Review
Year 2023,
Volume: 8 Issue: 2, 159 - 166, 31.08.2023
Abstract
Süt proteinleri yapısında sadece esansiyel aminoasit içermeyip, aynı zamanda besleyici, fonksiyonel ve sağlığa yararlı biyolojik olarak aktif peptidlerin de temel kaynağıdır. Biyoaktif peptidler protein içerisinde inaktif formda bulunur ve süte ısıl işlem uygulaması, sütün proteolitik starter kültür ile fermantasyonu, sütün gastrointestinal sistemde sindirimi veya proteolitik enzimlerle (pepsin, tripsin ve kimotripsin, bitkisel kaynaklı papain, mikrobiyal kaynaklı subtilisin, termolisin, proteinaz K ve diğerleri) hidrolizi gibi farklı metodlar uygulanarak serbest hale geçerler. Son yıllarda süt proteinlerine ve özellikle de ana proteinden serbest hale geçen biyoaktif peptidlere olan ilgi artış göstermiştir. Yapılan in vivo çalışmalarda süt proteini türevli bu peptidlerin sindirim, bağışıklık, dolaşım ve sinir sistemini etkileyen aktiviteye sahip olduğu belirlenmiştir. Ayrıca ACE-inhibitörü, antihipertansif ve antioksidatif etkiye de sahip olduğu tespit edilmiştir. Çoğu araştırmada bu peptidleri belirlemek için inek sütü proteini kullanılmıştır. Fakat bazı çalışmalarda koyun, keçi, manda gibi diğer türlerden alınan süt örneklerinde de biyoaktif peptidlerin bulunduğu tespit edilmiştir. Türler arasındaki genetik varyasyonlar nedeniyle süt proteinlerinin temel yapısı değişim gösterebilmektedir. Bundan dolayı oluşan biyoaktif peptidlerin potansiyel aktiviteleri de farklılık oluşturabilmektedir. Bu araştırma da biyoaktif peptidlerle ilgili bilgi vermek ve üzerinde daha az çalışılmış olan koyun, keçi, deve, eşek, manda sütlerinin bazı besinsel özellikleri ile içermiş oldukları biyoaktif peptidler ve bunların inek sütüyle kısmen kıyaslanılmasına değinilmiştir.
References
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- Kınık Ö, Gürsoy O: Süt proteinleri kaynaklı biyoaktif peptitler. Mühendislik Bilimleri Dergisi, 8(2), 195-203, 2002.
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- López-Fandiño R, Otte J, Van Camp J: Physiological, chemical and technological aspects of milk-protein-derived peptides with antihypertensive and ACE-inhibitory activity. International Dairy Journal, 16: 1277–1293, 2006. doi: 10.1016/j.idairyj.2006.06.004
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- Giacometti J, Buretić-Tomljanović A: Peptidomics as a tool for characterizing bioactive milk peptides. Food Chemistry 230: 91–98, 2017. doi: 10.1016/j.foodchem.2017.03.016
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- Dalziel JE, Smolenskic GA, McKenzied CM, Hainese SR, Day L: Differential effects of sheep and cow skim milk before and after fermentation on gastrointestinal transit of solids in a rat model. Journal of Functional Foods, 47: 116–126, 2018. doi: 10.1016/j.jff.2018.05.039
- Juarez M: Dairy Foods Symposium: Bioactive components in milk and dairy products: recent international perspectives and progresses in different dairy species. J. Anim. Sci., 90, Suppl. 3/J. Dairy Sci. Vol. 95, Suppl. 2, 2012.
- Moatsou G, Sakkas L: Sheep milk components: focus on nutritional advantages and biofunctional potential. In press, 2019. doi: 10.1016/j.smallrumres.2019.07.009
- Vorland LH, Ulvatne H, Andersen J, Haukland HH, Rekdal Ø, Svendsen JS, Gutteberg TJ: Lactoferricin of bovine origin is more active than lactoferricins of human, murine and caprine origin. Scandinavian J. Infect. Dis., 30: 513–517, 1998. doi: 10.1080/00365549850161557
- Park YW, Juárez M, Ramos M, Haenlein GFW: Physico-chemical characteristics of goat and sheep milk. Small Ruminant Research, 68: 88–113, 2007. doi: 10.1016/j.smallrumres.2006.09.013
- Verruck S, Dantas A, Prudencio ES: Functionality of the components from goat’s milk, recent advances for functional dairy products development and its implications on human health. Journal of Functional Foods, 52: 243–257, 2019. doi: 10.1016/j.jff.2018.11.017
- Öztürkoğlu-Budak Ş, Gürsel A: Alternatif bir süt: eşek sütü. GIDA, 37 (4): 243-250, 2012.
