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Kurkumin Etken Maddesinin Etkileri ve Kalite Kontrol Çalışmaları

Year 2023, Volume: 6 Issue: 1, 14 - 21, 19.06.2023

Aysu Günaydın Zafer Ömer Özdemir

Abstract

Son yıllarda, çeşitli hastalık ve semptomların tedavisinde bitkisel kökenli ilaçlar daha çok tercih edilmeye başlanmıştır. Curcuma longa L. uzun yıllardır tedavi edici etkilerinden faydalanılan bir bitkidir. Bu bitkinin ana bileşenlerinden biri kurkumindir. Doğal bir polifenol olan kurkumin, tıbbi özellikleriyle yaygın olarak bilinir. Yüzyıllardır çeşitli rahatsızlıkları tedavi etmek için geleneksel tıpta kullanılmıştır. Kurkuminin anti-enflamatuvar, antioksidan, antikanser ve antimikrobiyal aktiviteler gibi çok sayıda farmakolojik özelliğe sahip olduğu bulunmuştur. Bununla birlikte, kurkuminin etkileri, kalitesi de dahil olmak üzere çeşitli faktörlerden etkilenebilir. Bu nedenle, kurkuminin kalite kontrol çalışmaları, güvenliğini ve etkinliğini sağlamak için gereklidir. Bu araştırma makalesi, kurkuminin etkilerini ve üzerinde yapılan kalite kontrol çalışmalarını gözden geçirmeyi amaçlamaktadır.

