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Akut Malnütrisyonlu Çocuk Hastalarda Albumin ve İskemi Modifiye Albumin Düzeylerinin Değerlendirilmesi

Year 2023, Volume: 20 Issue: 1, 190 - 194, 27.04.2023
https://doi.org/10.35440/hutfd.1186505

Abstract

Amaç: Çocukların büyümek için özel beslenme ihtiyaçları nedeniyle yetersiz beslenme olasılığı önemli ölçüde daha yüksektir. İskemi Değiştirilmiş Albümin (IMA), serum albümini kalbin iskemik dokularıyla temas ettiğinde ortaya çıkan yeni bir iskemi belirtecidir. IMA birkaç akut durumu ölçmek için kullanılmıştır. Ancak çocuklarda akut yetersiz beslenmeyi ölçmek için daha önce kullanılmamıştır. Bu çalışma, yetersiz beslenen çocuklarda albümin ve IMA'nın, çocuklarda yetersiz beslenme belirteçleri olarak kullanılıp kullanılamayacaklarını görmek için incelemeyi amaçlamaktadır.
Materyal ve Metod: 20 Ekim-20 Mayıs 2020 tarihleri arasında hastaneye sevk edilen 84 çocuk (41 erkek ve 43 kız, ortalama yaş (SD): 6.18 (3.89); yaş aralığı: 0.92-16.75 yıl) muayene edildi. Bir uzman çocukların beslenme muayenelerini yaptı. BMI'nin 18.5'in altında olması yetersiz beslenen çocuklar olarak kabul edildi. Değişkenle-rin normalliği hipotezi Kolmogorov-Smirnov testi ile kabul edildi. Değişken ortalamalarındaki farkı gruplarda incelemek için T-testi ve Phi-Korelasyon kullanıldı. ANCOVA testi, değişkenler ile Albümin ve IMA değerleri arasındaki ilişkiyi farklı seviyelerde incelemek için kullanıldı.
Bulgular: Çalışma grubundaki albümin miktarı 4.10 ile 5.15 arasında (ortalama ± SD 4.82± 0.17) ve çalışma grubundaki IMA aralığı 0.56 ile 1.25 arasında (ortalama ± SD 0.74± 0.13) idi. Kontrol grubundaki albümin mikta-rı 4,19 ila 5,19 (ortalama ± SD 4,83±0,18) ve kontrol grubundaki IMA aralığı 0,44 ila 1,11 (ortalama ± SD 0,67± 0,13) arasında değişmektedir. Yetersiz beslenen ve sağlıklı çocuklar arasında albümin değerleri (p değeri = 0.752) arasında anlamlı bir fark gözlenmedi. Bununla birlikte, yetersiz beslenen çocuklarda IMA düzeyi sağlıklı çocuklara göre anlamlı olarak daha yüksekti (p-değeri = 0.19).
Sonuç: Albümin iki grup arasında anlamlı farklılık göstermemesine rağmen, malnütrisyonlu çocukların IMA'sı sağlıklı çocuklara göre anlamlı olarak daha yüksekti. Bu sonuç, IMA'nın çocuklarda yetersiz beslenme için bir belirteç olarak kullanılabileceği anlamına gelir. Bu çalışma, malnütrisyonlu çocuklarda IMA'nın malnütrisyon belirteci olarak kullanılabileceğini gösteren bir ön çalışmadır ve literatüre katkı sağlayacağına inanıyoruz.