- Park YW: Dairy Foods Symposium: Bioactive components in milk and dairy products: recent international perspectives and progresses in different dairy species. J. Anim. Sci., 90, Suppl. 3/J. Dairy Sci. Vol. 95, Suppl. 2, 2012.
- Guo M: Dairy foods symposium: bioactive components in milk and dairy products: recent international perspectives and progresses in different dairy species. J. Anim. Sci., 90, Suppl. 3/J. Dairy Sci. Vol. 95, Suppl. 2, 2012.
- Ibrahim HR, Ahmed AS, Miyata T: Novel angiotensin-converting enzyme inhibitory peptides from caseins and whey proteins of goat milk. Journal of Advanced Research, 8: 63–71, 2017. doi: 10.1016/j.jare.2016.12.002
- Rani S, Pooja K, Pal GK: Exploration of potential angiotensin converting enzyme inhibitory peptides generated from enzymatic hydrolysis of goat milk proteins. Biocatalysis and Agricultural Biotechnology, 11: 83-88, 2017. doi: 10.1016/j.bcab.2017.06.008
- Mudgil P, Baby B, Ngoh YY, Kamal H, Vijayan R, Gan CY, Maqsood S: Molecular binding mechanism and identification of novel anti-hypertensive and anti-inflammatory bioactive peptides from camel milk protein hydrolysates. LWT - Food Science and Technology 112: 108193, 2019. doi: 10.1016/j.lwt.2019.05.091
- Ibrahim HR, Isono H, Miyata T: Potential antioxidant bioactive peptides from camel milk proteins. Animal Nutrition 4: 273-280, 2018. doi: 10.1016/j.aninu.2018.05.004
- Mudgil P, Kamal H, Yuen GC, Maqsood S: Characterization and identification of novel antidiabetic and anti-obesity peptides from camel milk protein hydrolysates. Food Chemistry, 259: 46–54, 2018. doi: 10.1016/j.foodchem.2018.03.082
- Tagliazucchi D, Shamsia S, Conte A: Release of angiotensin converting enzyme-inhibitory peptides during in vitro gastro-intestinal digestion of camel milk. International Dairy Journal, 56: 119–128, 2016. doi: 10.1016/j.idairyj.2016.01.009
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- El-Agamy EI: Bioactive components in camel milk. In Bioactive Components in Milk and Dairy Products; Park, Y.W., Ed.; Wiley-Blackwell: Ames, IA, pp 159–194, 2009.
- Aspri M, Leni G, Galaverna G, Papademas P: Bioactive properties of fermented donkey milk, before and after in vitro simulated gastrointestinal digestion. Food Chemistry 268: 476–484, 2018. doi: 10.1016/j.foodchem.2018.06.119
- Minervini F, Algaron F, Rizzello CG, Fox PF, Monnet, V, Gobbetti, M: Angiotensin I-converting-enzymeinhibitory and antibacterial peptides from Lactobacillus helveticus PR4 proteinase-hydrolyzed caseins of milk from six species. Appl. Environ. Microbiol. 69: 5297–5305, 2003. doi: 10.1128/AEM.69.9.5297-5305.2003
- Cunsolo V, Saletti R, Muccilli V, Foti S: Characterization of the protein profile of donkey’s milk whey fraction. J. Mass Spectrom. 42: 1162–1174, 2007. doi: 10.1002/jms.1247
- Tafaro A, Magrone T, Jirillo F, Martemucci G, D’Alessandro AG, Amati L, Jirillo E: Immunological properties of donkey's milk: its potential use in the prevention of atherosclerosis. Curr Pharmaceut Design, 13: 3711-3717, 2007. doi: 10.2174/138161207783018590
- Bidasolo IB, Ramos M, Gomez-Ruiz JA: In vitro simulated gastrointestinal digestion of donkeys’ milk. Peptide characterization by high performance liquid chromatography-tandem mass spectrometry. Int Dairy J., 24: 146-152, 2012. doi: 10.1016/j.idairyj.2011.04.014
- Abd El-Salam MH, El Shibiny S: A comprehensive review on the composition and properties of buffalo milk. Dairy Sci. & Technol., 91:663–699, 2011. doi: 10.1007/s13594-011-0029-2
- Durmuş N, Kılıç Akyılmaz M, Özçelik B: Süt proteinlerinden biyoaktif peptid eldesi. Gıda, Metabolizma ve Sağlık: Biyoaktif Bileşenler ve Doğal Katkılar Kongresi, İstanbul. 276 p, 2016. ISBN 978-975-561-477-9
Year 2023,
Volume: 8 Issue: 2, 159 - 166, 31.08.2023
Abstract