Keywords

Kurkumin farmakolojik etki kalite kontrol tağşiş

References

  • Adrian, L. L. (2018). The problem of curcumin and its bioavailability: Could its gastrointestinal influence contribute to its overall health-enhancing effects?. Advances in Nutrition, 9(1), 41-50. https://doi.org/10.1093/advances/nmx011
  • Astinfeshan, M., Rasmi, Y., Kheradmand, F., Karimipour, M., Rahbarghazi, R., Aramwit, P. … Saboory, E. (2019). Curcumin inhibits angiogenesis in endothelial cells using downregulation of the PI3K/Akt signaling pathway. Food Biosci., 29, 86-93. https://doi.org/10.1016/j.fbio.2019.04.005
  • Barati, N., Momtazi-Borojeni, A. A., Majeed, M., & Sahebkar, A. (2019). Potential therapeutic effects of curcumin in gastric cancer. J. Cell. Physiol., 234 (3), 2317-2328. https://doi.org/10.1002/jcp.27229
  • Bejar, E. (2018). Turmeric (Curcuma longa) root and rhizome, and root and rhizome extracts. Botanical Adulterants Bulletin, May, 1-11.
  • Cao, Q., Zhang, J., Gao, L., Zhang, Y., Dai, M., & Bao, M. (2018). Dickkopf-3 upregulation mediates the cardioprotective effects of curcumin on chronic heart failure. Mol Med Rep, 17, 7249-7257. https://doi.org/10.3892/mmr.2018.8783
  • Dhakal, S., Chao, K., Schmidt, W., Qin, J., Kim, M., & Chan, D. (2016). Evaluation of turmeric powder adulterated with metanil yellow using ft-raman and ft-ir spectroscopy. Foods, 5(2), 1-15. https://doi.org/10.3390/foods5020036
  • Disilvestro, R. A., Joseph, E., Zhao, S., & Bomser, J. (2012). Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people. Nutrition Journal, 11(1), 2-9. https://doi.org/10.1186/1475-2891-11-79
  • Farzaei, M. H., Zobeiri, M., Parvizi, F., El-Senduny, F. F., Marmouzi, I., CoyBarrera, E. … Abdollahi, M. (2018). Curcumin in liver diseases: A systematic review of the cellular mechanisms of oxidative stress and clinical perspective. Nutrients, 10(7), 855. https://doi.org/10.3390/nu10070855
  • Fuloria, S., Mehta, J., Chandel, A., Sekar, M., Rani, N. N. I. M., Begum, M. Y. … Fuloria, N. K. (2022). A comprehensive review on the therapeutic potential of Curcuma longa Linn. in relation to its major active constituent curcumin. Frontiers in Pharmacology, 13, 1-27. https://doi.org/10.3389/fphar.2022.820806
  • Gleason, K., Shine, J. P., Shobnam, N., Rokoff, L. B., Suchanda, H. S., Ibne Hasan, M. O. S. … Mazumdar, M. (2014). Contaminated turmeric is a potential source of lead exposure for children in rural Bangladesh. Journal of Environmental and Public Health, 3-8. https://doi.org/10.1155/2014/730636
  • Gupta, S. C., Patchva, S., & Aggarwal, B. B. (2013). Therapeutic roles of curcumin: Lessons learned from clinical trials. AAPS Journal, 15(1), 195-218. https://doi.org/10.1208/s12248-012-9432-8
  • Kharat, M., Du, Z., Zhang, G., & McClements, D. J. (2017). Physical and chemical stability of curcumin in aqueous solutions and emulsions: Impact of pH, temperature, and molecular environment. Journal of agricultural and food chemistry, 65(8), 1525–1532. https://doi.org/10.1021/acs.jafc.6b04815
  • Kotha, R. R., & Luthria, D. L. (2019). Curcumin: Biological, pharmaceutical, nutraceutical, and analytical aspects. Molecules, 24(16), 1-27. https://doi.org/10.3390/molecules24162930
  • Li, S. (2011). Chemical composition and product quality control of turmeric (Curcuma longa L.). Pharmaceutical Crops, 5(1), 28-54. https://doi.org/10.2174/2210290601102010028
