Phenolic Content, Antioxidant and Antimicrobial Potential of Endemic Ferulago platycarpa

Falah Saleh Mohammed; Selami Günal; Mustafa Pehlivan; Muhittin Doğan; Mustafa Sevindik; Hasan Akgül

doi:10.35378/gujs.707555

Research Article

Year 2020, Volume: 33 Issue: 4, 670 - 677, 01.12.2020

Falah Saleh Mohammed Selami Günal Mustafa Pehlivan Muhittin Doğan Mustafa Sevindik Hasan Akgül

https://doi.org/10.35378/gujs.707555

Cited By: 12

Abstract

References

[1] Mohammed, F.S., Karakaş, M., Akgül, H., Sevindik, M., “Medicinal Properties of Allium calocephalum Collected from Gara Mountain (Iraq)”, Fresen Environ Bull, 28(10): 7419-7426, (2019).
[2] Saxena, M., Saxena, J., Nema, R., Singh, D., Gupta, A., “Phytochemistry of medicinal plants”, J Pharmacogn Phytochem, 1: 168-182, (2013).
[3] Mohammed, F. S., Akgul, H., Sevindik, M., Khaled, B. M. T., “Phenolic content and biological activities of Rhus coriaria var. zebaria”, Fresenius Environmental Bulletin, 27(8), 5694-5702, (2018).
[4] Ji, H.F., Li, X.J., Zhang, H.Y., “Natural products and drug discovery: can thousands of years of ancient medical knowledge lead us to new and powerful drug combinations in the fight against cancer and dementia? ”, EMBO reports, 10:194-200, (2009).
[5] Ekor, M., “The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety”, Front. Pharmacol, 4: 177, (2014).
[6] Pan, S.Y., Zhou, S.F., Gao, S.H., Yu, Z.L., Zhang, S.F., Tang, M.K., Sun, J.N., Ma, D.L., Han, Y.F., Fong, W.F., Ko, K.M., “New perspectives on how to discover drugs from herbal medicines: CAM's outstanding contribution to modern therapeutics”, Evid.-Based Complement. Altern. Med., (2013). http://dx.doi.org/10.1155/2013/627375
[7] Ghasemi Pirbalouti, A., Izadi, A., Malek Poor, F., Hamedi, B., “Chemical composition, antioxidant and antibacterial activities of essential oils from Ferulago angulata”, Pharm. Biol, 54: 2515-2520, (2016).
[8] Bakar, F., Karakay, S., Delimustafaoğlu, B., Gül, F., Sibel, K.C., “Anticancer effect of Ferulago mughlea Peşmen (Apiaceae) on cancer cell proliferation”, Iran J Pharm Res, 15: 501, (2016).
[9] Harborne, J.B., “The Natural Coumarıns: Occurrence, Chemıstry And Bıochemıstry (Book) ”, Plant, Cell & Environ, 5: 435-436, (1982).
[10] Shahbazi, Y., Shavisi, N., Karami, N., Shabnam, K., “Chemical Composition and in Vitro Antibacterial Activity of Ferulago angulata (Schlecht.) Boiss Essential Oil”, Pharm Sci. 21: 6-11, (2015).
[11] El-Thaher, T.S., Matalka, K.Z., Taha, H.A., Badwan, A.A., “Ferula harmonis ‘zallouh’and enhancing erectile function in rats: efficacy and toxicity study”, Int J Impot Res, 13: 247, (2001).
[12] Ameen, B. A. H., “Phytochemical study and cytotoxic activity of Ferulago angulata (Schlecht) Boiss, from Kurdistan-region of Iraq”, IJIRAE 2014;1: 1-5, (2014).
[13] Caponio, F., Alloggio, V., Gomes, T., “Phenolic Compounds of Virgin Olive Oil: Influence of Paste Preparation Techniques”, Food Chem, 64: 203-209, (1999).
[14] Erel, O., “A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation”, Clin. Biochem, 37: 277-285, (2004).
[15] Erel, O., “A new automated colorimetric method for measuring total oxidant status”, Clin. Biochem, 38: 1103-1111, (2005).
[16] Bauer, A.W., Kirby, W.M., Sherris, J.C., Turck, M., “Antibiotic susceptibility testing by a standardized single disk method”, Am J Clin Pathol, 45: 493-496, (1966).
