Clinical Research
BibTex RIS Cite
Year 2023, Volume: 51 Issue: 4, 381 - 388, 07.11.2023
https://doi.org/10.15671/hjbc.1302331

Abstract

Supporting Institution

Gazi Üniversitesi

Project Number

095 nolu BAP projesi

References

  • Z. Chegini, M. Didehdar, A. Khoshbayan, J. Karami, M. Yousefimashouf and A. Shariati, The role of Staphylococcus aureus enterotoxin B in chronic rhinosinusitis with nasal polyposis, Cell Communication and Signaling, (2022) 20-29.
  • M.S. Rha, S.W. Kim, D.Y. Chang, J.K. Lee, J. Kim, S.H. Park, R. Khalmuratova, H.S. Lim, K.M. Eun, S.N. Hong, Superantigen-related TH2 CD4+ T cells in nonasthmatic chronic rhinosinusitis with nasal polyps, J. Allergy Clin. Immunol., 145 (2020) 1378-1388.
  • W. Ivy, N. Maina & Neil, Patel & Noam, A. Cohen, Understanding the Role of Biofilms and Superantigens in Chronic Rhinosinusitis, Current Otorhinolaryngology Reports, 6 (2018) 253–262.
  • R.P. Schleimer, A. Kato, A. Peters, D.B. Conley, Epithelium, inflammation, and immunity in the upper airways of humans; studies in chronic rhinosinusitis, Proc. Am. Thorac. Soc., 6 (2009) 288–294.
  • R.G. Slavin, Sinusitis: Viral, bacterial, or fungal and what is the role of staph?, Allergy Asthma Proc.,27 (2006) 447–450.
  • T. Delemarre, N. De Ruyck, G. Holtappels, C. Bachert, E. Gevaert, Unravellingthe expression of interleukin-9 in chronic rhinosinusitis: a possible role for Staphylococcus aureus, Clin. Transl. Allergy. 10 (2020) 1–4.
  • N. Zhang, P. Gevaert, T. van Zele, N.C. Perez et al, An update on the impact of Staphylococcus aureus enterotoxins in chronic sinusitis with nasal polyposis, Rhinology, 43 (2005) 162–168.
  • C. Bachert, B. Marple, R. J. Schlosser, C. Hopkins, R. P. Schleimer, B. N. Lambrecht, B. M. Bröker, T. Laidlaw and Woo- Jung Song, Adult chronic rhinosinusitis, Nature reviews Disease Primers Article citation, 6 (2020) 86.
  • C. Bachert et al., Staphylococcus aureus and its IgE-inducing enterotoxins in asthma: current knowledge, Eur. Respir. J., 55 (2020) 190-192.
  • Y. Chan, F.A. Kuhn, An update on the classifications, diagnosis, and treatment of rhinosinusitis, Curr. Opin. Otolaryngol. Head Neck Surg., 17 (2009) 204–208.
  • Mde L. da Cunha, R.A. Calsolari, J.P. Júnior, Detection of enterotoxin and toxic shock syndrome toxin 1 genes in staphylococcus, with emphasis on coagulase-negative staphylococci, Microbiol. Immunol., 51 (2007) 381–390.
  • L.M. el Fiky, N. Khamis, Bel D. Mostafa, A.M. Adly, Staphylococcal infection and toxin production in chronic rhinosinusitis, Am. J. Rhinol. Allergy, 23 (2009) 264–267.
  • M. Nagao, A. Okamoto, K. Yamada, T. Hasegawa et al, Variations in amount of TSST-1 produced by clinical methicillin resistant Staphylococcus aureus (MRSA) isolates and allelic variation in accessory gene regulator (agr) locus, BMC Microbiol., 9 (2009) 52.
  • J. Patou, P. Gevaert, T. van Zele, G. Holtappels et al, Staphylococcus aureus enterotoxin b, protein a and lipoteichoic acid stimulations in nasal polyps, J. Allergy Clin. Immunol., 121 (2008) 110–115.
