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Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study

Year 2018, Volume: 31 Issue: 2, 399 - 406, 01.06.2018

Fatma Gökçe Apaydın Kaan Kaltalıoğlu Barbaros Balabanlı Şule Coskun Cevher

Abstract

In this study, we investigated that the histopathological
changes of rat kidney and liver tissues after cisplatin administration and potential
beneficial effects of morin and hesperidin administration. Wistar rats were
randomly divided in 7 groups: control, morin (M), hesperidin (H), cisplatin
(CP), cisplatin+morin (CP+M), cisplatin+hesperidin (CP+H), cisplatin+morin+hesperidin
(CP+M+H). Kidney and liver tissues were collected at the end of the experiment
and were evaluated histopathological changes. Various histopathological changes
in kidney and liver tissues of cisplatin-induced group were revealed. However, pre-
and co-treatment of morin and/or hesperidin partially prevented these
hepatotoxic and nephrotoxic changes in cisplatin-induced groups.

Keywords

Cisplatin Hepatotoxicity Hesperidin Histopathology Morin

References

  • [1] Radwan, R.R., and Abdel Fattah, S.M., “Mechanisms involved in the possible nephroprotective effect of rutin and low dose γ irradiation against cisplatin-induced nephropathy in rats”, J. Photochem. Photobiol. B Biol., 169: 56–62, (2017).
  • [2] Shaik, A.N., Altomare, D.A., Lesko, L.J., and Trame, M.N., “Development and validation of a LC–MS/MS assay for quantification of cisplatin in rat plasma and urine”, J. Chromatogr. B 1046: 243–249, (2017).
  • [3] Nasr, A.Y., “Protective effect of aged garlic extract against the oxidative stress induced by cisplatin on blood cells parameters and hepatic antioxidant enzymes in rats”, Toxicol. Reports. 1: 682–691, (2014).
  • [4] Yang, Z., Schumake, L.M., Egorin, M.J., E.G., Zuhowski, Z., and Guo, K.J., “Cisplatin preferentially binds mitochondrial DNA and voltage-dependent anion channel protein in the mitochondrial membrane of head and neck squamous cell carcinoma: possible role in apoptosis”, Clin. Cancer Res. 12: 5817–5825, (2006).
  • [5] Omar, H.A., Mohameda, W.R., Arafa, E.A., Shehata, B.A., El Sherbincy, G.A., Arab, H.H., and Elgendy, A.N., “Hesperidin alleviates cisplatin-induced hepatotoxicity in rats without inhibiting its antitumor activity”, Pharmacol. Reports. 68: 349–356, (2016).
  • [6] Callejo, A., Durochat, A., Bressieux, S., Saleur, A., Chabbert, C., Juan, I.D., Llorens, J., and Gaboyard-Niay, S., “Dose-dependent cochlear and vestibular toxicity of trans-tympanic cisplatin in the rat”, NeuroToxicology, 60: 1–9, (2017).
  • [7] Heeba, G.H., Hamza, A.A., and Hassanin, S.O., “Induction of heme oxygenase-1 with hemin alleviates cisplatin-induced reproductive toxicity in male rats and enhances its cytotoxicity in prostate cancer cell line”, Toxicol. Lett. 264: 38–50, (2016).
  • [8] Reddy, K.P., Madhu, P., and Reddy, P.S., “Protective effects of resveratrol against cisplatin-induced testicular and epididymal toxicity in rats”, Food Chem. Toxicol. 91: 65-72, (2016).
  • [9] El-Awady, E.E., Moustafa, Y.M., Abo-Elmatty, D.M., and Radwan, A., “Cisplatin-induced cardiotoxicity: Mechanisms and cardioprotective strategies”, Eur. J. Pharmacol. 650: 335–341, (2011).
  • [10] Hassan, M.S., Morgan, A.M., Mekawy, M.M., Zaki, A.R., and Ghazi, Z.M., “Teratogenic effect of cisplatin in rats and the protective role of sodium selenite”, Exp. Toxicol. Pathol. 68: 277–287, (2016).
  • [11] Szentmihályi, K., Maya, Z., Szénási, G., Máthé, C., Sebestény, A., Albert, M., Hegyi, G., and Blázovics, A., “Changes of essential element content and prevention of cisplatin induced oxidative stress in rat liver by CV247 administration”, Eu. JIM. 8: 36–41, (2016).