  • Macêdo, I. Y. L., Machado, F. B., Ramos, G. S., Costa, A. G. D. C., Batista, R. D., Filho, A. R. G. … Gil, E. S. (2021). Starch adulteration in turmeric samples through multivariate analysis with infrared spectroscopy. Food Chemistry, 340, 127899. https://doi.org/10.1016/j.foodchem.2020.127899
  • Mansouri, K., Rasoulpoor, S., Daneshkhah, A., Abolfathi, S., Salari, N., Mohammadi, M. … Shabani, S. (2020). Clinical effects of curcumin in enhancing cancer therapy: A systematic review. BMC Cancer, 20(1), 1-11. https://doi.org/10.1186/s12885-020-07256-8
  • Mohammadi, A., Blesso, C. N., Barreto, G.E., Banach, M., Majeed, M., & Sahebkar, A. (2019). Macrophage plasticity, polarization and function in response to curcumin, a diet-derived polyphenol, as an immunomodulatory agent. J Nutr Biochem, 66, 1-16. doi: 10.1016/j.jnutbio.2018.12.005
  • Mukherjee, P. K. (2019). Quality assurance of herbal drugs and stability testing. Quality Control and Evaluation of Herbal Drugs, chapter 19, Elsevier. https://doi.org/10.1016/b978-0-12-813374-3.00019-3
  • Paranthaman, R., Moses, J. A., & Anandharamakrishnan, C. (2021). Development of a method for qualitative detection of lead chromate adulteration in turmeric powder using X-ray powder diffraction. Food Control, 126, 107992. https://doi.org/10.1016/j.foodcont.2021.107992
  • Parvathy, V. A., Swetha, V. P., Sheeja, T. E., & Sasikumar, B. (2015). Detection of plant-based adulterants in turmeric powder using DNA barcoding. Pharmaceutical Biology, 53(12), 1774-1779. https://doi.org/10.3109/13880209.2015.1005756
  • Peng, Y., Ao, M., Dong, B., Jiang, Y., Yu, L., Chen, Z. … Xu, R. (2021). Anti-inflammatory effects of curcumin in the inflammatory diseases: Status, limitations and countermeasures. Drug Design Development and Therapy, 15, 4503-4525. https://doi.org/10.2147/DDDT.S327378
  • Shereema, R. M., Rao, T. P., Sameer Kumar, V. B., Sruthi, T. v., Vishnu, R., Prabhu, G. R. D. … Sharath Shankar, S. (2018). Individual and simultaneous electrochemical determination of metanil yellow and curcumin on carbon quantum dots based glassy carbon electrode. Materials Science and Engineering C, 93, 21-27. https://doi.org/10.1016/j.msec.2018.07.055
  • Srivastava, S., Saksena, A. K., Khattri, S., Kumar, S., & Dagur, R. S. (2016). Curcuma longa extract reduces inflammatory and oxidative stress biomarkers in osteoarthritis of knee: A four-month, double-blind, randomized, placebo-controlled trial. Inflammopharmacology, 24(6), 377-388. https://doi.org/10.1007/s10787-016-0289-9
  • Windarsih, A., Rohman, A., & Swasono, R. T. (2019). Application of 1H-NMR based metabolite fingerprinting and chemometrics for authentication of Curcuma longa adulterated with C. heyneana. Journal of Applied Research on Medicinal and Aromatic Plants, 13, 100203. https://doi.org/10.1016/j.jarmap.2019.100203
  • You, H., Gershon, H., Goren, F., Xue, F., Kantowski, T., & Monheit, L. (2022). Analytical strategies to determine the labelling accuracy and economically-motivated adulteration of “natural” dietary supplements in the marketplace: Turmeric case study. Food Chemistry, 370, 131007. https://doi.org/10.1016/j.foodchem.2021.131007
  • Moghadamtousi, S. Z., Kadir, H. A., Hassandarvish, P., Tajik, H., Abubakar, S., & Zandi, K. (2014). A review on antibacterial, antiviral, and antifungal activity of curcumin. BioMed Research International, 2014, 186864. https://doi.org/10.1155/2014/186864