[17] CLSI (The Clinical and Laboratory Standards Institute). “Antimicrobial Susceptibility Testing of Anaerobic Bacteria; Approved Standard—Eighth Edition (M11-A8)”, (2012).
[18] EUCAST (European Committee on Antimicrobial Susceptibility Testing). “Breakpoint tables Fungal isolate for interpretation of MICs”, Version 7.0. (2014).
[19] EUCAST (European Committee on Antimicrobial Susceptibility Testing). “Breakpoint tables for Bacteria interpretation of MICs and zone diameters”, Version 5.0 (2015).
[20] Hindler, J., Hochstein, L., Howell, A., “Preparation of routine media and reagents used in antimicrobial susceptibility testing”, Part 1. McFarland standards, p. 5.19.1-5.19.6. In H. D. Isenberg (ed) Clinical microbiology procedures handbook, vol. 1. American Society for Microbiology, Washington, D.C. (1992).
[21] Matuschek, E., Brown, D.F., Kahlmeter, G., “Development of the EUCAST disk diffusion antimicrobial susceptibility testing method and its implementation in routine microbiology laboratories”, Clin Microbiol Infect, 20: 255-266, (2014).
[22] Kroes, B.H., van den Berg, A.J., van Ufford, H.C.Q., van Dijk, H., Labadie, R.P., “Anti-inflammatory activity of gallic acid”, Planta Med, 58: 499-504, (1992).
[23] Griffith, R., Chanphen, R., Leach, S.P., Keller, P.A., “New anti-malarial compounds from database searching”, Bioorg Med Chem Lett, 12: 539-542, (2002).
[24] Prasad, C.N., Anjana, T., Banerji, A., Gopalakrishnapillai, A., “Gallic acid induces GLUT4 translocation and glucose uptake activity in 3T3-L1 cells”, FEBS Lett, 584:531-536, (2010).
[25] Guan, H.H., Ming, H.H., Chuan, S.C., Shyh, S.H., Pei, H.S.H., Ming, T.Y., Bor, S.W., “Analgesic and Anti-Inflammatory Activities of Aqueous Extracts of Fructus Ligustri Lucidi”, J. Food Drug Anal, 20: 617-627, (2012).
[26] Angelica, G.C., Candida, A.L., Kassuya, I.I., Joao, B.C., Petrovick, P.R., “Antiinflammatory, antiallodynic effects and quantitative analysis of gallic acid in spray dried powders from Phyllanthus niruri leaves, stems, roots and whole plant”, Rev bras farmacognosia, 23: 124-31, (2013).
[27] Borges, A., Ferreira, C., Saavedra, M.J., SimÃμes, M., “Antibacterial activity and mode of action of ferulic and gallic acids against pathogenic bacteria”, Microb Drug Resist, 19: 256-265, (2013).
[28] Chhillar, R., Dhingra, D., “Antidepressant-like activity of gallic acid in mice subjected to unpredictable chronic mild stress”, Fundam Clin Pharmacol, 27: 409-418, (2013).
[29] Roberto, D.G., Remigio, L.S., Elias, O.S., Hector, T.A., “Comparative antibacterial effect of gallic acid and catechin against Helicobacter pylori”, LWT - Food Sci. Tec, 54: 331-335, (2013).
[30] Nayeem, N., Asdaq, S.M.B., Salem, H., Ahel-Alfqy, S., “Gallic Acid: A Promising Lead Molecule for Drug Development”, J App Pharm, 8: 213, (2016).
[31] Zhao, M., Wang, H., Yang, B., Tao, H., “Identification of cyclodextrin inclusion complex of chlorogenic acid and its antimicrobial activity”, Food Chem, 120: 1138-1142, (2010).
[32] Maalik, A., Bukhari, S.M., Zaidi, A.S.M.A., Shah, K.H., Khan, F.A., “Chlorogenic acid: a pharmacologically potent molecule”, Acta Pol Pharm, 73: 851-854, (2016).
