yuan, J., et al. (2018). "Hydrogen-rich water attenuates oxidative stress in rats with ‎traumatic brain injury via Nrf2 pathway." Journal of Surgical Research 228: 238-246.‎
  • Zolotarenko, A. D., et al. (2021). "The use of ultrapure molecular hydrogen enriched with ‎atomic hydrogen in apparatuses of artificial lung ventilation in the fight against virus ‎COVID-19." International Journal of Hydrogen Energy.‎
Year 2022, Volume: 3 Issue: 1, 58 - 66, 30.06.2022

Abstract

References

  • Alwazeer, D. Potential Cheap and effective Drug for COVID-19 ‎https://www.researchgate.net/post/Potential_Cheap_and_effective_Drug_for_COVID-19 ‎‎(accessed June 26, 2021).‎
  • Alwazeer, D. and Al, S. (2021). Moleküler Hidrojenin Sağlık Alanında Kullanımı. Karya ‎Journal of Health Science. (Yayın sürecinde)‎
  • Cabler, S., et al. (2020). "A Cytokine Circus with a Viral Ringleader: SARS-CoV-2-‎Associated Cytokine Storm Syndromes." Trends in Molecular Medicine.‎
  • Cejka, C., et al. (2020). "An Immunohistochemical Study of the Increase in Antioxidant ‎Capacity of Corneal Epithelial Cells by Molecular Hydrogen, Leading to the Suppression of ‎Alkali-Induced Oxidative Stress." Oxid Med Cell Longev 2020: 7435260.‎
  • Chen, N., et al. (2020). "Epidemiological and clinical characteristics of 99 cases of 2019 ‎novel coronavirus pneumonia in Wuhan, China: a descriptive study." The lancet 395(10223): ‎‎507-513.‎
  • Conti, P., et al. (2020). "Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung ‎inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies." ‎J Biol Regul Homeost Agents 34(2): 1.‎
  • Farooqi, F., et al. (2020). "Treatment of severe COVID-19 with tocilizumab mitigates ‎cytokine storm and averts mechanical ventilation during acute respiratory distress: a case ‎report and literature review." Trop Med Infect Dis 5(3): 112.‎
  • Guan, W.-J., et al. (2020). "Hydrogen/oxygen mixed gas inhalation improves disease severity ‎and dyspnea in patients with Coronavirus disease 2019 in a recent multicenter, open-label ‎clinical trial." J Thorac Dis 12(6): 3448.‎
  • Iketani, M. and I. Ohsawa (2017). "Molecular hydrogen as a neuroprotective agent." Current ‎neuropharmacology 15(2): 324-331.‎
  • LeBaron, T., et al. (2020). "A novel functional beverage for COVID-19 and other conditions: ‎hypothesis and preliminary data, increased blood flow, and wound healing." J Transl Sci 6: ‎‎1-6.‎
  • Liu, Y., et al. (2020). "The reproductive number of COVID-19 is higher compared to SARS ‎coronavirus." Journal of travel medicine.‎
  • Menshchikova, E., et al. (2013). "Oxidative stress and free-radical oxidation in bcg ‎granulomatosis development." Oxid Med Cell Longev 2013.‎
  • Ohsawa, I., et al. (2007). "Hydrogen acts as a therapeutic antioxidant by selectively reducing ‎cytotoxic oxygen radicals." Nat Med 13(6): 688-694.‎
  • Ohta, S. (2015). "Molecular hydrogen as a novel antioxidant: overview of the advantages of ‎hydrogen for medical applications." Methods Enzymol 555: 289-317.‎
  • Rothan, H. A. and S. N. Byrareddy (2020). "The epidemiology and pathogenesis of ‎coronavirus disease (COVID-19) outbreak." Journal of autoimmunity 109: 102433.‎
  • Russell, G., et al. "Oxy-hydrogen Gas: The Rationale Behind Its Use as a Novel and ‎Sustainable Treatment for COVID-19 and Other Respiratory Diseases."‎
  • Russell, G., et al. (2020). "An overview of SARS-CoV-2 (COVID-19) infection and the ‎importance of molecular hydrogen as an adjunctive therapy." Reactive Oxygen Species ‎‎10(28): 150–165-150–165.‎
  • Sawalha, A. H., et al. (2020). "Epigenetic dysregulation of ACE2 and interferon-regulated ‎genes might suggest increased COVID-19 susceptibility and severity in lupus patients." ‎Clinical Immunology 215: 108410.‎
  • Wang, M., et al. (2021). "Hydrogen therapy as an effective and novel adjuvant treatment ‎against COVID-19." QJM: An International Journal of Medicine 114(1): 74-75.‎
  • Wang, S.-T., et al. (2020). "Hydrogen gas (XEN) inhalation ameliorates airway ‎inflammation in asthma and COPD patients." QJM: An International Journal of Medicine ‎‎113(12): 870-875.‎
  • Xiao, M., et al. (2013). "Hydrogen-rich saline reduces airway remodeling via inactivation of ‎NF-kappaB in a murine model of asthma." Eur Rev Med Pharmacol Sci 17(8): 1033-1043.‎
  • Xu, K. (2020). Hydrogen-oxygen Inhalation For Treatment Of Covid-19, World Scientific.‎
  • Yang, F., et al. (2020). "Hydrogen: a potential new adjuvant therapy for COVID-19 patients." ‎Front Pharmacol 11: 1420.‎
  • Yang, Y., et al. (2012). "Hydrogen-rich saline protects immunocytes from radiation-induced ‎apoptosis." Medical science monitor: international medical journal of experimental and ‎clinical research 18(4): BR144.‎
  • Yuan, J., et al. (2018). "Hydrogen-rich water attenuates oxidative stress in rats with ‎traumatic brain injury via Nrf2 pathway." Journal of Surgical Research 228: 238-246.‎
  • Zolotarenko, A. D., et al. (2021). "The use of ultrapure molecular hydrogen enriched with ‎atomic hydrogen in apparatuses of artificial lung ventilation in the fight against virus ‎COVID-19." International Journal of Hydrogen Energy.‎
There are 26 citations in total.