  • A.N. Pearlman, D.B. Conley, Review of current guidelines related to the diagnosis and treatment of rinosinusitis, Curr. Opin. Otolaryngol. Head Neck Surg., 16 (2009) 226–230.
  • T. Proft, J. D. Fraser, Bacterial superantigens, Clin. Exp. Immunol., 133 (2003) 299–306.
  • S.Tuff, S. Haeryfar, J. McCormick, Manipulation of innate and adaptive immunity by staphylococcal superantigens, Pathogens, 7 (2018) 53.
  • B.Fleischer, H. Schrezenmeier, T cell stimulation by staphylococcal enterotoxins. Clonally variable response and requirement for major histocompatibility complex class II molecules on accessory or target cells, J. Exp. Med., 167 (1988) 1697–1707.
  • M. Yarıktas, M. Demirci, F. Döner, M. Tuz et al, Microbiologic findings of sinusitis by a novel method for obtaining culture, Diagn. Microbiol. Infect. Dis., 58 (2007) 49–52.
  • W.E. Kloos, Natural populations of the genus Staphyloccus. Annu. Rev. Microbiol., 34 (1980) 559–592.
  • M. Nagao, A. Okamoto, K. Yamada, T. Hasegawa, et al, Variations in amount of TSST-1 produced by clinical methicillin resistant Staphylococcus aureus (MRSA) isolates and allelic variation in accessory gene regulator (agr) locus. BMC Microbiol., 9 (2009) 52.
  • Y. Lee, B. Moon, J. Park, H. Chang, et al, Expression of enterotoxin genes in Staphylococcus aureus isolates based on mRNA analysis, Microbiol. Biotechnol., 17 (2007) 461–467.
  • G. Raymond, R. Slavin, SL. Spector, I.L. Bernstein, The diagnosis and management of sinusitis: A practice parameter update, J. Allergy. Clin. Immunol. 116 (2005) 13–47.
  • M. Wang, P. Shi, B. Chen, H. Zhang. et al, The role of superantigens in chronic rhinosinusitis with nasal polyps, ORL J. Otorhinolaryngol. Relat. Spec., 70 (2007) 97–103.
  • F. Heymans, A. Fischer, N.W. Stow, M. Girard, et al, screening for staphylococcal superantigen genes shows no correlation with the presence or the severity of chronic rhinosinusitis and nasal polyposis, PLoS One (2005).
  • K.A. Seiberling, D.B. Conley, A. Tripathi, L.C. Grammer, et al, Superantigens and chronic rhinosinusitis: detection of staphylococcal exotoxins in nasal polyps. Laryngoscope 115 (2005) 1580–1585.
  • T. Van Zele, M. Vaneechoutte, G. Holtappels, P. Gevaert et al, Detection of enterotoxin DNA in Staphylococcus aureus strains obtained from the middle meatus in controls and nasal polyp patients, Am. J. Rhinol. 22 (2008) 223–227.
  • M. Laudien, S.D. Gadola, R. Podschun, J. Hedderich et al, Nasal carriage of Staphylococcus aureus and endonasal activity in Wegener s granulomatosis as compared to rheumatoid arthritis and chronic rhinosinusitis with nasal polyps, Clin. Exp. Rheumatol. 28 (2010) 51–55.
  • A. Niederfuhr, H. Kirsche, T. Deutschle, S. Poppert, et al, Staphylococcus aureus in nasal lavage and biopsy of patients with chronic rhinosinusitis. Allergy 63 (2008) 1359–1367.
  • M. Burian, C. Wolz, C. Goerke, Regulatory adaptation of Staphylococcus aureus during nasal colonization of humans, PLoS One (2010).