Milk proteins not only contain essential amino acids in their structure, but also they are the main source of nutrient, functional and health beneficial biologically active peptides. Bioactive peptides (BAPs) are present in protein in inactive form and released active form by heat treatment, fermentation of milk by proteolytic starter culture, digestion of milk in the gastrointestinal tract or hydrolysis by proteolytic enzymes (pepsin, trypsin and chymotrypsin, plant-derived papain, microbial-derived subtilisin, thermolysin, proteinase K and others). In recent years, interest in milk proteins and especially BAPs released from the parent protein has increased. In vivo studies have shown that these milk protein derived peptides have activity affecting digestion, immunity, circulation and nervous system. In addition, it has been found to have ACE-inhibitor, antihypertensive and antioxidative effects. Most studies have used cow milk protein to identify these peptides. However, some other studies have found that BAPs are also found in milk samples taken from other species such as sheep, goat and buffalo. The basic structure of milk proteins may vary due to genetic variations between species. Therefore, the potential activities of the resulting BAPs may also differ. In this study, some nutritional properties of BAPs, least studied animals such as sheep, goat, camel, donkey, buffalo milk and some of their BAPs and their comparison with cow 's milk are discussed.
References
- Semen S, Altıntaş A: Sütte biyoaktif peptitler ve biyolojik önemi. Türk Veteriner Hekimleri Birliği Dergisi, 3 – 4, 2015.
- Korhonen H: Milk-derived bioactive peptides: from science to applications. Journal of Functional Foods, I: 177-187, 2009. doi: 10.1016/j.jff.2009.01.007
- Nielsen SD, Beverly RL, Qu Y, Dallas DC: Milk bioactive peptide database: A comprehensive database of milk protein-derived bioactive peptides and novel visualization. Food Chemistry, 232: 673–682, 2017. doi: 10.1016/j.foodchem.2017.04.056
- Otağ FB, Hayta M: Gıdalarda biyoaktif peptit oluşumu ve aktivitesi üzerine ısıl işlem ve fermantasyonun etkileri. GIDA, 38 (5): 307-314, 2013. doi: 10.5505/gida.2013.99609
- Egger L, Ménard, O: Update on bioactive peptides after milk and cheese digestion. Current Opinion in Food Science, 14: 116-121, 2017. doi: 10.1016/j.cofs.2017.03.003
- Kınık Ö, Gürsoy O: Süt proteinleri kaynaklı biyoaktif peptitler. Mühendislik Bilimleri Dergisi, 8(2), 195-203, 2002.
- Korhonen, H, Pihlanto-Leppälä A: Bioactive peptides: production and functionality. International Dairy Journal, 16: 945-960, 2006. doi: 10.1016/j.idairyj.2005.10.012
- Korhonen, H, Pihlanto- Leppälä A: Milk protein-derived bioactive peptides-novel opportunities for health promotion. IDF Bulletin, 363: 17–26, 2001.
- Mohanty DP, Mohapatra S, Misra S, Sahu PS: Milk derived bioactive peptides and their impact on human health – A review. Saudi Journal of Biological Sciences, 23: 577–583, 2016. doi: 10.1016/j.sjbs.2015.06.005
- Christensen JE, Dudley EG, Pederson JA, Steele JL: Peptidases and amino acid catabolism in lactic acid bacteria. Antonie Van Leeuwenhoek, 76: 217–246, 1999. doi: 10.1023/A:1002001919720
- Piovesana S, Capriotti AL, Cavaliere C, La Barbera G, Samperi R, Zenezini Chiozzi R, Laganà A: Peptidome characterization and bioactivity analysis of donkey milk. J. Proteom. 119: 21–29, 2015. doi: 10.1016/j.jprot.2015.01.020
- Meisel H: Overview on milk protein derived peptides. Int. Dairy Journal, 8: 363-373, 1998. doi: 10.1016/S0958-6946(98)00059-4
- Clare DA, Swaisgood HE: Bioactive milk peptides: a prospectus. J Dairy Sci, 83:1187–1195, 2000. doi: 10.3168/jds.S0022-0302(00)74983-6
- Pihlanto A: Bioactive peptides. In: Encyclopaedia of Dairy Science, 2nd edn (eds H. Roginski, J.W. Fuquay & P.F. Fox), Vol. 3, pp. 879-886. Academic Press, London, 2011.