[33] Pushp, P., Sharma, N., Joseph., G.S., Singh, R.P., “Antioxidant activity and detection of (−) epicatechin in the methanolic extract of stem of Tinospora cordifolia”, J. Food Sci. Tec, 50: 567-572, (2013).
[34] Duangyod, T., Palanuvej, C., Ruangrungsi, N., “Pharmacognostic evaluation with reference to catechin content and antioxidant activities of pale catechu in Thailand”, J Adv Pharm Technol Res 6: 97, (2015).
[35] Shay, J., Elbaz, H.A., Lee, I., Zielske, S.P., Malek, M.H., Hüttemann M “Molecular mechanisms and therapeutic effects of (−)-epicatechin and other polyphenols in cancer, inflammation, diabetes, and neurodegeneration”, Oxidative Med. Cell. Longevity, (2015). http://dx.doi.org/10.1155/2015/181260
[36] Peperidou, A., Pontiki, E., Hadjipavlou-Litina, D., Voulgari, E., Avgoustakis, K., “Multifunctional cinnamic acid derivatives”, Molecules, 22: 1247, (2017).
[37] Cikman, O., Soylemez, O., Ozkan, O.F., Kiraz, H.A., Sayar, I., Ademoglu, S., Taysi, S., Karaayvaz, M., “Antioxidant Activity of Syringic Acid Prevents Oxidative Stress in L-arginine–Induced Acute Pancreatitis: An Experimental Study on Rats”, Int. Surg, 100: 891-896, (2015).
[38] Cushnie, T.T., Lamb, A.J., “Antimicrobial activity of flavonoids”, Int. J. Antimicrob. Agents, 26: 343-356, (2005).
[39] Alrawaiq, N.S., Abdullah, A., “A review of flavonoid quercetin: metabolism, bioactivity and antioxidant properties”, Int J PharmTech Res, 6: 933-941, (2014).
[40] Mello, T., Zanieri, F., Ceni, E., Galli, A., “Oxidative stress in the healthy and wounded hepatocyte: a cellular organelles perspective”, Oxidative Med. Cell. Longevity, (2016). http://dx.doi.org/10.1155/2016/8327410
[41] Sevindik, M., “The novel biological tests on various extracts of Cerioporus varius”, Fresenius Environmental Bulletin, 28(5), 3713-3717, (2019).
[42] Sevindik, M., Akgul, H., Bal, C., Selamoglu, Z., “Phenolic contents, oxidant/antioxidant potential and heavy metal levels in Cyclocybe cylindracea”, Indian Journal of Pharmaceutical Education and Research, 52(3), 437-441, (2018).
[43] Sevindik, M., Akgul, H., Pehlivan, M., Selamoglu, Z., “Determination of Therapeutic Potential of Mentha longifolia ssp. longifolia”, Fresen Environ Bull, 26: 4757-4563, (2017).
[44] Aksoy, L., Kolay, E., Ağılönü, Y., Aslan, Z., Kargıoğlu, M., “Free radical scavenging activity, total phenolic content, total antioxidant status, and total oxidant status of endemic Thermopsis turcica”, Saudi J. Biol. Sci, 20: 235-239, (2013).
[45] Gul, S., Ahmed, S., Gul, H., Shad, K.F., Zia-Ul-Haq, M., Badiu, D., “The antioxidant potential of Brassica rapa L. on glutathione peroxidase, superoxide dismutase enzymes and total antioxidant status”, RJLabM, 21:161-169, (2013).
[46] Sevindik, M., “Investigation of antioxidant/oxidant status and antimicrobial activities of Lentinus tigrinus”, Advances in pharmacological sciences, (2018).
[47] Sevindik, M., Akgul, H., Selamoglu, Z., Braidy, N., “Antioxidant and Antigenotoxic Potential of Infundibulicybe geotropa Mushroom Collected from Northwestern Turkey”, Oxidative Medicine and Cellular Longevity, (2020).
[48] Abdallah, E.M., “Plants: An alternative source for antimicrobials”, J. Appl. Pharm. Sci, 1: 16-20, (2011).
[49] Satır, E., “Ferulago platycarpa Boiss. & Hon. Research on Pharmaceutical Botany”, Ankara University Institute of Health Sciences. Master Thesis. Ankara (Turkey), (2006).

