Research Article
Year 2019,
Volume: 2 Issue: 3, 221 - 230, 28.12.2019
Abstract
Supporting Institution
Harran Üniversitesi
Project Number
18240
Thanks
Bu çalışmaya katkı sağlayan Harran Üniversitesi HÜBAK a teşekkürlerimizi sunarız.
References
- 1. Işık, M., Beydemir, Ş., Yılmaz, A., Naldan, M. E., Aslan, H. E., & Gülçin, İ. Oxidative stress and mRNA expression of acetylcholinesterase in the leukocytes of ischemic patients. Biomedicine & pharmacotherapy, 2017. 87, 561-567.2. Mukherjee, P. K., Kumar, V., Mal, M., & Houghton, P. J. Acetylcholinesterase inhibitors from plants. Phytomedicine, 2007. 14(4), 289-300.3. Choudhary, M. I. Bioactive natural products as a potential source of new pharmacophores. A theory of memory. Pure and Applied Chemistry, 2001. 73(3), 555-560.4. Chaudière, J., & Ferrari-Iliou, R. Intracellular antioxidants: from chemical to biochemical mechanisms. Food and chemical toxicology, 1999. 37(9-10), 949-962. 5. Göçer, H., Akincioğlu, A., Göksu, S., Gülçin, İ., & Supuran, C. T. Carbonic anhydrase and acetylcholinesterase inhibitory effects of carbamates and sulfamoylcarbamates. Journal of enzyme inhibition and medicinal chemistry, 2015. 30(2), 316-320.6. Işık, M. The Binding Mechanisms and Inhibitory Effect of Intravenous Anesthetics on AChE In Vitro and In Vivo: Kinetic Analysis and Molecular Docking. Neurochemical research, 2019. 44, 2147–2155.7. Gulcin, I.. "Antioxidant activity of food constituents: an overview." Archives of Toxicology, 2012. 86(3): 345-391.8. Pokorny, J. . "Are natural antioxidants better - and safer - than synthetic antioxidants? (vol 109, pg 629, 2007)." European Journal of Lipid Science and Technology, 2007. 109(8): 883-883.9. Heim, K. E., A. R. Tagliaferro and D. J. Bobilya. "Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships." Journal of Nutritional Biochemistry, 2002. 13(10): 572-584.10. Hertog, M. G. L., E. J. M. Feskens, P. C. H. Hollman, M. B. Katan and D. Kromhout . "Dietary Antioxidant Flavonoids and Risk of Coronary Heart-Disease - the Zutphen Elderly Study." Lancet, 1993. 342(8878): 1007-1011.11. Kasper, S. Hypericum perforatum: a review of clinical studies. Pharmacopsychiatry 2001, 34 (Suppl. 1), S51-S55.12. Barnes, J.; Anderson, L. A.; Phillipson, J. D. St John’s wort (Hypericum perforatum L.): a review of its chemistry, pharmacology, and clinical properties. J. Pharm. Pharmacol. 2001, 53,583-600.13. Linde K.. St. John’s wort–an overview, Complementary Medicine Research, 2009. 16(3): 146-155.14. Hunt, E. J., Lester, C. E., Lester, E. A., & Tackett, R. L.. Effect of St. John’s wort on free radical production. Life Sciences, 2001. 69, 181–190.15. Hostettmann K., Wolfender J.L. St. John’s Wort and its Active Principles in Depression and Anxiety, Phytochemistry, 2005. 5-20.16. Kozak, A., Bernath, J., Zeitschrift Für Arznei- Und Gewürzpflanzenbau, 11, No. 1, 2006. P. 3417. Pallag, A., Botanicã Farmaceuticã, Sistematica, Cormobionta, Editura Universitatii Din Oradea, 2015. P 29-31.18. Grieve, M.. Horsetails. In:A Modern Herbal. New York: DoverPublishers. 1971; Available from: http://www.botanical.com/botanical/mgmh/mgmh.html (accessed 7 June 2006).19. Veit, M., Beckert, C., Hohne, C., Bauer, K. & Geiger, H.. Interspecific and intraspecific variation of phenolics in the Equisetum.Phytochemistry, 1995. 38, 881–891.20. Asgarpanah, J., Roohı, E., Journal Of Medicinal Plant Research, 2012. 6, No. 21, p. 3689. 21. Hoffman Martins Do Monte, F., Guilherme dos Santos, J. Jr, Russi,M., Nascimento Bispo Lanziotti, V.M., Almeida Moreira Leal,L.K.M. & de Andrade Cunha, G.M. (2004).22. Oh, H., Kim, D.-H., Cho, J.-H. & Kim, Y.-C.. Hepatoprotec-tive and free radical scavenging activities of phenolic petrosins andflavonoids isolated from Equisetum arvense L. Journal of Ethno-pharmacology, 2005. 95, 421–424.23. Beckert, C., Horn, C., Schnitzler, J.-P., Lehning, A., Heller, W. & Veit,M.. Styrylpyrone biosynthesis inEquisetum arvense. Phyto-chemistry, 1997. 44, 275–283.24. Oyaizu, M.. Studies on products of browning reaction: antioxidative activity of products of browning reaction. Jpn. J. Nutr, 1986. 44(6), 307-315.25. Bursal, E., Köksal, E., & Gülçin, I.. In vitro Antioxidant Properties and Phenolic Content of Ginger (Zingiber officinale Rosc) Root. Department of Chemistry, 2012. 