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Ranunculus Türlerinin Kimyasal Bileşikleri ve Biyolojik Aktiviteleri

Year 2013, Issue: 1, 105 - 116, 01.01.2013

Tuğçe Fafal Erdoğan

Abstract

Ranunculaceae familyasında yer alan Ranunculus L.türleri fitokimyasal içerikleri ve biyolojik aktiviteleri yönünden ilgili literatürler taranarak araştırılmıştır. Özellikle flavonoit, alkaloit ve saponinlerinin izole edildiği çalışmalar mevcuttur. Bu derlemede, Ranunculus türlerinin halk arasındaki kullanılışları, kimyasal bileşikleri, ve biyolojik aktiviteleri hakkında bilgi verilmiştir.

Keywords

Ranunculus L. Kimyasal bileşikler Biyolojik aktivite

References

  • Davis, P.H., Ranunculus L. (Ranunculaceae). Flora of Turkey and the East Aegeaen Islands, Edinburgh University Press, Edinburgh (1965), Vol. I, 146-197.
  • Davis, P.H., Ranunculus L. (Ranunculaceae). Flora of Turkey and the East Aegeaen Is- lands Supplement, Edinburgh University Press, Edinburgh (1988), Vol. X, 18-22, 231.
  • Güner, A., Ranunculus L. In: Güner, A., Özhatay, N., Ekim, T., Başer, K.H.C. eds., Flora of Turkey and East Aegean Islands Supplement 2, Edinburgh University Press, Edin- burgh, (2000), Vol. XI, 14.
  • Baytop, T., Theraphy with Medicinal Plants in Turkey (Past and Present), 2nd ed, Nobel Tıp Kitabevleri (1999).
  • Uğurlu, E., Seçmen, Ö., Medicinal plants popularly used in the villages of Yunt moun- tain (Manisa-Turkey), Fitoterapia, 79, 126-131 (2008).
  • Gürhan, G., Ezer, N., Plants used for hemorrhoid treatment in folk medicine I., Hacette- pe University Journal of the Faculty of Pharmacy, 24, 37-55 (2004).
  • Newall, C.A., Anderson, L.A., Phillipson, J.D., Herbal Medicines, Pharmaceutical Press, London (1996).
  • Passalacqua, N.G., Guarrea, P.M., De Fine, G., Constribution to the knowledge of the folk plant medicine in Calabria Region (Southern Italy), Fitoterapia, 78, 52-68 (2007).
  • Mantle, D., Gok, M.A., Lennard, T.W., Adverse and Benefical Effects of Plant Extract on Skin and Skin Disorders, Adverse Drug Reactions and Toxicological Reviews, 20, 89- 103 (2001).
  • Honda,G., Yeşilada, E., Tabata, M., Sezik, E., Fujita, T., Takeda, Y., Takaishi, Y., Tana- ka, T., Traditional medicine in Turkey VI. medicine in west Anatolia: Afyon, Kütahya, Denizli, Muğla, Aydın Proniences, Journal of Ethnopharmacology, 53, 75-87 (1991).
  • Sezik, E., Yeşilada, E., Honda, G., Takaishi, Y., Takeda, Y., Tanaka, T., Traditional medicine in Turkey X. Folk medicine in central Anatolia, Journal of Ethnopharmacol- ogy 75, 95-115 (2001).
  • Özgen, U., Kaya, Y., Houghton, P., Folk Medicines in the villages of Ilıca district (Er- zurum, Turkey), Turkish Journal of Biology, 36, 93-106 (2012).
  • Baytop, T., Türkiye’de Bitkilerle Tedavi, Sanal Matbaacılık, İstanbul (1984) 165, 375.
  • Sadıkoğlu, N., Alpınar, K., Bartın: from an ethnobotanical ponit of view. In:Gürkan, E., Tuzlacı, E. Eds. XIII th meeting on Plant Originated Crude Drugs Proceeding Book, Marmara University pres, 2000, 87-100
  • Töngel, M.Ö., Samsun İli Çayır ve Meralarında Yetişen Bazı Zararlı Bitkiler ve Hayvan- lar Üzerindeki Etkileri, Journal of Faculty of Agriculture of OMU, 20(1), 84-93 (2005).
  • Turner, N.J.: Counter-irritant Sand Other Medicinal Uses of Plants in the Ranuncula- ceae by Native People in British Columbia and Neighboring Areas, Journal of Ethno- pharmacology, 11, 181-201 (1984).
  • Lubenov, Y.: Zararlı Otlar Yaşam ve Ölüm Kaynağıdır. Bulgarcadan çevirenler: Basri Makaklı, Mustafa Dinçer, Çağ Matbaası, Ankara (1985).
  • Toki, K., Takeuchi, M., Saito, N., Honda, T., Two malonylated antocyanidin glycosides in R. asiaticus, Phytochemistry, 42 (4), 1055-1057 (1996).