Phenolic Content, Antioxidant and Antimicrobial Potential of Endemic Ferulago platycarpa

Year 2020, Volume: 33 Issue: 4, 670 - 677, 01.12.2020

Falah Saleh Mohammed Selami Günal Mustafa Pehlivan Muhittin Doğan Mustafa Sevindik Hasan Akgül

https://doi.org/10.35378/gujs.707555

Cited By: 12

Abstract

In this study, biological activities and phenolic contents of endemic Ferulago platycarpa Boiss. & Bal. were determined. Within the scope of biological activity, antimicrobial activity, antioxidant and oxidant status of plant extracts were determined. Phenolic contents were determined by using HPLC. Antimicrobial activity was determined against bacteria and fungus strains using the modified agar method. Antioxidant and oxidant status were calculated with Rel Assay kits. Gallic, chlorogenic, cinnamic, syringic acids, epicatechin, catechin and quercetin were found in the plant. It was also determined that the plant has antioxidant and antimicrobial potential. But, because of higher TOS value, it was considered that the plants, which were collected from region suitable for OSI value, could be a natural antioxidant source.

Keywords

Ferulago platycarpa, Endemic, Antioxidant, Antimicrobial, Phenolic content

References

[1] Mohammed, F.S., Karakaş, M., Akgül, H., Sevindik, M., “Medicinal Properties of Allium calocephalum Collected from Gara Mountain (Iraq)”, Fresen Environ Bull, 28(10): 7419-7426, (2019).
[2] Saxena, M., Saxena, J., Nema, R., Singh, D., Gupta, A., “Phytochemistry of medicinal plants”, J Pharmacogn Phytochem, 1: 168-182, (2013).
[3] Mohammed, F. S., Akgul, H., Sevindik, M., Khaled, B. M. T., “Phenolic content and biological activities of Rhus coriaria var. zebaria”, Fresenius Environmental Bulletin, 27(8), 5694-5702, (2018).
[4] Ji, H.F., Li, X.J., Zhang, H.Y., “Natural products and drug discovery: can thousands of years of ancient medical knowledge lead us to new and powerful drug combinations in the fight against cancer and dementia? ”, EMBO reports, 10:194-200, (2009).
[5] Ekor, M., “The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety”, Front. Pharmacol, 4: 177, (2014).
[6] Pan, S.Y., Zhou, S.F., Gao, S.H., Yu, Z.L., Zhang, S.F., Tang, M.K., Sun, J.N., Ma, D.L., Han, Y.F., Fong, W.F., Ko, K.M., “New perspectives on how to discover drugs from herbal medicines: CAM's outstanding contribution to modern therapeutics”, Evid.-Based Complement. Altern. Med., (2013). http://dx.doi.org/10.1155/2013/627375
[7] Ghasemi Pirbalouti, A., Izadi, A., Malek Poor, F., Hamedi, B., “Chemical composition, antioxidant and antibacterial activities of essential oils from Ferulago angulata”, Pharm. Biol, 54: 2515-2520, (2016).
[8] Bakar, F., Karakay, S., Delimustafaoğlu, B., Gül, F., Sibel, K.C., “Anticancer effect of Ferulago mughlea Peşmen (Apiaceae) on cancer cell proliferation”, Iran J Pharm Res, 15: 501, (2016).
[9] Harborne, J.B., “The Natural Coumarıns: Occurrence, Chemıstry And Bıochemıstry (Book) ”, Plant, Cell & Environ, 5: 435-436, (1982).
[10] Shahbazi, Y., Shavisi, N., Karami, N., Shabnam, K., “Chemical Composition and in Vitro Antibacterial Activity of Ferulago angulata (Schlecht.) Boiss Essential Oil”, Pharm Sci. 21: 6-11, (2015).
[11] El-Thaher, T.S., Matalka, K.Z., Taha, H.A., Badwan, A.A., “Ferula harmonis ‘zallouh’and enhancing erectile function in rats: efficacy and toxicity study”, Int J Impot Res, 13: 247, (2001).
[12] Ameen, B. A. H., “Phytochemical study and cytotoxic activity of Ferulago angulata (Schlecht) Boiss, from Kurdistan-region of Iraq”, IJIRAE 2014;1: 1-5, (2014).
