Peptide Based Biological Active Molecules

Deniz Ekinci; Zafer Ömer Özdemir; Murat Şentürk

Peptide Based Biological Active Molecules

Year 2011, Volume: 39 Issue: 4, 351 - 357, 01.12.2011

Deniz Ekinci Zafer Ömer Özdemir Murat Şentürk

Abstract

There has been an enormous development in peptide chemistry with regard not only to the isolation, synthesis, structure identification, and elucidation of the mode of action of peptides, but also to their applications as tools in the life sciences. Peptides have been of interest in biochemistry, chemistry, biology, pharmacology, medicinal chemistry, biotechnology, and gene technology. These important natural products have a broad range with in point of their complexity. Since different amino acids are connected via peptide bonds to produce a peptide or a protein, a number of different sequences are possible–depending on the different building blocks and length of the peptide. As all peptides display a high degree of conformational diversity, it follows that many diverse and highly specific structures can be observed. Although many researches have dealt with the synthetic aspects of peptide chemistry, this review covers its biological applications of peptide based molecules.

Keywords

Peptide, hormones, neuropeptides, Antimicrobial, antibiotics, dendrimer

References

N. Sewald, H. D. Jakubke, Peptides, Chem. Biol., Wiley Verlag GmbH & Co. KGaA (2002).
J H. Jones, J. Pept. Sci., 6 (2000) 201.
M. Goodman, A. Felix, L. Moroder, C. Toniolo, Synthesis of Peptides and Peptidomimetics in Houben-Weyl- Methoden der Organischen Chemie, Büchel, K.H.(Ed.), Thieme, Stuttgart (2002) 22.
J. Porath, P. Flodin, Nature, 183 (1959) 1657, .
E. A. Peterson, H. A. Sober, J. Am. Chem. Soc., 78 (1956) 751.
L. C. Craig, T P. King, Fed. Proc., 17 (1958) 1126. 7. C. H. Li, I. I. Geschwind, R. D. Cole, I. D. Raacke, J. I. Harris, J. S. Dixon, Nature, 176 (1955) 687.
K. Folkers, F. Enzmann, J. Baler, C. Y. Bowers, A. V. Schally, Biochem. Biophys. Res. Commun., 37 (1969) 123.
R. Burgus, T. F. Dunn, D. Desiderio, R. Guillemin, C. R. Hebd., Seances Acad. Sci., 269 (1969) 1870.
M. H. Le Breton, S. Rochereau-Roulet, S. Chreau, G. Pinel, T. Delatour, B. Le Bizec, J. Agric. Food Chem., 58 (2010) 729.
J. H. Schwarz, Principles of Neural Science, E. R. Kandel, J. H. Schwarz, T. M. Jessel (Eds.), Elsevier, Amsterdam, 1991.
V. du Vigneaud, H. C. Lawler, E. A. Popenoe, J. Am. Chem. Soc., 75 (1953) 4880.
D. Alan, Borthwick, J. Med. Chem., 53 (2010) 6525.
S. G. Schultz, G. M. Makblout, Handbook of Physiology, The Gastrointestinal System II, Bethesda, M. D., Am. Physiol. Soc., (1989) 87.
J. H. Walsh, G. J. Dockray, Gut Peptides, Raven, New York, (1994).
J. G. Tang, Biochemistry., 42 (2003) 2731.
T. L. Blundell, Diabetes, 21 (1972) 492.
K. Huus, Biochemistry, 44 (2005) 11171,.
M. L. Bender, R. J. Bergeron, M. Komiyama, The Bioorganic Chemistry of Enzymatic Catalysis, Wiley, New York (1984).
J. P. Smith, R. L. Conter, S. I. Bingaman, H. A. Harvey, D. T. Mauger, M. Ahmad, L. M. Demers, W. B. Stanley, P. J. McLaughlin, I. S. Zagon, Anti-Cancer Drugs, 15 (2004) 203.
C. A. Maggi, R. Patacchini, P. Rovero, A J. Giachetti, Auton. Pharmacol., 13(1993)23.
S. Nakanishi, Annu. Reu. Neurosci., 14 (1991) 123.
R. E. W. Hancock, Lancet., 349 (1997) 418.
H. Kleinkauf, H. von Döhren, Biochemistry of Peptide Antibiotics, de Gruyter, Berlin (1990).
R. E. W. Hancock, D S. Chapple, Antimicrob. Agents Chemother., 43 (1999) 1317.
S. Vos., Biochemistry, 41 (2002) 5383.
X. Tang, J. Proteome Res., 9 (2010) 2550.
P. Alessi, C. Ebbinghaus, D. Neri, Biochim. Biophys. Acta., 1654 (2004) 39.
S. M. Moghimi, A. C. Hunter, J. C. Murray, J. Faseb., 19 (2005) 311.
W. Sadee, Z. Dai, Hum. Mol. Genet., 14 (2005) R207- 14.
L. Benedict, Biomacromolecules., 7 (2006) 1261.
C. E. B. Brattwall, J. Am. Chem. Soc., 125 (2003) 14214.
F. F. Davis, G. M. Kazo, M. L. Nucci, A. Abuchowski, In Peptide and Protein Drug Delivery, V. H. L. Lee, Ed., M. Dekker, New York (1991) 831.
U. Boas, P. M. H. Heegaard, Chem. Soc. Rev., 33 (2004) 43.
R. Duncan, Nat. Rev. Drug Discovery., 2 (2003) 347.
B. Rihova, Adv. Drug Delivery Rev., 21 (1996) 157.
H. Leontiadou, J. Am. Chem. Soc., 128 (2006) 12156.
Y. Yagi., BMC Bioinformatics, 8 (2007) 11.