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References

  • 1. Collins S, Dent N, Binns P, Bahwere P, Sadler K, Hallam A. Management of severe acute malnutrition in children. The lancet, 2006;368 (9551):1992-2000.
  • 2. Hien NN and Kam S. Nutritional status and the characteristics related to malnutrition in children under five years of age in Nghean, Vietnam. Journal of preventive medicine and public health, 2008;41(4):232-240.
  • 3. Khor GL. Update on the prevalence of malnutrition among children in Asia. Nepal Med Coll J. 2003;5(2):113-22.
  • 4. Nnyepi M, Bandeke T, Mahgoub S. Factors affecting prevalence of malnutrition among children under three years of age in Botswana. 2006.
  • 5. Silveira KBR, Alves JFR, Ferreira HS, Sawaya AL, Florêncio TMMT. Association between malnutrition in children living in favelas, maternal nutritional status, and environmental factors. J Pediatr. 2010; 86(3):215-220.
  • 6. Arrieta O, Ortega RMM, Villanueva-Rodríguez G, Serna-Thomé MG, Flores-Estrada D, Diaz-Romero C, et al., Association of nutritional status and serum albumin levels with development of toxicity in patients with advanced non-small cell lung cancer treated with paclitaxel-cisplatin chemotherapy: a prospective study. BMC cancer, 2010;10(1):50-7.
  • 7. Don BR, Kaysen G. Poor nutritional status and inflammation: serum albumin: relationship to inflammation and nutrition. in Seminars in dialysis. 2004. Wiley Online Library.
  • 8. Karayiannakis AJ, Syrigos KN, Polychronidis A, Pitiakoudis M, Bounovas A, Simopoulos K. Serum levels of tumor necrosis factor-alpha and nutritional status in pancreatic cancer patients. Anticancer research, 2001;21(2B):1355-58.
  • 9. Reddy CB, Cyriac C, Desle HB. Role of “Ischemia Modified Albumin”(IMA) in acute coronary syndromes. Indian heart journal, 2014. 66(6): 656-662.
  • 10. Sbarouni E, Georgiadou P, Voudris V. Ischemia modified albumin changes–review and clinical implications. Clinical Chemistry and Laboratory Medicine (CCLM). 2011;49(2):177-84.
  • 11. Piva SJ, Duarte MMF, Da Cruz IBM, Coelho AC, Moreira APL, Tonello R, et al. Ischemia-modified albumin as an oxidative stress biomarker in obesity. Clinical biochemistry, 2011;44(4):345-347. 12. Gunduz A, Turedi S, Mentese A, Karahan SC, Hos G, Tatli O, et al., Ischemia-modified albumin in the diagnosis of acute mesenteric ischemia: a preliminary study. The American journal of emergency medicine. 2008;26(2):202-5.
  • 13. Lippi G, Montagnana M, Salvagno GL, Guidi GC. Standardization of ischemia-modified albumin testing: adjustment for serum albumin. Clinical Chemical Laboratory Medicine, 2007;45(2):261-2.
  • 14. Abboud H, Labreuche J, Meseguer E, Lavallee FC, Simon O, Olivot JM, et al., Ischemia-modified albumin in acute stroke. Cerebrovascular Diseases, 2007;23(2-3):216-20.
  • 15. Slattery E, Patchett S. Albumin as a marker of nutrition: a common pitfall. Annals of surgery, 2011;254(4):667-8.
  • 16. Bouillanne O, Hay P, Liabaud B, Duché C , Cynober L, Aussel C. Evidence that albumin is not a suitable marker of body composition-related nutritional status in elderly patients. Nutrition, 2011;27(2):165-9.
  • 17. Ellidag HY, Eren E, Yılmaz N, Cekin Y. Oxidative stress and ischemia-modified albumin in chronic ischemic heart failure. Redox Report. 2014;19(3):118-23.
  • 18. Awadallah SM, Atoum MF, Nimer NA, Saleh SA. Ischemia modified albumin: An oxidative stress marker in β-thalassemia major. Clinica Chimica Acta, 2012;413(9-10): 907-10.
  • 19. Üstün EY, Oztürk O, Alanbay I, Yaman H. Ischemia-modified albumin as an oxidative stress marker in preeclampsia. The Journal of Maternal-Fetal and Neonatal Medicine. 2011;24(3): 418-21.
  • 20. Kurban S, Mehmetoglu I, Yerlikaya HF, Gönen S, Erdem S. Effect of chronic regular exercise on serum ischemia-modified albumin levels and oxidative stress in type 2 diabetes mellitus. Endocrine research. 2011;36(3): 116-23.
  • 21. Duarte MM, Rocha JBT, Moresco RN, Duarte T, Da Cruz IBM, Loro VL, et al. Association between ischemia-modified albumin, lipids and inflammation biomarkers in patients with hypercholesterolemia. Clinical biochemistry. 2009;42(7-8): 666-71.
  • 22. Borderie D, Allanore Y, Meune C, Devaux JY, Ekindjian OG, Kahan A. High ischemia-modified albumin concentration reflects oxidative stress but not myocardial involvement in systemic sclerosis. Clinical chemistry. 2004;50(11): 2190-3.
  • 23. Von Zglinicki T. Oxidative stress shortens telomeres. Trends in biochemical sciences, 2002;27(7):339-44.
  • 24. Mittler R. Oxidative stress, antioxidants and stress tolerance. Trends in plant science, 2002;7(9): 405-410.
  • 25. Sies H. What is oxidative stress?, in Oxidative stress and vascular disease. Springer. 2000; p. 1-8.
  • 26. Storz G, Imlayt JA. Oxidative stress. Current opinion in microbiology, 1999;2(2):188-94.
  • 27. Aly GS, Ashraf Hamed Shaalan AH, Mattar MK, Ahmed HH, Zaki ME, Abdallah HR. Oxidative stress status in nutritionally stunted children. Egyptian pediatric association gazette. 2014;62(1): 8-33.