[13] Caponio, F., Alloggio, V., Gomes, T., “Phenolic Compounds of Virgin Olive Oil: Influence of Paste Preparation Techniques”, Food Chem, 64: 203-209, (1999).
[14] Erel, O., “A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation”, Clin. Biochem, 37: 277-285, (2004).
[15] Erel, O., “A new automated colorimetric method for measuring total oxidant status”, Clin. Biochem, 38: 1103-1111, (2005).
[16] Bauer, A.W., Kirby, W.M., Sherris, J.C., Turck, M., “Antibiotic susceptibility testing by a standardized single disk method”, Am J Clin Pathol, 45: 493-496, (1966).
[17] CLSI (The Clinical and Laboratory Standards Institute). “Antimicrobial Susceptibility Testing of Anaerobic Bacteria; Approved Standard—Eighth Edition (M11-A8)”, (2012).
[18] EUCAST (European Committee on Antimicrobial Susceptibility Testing). “Breakpoint tables Fungal isolate for interpretation of MICs”, Version 7.0. (2014).
[19] EUCAST (European Committee on Antimicrobial Susceptibility Testing). “Breakpoint tables for Bacteria interpretation of MICs and zone diameters”, Version 5.0 (2015).
[20] Hindler, J., Hochstein, L., Howell, A., “Preparation of routine media and reagents used in antimicrobial susceptibility testing”, Part 1. McFarland standards, p. 5.19.1-5.19.6. In H. D. Isenberg (ed) Clinical microbiology procedures handbook, vol. 1. American Society for Microbiology, Washington, D.C. (1992).
[21] Matuschek, E., Brown, D.F., Kahlmeter, G., “Development of the EUCAST disk diffusion antimicrobial susceptibility testing method and its implementation in routine microbiology laboratories”, Clin Microbiol Infect, 20: 255-266, (2014).
[22] Kroes, B.H., van den Berg, A.J., van Ufford, H.C.Q., van Dijk, H., Labadie, R.P., “Anti-inflammatory activity of gallic acid”, Planta Med, 58: 499-504, (1992).
[23] Griffith, R., Chanphen, R., Leach, S.P., Keller, P.A., “New anti-malarial compounds from database searching”, Bioorg Med Chem Lett, 12: 539-542, (2002).
[24] Prasad, C.N., Anjana, T., Banerji, A., Gopalakrishnapillai, A., “Gallic acid induces GLUT4 translocation and glucose uptake activity in 3T3-L1 cells”, FEBS Lett, 584:531-536, (2010).
[25] Guan, H.H., Ming, H.H., Chuan, S.C., Shyh, S.H., Pei, H.S.H., Ming, T.Y., Bor, S.W., “Analgesic and Anti-Inflammatory Activities of Aqueous Extracts of Fructus Ligustri Lucidi”, J. Food Drug Anal, 20: 617-627, (2012).
[26] Angelica, G.C., Candida, A.L., Kassuya, I.I., Joao, B.C., Petrovick, P.R., “Antiinflammatory, antiallodynic effects and quantitative analysis of gallic acid in spray dried powders from Phyllanthus niruri leaves, stems, roots and whole plant”, Rev bras farmacognosia, 23: 124-31, (2013).
[27] Borges, A., Ferreira, C., Saavedra, M.J., SimÃμes, M., “Antibacterial activity and mode of action of ferulic and gallic acids against pathogenic bacteria”, Microb Drug Resist, 19: 256-265, (2013).
[28] Chhillar, R., Dhingra, D., “Antidepressant-like activity of gallic acid in mice subjected to unpredictable chronic mild stress”, Fundam Clin Pharmacol, 27: 409-418, (2013).
[29] Roberto, D.G., Remigio, L.S., Elias, O.S., Hector, T.A., “Comparative antibacterial effect of gallic acid and catechin against Helicobacter pylori”, LWT - Food Sci. Tec, 54: 331-335, (2013).
[30] Nayeem, N., Asdaq, S.M.B., Salem, H., Ahel-Alfqy, S., “Gallic Acid: A Promising Lead Molecule for Drug Development”, J App Pharm, 8: 213, (2016).
[31] Zhao, M., Wang, H., Yang, B., Tao, H., “Identification of cyclodextrin inclusion complex of chlorogenic acid and its antimicrobial activity”, Food Chem, 120: 1138-1142, (2010).