Assessment of Staphylococcal toxins acting as superantigens in different nasal specimens in the etiology of chronic rhinosinusitis

Year 2023, Volume: 51 Issue: 4, 381 - 388, 07.11.2023
https://doi.org/10.15671/hjbc.1302331

Abstract

The mechanism of development of chronic rhinosinusitis(CRS) is not fully known. However, bacteria are thought to play an important role in this clinic. It has been suggested that toxins with superantigen(SAgs) properties produced by one of these bacteria, Staphylococcus aureus(S.aureus), play a role in the development of inflammation associated with sinusitis. In this study, S.aureus was isolated by taking endoscopic sinus biopsy samples and nasal swab samples from patients with CRS and the control group. It was aimed to examine the frequency of S.aureus presence in the samples taken, the presence of toxin genes showing superantigen quality in these isolated bacteria, and to evaluate the roles of these parameters in the development of CRS. More S.aureus was isolated in the samples taken from patients with CRS than in the control group. The isolated S.aureus samples were analysed by real-time PCR method. The presence of enterotoxin A, B, C and D genes in the S.aureus samples isolated from the patient group were found at the rates of 54%, 32%, 16% and 16%, respectively, while these rates were 46%, 24%, 14% and 14% in the control group. The Toxic Shock Syndrome Toxin-1(TSST-1) gene was detected in 20% of the samples isolated from the patient and 46% in the control group bacteria. The fact that S.aureus was isolated in 20% of the patients shows that this bacterium is not necessary for CRS. The frequency of superantigen toxin genes in S.aureus isolates shows that these toxins are not necessary for the development of the disease.