Evaluation of Albumin and Ischemia Modified Albumin Levels in Children with Acute Malnutrition

Year 2023, Volume: 20 Issue: 1, 190 - 194, 27.04.2023
https://doi.org/10.35440/hutfd.1186505

Abstract

Background: Children are significantly more likely to be malnourished due to their special nutritional needs for growth. Ischemia Modified Albumin (IMA) is a new marker of ischemia that occurs when serum albumin comes in contact with the heart's ischemic tissues. IMA has been used to measure several acute conditions but has never been used to measure acute malnutrition in children. This study aims to examine albumin and IMA in malnourished children to see if they can be used as markers of malnutrition in children.
Materials and Methods: 84 children were examined (41 boys and 43 girls, mean age (SD): 6.18 (3.89); range: 0.92-16.75 years) who were referred to the hospital from 20 October to May 20, 2020. A physician performed nutrition examinations on children. BMI of less than 18.5 was considered malnourished children. The hypothesis of the normality of variables was accepted with the Kolmogorov–Smirnov test. To study the difference in variables means at groups, the T-test and Phi-Correlation were used. The ANCOVA was used to study the relationship between variables and Albumin and IMA values at different levels.
Results: The amount of albumin in the study group ranged from 4.10 to 5.15 (mean ± SD 4.82± 0.17), and the IMA range in the study group was 0.56 to 1.25 (mean ± SD 0.74± 0.13). The amount of albumin in the control group ranged from 4.19 to 5.19 (mean ± SD 4.83± 0.18), and the IMA range in the control group was 0.44 to 1.11 (mean ± SD 0.67± 0.13). No significant difference was observed between the albumin values (p-value = 0.752) between malnourished and healthy children. However, the IMA level in malnourished children was significantly higher (p-value = 0.19) than in healthy children.
Conclusions: Although albumin was not significantly different between the two groups, the IMA of malnour-ished children was significantly higher than that of healthy children. This result means that IMA can be used as a marker for malnutrition in children. This study is a preliminary study showing that IMA can be used as a malnutrition marker in children with malnutrition and we believe that it will contribute to the literature.