  • Gürhan, G., Ezer, N., Plants used for hemorrhoid treatment in folk medicine I., Hacette- pe University Journal of the Faculty of Pharmacy, 24, 37-55 (2004).
  • Newall, C.A., Anderson, L.A., Phillipson, J.D., 1996. Herbal Medicines, Pharmaceutical Press, London (1996).
  • Zhou, X., Peng, J., Fan, G., Wu, Y., Isolation and Purification of Flavonoid Glycosides from Trollius ledebouri Using High Speed Counter Current Chromatography by Step- wise Increasing the Flow-Rate of the Mobile Phase, Journal of Chromatography A, 1091 (2), 216-221 (2005).
  • Akkol, E.K., Süntar, İ., Erdoğan, T.F., Keleş, H., Gönenç, T.M., Kıvçak, B., Wound healing and anti-inflammatory properties of Ranunculus pedatus and Ranunculus con- stantinapolitanus: A comparitive study, Journal of Ethnopharmacology, 139, 478-484 (2012).
  • Webster, S.D., A chromatographic investigation of the flavonoids of Ranunculus L. sub- genus batrachium (DC.) a gary and selected species in subgenus Ranunculus, Aquatic Botany, 40, 11-26 (1991).
  • Fiasson, J.L., Gluchoff-Fiasson, K., Favre-Bonvin, J., Quercetin glycosides from antar- tic Ranunculus species, Phytochemistry, 37(6), 1629-1633 (1994).
  • Markham, K.R., Campos, M., Mitchell, K.A., An Unusually lipophilic flavonol glycoside from R. sardous Pollen., Phytochemistry, 45 (1), 203-204 (1997).
  • Prieto, J.M., Braca, A., Morelli, F., Barker, A., Schaffner, M., A new acylated quercetin glycoside from R. lanuginosus , Fitoterapia, 75, 533-538 (2004).
  • Liang, Y., Chen, Z., Liu, L., Studies on chemical constituents of Ranunculus japonicus, Zhongguo Zhongyao Zazki, 33, 2201-2203 (2008).
  • Wegner, C., Hamburger, M., Tensioactive compounds from the aquatic Plant Ranuncu- lus fluitans L. (Ranunculaceae) Helvetica Chimica Acta, 83, 1454-1464 (2000).
  • Marston, A, Cabo, M., Lubrano, C., Clarification of the saponin composition of Ranun- culus ficaria tubers, Natural Product Communications, 1, 27-32 (2006).
  • Zhao, Y., Ruan, J.L., Wang, J.H., Cong, Y., Song, S., Caı, Y.L., Zhou, D.N., Chemical constituents of Radix Ranunculi ternati, Nat. Prod. Res., 22 (3), 233-240 (2008).
  • Bonora, A., Tosi, A., Dallolio, G., Bruni, A., Quaternary alkaloids in rhizomes of R. ser- bicus” , Phytochemistry, 29(7), 2389-2390 (1990).
  • Zhang, L., Yang, Z., Tian, J.K., Two new indolopyridoquinazoline alkaloidal glycosides from Ranunculus ternatus, Chemical & Pharmaceutical Bulletin, 55(8), 1267-1269 (2007).
  • Toki, K., Takeuchi, M., Saito, N., Honda, T., Two malonylated antocyanidin glycosides in R. asiaticus, Phytochemistry, 42 (4), 1055-1057 (1996).
  • Tian, J.K., Wu, L.M., Wang, M., Deng, L.Q., Studies on chemical constituents of Ranun- culus ternatus, Chinese Pharmaceutical Journal, 39 (9), 661-662 (2004).
  • Tian, J.K., Sun, F., Cheng, Y., Chemical constituents from the roots of Ranunculus ternatus, Journal of Asian Natural Product Research, 8 (1-2), 35-39 (2006).
  • Zou, Y., Tan, C., Wang, B., Jiang, S., Zhu, D., Phenolic compounds from Ranunculus chinensis, Chemistry of Natural Compounds, 46 (1), 19-21 (2010).
  • Erdoğan, T., Brine Shrimp lethality bioassay on some Ranunculus species”, Journal of Faculty of Pharmacy of Ankara University, 37 (3), 171-177 (2008).
  • Karagöz, A., Cevahir, G., Özcan, T., Sadıkoğlu, N., Yentür, S., Kuru, A. (29-31 Mayıs 2002). Bazı yüksek bitkilerden hazırlanan sulu ekstrelerin antiviral aktivite potansiyel- lerin değerlendirilmesi, 14.BİHAT, Eskişehir, 318-321
  • Qasem, J.R., Fungisidal activity of Ranunculus asiaticus and other weeds against Fu- sarium oxysporum f. sp. lycopersici, Annals of Applied Biology 128, 533-540 (1996).