- Ay C, Şanlı T: Süt ürünlerinde biyoaktif peptitlerin oluşumu ve fonksiyonel özellikleri. ADÜ Ziraat Derg, 15 (1):115-120, 2018. doi: 10.25308/aduziraat.340581
- López-Fandiño R, Otte J, Van Camp J: Physiological, chemical and technological aspects of milk-protein-derived peptides with antihypertensive and ACE-inhibitory activity. International Dairy Journal, 16: 1277–1293, 2006. doi: 10.1016/j.idairyj.2006.06.004
- Abd El-Salam MH, El Shibiny S: Bioactive peptides of buffalo, camel, goat, sheep, mare, and yak milks and milk products, Food Reviews International, 29 (1): 1-23, 2013. doi: 10.1080/87559129.2012.692137
- Giacometti J, Buretić-Tomljanović A: Peptidomics as a tool for characterizing bioactive milk peptides. Food Chemistry 230: 91–98, 2017. doi: 10.1016/j.foodchem.2017.03.016
- Abdel-Hamid M, Otte, J, De Gobba C, Osman A, Hamad E: Angiotensin I-converting enzyme inhibitory activity and antioxidant capacity of bioactive peptides derived from enzymatic hydrolysis of buffalo milk proteins. International Dairy Journal 66: 91-98, 2017. doi: 10.1016/j.idairyj.2016.11.006
- Tagliazucchi D, Martini S, Shamsia S, Helal A, Conte A: Biological activities and peptidomic profile of in vitro-digested cow, camel, goat and sheep milk. International Dairy Journal, 81: 19-27, 2018. doi: 10.1016/j.idairyj.2018.01.014
- Vargas-Bello-Pérez E, Márquez-Hernández RI, Hernández Castellano LE: Bioactive peptides from milk: animal determinants and their implications in human health. Journal of Dairy Research, 86: 136–144, 2019. doi: 10.1017/ S0022029919000384
- Dalziel JE, Smolenskic GA, McKenzied CM, Hainese SR, Day L: Differential effects of sheep and cow skim milk before and after fermentation on gastrointestinal transit of solids in a rat model. Journal of Functional Foods, 47: 116–126, 2018. doi: 10.1016/j.jff.2018.05.039
- Juarez M: Dairy Foods Symposium: Bioactive components in milk and dairy products: recent international perspectives and progresses in different dairy species. J. Anim. Sci., 90, Suppl. 3/J. Dairy Sci. Vol. 95, Suppl. 2, 2012.
- Moatsou G, Sakkas L: Sheep milk components: focus on nutritional advantages and biofunctional potential. In press, 2019. doi: 10.1016/j.smallrumres.2019.07.009
- Vorland LH, Ulvatne H, Andersen J, Haukland HH, Rekdal Ø, Svendsen JS, Gutteberg TJ: Lactoferricin of bovine origin is more active than lactoferricins of human, murine and caprine origin. Scandinavian J. Infect. Dis., 30: 513–517, 1998. doi: 10.1080/00365549850161557
- Park YW, Juárez M, Ramos M, Haenlein GFW: Physico-chemical characteristics of goat and sheep milk. Small Ruminant Research, 68: 88–113, 2007. doi: 10.1016/j.smallrumres.2006.09.013
- Verruck S, Dantas A, Prudencio ES: Functionality of the components from goat’s milk, recent advances for functional dairy products development and its implications on human health. Journal of Functional Foods, 52: 243–257, 2019. doi: 10.1016/j.jff.2018.11.017
- Öztürkoğlu-Budak Ş, Gürsel A: Alternatif bir süt: eşek sütü. GIDA, 37 (4): 243-250, 2012.
- Park YW: Dairy Foods Symposium: Bioactive components in milk and dairy products: recent international perspectives and progresses in different dairy species. J. Anim. Sci., 90, Suppl. 3/J. Dairy Sci. Vol. 95, Suppl. 2, 2012.
- Guo M: Dairy foods symposium: bioactive components in milk and dairy products: recent international perspectives and progresses in different dairy species. J. Anim. Sci., 90, Suppl. 3/J. Dairy Sci. Vol. 95, Suppl. 2, 2012.