  • [12] Kılıc, C., Gülec-Peker, E.G., Acartürk, F., Sarı Kılıcaslan, S.M., and Coskun-Cevher, S., “Investigation of the effects of local glutathione and chitosan administration on incisional oral mucosal wound healing in rabbits”, Colloid Surface, B 112: 499–507, (2013).
  • [13] Kaltalioglu, K.,and Coskun-Cevher, S., “Potential of morin and hesperidin in the prevention of cisplatin-induced nephrotoxicity”, Renal Failure, 38: 1291–1299, (2016).
  • [14] Apaydın, F.G., Bas, H., Kalender, S., and Kalender, Y., “Bendiocarb induced histopathological and biochemical alterations in rat liver and preventive role of vitamins C and E”. Environ. Toxicol. Pharmacol. 49: 148–155, (2017).
  • [15] Uzun, F.G., and Kalender, Y., “Chlorpyrifos induced hepatotoxic and hematologic changes in rats: The role of quercetin and catechin”, Food Chem. Toxicol. 55: 549-556, (2013).
  • [16] Shehata, A.S., Amera, M.G., Abd El-Haleem, M.R., and Karam RA., “The ability of hesperidin compared to that of insulin for preventing osteoporosis induced by type I diabetes in young male albino rats: A histological and biochemical study”, Exp. Toxicol. Pathol. 69: 203–212, (2017).
  • [17] Zareei, S., Boojar, M.M.A., and Amanlou, M., “Inhibition of liver alanine aminotransferase and aspartate aminotransferase by hesperidin and its aglycone hesperetin: An in vitro and in silico study”, Life Sciences, 178: 49–55, (2017).
  • [18] Sultana, F., Neog, M.K., and Rasool, M.K., “Targeted delivery of morin, a dietary bioflavanol encapsulated mannosylated liposomes to the macrophages of adjuvant-induced arthritis rats inhibits inflammatory immune response and osteoclastogenesis”, Eur. J. Pharm. Biopharm. 115: 229–242, (2017). [19] Khan, M.H.A., and Parvez, S., “Hesperidin ameliorates heavy metal induced toxicity mediated by oxidative stress in brain of Wistar rats”, J. Trace Elem. Med. Bio. 31: 53–60, (2015).
  • [20] Mahmoud, A..M, Ashour, M.B., Abdel-Moneim, A., and Ahmed, O.M., “Hesperidin and naringin attenuate hyperglycemia-mediated oxidative stress and proinflammatory cytokine production in high fat fed/streptozotocin-induced type 2 diabetic rats”, J. Diabetes Complicat. 26: 483–90, (2012).
  • [21] Jung, K., An, J.M., Eom, D., Kang, K.S., and Kim, S., “Preventive effect of fermented black ginseng against cisplatin-induced nephrotoxicity in rats”, J. Ginseng Res., 41: 188-194, (2017).
  • [22] Tilyek, A., Chai, C., Hou, X., Zhou, B., Zhang, C., Cao, Z., and Yu, B., “The protective effects of Ribes diacanthum Pallon cisplatin-induced nephrotoxicity in mice”, J. Ethnopharmacol. 178: 297–306, (2016).
  • [23] Ongjanović, B.I., Marković, S.D., ĐorŠđević, N.Z., Trbojević, I.S., Štajn, A.Š., and Saičić, Z.S., “Cadmium-induced lipid peroxidation and changes in antioxidant defense system in the rat testes: Protective role of coenzyme Q10 and Vitamin E”, Reprod. Toxicol. 29: 191-197, (2010).
  • [24] Elhalwagy, M.E.A., Darwish, N.S., and Zaher, E.M., “Prophylactic effect of green tea polyphenols against liver and kidney injury induced by fenitrothion insecticide”, Pestic. Biochem. Phys. 91: 81-89, (2008).
  • [25] Manucha, W., and Vallés, P.G., “Apoptosis modulated by oxidative stress and inflammation during obstructive nephropathy”, Inflamm. Allergy Drug Targets. 11: 303-12, (2012).
  • [26] Ozbek, E., “Induction of oxidative stress in kidney”, Int. J. Nephrol. 2012: 465-897, (2012).
  • [27] Harborne, J.B., and Williams, C.A., “Advantages in flavonoid research since 1992”, Phytochemistry, 55: 481-504, (2000).
  • [28] Ke, Y., Liu, C., Hao, J., Lu, L., Lu, N., Wu, Z., Zhu, S., and Chen, X., “Morin inhibits cell proliferation and fibronectin accumulation in rat glomerular mesangial cells cultured under high glucose condition”, Biomed. Pharmacother. 84: 622–627, (2016).