  • Orhan, İ., Wisespongpand, P., Atıcı, T., Şener, B., Toxicity propensities of some marine and fresh-water algae as their chemical defense, Journal of Faculty of Pharmacy of Ankara University, 32 (1), 19-29 (2003).
  • Barbour, E.K., Shraif, M.A., Sagherion, A.N., Habre, R.S., Talhouk, S.N., Screening of selected indigenous plants of Lebanon for antimicrobial activity, Journal of Ethnophar- macology, 93, 1-7 (2004).
  • Orhan, I., Şener, B., Atıcı, T., Brun, R., Perozzo, R., Taşdemir, D., Turkish freshwater and marine macrophyte extracts show in-vitro antiprotozoal activity and inhibit FabI, a key enzyme of Plasmodium falciparum fatty acid biosynthesis, Phytomedicine, 13, 388- 393 (2006).
  • Terzioğlu, S., Yaşar, A., Yaylı, N., Yılmaz, N., Karaoğlu, S., Yaylı, N., Antimicrobial aci- tivity and essential oil compositions of two Ranunculus species from Turkey: R. constan- tinapolitanus and R. arvensis, Asian Journal of Chemistry, 20 (4), 3277-3283 (2008).
  • Kaya, G.I., Somer, N.U., Konyalıoğlu, S., Yalçın, H.T., Yavaşoğlu, U., Sarıkayai B., Onur, M.A., Antioxidant and antibacterial activities of Ranunculus marginatus var. trachycar- pus and R. sprunerianus, Turkish Journal of Biology, 34, 1-8 (2010).
  • Hussain, J., Hussain, H., Shinwari, Z.K., Ahmad, I., Hussain, T., Ahmad, V., Antibacte- rial activity of the chemical constituents from Ranunculus laetus, Chemistry of Natural Products, 45 (5), 720-721 (2009).
  • Coban, E.P., Bıyık, H., Antimicrobial activity of the ethanol extracts of some plants natural growing in Aydın, Turkey, African Journal of Microbiology Research, 4 (21), 2318-2323 (2010).
  • Hussain, I., Khattak, M., Muhammed, Z., Khan, N., Khan, f., Ullah, Z., Haider, S., Phytochemicals screening and antimicrobial activities of selected medicinal plants of Khyberpakhtunkhwa Pakistana, African Journal of Pharmacy and Pharmacology, 5 (6), 746-750 (2011).
  • Marja, P.K., Hopia, A., Vuorela, H., Rauha, J., Pihlaja, K., Kujala, T.S., Heinonen, M., Antioxidant activity of plant extracts containing phenolic compounds, Journal of Agri- cultural Food Chemistry, 47, 3954-3962 (1999).
  • Mantle, D., Gok, M.A., Lennard, T.W., Adverse and benefical effects of plant extract on skin and skin disorders, Adverse Drug Reactions and Toxicological Reviews., 20, 89- 103 (2001).
  • Cuellar, M.J., Giner, R.M., Recio, R.M., Just, M.C., Manez, S., Cerda, S., Rios, J.L., Screening of antiinflammatory medicinal plants used in traditional medicine against skin diseases, Phytotheray Research, 12, 18-23 (1998).
  • Prieto, J.M., Recio, M.C., Giner, S.M., Rios, J.L., Pharmacological approach to the pro and anti-inflammatory effects of Ranunculus sceleratus L., Journal of Ethnopharma- cology, 89, 131-137 (2003).
  • Schinella, G.R., Tournier, H.A., Prieto, J.M., Rios, J.L., Buschiazzo, H., Zaidenbergi A., Inhibition of Trypanosoma cruzi growth by medicinal plant extracts, Fitoterapia, 73, 569-575 (2002).
  • Chi, Y., Yigin, Y., Sheng, Y., Effect and composition of organic acid of Ranunculus ter- nati, Zhongyiyao Daxue Xuebao, 23 (6), 365-367 (2007).
  • Zhou, Q., Yu, H., Effect of Ranunculs ternate saponins on apoptosis and mitochon- dria membrane potential in human colon carcinoma LoVo cells, Zhonghua Zhongyiyao Xuekan, 27 (5), 1079-1081 (2009).
  • Kondo, T., Timing of skin wounds, Legal Medicine, 9, 109-114 (2007).
  • Campos, M.G., Webby, R.F., Markham, K.R., Age-induced diminution of free radical scavening capacity in bee pollens and the contribution of constituent flavonoids, Jour- nal of Agricultural Food Chemistry, 51, 742-745 (2008).
  • Cowan, M.M., Plant products as antimicrobial agents. Clinical Microbiology Reviews, 564-582 (1999).