Details

Primary Language Turkish
Subjects Agricultural Engineering
Journal Section Derleme Makaleler
Authors

Duried Alvazeer 0000-0002-2291-1628

Sümeyra Al 0000-0001-5269-6685

Mehmet Hakkı Alma 0000-0001-6323-7230

Publication Date June 30, 2022
Submission Date February 9, 2022
Acceptance Date July 9, 2022
Published in Issue Year 2022 Volume: 3 Issue: 1

Cite

APA Alvazeer, D., Al, S., & Alma, M. H. (2022). Covid-19 Hastalarının Tedavisinde Moleküler Hidrojen İnhalasyonunun ‎Potansiyel Uygulaması. Uluslararası Biyosistem Mühendisliği Dergisi, 3(1), 58-66.
AMA Alvazeer D, Al S, Alma MH. Covid-19 Hastalarının Tedavisinde Moleküler Hidrojen İnhalasyonunun ‎Potansiyel Uygulaması. UBSMD. June 2022;3(1):58-66.
Chicago Alvazeer, Duried, Sümeyra Al, and Mehmet Hakkı Alma. “Covid-19 Hastalarının Tedavisinde Moleküler Hidrojen İnhalasyonunun ‎Potansiyel Uygulaması”. Uluslararası Biyosistem Mühendisliği Dergisi 3, no. 1 (June 2022): 58-66.
EndNote Alvazeer D, Al S, Alma MH (June 1, 2022) Covid-19 Hastalarının Tedavisinde Moleküler Hidrojen İnhalasyonunun ‎Potansiyel Uygulaması. Uluslararası Biyosistem Mühendisliği Dergisi 3 1 58–66.
IEEE D. Alvazeer, S. Al, and M. H. Alma, “Covid-19 Hastalarının Tedavisinde Moleküler Hidrojen İnhalasyonunun ‎Potansiyel Uygulaması”, UBSMD, vol. 3, no. 1, pp. 58–66, 2022.
ISNAD Alvazeer, Duried et al. “Covid-19 Hastalarının Tedavisinde Moleküler Hidrojen İnhalasyonunun ‎Potansiyel Uygulaması”. Uluslararası Biyosistem Mühendisliği Dergisi 3/1 (June 2022), 58-66.
JAMA Alvazeer D, Al S, Alma MH. Covid-19 Hastalarının Tedavisinde Moleküler Hidrojen İnhalasyonunun ‎Potansiyel Uygulaması. UBSMD. 2022;3:58–66.
MLA Alvazeer, Duried et al. “Covid-19 Hastalarının Tedavisinde Moleküler Hidrojen İnhalasyonunun ‎Potansiyel Uygulaması”. Uluslararası Biyosistem Mühendisliği Dergisi, vol. 3, no. 1, 2022, pp. 58-66.
Vancouver Alvazeer D, Al S, Alma MH. Covid-19 Hastalarının Tedavisinde Moleküler Hidrojen İnhalasyonunun ‎Potansiyel Uygulaması. UBSMD. 2022;3(1):58-66.