Project Number

095 nolu BAP projesi

References

  • Z. Chegini, M. Didehdar, A. Khoshbayan, J. Karami, M. Yousefimashouf and A. Shariati, The role of Staphylococcus aureus enterotoxin B in chronic rhinosinusitis with nasal polyposis, Cell Communication and Signaling, (2022) 20-29.
  • M.S. Rha, S.W. Kim, D.Y. Chang, J.K. Lee, J. Kim, S.H. Park, R. Khalmuratova, H.S. Lim, K.M. Eun, S.N. Hong, Superantigen-related TH2 CD4+ T cells in nonasthmatic chronic rhinosinusitis with nasal polyps, J. Allergy Clin. Immunol., 145 (2020) 1378-1388.
  • W. Ivy, N. Maina & Neil, Patel & Noam, A. Cohen, Understanding the Role of Biofilms and Superantigens in Chronic Rhinosinusitis, Current Otorhinolaryngology Reports, 6 (2018) 253–262.
  • R.P. Schleimer, A. Kato, A. Peters, D.B. Conley, Epithelium, inflammation, and immunity in the upper airways of humans; studies in chronic rhinosinusitis, Proc. Am. Thorac. Soc., 6 (2009) 288–294.
  • R.G. Slavin, Sinusitis: Viral, bacterial, or fungal and what is the role of staph?, Allergy Asthma Proc.,27 (2006) 447–450.
  • T. Delemarre, N. De Ruyck, G. Holtappels, C. Bachert, E. Gevaert, Unravellingthe expression of interleukin-9 in chronic rhinosinusitis: a possible role for Staphylococcus aureus, Clin. Transl. Allergy. 10 (2020) 1–4.
  • N. Zhang, P. Gevaert, T. van Zele, N.C. Perez et al, An update on the impact of Staphylococcus aureus enterotoxins in chronic sinusitis with nasal polyposis, Rhinology, 43 (2005) 162–168.
  • C. Bachert, B. Marple, R. J. Schlosser, C. Hopkins, R. P. Schleimer, B. N. Lambrecht, B. M. Bröker, T. Laidlaw and Woo- Jung Song, Adult chronic rhinosinusitis, Nature reviews Disease Primers Article citation, 6 (2020) 86.
  • C. Bachert et al., Staphylococcus aureus and its IgE-inducing enterotoxins in asthma: current knowledge, Eur. Respir. J., 55 (2020) 190-192.
  • Y. Chan, F.A. Kuhn, An update on the classifications, diagnosis, and treatment of rhinosinusitis, Curr. Opin. Otolaryngol. Head Neck Surg., 17 (2009) 204–208.
  • Mde L. da Cunha, R.A. Calsolari, J.P. Júnior, Detection of enterotoxin and toxic shock syndrome toxin 1 genes in staphylococcus, with emphasis on coagulase-negative staphylococci, Microbiol. Immunol., 51 (2007) 381–390.
  • L.M. el Fiky, N. Khamis, Bel D. Mostafa, A.M. Adly, Staphylococcal infection and toxin production in chronic rhinosinusitis, Am. J. Rhinol. Allergy, 23 (2009) 264–267.
  • M. Nagao, A. Okamoto, K. Yamada, T. Hasegawa et al, Variations in amount of TSST-1 produced by clinical methicillin resistant Staphylococcus aureus (MRSA) isolates and allelic variation in accessory gene regulator (agr) locus, BMC Microbiol., 9 (2009) 52.
  • J. Patou, P. Gevaert, T. van Zele, G. Holtappels et al, Staphylococcus aureus enterotoxin b, protein a and lipoteichoic acid stimulations in nasal polyps, J. Allergy Clin. Immunol., 121 (2008) 110–115.
  • A.N. Pearlman, D.B. Conley, Review of current guidelines related to the diagnosis and treatment of rinosinusitis, Curr. Opin. Otolaryngol. Head Neck Surg., 16 (2009) 226–230.
  • T. Proft, J. D. Fraser, Bacterial superantigens, Clin. Exp. Immunol., 133 (2003) 299–306.
  • S.Tuff, S. Haeryfar, J. McCormick, Manipulation of innate and adaptive immunity by staphylococcal superantigens, Pathogens, 7 (2018) 53.
  • B.Fleischer, H. Schrezenmeier, T cell stimulation by staphylococcal enterotoxins. Clonally variable response and requirement for major histocompatibility complex class II molecules on accessory or target cells, J. Exp. Med., 167 (1988) 1697–1707.
  • M. Yarıktas, M. Demirci, F. Döner, M. Tuz et al, Microbiologic findings of sinusitis by a novel method for obtaining culture, Diagn. Microbiol. Infect. Dis., 58 (2007) 49–52.
  • W.E. Kloos, Natural populations of the genus Staphyloccus. Annu. Rev. Microbiol., 34 (1980) 559–592.
  • M. Nagao, A. Okamoto, K. Yamada, T. Hasegawa, et al, Variations in amount of TSST-1 produced by clinical methicillin resistant Staphylococcus aureus (MRSA) isolates and allelic variation in accessory gene regulator (agr) locus. BMC Microbiol., 9 (2009) 52.
  • Y. Lee, B. Moon, J. Park, H. Chang, et al, Expression of enterotoxin genes in Staphylococcus aureus isolates based on mRNA analysis, Microbiol. Biotechnol., 17 (2007) 461–467.
  • G. Raymond, R. Slavin, SL. Spector, I.L. Bernstein, The diagnosis and management of sinusitis: A practice parameter update, J. Allergy. Clin. Immunol. 116 (2005) 13–47.
  • M. Wang, P. Shi, B. Chen, H. Zhang. et al, The role of superantigens in chronic rhinosinusitis with nasal polyps, ORL J. Otorhinolaryngol. Relat. Spec., 70 (2007) 97–103.
  • F. Heymans, A. Fischer, N.W. Stow, M. Girard, et al, screening for staphylococcal superantigen genes shows no correlation with the presence or the severity of chronic rhinosinusitis and nasal polyposis, PLoS One (2005).
  • K.A. Seiberling, D.B. Conley, A. Tripathi, L.C. Grammer, et al, Superantigens and chronic rhinosinusitis: detection of staphylococcal exotoxins in nasal polyps. Laryngoscope 115 (2005) 1580–1585.
  • T. Van Zele, M. Vaneechoutte, G. Holtappels, P. Gevaert et al, Detection of enterotoxin DNA in Staphylococcus aureus strains obtained from the middle meatus in controls and nasal polyp patients, Am. J. Rhinol. 22 (2008) 223–227.
  • M. Laudien, S.D. Gadola, R. Podschun, J. Hedderich et al, Nasal carriage of Staphylococcus aureus and endonasal activity in Wegener s granulomatosis as compared to rheumatoid arthritis and chronic rhinosinusitis with nasal polyps, Clin. Exp. Rheumatol. 28 (2010) 51–55.
  • A. Niederfuhr, H. Kirsche, T. Deutschle, S. Poppert, et al, Staphylococcus aureus in nasal lavage and biopsy of patients with chronic rhinosinusitis. Allergy 63 (2008) 1359–1367.
  • M. Burian, C. Wolz, C. Goerke, Regulatory adaptation of Staphylococcus aureus during nasal colonization of humans, PLoS One (2010).
There are 30 citations in total.