Peptid Temelli Biyolojik Aktif Moleküller

Year 2011, Volume: 39 Issue: 4, 351 - 357, 01.12.2011

Deniz Ekinci Zafer Ömer Özdemir Murat Şentürk

Abstract

P eptit kimyasındaki muazzam gelişmeler sadece izolasyon, sentez, yapı tanımlama ve peptidlerin eylem şeklinin aydınlatılması açısından olmamış, aynı zamanda yaşam bilimleri araçları olarak uygulamalarında da büyük gelişmeler olmuştur. Peptitlere, biyokimya, kimya, biyoloji, farmakoloji, tıbbi kimya, biyoteknoloji ve gen teknolojisi alanlarının da ilgileri vardır.Bu önemli doğal ürünlerin karmaşık yapıları nedeniyle geniş bir yelpazesi vardır. Farklı amino asitler, peptid bağı ile birleşerek peptid veya proteinleri oluştururlar. Böylelikle farklı yapı blokları ve uzunluğa bağlı olarak farklı dizilerin oluşması mümkündür. Tüm peptidler yüksek derecede konformasyonel çeşitlilik gösterirler. Buna bağlı olarak pek çok farklı ve çok özel yapılar gözlenebilir. Pek çok araştırma, sentetik peptid kimyası alanıyla ilgili olmasına rağmen, bu derleme peptid bazlı moleküllerin biyolojik uygulamalarını kapsar