Chemical Constituents and Biological Activities of Ranunculus L. Species

Year 2013, Issue: 1, 105 - 116, 01.01.2013

Tuğçe Fafal Erdoğan

Abstract

Ranunculus L. species from Ranunculaceae family have been investigated by literature review for their phytochemical contents and biological activities. Especially, there have been studies on the isolation of flavonoids, alkaloids and saponins. In this review, some informations have been given about traditional utilizations, phytochemical studies and biological activities of Ranunculus species.

Keywords

Ranunculus L. Chemical constituents Biological activity

References

  • Davis, P.H., Ranunculus L. (Ranunculaceae). Flora of Turkey and the East Aegeaen Islands, Edinburgh University Press, Edinburgh (1965), Vol. I, 146-197.
  • Davis, P.H., Ranunculus L. (Ranunculaceae). Flora of Turkey and the East Aegeaen Is- lands Supplement, Edinburgh University Press, Edinburgh (1988), Vol. X, 18-22, 231.
  • Güner, A., Ranunculus L. In: Güner, A., Özhatay, N., Ekim, T., Başer, K.H.C. eds., Flora of Turkey and East Aegean Islands Supplement 2, Edinburgh University Press, Edin- burgh, (2000), Vol. XI, 14.
  • Baytop, T., Theraphy with Medicinal Plants in Turkey (Past and Present), 2nd ed, Nobel Tıp Kitabevleri (1999).
  • Uğurlu, E., Seçmen, Ö., Medicinal plants popularly used in the villages of Yunt moun- tain (Manisa-Turkey), Fitoterapia, 79, 126-131 (2008).
  • Gürhan, G., Ezer, N., Plants used for hemorrhoid treatment in folk medicine I., Hacette- pe University Journal of the Faculty of Pharmacy, 24, 37-55 (2004).
  • Newall, C.A., Anderson, L.A., Phillipson, J.D., Herbal Medicines, Pharmaceutical Press, London (1996).
  • Passalacqua, N.G., Guarrea, P.M., De Fine, G., Constribution to the knowledge of the folk plant medicine in Calabria Region (Southern Italy), Fitoterapia, 78, 52-68 (2007).
  • Mantle, D., Gok, M.A., Lennard, T.W., Adverse and Benefical Effects of Plant Extract on Skin and Skin Disorders, Adverse Drug Reactions and Toxicological Reviews, 20, 89- 103 (2001).
  • Honda,G., Yeşilada, E., Tabata, M., Sezik, E., Fujita, T., Takeda, Y., Takaishi, Y., Tana- ka, T., Traditional medicine in Turkey VI. medicine in west Anatolia: Afyon, Kütahya, Denizli, Muğla, Aydın Proniences, Journal of Ethnopharmacology, 53, 75-87 (1991).
  • Sezik, E., Yeşilada, E., Honda, G., Takaishi, Y., Takeda, Y., Tanaka, T., Traditional medicine in Turkey X. Folk medicine in central Anatolia, Journal of Ethnopharmacol- ogy 75, 95-115 (2001).
  • Özgen, U., Kaya, Y., Houghton, P., Folk Medicines in the villages of Ilıca district (Er- zurum, Turkey), Turkish Journal of Biology, 36, 93-106 (2012).
  • Baytop, T., Türkiye’de Bitkilerle Tedavi, Sanal Matbaacılık, İstanbul (1984) 165, 375.