Details

Primary Language English
Subjects Engineering
Journal Section Research Article
Authors

Gülden Vural 0009-0000-6071-4548

Alper Ceylan 0000-0002-6305-4714

M. Nedim Sultan 0000-0002-7450-8515

Project Number 095 nolu BAP projesi
Publication Date November 7, 2023
Acceptance Date September 20, 2023
Published in Issue Year 2023 Volume: 51 Issue: 4

Cite

APA Vural, G., Ceylan, A., & Sultan, M. N. (2023). Assessment of Staphylococcal toxins acting as superantigens in different nasal specimens in the etiology of chronic rhinosinusitis. Hacettepe Journal of Biology and Chemistry, 51(4), 381-388. https://doi.org/10.15671/hjbc.1302331
AMA Vural G, Ceylan A, Sultan MN. Assessment of Staphylococcal toxins acting as superantigens in different nasal specimens in the etiology of chronic rhinosinusitis. HJBC. November 2023;51(4):381-388. doi:10.15671/hjbc.1302331
Chicago Vural, Gülden, Alper Ceylan, and M. Nedim Sultan. “Assessment of Staphylococcal Toxins Acting As Superantigens in Different Nasal Specimens in the Etiology of Chronic Rhinosinusitis”. Hacettepe Journal of Biology and Chemistry 51, no. 4 (November 2023): 381-88. https://doi.org/10.15671/hjbc.1302331.
EndNote Vural G, Ceylan A, Sultan MN (November 1, 2023) Assessment of Staphylococcal toxins acting as superantigens in different nasal specimens in the etiology of chronic rhinosinusitis. Hacettepe Journal of Biology and Chemistry 51 4 381–388.
IEEE G. Vural, A. Ceylan, and M. N. Sultan, “Assessment of Staphylococcal toxins acting as superantigens in different nasal specimens in the etiology of chronic rhinosinusitis”, HJBC, vol. 51, no. 4, pp. 381–388, 2023, doi: 10.15671/hjbc.1302331.
ISNAD Vural, Gülden et al. “Assessment of Staphylococcal Toxins Acting As Superantigens in Different Nasal Specimens in the Etiology of Chronic Rhinosinusitis”. Hacettepe Journal of Biology and Chemistry 51/4 (November 2023), 381-388. https://doi.org/10.15671/hjbc.1302331.
JAMA Vural G, Ceylan A, Sultan MN. Assessment of Staphylococcal toxins acting as superantigens in different nasal specimens in the etiology of chronic rhinosinusitis. HJBC. 2023;51:381–388.
MLA Vural, Gülden et al. “Assessment of Staphylococcal Toxins Acting As Superantigens in Different Nasal Specimens in the Etiology of Chronic Rhinosinusitis”. Hacettepe Journal of Biology and Chemistry, vol. 51, no. 4, 2023, pp. 381-8, doi:10.15671/hjbc.1302331.
Vancouver Vural G, Ceylan A, Sultan MN. Assessment of Staphylococcal toxins acting as superantigens in different nasal specimens in the etiology of chronic rhinosinusitis. HJBC. 2023;51(4):381-8.

HACETTEPE JOURNAL OF BIOLOGY AND CHEMİSTRY

Copyright © Hacettepe University Faculty of Science

http://www.hjbc.hacettepe.edu.tr/

https://dergipark.org.tr/tr/pub/hjbc