Year 2018, Volume: 31 Issue: 2, 399 - 406, 01.06.2018

Fatma Gökçe Apaydın Kaan Kaltalıoğlu Barbaros Balabanlı Şule Coskun Cevher

Abstract

References

  • [1] Radwan, R.R., and Abdel Fattah, S.M., “Mechanisms involved in the possible nephroprotective effect of rutin and low dose γ irradiation against cisplatin-induced nephropathy in rats”, J. Photochem. Photobiol. B Biol., 169: 56–62, (2017).
  • [2] Shaik, A.N., Altomare, D.A., Lesko, L.J., and Trame, M.N., “Development and validation of a LC–MS/MS assay for quantification of cisplatin in rat plasma and urine”, J. Chromatogr. B 1046: 243–249, (2017).
  • [3] Nasr, A.Y., “Protective effect of aged garlic extract against the oxidative stress induced by cisplatin on blood cells parameters and hepatic antioxidant enzymes in rats”, Toxicol. Reports. 1: 682–691, (2014).
  • [4] Yang, Z., Schumake, L.M., Egorin, M.J., E.G., Zuhowski, Z., and Guo, K.J., “Cisplatin preferentially binds mitochondrial DNA and voltage-dependent anion channel protein in the mitochondrial membrane of head and neck squamous cell carcinoma: possible role in apoptosis”, Clin. Cancer Res. 12: 5817–5825, (2006).
  • [5] Omar, H.A., Mohameda, W.R., Arafa, E.A., Shehata, B.A., El Sherbincy, G.A., Arab, H.H., and Elgendy, A.N., “Hesperidin alleviates cisplatin-induced hepatotoxicity in rats without inhibiting its antitumor activity”, Pharmacol. Reports. 68: 349–356, (2016).
  • [6] Callejo, A., Durochat, A., Bressieux, S., Saleur, A., Chabbert, C., Juan, I.D., Llorens, J., and Gaboyard-Niay, S., “Dose-dependent cochlear and vestibular toxicity of trans-tympanic cisplatin in the rat”, NeuroToxicology, 60: 1–9, (2017).
  • [7] Heeba, G.H., Hamza, A.A., and Hassanin, S.O., “Induction of heme oxygenase-1 with hemin alleviates cisplatin-induced reproductive toxicity in male rats and enhances its cytotoxicity in prostate cancer cell line”, Toxicol. Lett. 264: 38–50, (2016).
  • [8] Reddy, K.P., Madhu, P., and Reddy, P.S., “Protective effects of resveratrol against cisplatin-induced testicular and epididymal toxicity in rats”, Food Chem. Toxicol. 91: 65-72, (2016).
  • [9] El-Awady, E.E., Moustafa, Y.M., Abo-Elmatty, D.M., and Radwan, A., “Cisplatin-induced cardiotoxicity: Mechanisms and cardioprotective strategies”, Eur. J. Pharmacol. 650: 335–341, (2011).
  • [10] Hassan, M.S., Morgan, A.M., Mekawy, M.M., Zaki, A.R., and Ghazi, Z.M., “Teratogenic effect of cisplatin in rats and the protective role of sodium selenite”, Exp. Toxicol. Pathol. 68: 277–287, (2016).
  • [11] Szentmihályi, K., Maya, Z., Szénási, G., Máthé, C., Sebestény, A., Albert, M., Hegyi, G., and Blázovics, A., “Changes of essential element content and prevention of cisplatin induced oxidative stress in rat liver by CV247 administration”, Eu. JIM. 8: 36–41, (2016).
  • [12] Kılıc, C., Gülec-Peker, E.G., Acartürk, F., Sarı Kılıcaslan, S.M., and Coskun-Cevher, S., “Investigation of the effects of local glutathione and chitosan administration on incisional oral mucosal wound healing in rabbits”, Colloid Surface, B 112: 499–507, (2013).
  • [13] Kaltalioglu, K.,and Coskun-Cevher, S., “Potential of morin and hesperidin in the prevention of cisplatin-induced nephrotoxicity”, Renal Failure, 38: 1291–1299, (2016).
  • [14] Apaydın, F.G., Bas, H., Kalender, S., and Kalender, Y., “Bendiocarb induced histopathological and biochemical alterations in rat liver and preventive role of vitamins C and E”. Environ. Toxicol. Pharmacol. 49: 148–155, (2017).
  • [15] Uzun, F.G., and Kalender, Y., “Chlorpyrifos induced hepatotoxic and hematologic changes in rats: The role of quercetin and catechin”, Food Chem. Toxicol. 55: 549-556, (2013).
  • [16] Shehata, A.S., Amera, M.G., Abd El-Haleem, M.R., and Karam RA., “The ability of hesperidin compared to that of insulin for preventing osteoporosis induced by type I diabetes in young male albino rats: A histological and biochemical study”, Exp. Toxicol. Pathol. 69: 203–212, (2017).
  • [17] Zareei, S., Boojar, M.M.A., and Amanlou, M., “Inhibition of liver alanine aminotransferase and aspartate aminotransferase by hesperidin and its aglycone hesperetin: An in vitro and in silico study”, Life Sciences, 178: 49–55, (2017).
  • [18] Sultana, F., Neog, M.K., and Rasool, M.K., “Targeted delivery of morin, a dietary bioflavanol encapsulated mannosylated liposomes to the macrophages of adjuvant-induced arthritis rats inhibits inflammatory immune response and osteoclastogenesis”, Eur. J. Pharm. Biopharm. 115: 229–242, (2017). [19] Khan, M.H.A., and Parvez, S., “Hesperidin ameliorates heavy metal induced toxicity mediated by oxidative stress in brain of Wistar rats”, J. Trace Elem. Med. Bio. 31: 53–60, (2015).
  • [20] Mahmoud, A..M, Ashour, M.B., Abdel-Moneim, A., and Ahmed, O.M., “Hesperidin and naringin attenuate hyperglycemia-mediated oxidative stress and proinflammatory cytokine production in high fat fed/streptozotocin-induced type 2 diabetic rats”, J. Diabetes Complicat. 26: 483–90, (2012).
  • [21] Jung, K., An, J.M., Eom, D., Kang, K.S., and Kim, S., “Preventive effect of fermented black ginseng against cisplatin-induced nephrotoxicity in rats”, J. Ginseng Res., 41: 188-194, (2017).
  • [22] Tilyek, A., Chai, C., Hou, X., Zhou, B., Zhang, C., Cao, Z., and Yu, B., “The protective effects of Ribes diacanthum Pallon cisplatin-induced nephrotoxicity in mice”, J. Ethnopharmacol. 178: 297–306, (2016).
  • [23] Ongjanović, B.I., Marković, S.D., ĐorŠđević, N.Z., Trbojević, I.S., Štajn, A.Š., and Saičić, Z.S., “Cadmium-induced lipid peroxidation and changes in antioxidant defense system in the rat testes: Protective role of coenzyme Q10 and Vitamin E”, Reprod. Toxicol. 29: 191-197, (2010).
  • [24] Elhalwagy, M.E.A., Darwish, N.S., and Zaher, E.M., “Prophylactic effect of green tea polyphenols against liver and kidney injury induced by fenitrothion insecticide”, Pestic. Biochem. Phys. 91: 81-89, (2008).
  • [25] Manucha, W., and Vallés, P.G., “Apoptosis modulated by oxidative stress and inflammation during obstructive nephropathy”, Inflamm. Allergy Drug Targets. 11: 303-12, (2012).
  • [26] Ozbek, E., “Induction of oxidative stress in kidney”, Int. J. Nephrol. 2012: 465-897, (2012).
  • [27] Harborne, J.B., and Williams, C.A., “Advantages in flavonoid research since 1992”, Phytochemistry, 55: 481-504, (2000).
  • [28] Ke, Y., Liu, C., Hao, J., Lu, L., Lu, N., Wu, Z., Zhu, S., and Chen, X., “Morin inhibits cell proliferation and fibronectin accumulation in rat glomerular mesangial cells cultured under high glucose condition”, Biomed. Pharmacother. 84: 622–627, (2016).
There are 27 citations in total.