Project Number

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References

  • 1. Collins S, Dent N, Binns P, Bahwere P, Sadler K, Hallam A. Management of severe acute malnutrition in children. The lancet, 2006;368 (9551):1992-2000.
  • 2. Hien NN and Kam S. Nutritional status and the characteristics related to malnutrition in children under five years of age in Nghean, Vietnam. Journal of preventive medicine and public health, 2008;41(4):232-240.
  • 3. Khor GL. Update on the prevalence of malnutrition among children in Asia. Nepal Med Coll J. 2003;5(2):113-22.
  • 4. Nnyepi M, Bandeke T, Mahgoub S. Factors affecting prevalence of malnutrition among children under three years of age in Botswana. 2006.
  • 5. Silveira KBR, Alves JFR, Ferreira HS, Sawaya AL, Florêncio TMMT. Association between malnutrition in children living in favelas, maternal nutritional status, and environmental factors. J Pediatr. 2010; 86(3):215-220.
  • 6. Arrieta O, Ortega RMM, Villanueva-Rodríguez G, Serna-Thomé MG, Flores-Estrada D, Diaz-Romero C, et al., Association of nutritional status and serum albumin levels with development of toxicity in patients with advanced non-small cell lung cancer treated with paclitaxel-cisplatin chemotherapy: a prospective study. BMC cancer, 2010;10(1):50-7.
  • 7. Don BR, Kaysen G. Poor nutritional status and inflammation: serum albumin: relationship to inflammation and nutrition. in Seminars in dialysis. 2004. Wiley Online Library.
  • 8. Karayiannakis AJ, Syrigos KN, Polychronidis A, Pitiakoudis M, Bounovas A, Simopoulos K. Serum levels of tumor necrosis factor-alpha and nutritional status in pancreatic cancer patients. Anticancer research, 2001;21(2B):1355-58.
  • 9. Reddy CB, Cyriac C, Desle HB. Role of “Ischemia Modified Albumin”(IMA) in acute coronary syndromes. Indian heart journal, 2014. 66(6): 656-662.
  • 10. Sbarouni E, Georgiadou P, Voudris V. Ischemia modified albumin changes–review and clinical implications. Clinical Chemistry and Laboratory Medicine (CCLM). 2011;49(2):177-84.
  • 11. Piva SJ, Duarte MMF, Da Cruz IBM, Coelho AC, Moreira APL, Tonello R, et al. Ischemia-modified albumin as an oxidative stress biomarker in obesity. Clinical biochemistry, 2011;44(4):345-347. 12. Gunduz A, Turedi S, Mentese A, Karahan SC, Hos G, Tatli O, et al., Ischemia-modified albumin in the diagnosis of acute mesenteric ischemia: a preliminary study. The American journal of emergency medicine. 2008;26(2):202-5.
  • 13. Lippi G, Montagnana M, Salvagno GL, Guidi GC. Standardization of ischemia-modified albumin testing: adjustment for serum albumin. Clinical Chemical Laboratory Medicine, 2007;45(2):261-2.
  • 14. Abboud H, Labreuche J, Meseguer E, Lavallee FC, Simon O, Olivot JM, et al., Ischemia-modified albumin in acute stroke. Cerebrovascular Diseases, 2007;23(2-3):216-20.
  • 15. Slattery E, Patchett S. Albumin as a marker of nutrition: a common pitfall. Annals of surgery, 2011;254(4):667-8.
  • 16. Bouillanne O, Hay P, Liabaud B, Duché C , Cynober L, Aussel C. Evidence that albumin is not a suitable marker of body composition-related nutritional status in elderly patients. Nutrition, 2011;27(2):165-9.
  • 17. Ellidag HY, Eren E, Yılmaz N, Cekin Y. Oxidative stress and ischemia-modified albumin in chronic ischemic heart failure. Redox Report. 2014;19(3):118-23.
  • 18. Awadallah SM, Atoum MF, Nimer NA, Saleh SA. Ischemia modified albumin: An oxidative stress marker in β-thalassemia major. Clinica Chimica Acta, 2012;413(9-10): 907-10.
  • 19. Üstün EY, Oztürk O, Alanbay I, Yaman H. Ischemia-modified albumin as an oxidative stress marker in preeclampsia. The Journal of Maternal-Fetal and Neonatal Medicine. 2011;24(3): 418-21.
  • 20. Kurban S, Mehmetoglu I, Yerlikaya HF, Gönen S, Erdem S. Effect of chronic regular exercise on serum ischemia-modified albumin levels and oxidative stress in type 2 diabetes mellitus. Endocrine research. 2011;36(3): 116-23.
  • 21. Duarte MM, Rocha JBT, Moresco RN, Duarte T, Da Cruz IBM, Loro VL, et al. Association between ischemia-modified albumin, lipids and inflammation biomarkers in patients with hypercholesterolemia. Clinical biochemistry. 2009;42(7-8): 666-71.
  • 22. Borderie D, Allanore Y, Meune C, Devaux JY, Ekindjian OG, Kahan A. High ischemia-modified albumin concentration reflects oxidative stress but not myocardial involvement in systemic sclerosis. Clinical chemistry. 2004;50(11): 2190-3.
  • 23. Von Zglinicki T. Oxidative stress shortens telomeres. Trends in biochemical sciences, 2002;27(7):339-44.
  • 24. Mittler R. Oxidative stress, antioxidants and stress tolerance. Trends in plant science, 2002;7(9): 405-410.
  • 25. Sies H. What is oxidative stress?, in Oxidative stress and vascular disease. Springer. 2000; p. 1-8.
  • 26. Storz G, Imlayt JA. Oxidative stress. Current opinion in microbiology, 1999;2(2):188-94.
  • 27. Aly GS, Ashraf Hamed Shaalan AH, Mattar MK, Ahmed HH, Zaki ME, Abdallah HR. Oxidative stress status in nutritionally stunted children. Egyptian pediatric association gazette. 2014;62(1): 8-33.
There are 26 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Research Article
Authors

Ahmet Güzelçiçek 0000-0002-9733-3957

Mahmut Demir 0000-0002-0983-9457

Abdullah Solmaz 0000-0002-9479-8679

Hüseyin Gümüş 0000-0002-9326-2194

Adnan Kirmit 0000-0003-2799-8416

Project Number yok
Early Pub Date April 27, 2023
Publication Date April 27, 2023
Submission Date October 10, 2022
Acceptance Date February 21, 2023
Published in Issue Year 2023 Volume: 20 Issue: 1

Cite

Vancouver Güzelçiçek A, Demir M, Solmaz A, Gümüş H, Kirmit A. Evaluation of Albumin and Ischemia Modified Albumin Levels in Children with Acute Malnutrition. Harran Üniversitesi Tıp Fakültesi Dergisi. 2023;20(1):190-4.

Harran Üniversitesi Tıp Fakültesi Dergisi  / Journal of Harran University Medical Faculty