- Ibrahim HR, Ahmed AS, Miyata T: Novel angiotensin-converting enzyme inhibitory peptides from caseins and whey proteins of goat milk. Journal of Advanced Research, 8: 63–71, 2017. doi: 10.1016/j.jare.2016.12.002
- Rani S, Pooja K, Pal GK: Exploration of potential angiotensin converting enzyme inhibitory peptides generated from enzymatic hydrolysis of goat milk proteins. Biocatalysis and Agricultural Biotechnology, 11: 83-88, 2017. doi: 10.1016/j.bcab.2017.06.008
- Mudgil P, Baby B, Ngoh YY, Kamal H, Vijayan R, Gan CY, Maqsood S: Molecular binding mechanism and identification of novel anti-hypertensive and anti-inflammatory bioactive peptides from camel milk protein hydrolysates. LWT - Food Science and Technology 112: 108193, 2019. doi: 10.1016/j.lwt.2019.05.091
- Ibrahim HR, Isono H, Miyata T: Potential antioxidant bioactive peptides from camel milk proteins. Animal Nutrition 4: 273-280, 2018. doi: 10.1016/j.aninu.2018.05.004
- Mudgil P, Kamal H, Yuen GC, Maqsood S: Characterization and identification of novel antidiabetic and anti-obesity peptides from camel milk protein hydrolysates. Food Chemistry, 259: 46–54, 2018. doi: 10.1016/j.foodchem.2018.03.082
- Tagliazucchi D, Shamsia S, Conte A: Release of angiotensin converting enzyme-inhibitory peptides during in vitro gastro-intestinal digestion of camel milk. International Dairy Journal, 56: 119–128, 2016. doi: 10.1016/j.idairyj.2016.01.009
- Yerlikaya O, Saygılı D, Karagözlü C: Deve sütü: bileşimi, sağlık üzerine etkileri, deve sütü ürünleri. I.Uluslararası Devecilik Kültürü ve Deve Güreşleri Sempozyumu, Selçuk, İzmir, 2016.
- Food and Agriculture Organization: www.fao.org/3/i3396e/i3396e.pdf, 2013.
- El-Agamy EI: Bioactive components in camel milk. In Bioactive Components in Milk and Dairy Products; Park, Y.W., Ed.; Wiley-Blackwell: Ames, IA, pp 159–194, 2009.
- Aspri M, Leni G, Galaverna G, Papademas P: Bioactive properties of fermented donkey milk, before and after in vitro simulated gastrointestinal digestion. Food Chemistry 268: 476–484, 2018. doi: 10.1016/j.foodchem.2018.06.119
- Minervini F, Algaron F, Rizzello CG, Fox PF, Monnet, V, Gobbetti, M: Angiotensin I-converting-enzymeinhibitory and antibacterial peptides from Lactobacillus helveticus PR4 proteinase-hydrolyzed caseins of milk from six species. Appl. Environ. Microbiol. 69: 5297–5305, 2003. doi: 10.1128/AEM.69.9.5297-5305.2003
- Cunsolo V, Saletti R, Muccilli V, Foti S: Characterization of the protein profile of donkey’s milk whey fraction. J. Mass Spectrom. 42: 1162–1174, 2007. doi: 10.1002/jms.1247
- Tafaro A, Magrone T, Jirillo F, Martemucci G, D’Alessandro AG, Amati L, Jirillo E: Immunological properties of donkey's milk: its potential use in the prevention of atherosclerosis. Curr Pharmaceut Design, 13: 3711-3717, 2007. doi: 10.2174/138161207783018590
- Bidasolo IB, Ramos M, Gomez-Ruiz JA: In vitro simulated gastrointestinal digestion of donkeys’ milk. Peptide characterization by high performance liquid chromatography-tandem mass spectrometry. Int Dairy J., 24: 146-152, 2012. doi: 10.1016/j.idairyj.2011.04.014
- Abd El-Salam MH, El Shibiny S: A comprehensive review on the composition and properties of buffalo milk. Dairy Sci. & Technol., 91:663–699, 2011. doi: 10.1007/s13594-011-0029-2
- Durmuş N, Kılıç Akyılmaz M, Özçelik B: Süt proteinlerinden biyoaktif peptid eldesi. Gıda, Metabolizma ve Sağlık: Biyoaktif Bileşenler ve Doğal Katkılar Kongresi, İstanbul. 276 p, 2016. ISBN 978-975-561-477-9
There are 46 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Food Engineering |
| Journal Section | Review Articles |
| Authors | |
| Early Pub Date | August 30, 2023 |
| Publication Date | August 31, 2023 |
| Submission Date | April 11, 2023 |
| Acceptance Date | July 27, 2023 |
| Published in Issue | Year 2023 Volume: 8 Issue: 2 |