Keywords

Peptid, hormonlar, nöropeptidler, antimikrobiyal, antibiyotikler, dendrimer

References

N. Sewald, H. D. Jakubke, Peptides, Chem. Biol., Wiley Verlag GmbH & Co. KGaA (2002).
J H. Jones, J. Pept. Sci., 6 (2000) 201.
M. Goodman, A. Felix, L. Moroder, C. Toniolo, Synthesis of Peptides and Peptidomimetics in Houben-Weyl- Methoden der Organischen Chemie, Büchel, K.H.(Ed.), Thieme, Stuttgart (2002) 22.
J. Porath, P. Flodin, Nature, 183 (1959) 1657, .
E. A. Peterson, H. A. Sober, J. Am. Chem. Soc., 78 (1956) 751.
L. C. Craig, T P. King, Fed. Proc., 17 (1958) 1126. 7. C. H. Li, I. I. Geschwind, R. D. Cole, I. D. Raacke, J. I. Harris, J. S. Dixon, Nature, 176 (1955) 687.
K. Folkers, F. Enzmann, J. Baler, C. Y. Bowers, A. V. Schally, Biochem. Biophys. Res. Commun., 37 (1969) 123.
R. Burgus, T. F. Dunn, D. Desiderio, R. Guillemin, C. R. Hebd., Seances Acad. Sci., 269 (1969) 1870.
M. H. Le Breton, S. Rochereau-Roulet, S. Chreau, G. Pinel, T. Delatour, B. Le Bizec, J. Agric. Food Chem., 58 (2010) 729.
J. H. Schwarz, Principles of Neural Science, E. R. Kandel, J. H. Schwarz, T. M. Jessel (Eds.), Elsevier, Amsterdam, 1991.
V. du Vigneaud, H. C. Lawler, E. A. Popenoe, J. Am. Chem. Soc., 75 (1953) 4880.
D. Alan, Borthwick, J. Med. Chem., 53 (2010) 6525.
S. G. Schultz, G. M. Makblout, Handbook of Physiology, The Gastrointestinal System II, Bethesda, M. D., Am. Physiol. Soc., (1989) 87.
J. H. Walsh, G. J. Dockray, Gut Peptides, Raven, New York, (1994).
J. G. Tang, Biochemistry., 42 (2003) 2731.
T. L. Blundell, Diabetes, 21 (1972) 492.
K. Huus, Biochemistry, 44 (2005) 11171,.
M. L. Bender, R. J. Bergeron, M. Komiyama, The Bioorganic Chemistry of Enzymatic Catalysis, Wiley, New York (1984).
J. P. Smith, R. L. Conter, S. I. Bingaman, H. A. Harvey, D. T. Mauger, M. Ahmad, L. M. Demers, W. B. Stanley, P. J. McLaughlin, I. S. Zagon, Anti-Cancer Drugs, 15 (2004) 203.
C. A. Maggi, R. Patacchini, P. Rovero, A J. Giachetti, Auton. Pharmacol., 13(1993)23.
S. Nakanishi, Annu. Reu. Neurosci., 14 (1991) 123.
R. E. W. Hancock, Lancet., 349 (1997) 418.
H. Kleinkauf, H. von Döhren, Biochemistry of Peptide Antibiotics, de Gruyter, Berlin (1990).
R. E. W. Hancock, D S. Chapple, Antimicrob. Agents Chemother., 43 (1999) 1317.
S. Vos., Biochemistry, 41 (2002) 5383.
X. Tang, J. Proteome Res., 9 (2010) 2550.
P. Alessi, C. Ebbinghaus, D. Neri, Biochim. Biophys. Acta., 1654 (2004) 39.
S. M. Moghimi, A. C. Hunter, J. C. Murray, J. Faseb., 19 (2005) 311.
W. Sadee, Z. Dai, Hum. Mol. Genet., 14 (2005) R207- 14.
L. Benedict, Biomacromolecules., 7 (2006) 1261.
C. E. B. Brattwall, J. Am. Chem. Soc., 125 (2003) 14214.
F. F. Davis, G. M. Kazo, M. L. Nucci, A. Abuchowski, In Peptide and Protein Drug Delivery, V. H. L. Lee, Ed., M. Dekker, New York (1991) 831.
U. Boas, P. M. H. Heegaard, Chem. Soc. Rev., 33 (2004) 43.
R. Duncan, Nat. Rev. Drug Discovery., 2 (2003) 347.
B. Rihova, Adv. Drug Delivery Rev., 21 (1996) 157.
H. Leontiadou, J. Am. Chem. Soc., 128 (2006) 12156.
Y. Yagi., BMC Bioinformatics, 8 (2007) 11.

There are 37 citations in total.

Details

Primary Language	English
Journal Section	Research Article
Authors	Deniz Ekinci This is me Zafer Ömer Özdemir Murat Şentürk This is me
Publication Date	December 1, 2011
Published in Issue	Year 2011 Volume: 39 Issue: 4

Cite

APA	Ekinci, D., Özdemir, Z. Ö., & Şentürk, M. (2011). Peptide Based Biological Active Molecules. Hacettepe Journal of Biology and Chemistry, 39(4), 351-357.
AMA	Ekinci D, Özdemir ZÖ, Şentürk M. Peptide Based Biological Active Molecules. HJBC. December 2011;39(4):351-357.
Chicago	Ekinci, Deniz, Zafer Ömer Özdemir, and Murat Şentürk. “Peptide Based Biological Active Molecules”. Hacettepe Journal of Biology and Chemistry 39, no. 4 (December 2011): 351-57.
EndNote	Ekinci D, Özdemir ZÖ, Şentürk M (December 1, 2011) Peptide Based Biological Active Molecules. Hacettepe Journal of Biology and Chemistry 39 4 351–357.
IEEE	D. Ekinci, Z. Ö. Özdemir, and M. Şentürk, “Peptide Based Biological Active Molecules”, HJBC, vol. 39, no. 4, pp. 351–357, 2011.
ISNAD	Ekinci, Deniz et al. “Peptide Based Biological Active Molecules”. Hacettepe Journal of Biology and Chemistry 39/4 (December 2011), 351-357.
JAMA	Ekinci D, Özdemir ZÖ, Şentürk M. Peptide Based Biological Active Molecules. HJBC. 2011;39:351–357.
MLA	Ekinci, Deniz et al. “Peptide Based Biological Active Molecules”. Hacettepe Journal of Biology and Chemistry, vol. 39, no. 4, 2011, pp. 351-7.
Vancouver	Ekinci D, Özdemir ZÖ, Şentürk M. Peptide Based Biological Active Molecules. HJBC. 2011;39(4):351-7.

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