Effects and Quality Control Studies of Curcumin

Year 2023, Volume: 6 Issue: 1, 14 - 21, 19.06.2023

Aysu Günaydın Zafer Ömer Özdemir

Abstract

In recent years, herbal medicines have started to be preferred more in the treatment of various diseases and symptoms. Curcuma longa L. is a plant that has been used for its therapeutic effects for many years. Curcumin, is one of the main components of this plant. Curcumin, a natural polyphenol, is widely known for its medicinal properties. It has been used in traditional medicine to treat a variety of ailments for centuries. Curcumin has been found to possess numerous pharmacological properties, such as anti-inflammatory, antioxidant, anticancer, and antimicrobial activities. However, the effects of curcumin can be influenced by various factors, including its quality. Therefore, quality control studies of curcumin are essential to ensure its safety and efficacy. This research paper aims to review the effects of curcumin and quality control studies conducted on it.

Keywords

curcumin pharmacological effect quality control adulteration

References

  • Adrian, L. L. (2018). The problem of curcumin and its bioavailability: Could its gastrointestinal influence contribute to its overall health-enhancing effects?. Advances in Nutrition, 9(1), 41-50. https://doi.org/10.1093/advances/nmx011
  • Astinfeshan, M., Rasmi, Y., Kheradmand, F., Karimipour, M., Rahbarghazi, R., Aramwit, P. … Saboory, E. (2019). Curcumin inhibits angiogenesis in endothelial cells using downregulation of the PI3K/Akt signaling pathway. Food Biosci., 29, 86-93. https://doi.org/10.1016/j.fbio.2019.04.005
  • Barati, N., Momtazi-Borojeni, A. A., Majeed, M., & Sahebkar, A. (2019). Potential therapeutic effects of curcumin in gastric cancer. J. Cell. Physiol., 234 (3), 2317-2328. https://doi.org/10.1002/jcp.27229
  • Bejar, E. (2018). Turmeric (Curcuma longa) root and rhizome, and root and rhizome extracts. Botanical Adulterants Bulletin, May, 1-11.
  • Cao, Q., Zhang, J., Gao, L., Zhang, Y., Dai, M., & Bao, M. (2018). Dickkopf-3 upregulation mediates the cardioprotective effects of curcumin on chronic heart failure. Mol Med Rep, 17, 7249-7257. https://doi.org/10.3892/mmr.2018.8783
  • Dhakal, S., Chao, K., Schmidt, W., Qin, J., Kim, M., & Chan, D. (2016). Evaluation of turmeric powder adulterated with metanil yellow using ft-raman and ft-ir spectroscopy. Foods, 5(2), 1-15. https://doi.org/10.3390/foods5020036
  • Disilvestro, R. A., Joseph, E., Zhao, S., & Bomser, J. (2012). Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people. Nutrition Journal, 11(1), 2-9. https://doi.org/10.1186/1475-2891-11-79
  • Farzaei, M. H., Zobeiri, M., Parvizi, F., El-Senduny, F. F., Marmouzi, I., CoyBarrera, E. … Abdollahi, M. (2018). Curcumin in liver diseases: A systematic review of the cellular mechanisms of oxidative stress and clinical perspective. Nutrients, 10(7), 855. https://doi.org/10.3390/nu10070855
  • Fuloria, S., Mehta, J., Chandel, A., Sekar, M., Rani, N. N. I. M., Begum, M. Y. … Fuloria, N. K. (2022). A comprehensive review on the therapeutic potential of Curcuma longa Linn. in relation to its major active constituent curcumin. Frontiers in Pharmacology, 13, 1-27. https://doi.org/10.3389/fphar.2022.820806
  • Gleason, K., Shine, J. P., Shobnam, N., Rokoff, L. B., Suchanda, H. S., Ibne Hasan, M. O. S. … Mazumdar, M. (2014). Contaminated turmeric is a potential source of lead exposure for children in rural Bangladesh. Journal of Environmental and Public Health, 3-8. https://doi.org/10.1155/2014/730636
  • Gupta, S. C., Patchva, S., & Aggarwal, B. B. (2013). Therapeutic roles of curcumin: Lessons learned from clinical trials. AAPS Journal, 15(1), 195-218. https://doi.org/10.1208/s12248-012-9432-8
  • Kharat, M., Du, Z., Zhang, G., & McClements, D. J. (2017). Physical and chemical stability of curcumin in aqueous solutions and emulsions: Impact of pH, temperature, and molecular environment. Journal of agricultural and food chemistry, 65(8), 1525–1532. https://doi.org/10.1021/acs.jafc.6b04815
  • Kotha, R. R., & Luthria, D. L. (2019). Curcumin: Biological, pharmaceutical, nutraceutical, and analytical aspects. Molecules, 24(16), 1-27. https://doi.org/10.3390/molecules24162930