Details

Primary Language English
Subjects Engineering
Journal Section Biology
Authors

Fatma Gökçe Apaydın

Kaan Kaltalıoğlu

Barbaros Balabanlı

Şule Coskun Cevher

Publication Date June 1, 2018
Published in Issue Year 2018 Volume: 31 Issue: 2

Cite

APA Apaydın, F. G., Kaltalıoğlu, K., Balabanlı, B., Coskun Cevher, Ş. (2018). Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study. Gazi University Journal of Science, 31(2), 399-406.
AMA Apaydın FG, Kaltalıoğlu K, Balabanlı B, Coskun Cevher Ş. Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study. Gazi University Journal of Science. June 2018;31(2):399-406.
Chicago Apaydın, Fatma Gökçe, Kaan Kaltalıoğlu, Barbaros Balabanlı, and Şule Coskun Cevher. “Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study”. Gazi University Journal of Science 31, no. 2 (June 2018): 399-406.
EndNote Apaydın FG, Kaltalıoğlu K, Balabanlı B, Coskun Cevher Ş (June 1, 2018) Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study. Gazi University Journal of Science 31 2 399–406.
IEEE F. G. Apaydın, K. Kaltalıoğlu, B. Balabanlı, and Ş. Coskun Cevher, “Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study”, Gazi University Journal of Science, vol. 31, no. 2, pp. 399–406, 2018.
ISNAD Apaydın, Fatma Gökçe et al. “Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study”. Gazi University Journal of Science 31/2 (June 2018), 399-406.
JAMA Apaydın FG, Kaltalıoğlu K, Balabanlı B, Coskun Cevher Ş. Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study. Gazi University Journal of Science. 2018;31:399–406.
MLA Apaydın, Fatma Gökçe et al. “Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study”. Gazi University Journal of Science, vol. 31, no. 2, 2018, pp. 399-06.
Vancouver Apaydın FG, Kaltalıoğlu K, Balabanlı B, Coskun Cevher Ş. Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study. Gazi University Journal of Science. 2018;31(2):399-406.