  • Sadıkoğlu, N., Alpınar, K., Bartın: from an ethnobotanical ponit of view. In:Gürkan, E., Tuzlacı, E. Eds. XIII th meeting on Plant Originated Crude Drugs Proceeding Book, Marmara University pres, 2000, 87-100
  • Töngel, M.Ö., Samsun İli Çayır ve Meralarında Yetişen Bazı Zararlı Bitkiler ve Hayvan- lar Üzerindeki Etkileri, Journal of Faculty of Agriculture of OMU, 20(1), 84-93 (2005).
  • Turner, N.J.: Counter-irritant Sand Other Medicinal Uses of Plants in the Ranuncula- ceae by Native People in British Columbia and Neighboring Areas, Journal of Ethno- pharmacology, 11, 181-201 (1984).
  • Lubenov, Y.: Zararlı Otlar Yaşam ve Ölüm Kaynağıdır. Bulgarcadan çevirenler: Basri Makaklı, Mustafa Dinçer, Çağ Matbaası, Ankara (1985).
  • Toki, K., Takeuchi, M., Saito, N., Honda, T., Two malonylated antocyanidin glycosides in R. asiaticus, Phytochemistry, 42 (4), 1055-1057 (1996).
  • Gürhan, G., Ezer, N., Plants used for hemorrhoid treatment in folk medicine I., Hacette- pe University Journal of the Faculty of Pharmacy, 24, 37-55 (2004).
  • Newall, C.A., Anderson, L.A., Phillipson, J.D., 1996. Herbal Medicines, Pharmaceutical Press, London (1996).
  • Zhou, X., Peng, J., Fan, G., Wu, Y., Isolation and Purification of Flavonoid Glycosides from Trollius ledebouri Using High Speed Counter Current Chromatography by Step- wise Increasing the Flow-Rate of the Mobile Phase, Journal of Chromatography A, 1091 (2), 216-221 (2005).
  • Akkol, E.K., Süntar, İ., Erdoğan, T.F., Keleş, H., Gönenç, T.M., Kıvçak, B., Wound healing and anti-inflammatory properties of Ranunculus pedatus and Ranunculus con- stantinapolitanus: A comparitive study, Journal of Ethnopharmacology, 139, 478-484 (2012).
  • Webster, S.D., A chromatographic investigation of the flavonoids of Ranunculus L. sub- genus batrachium (DC.) a gary and selected species in subgenus Ranunculus, Aquatic Botany, 40, 11-26 (1991).
  • Fiasson, J.L., Gluchoff-Fiasson, K., Favre-Bonvin, J., Quercetin glycosides from antar- tic Ranunculus species, Phytochemistry, 37(6), 1629-1633 (1994).
  • Markham, K.R., Campos, M., Mitchell, K.A., An Unusually lipophilic flavonol glycoside from R. sardous Pollen., Phytochemistry, 45 (1), 203-204 (1997).
  • Prieto, J.M., Braca, A., Morelli, F., Barker, A., Schaffner, M., A new acylated quercetin glycoside from R. lanuginosus , Fitoterapia, 75, 533-538 (2004).
  • Liang, Y., Chen, Z., Liu, L., Studies on chemical constituents of Ranunculus japonicus, Zhongguo Zhongyao Zazki, 33, 2201-2203 (2008).
  • Wegner, C., Hamburger, M., Tensioactive compounds from the aquatic Plant Ranuncu- lus fluitans L. (Ranunculaceae) Helvetica Chimica Acta, 83, 1454-1464 (2000).
  • Marston, A, Cabo, M., Lubrano, C., Clarification of the saponin composition of Ranun- culus ficaria tubers, Natural Product Communications, 1, 27-32 (2006).