  • Li, S. (2011). Chemical composition and product quality control of turmeric (Curcuma longa L.). Pharmaceutical Crops, 5(1), 28-54. https://doi.org/10.2174/2210290601102010028
  • Macêdo, I. Y. L., Machado, F. B., Ramos, G. S., Costa, A. G. D. C., Batista, R. D., Filho, A. R. G. … Gil, E. S. (2021). Starch adulteration in turmeric samples through multivariate analysis with infrared spectroscopy. Food Chemistry, 340, 127899. https://doi.org/10.1016/j.foodchem.2020.127899
  • Mansouri, K., Rasoulpoor, S., Daneshkhah, A., Abolfathi, S., Salari, N., Mohammadi, M. … Shabani, S. (2020). Clinical effects of curcumin in enhancing cancer therapy: A systematic review. BMC Cancer, 20(1), 1-11. https://doi.org/10.1186/s12885-020-07256-8
  • Mohammadi, A., Blesso, C. N., Barreto, G.E., Banach, M., Majeed, M., & Sahebkar, A. (2019). Macrophage plasticity, polarization and function in response to curcumin, a diet-derived polyphenol, as an immunomodulatory agent. J Nutr Biochem, 66, 1-16. doi: 10.1016/j.jnutbio.2018.12.005
  • Mukherjee, P. K. (2019). Quality assurance of herbal drugs and stability testing. Quality Control and Evaluation of Herbal Drugs, chapter 19, Elsevier. https://doi.org/10.1016/b978-0-12-813374-3.00019-3
  • Paranthaman, R., Moses, J. A., & Anandharamakrishnan, C. (2021). Development of a method for qualitative detection of lead chromate adulteration in turmeric powder using X-ray powder diffraction. Food Control, 126, 107992. https://doi.org/10.1016/j.foodcont.2021.107992
  • Parvathy, V. A., Swetha, V. P., Sheeja, T. E., & Sasikumar, B. (2015). Detection of plant-based adulterants in turmeric powder using DNA barcoding. Pharmaceutical Biology, 53(12), 1774-1779. https://doi.org/10.3109/13880209.2015.1005756
  • Peng, Y., Ao, M., Dong, B., Jiang, Y., Yu, L., Chen, Z. … Xu, R. (2021). Anti-inflammatory effects of curcumin in the inflammatory diseases: Status, limitations and countermeasures. Drug Design Development and Therapy, 15, 4503-4525. https://doi.org/10.2147/DDDT.S327378
  • Shereema, R. M., Rao, T. P., Sameer Kumar, V. B., Sruthi, T. v., Vishnu, R., Prabhu, G. R. D. … Sharath Shankar, S. (2018). Individual and simultaneous electrochemical determination of metanil yellow and curcumin on carbon quantum dots based glassy carbon electrode. Materials Science and Engineering C, 93, 21-27. https://doi.org/10.1016/j.msec.2018.07.055
  • Srivastava, S., Saksena, A. K., Khattri, S., Kumar, S., & Dagur, R. S. (2016). Curcuma longa extract reduces inflammatory and oxidative stress biomarkers in osteoarthritis of knee: A four-month, double-blind, randomized, placebo-controlled trial. Inflammopharmacology, 24(6), 377-388. https://doi.org/10.1007/s10787-016-0289-9
  • Windarsih, A., Rohman, A., & Swasono, R. T. (2019). Application of 1H-NMR based metabolite fingerprinting and chemometrics for authentication of Curcuma longa adulterated with C. heyneana. Journal of Applied Research on Medicinal and Aromatic Plants, 13, 100203. https://doi.org/10.1016/j.jarmap.2019.100203
  • You, H., Gershon, H., Goren, F., Xue, F., Kantowski, T., & Monheit, L. (2022). Analytical strategies to determine the labelling accuracy and economically-motivated adulteration of “natural” dietary supplements in the marketplace: Turmeric case study. Food Chemistry, 370, 131007. https://doi.org/10.1016/j.foodchem.2021.131007
  • Moghadamtousi, S. Z., Kadir, H. A., Hassandarvish, P., Tajik, H., Abubakar, S., & Zandi, K. (2014). A review on antibacterial, antiviral, and antifungal activity of curcumin. BioMed Research International, 2014, 186864. https://doi.org/10.1155/2014/186864
There are 26 citations in total.

Details

Primary Language Turkish
Subjects Pharmacology and Pharmaceutical Sciences
Journal Section Articles
Authors

Aysu Günaydın

Zafer Ömer Özdemir 0000-0002-8362-3136

Publication Date June 19, 2023
Published in Issue Year 2023 Volume: 6 Issue: 1

Cite

APA Günaydın, A., & Özdemir, Z. Ö. (2023). Kurkumin Etken Maddesinin Etkileri ve Kalite Kontrol Çalışmaları. Dünya Sağlık Ve Tabiat Bilimleri Dergisi, 6(1), 14-21.
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