[32] Maalik, A., Bukhari, S.M., Zaidi, A.S.M.A., Shah, K.H., Khan, F.A., “Chlorogenic acid: a pharmacologically potent molecule”, Acta Pol Pharm, 73: 851-854, (2016).
[33] Pushp, P., Sharma, N., Joseph., G.S., Singh, R.P., “Antioxidant activity and detection of (−) epicatechin in the methanolic extract of stem of Tinospora cordifolia”, J. Food Sci. Tec, 50: 567-572, (2013).
[34] Duangyod, T., Palanuvej, C., Ruangrungsi, N., “Pharmacognostic evaluation with reference to catechin content and antioxidant activities of pale catechu in Thailand”, J Adv Pharm Technol Res 6: 97, (2015).
[35] Shay, J., Elbaz, H.A., Lee, I., Zielske, S.P., Malek, M.H., Hüttemann M “Molecular mechanisms and therapeutic effects of (−)-epicatechin and other polyphenols in cancer, inflammation, diabetes, and neurodegeneration”, Oxidative Med. Cell. Longevity, (2015). http://dx.doi.org/10.1155/2015/181260
[36] Peperidou, A., Pontiki, E., Hadjipavlou-Litina, D., Voulgari, E., Avgoustakis, K., “Multifunctional cinnamic acid derivatives”, Molecules, 22: 1247, (2017).
[37] Cikman, O., Soylemez, O., Ozkan, O.F., Kiraz, H.A., Sayar, I., Ademoglu, S., Taysi, S., Karaayvaz, M., “Antioxidant Activity of Syringic Acid Prevents Oxidative Stress in L-arginine–Induced Acute Pancreatitis: An Experimental Study on Rats”, Int. Surg, 100: 891-896, (2015).
[38] Cushnie, T.T., Lamb, A.J., “Antimicrobial activity of flavonoids”, Int. J. Antimicrob. Agents, 26: 343-356, (2005).
[39] Alrawaiq, N.S., Abdullah, A., “A review of flavonoid quercetin: metabolism, bioactivity and antioxidant properties”, Int J PharmTech Res, 6: 933-941, (2014).
[40] Mello, T., Zanieri, F., Ceni, E., Galli, A., “Oxidative stress in the healthy and wounded hepatocyte: a cellular organelles perspective”, Oxidative Med. Cell. Longevity, (2016). http://dx.doi.org/10.1155/2016/8327410
[41] Sevindik, M., “The novel biological tests on various extracts of Cerioporus varius”, Fresenius Environmental Bulletin, 28(5), 3713-3717, (2019).
[42] Sevindik, M., Akgul, H., Bal, C., Selamoglu, Z., “Phenolic contents, oxidant/antioxidant potential and heavy metal levels in Cyclocybe cylindracea”, Indian Journal of Pharmaceutical Education and Research, 52(3), 437-441, (2018).
[43] Sevindik, M., Akgul, H., Pehlivan, M., Selamoglu, Z., “Determination of Therapeutic Potential of Mentha longifolia ssp. longifolia”, Fresen Environ Bull, 26: 4757-4563, (2017).
[44] Aksoy, L., Kolay, E., Ağılönü, Y., Aslan, Z., Kargıoğlu, M., “Free radical scavenging activity, total phenolic content, total antioxidant status, and total oxidant status of endemic Thermopsis turcica”, Saudi J. Biol. Sci, 20: 235-239, (2013).
[45] Gul, S., Ahmed, S., Gul, H., Shad, K.F., Zia-Ul-Haq, M., Badiu, D., “The antioxidant potential of Brassica rapa L. on glutathione peroxidase, superoxide dismutase enzymes and total antioxidant status”, RJLabM, 21:161-169, (2013).
[46] Sevindik, M., “Investigation of antioxidant/oxidant status and antimicrobial activities of Lentinus tigrinus”, Advances in pharmacological sciences, (2018).
[47] Sevindik, M., Akgul, H., Selamoglu, Z., Braidy, N., “Antioxidant and Antigenotoxic Potential of Infundibulicybe geotropa Mushroom Collected from Northwestern Turkey”, Oxidative Medicine and Cellular Longevity, (2020).
[48] Abdallah, E.M., “Plants: An alternative source for antimicrobials”, J. Appl. Pharm. Sci, 1: 16-20, (2011).
[49] Satır, E., “Ferulago platycarpa Boiss. & Hon. Research on Pharmaceutical Botany”, Ankara University Institute of Health Sciences. Master Thesis. Ankara (Turkey), (2006).