  • Zhao, Y., Ruan, J.L., Wang, J.H., Cong, Y., Song, S., Caı, Y.L., Zhou, D.N., Chemical constituents of Radix Ranunculi ternati, Nat. Prod. Res., 22 (3), 233-240 (2008).
  • Bonora, A., Tosi, A., Dallolio, G., Bruni, A., Quaternary alkaloids in rhizomes of R. ser- bicus” , Phytochemistry, 29(7), 2389-2390 (1990).
  • Zhang, L., Yang, Z., Tian, J.K., Two new indolopyridoquinazoline alkaloidal glycosides from Ranunculus ternatus, Chemical & Pharmaceutical Bulletin, 55(8), 1267-1269 (2007).
  • Toki, K., Takeuchi, M., Saito, N., Honda, T., Two malonylated antocyanidin glycosides in R. asiaticus, Phytochemistry, 42 (4), 1055-1057 (1996).
  • Tian, J.K., Wu, L.M., Wang, M., Deng, L.Q., Studies on chemical constituents of Ranun- culus ternatus, Chinese Pharmaceutical Journal, 39 (9), 661-662 (2004).
  • Tian, J.K., Sun, F., Cheng, Y., Chemical constituents from the roots of Ranunculus ternatus, Journal of Asian Natural Product Research, 8 (1-2), 35-39 (2006).
  • Zou, Y., Tan, C., Wang, B., Jiang, S., Zhu, D., Phenolic compounds from Ranunculus chinensis, Chemistry of Natural Compounds, 46 (1), 19-21 (2010).
  • Erdoğan, T., Brine Shrimp lethality bioassay on some Ranunculus species”, Journal of Faculty of Pharmacy of Ankara University, 37 (3), 171-177 (2008).
  • Karagöz, A., Cevahir, G., Özcan, T., Sadıkoğlu, N., Yentür, S., Kuru, A. (29-31 Mayıs 2002). Bazı yüksek bitkilerden hazırlanan sulu ekstrelerin antiviral aktivite potansiyel- lerin değerlendirilmesi, 14.BİHAT, Eskişehir, 318-321
  • Qasem, J.R., Fungisidal activity of Ranunculus asiaticus and other weeds against Fu- sarium oxysporum f. sp. lycopersici, Annals of Applied Biology 128, 533-540 (1996).
  • Orhan, İ., Wisespongpand, P., Atıcı, T., Şener, B., Toxicity propensities of some marine and fresh-water algae as their chemical defense, Journal of Faculty of Pharmacy of Ankara University, 32 (1), 19-29 (2003).
  • Barbour, E.K., Shraif, M.A., Sagherion, A.N., Habre, R.S., Talhouk, S.N., Screening of selected indigenous plants of Lebanon for antimicrobial activity, Journal of Ethnophar- macology, 93, 1-7 (2004).
  • Orhan, I., Şener, B., Atıcı, T., Brun, R., Perozzo, R., Taşdemir, D., Turkish freshwater and marine macrophyte extracts show in-vitro antiprotozoal activity and inhibit FabI, a key enzyme of Plasmodium falciparum fatty acid biosynthesis, Phytomedicine, 13, 388- 393 (2006).
  • Terzioğlu, S., Yaşar, A., Yaylı, N., Yılmaz, N., Karaoğlu, S., Yaylı, N., Antimicrobial aci- tivity and essential oil compositions of two Ranunculus species from Turkey: R. constan- tinapolitanus and R. arvensis, Asian Journal of Chemistry, 20 (4), 3277-3283 (2008).
  • Kaya, G.I., Somer, N.U., Konyalıoğlu, S., Yalçın, H.T., Yavaşoğlu, U., Sarıkayai B., Onur, M.A., Antioxidant and antibacterial activities of Ranunculus marginatus var. trachycar- pus and R. sprunerianus, Turkish Journal of Biology, 34, 1-8 (2010).