There are 49 citations in total.

Details

Primary Language	English
Subjects	Engineering
Journal Section	Biology
Authors	Falah Saleh Mohammed 0000-0001-9083-1876 Selami Günal 0000-0002-4752-5176 Mustafa Pehlivan 0000-0002-8277-6085 Muhittin Doğan 0000-0001-5400-8065 Mustafa Sevindik 0000-0001-7223-2220 Hasan Akgül 0000-0001-8514-9776
Publication Date	December 1, 2020
Published in Issue	Year 2020 Volume: 33 Issue: 4

Cite

APA	Mohammed, F. S., Günal, S., Pehlivan, M., Doğan, M., et al. (2020). Phenolic Content, Antioxidant and Antimicrobial Potential of Endemic Ferulago platycarpa. Gazi University Journal of Science, 33(4), 670-677. https://doi.org/10.35378/gujs.707555
AMA	Mohammed FS, Günal S, Pehlivan M, Doğan M, Sevindik M, Akgül H. Phenolic Content, Antioxidant and Antimicrobial Potential of Endemic Ferulago platycarpa. Gazi University Journal of Science. December 2020;33(4):670-677. doi:10.35378/gujs.707555
Chicago	Mohammed, Falah Saleh, Selami Günal, Mustafa Pehlivan, Muhittin Doğan, Mustafa Sevindik, and Hasan Akgül. “Phenolic Content, Antioxidant and Antimicrobial Potential of Endemic Ferulago Platycarpa”. Gazi University Journal of Science 33, no. 4 (December 2020): 670-77. https://doi.org/10.35378/gujs.707555.
EndNote	Mohammed FS, Günal S, Pehlivan M, Doğan M, Sevindik M, Akgül H (December 1, 2020) Phenolic Content, Antioxidant and Antimicrobial Potential of Endemic Ferulago platycarpa. Gazi University Journal of Science 33 4 670–677.
IEEE	F. S. Mohammed, S. Günal, M. Pehlivan, M. Doğan, M. Sevindik, and H. Akgül, “Phenolic Content, Antioxidant and Antimicrobial Potential of Endemic Ferulago platycarpa”, Gazi University Journal of Science, vol. 33, no. 4, pp. 670–677, 2020, doi: 10.35378/gujs.707555.
ISNAD	Mohammed, Falah Saleh et al. “Phenolic Content, Antioxidant and Antimicrobial Potential of Endemic Ferulago Platycarpa”. Gazi University Journal of Science 33/4 (December 2020), 670-677. https://doi.org/10.35378/gujs.707555.
JAMA	Mohammed FS, Günal S, Pehlivan M, Doğan M, Sevindik M, Akgül H. Phenolic Content, Antioxidant and Antimicrobial Potential of Endemic Ferulago platycarpa. Gazi University Journal of Science. 2020;33:670–677.
MLA	Mohammed, Falah Saleh et al. “Phenolic Content, Antioxidant and Antimicrobial Potential of Endemic Ferulago Platycarpa”. Gazi University Journal of Science, vol. 33, no. 4, 2020, pp. 670-7, doi:10.35378/gujs.707555.
Vancouver	Mohammed FS, Günal S, Pehlivan M, Doğan M, Sevindik M, Akgül H. Phenolic Content, Antioxidant and Antimicrobial Potential of Endemic Ferulago platycarpa. Gazi University Journal of Science. 2020;33(4):670-7.