  • Hussain, J., Hussain, H., Shinwari, Z.K., Ahmad, I., Hussain, T., Ahmad, V., Antibacte- rial activity of the chemical constituents from Ranunculus laetus, Chemistry of Natural Products, 45 (5), 720-721 (2009).
  • Coban, E.P., Bıyık, H., Antimicrobial activity of the ethanol extracts of some plants natural growing in Aydın, Turkey, African Journal of Microbiology Research, 4 (21), 2318-2323 (2010).
  • Hussain, I., Khattak, M., Muhammed, Z., Khan, N., Khan, f., Ullah, Z., Haider, S., Phytochemicals screening and antimicrobial activities of selected medicinal plants of Khyberpakhtunkhwa Pakistana, African Journal of Pharmacy and Pharmacology, 5 (6), 746-750 (2011).
  • Marja, P.K., Hopia, A., Vuorela, H., Rauha, J., Pihlaja, K., Kujala, T.S., Heinonen, M., Antioxidant activity of plant extracts containing phenolic compounds, Journal of Agri- cultural Food Chemistry, 47, 3954-3962 (1999).
  • Mantle, D., Gok, M.A., Lennard, T.W., Adverse and benefical effects of plant extract on skin and skin disorders, Adverse Drug Reactions and Toxicological Reviews., 20, 89- 103 (2001).
  • Cuellar, M.J., Giner, R.M., Recio, R.M., Just, M.C., Manez, S., Cerda, S., Rios, J.L., Screening of antiinflammatory medicinal plants used in traditional medicine against skin diseases, Phytotheray Research, 12, 18-23 (1998).
  • Prieto, J.M., Recio, M.C., Giner, S.M., Rios, J.L., Pharmacological approach to the pro and anti-inflammatory effects of Ranunculus sceleratus L., Journal of Ethnopharma- cology, 89, 131-137 (2003).
  • Schinella, G.R., Tournier, H.A., Prieto, J.M., Rios, J.L., Buschiazzo, H., Zaidenbergi A., Inhibition of Trypanosoma cruzi growth by medicinal plant extracts, Fitoterapia, 73, 569-575 (2002).
  • Chi, Y., Yigin, Y., Sheng, Y., Effect and composition of organic acid of Ranunculus ter- nati, Zhongyiyao Daxue Xuebao, 23 (6), 365-367 (2007).
  • Zhou, Q., Yu, H., Effect of Ranunculs ternate saponins on apoptosis and mitochon- dria membrane potential in human colon carcinoma LoVo cells, Zhonghua Zhongyiyao Xuekan, 27 (5), 1079-1081 (2009).
  • Kondo, T., Timing of skin wounds, Legal Medicine, 9, 109-114 (2007).
  • Campos, M.G., Webby, R.F., Markham, K.R., Age-induced diminution of free radical scavening capacity in bee pollens and the contribution of constituent flavonoids, Jour- nal of Agricultural Food Chemistry, 51, 742-745 (2008).
  • Cowan, M.M., Plant products as antimicrobial agents. Clinical Microbiology Reviews, 564-582 (1999).
There are 57 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Tuğçe Fafal Erdoğan

Publication Date January 1, 2013
Published in Issue Year 2013 Issue: 1

Cite

Vancouver Erdoğan TF. Ranunculus Türlerinin Kimyasal Bileşikleri ve Biyolojik Aktiviteleri. HUJPHARM. 2013(1):105-16.