86-93.26. Işık, M., Demir, Y., Kırıcı, M., Demir, R., Şimşek, F., & Beydemir, Ş. . Changes in the anti-oxidant system in adult epilepsy patients receiving anti-epileptic drugs. Archives of physiology and biochemistry, 2015. 121(3), 97-102. 27. Blois, M. S.. Antioxidant determinations by the use of a stable free radical. Nature, 1985. 181(4617), 1199.28. Gülçin, İ., Elias, R., Gepdiremen, A., & Boyer, L.. Antioxidant activity of lignans from fringe tree (Chionanthus virginicus L.). European Food Research and Technology, 2006. 223(6), 75929. Ak, T., & Gülçin, İ.. Antioxidant and radical scavenging properties of curcumin. Chemico-biological interactions, 2008. 174(1), 27-37.30. Ellman GL, Courtney KD, Andres V, Featherstone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 1961; 7: 88-95.31. Gülçın, İlhami, et al. Sage (Salvia pilifera): determination of its polyphenol contents, anticholinergic, antidiabetic and antioxidant activities. Journal of Food Measurement and Characterization, 2019, 1-13.32. Chaudière, J., & Ferrari-Iliou, R.. Intracellular antioxidants: from chemical to biochemical mechanisms. Food and chemical toxicology, 1999. 37(9-10), 949-96233. Mukherjee, P. K., Kumar, V., Mal, M., & Houghton, P. J.. Acetylcholinesterase inhibitors from plants. Phytomedicine, 2007. 14(4), 289-300.34. Shekhar, C., & Kumar, S.. Kinetics of acetylcholinesterase inhibition by an aqueous extract of Mentha longifolia leaves. Int J Pharma Sci Drug Res, 2014. 6, 348-50.35. Vinutha, B., Prashanth, D., Salma, K., Sreeja, S. L., Pratiti, D., Padmaja, R., ... & Deepak, M.. Screening of selected Indian medicinal plants for acetylcholinesterase inhibitory activity. Journal of ethnopharmacology, 2007. 109(2), 359-363.36. Orhan, I., Aslan, S., Kartal, M., Şener, B., & Başer, K. H. C.. Inhibitory effect of Turkish Rosmarinus officinalis L. on acetylcholinesterase and butyrylcholinesterase enzymes. Food Chemistry, 2008. 108(2), 663-668.37. Mir M.Y., Kamili A.N., Hassan Q.P., Rafi S., Parray J.A., Jan S.. In vitro Regeneration and Free Radical Scavenging Assay of Hypericum perforatum L., National Academy Science Letters, 2016. 1-7.38. Rice-Evans, C. A., Miller, N. J., & Paganga, G.. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free radical biology and medicine, 1996. 20(7), 933-95639. Dey, T. B., Chakraborty, S., Jain, K. K., Sharma, A., & Kuhad, R. C.. Antioxidant phenolics and their microbial production by submerged and solid state fermentation process: A review. Trends in Food Science & Technology, 2016. 53, 60-74.40. Dragana D., et al. Antioxidative and antiproliferative activities of different horsetail (Equisetum arvense L.) extracts. Journal of medicinal food, 2010, 13.2: 452-459.41. Nagaı, takeshi; myoda, takao; nagashıma, toshio. antioxidative activities of water extract and ethanol extract from field horsetail (tsukushi) Equisetum arvense L. Food chemistry, 2005, 91.3: 389-394.42. PALLAG, Annamaria, et al. Comparative study of polyphenols, flavonoids and chlorophylls in Equisetum arvense L. populations. Revista de Chimie, 2016, 67.3: 530-533.43. Sılva, Bruno A., et al. Phytochemical and antioxidant characterization of Hypericum perforatum alcoholic extracts. Food chemistry, 2005, 90.1-2: 157-167.44. Lebeau, J., Furman, C., Bernier, J.-L., Duriez, P., Teissier, E., & Cotelle, N.. Antioxidant properties of di-tert -butylhydroxylated flavonoids. Free Radical Biology and Medicine, 2000. 29, 900–91243. Behl, C., & Mosmann, B.. Antioxidant neuroprotection in Alzheimer’s disease as preventive and therapeutic approach. Free Radical Biology and Medicine, 2002. 33, 182–191.44. Foy, C. J., Passmore, A. P., Vahidassr, M. D., Young, I. S., & Lawson, J. T.. Plasma chain-breaking antioxidants in Alzheimer’s disease, vascular dementia, and Parkinson’s disease. QJM Journal of the Association of Physicians, 1999. 92, 39–45.45. Hyun, D. H., Lee, M. H., Halwell, B., & Jenner, P.. Proteasomal dysfunction induced by 4-hydroxy-2,3-trans-nonenal, an end-product of lipid peroxidation: A mechanism contributing to neurodegeneration? Journal of Neurochemistry, 2002. 83, 360–370.46. Markesbery, W. R.. Oxidative stress hypothesis in Alzheimer’s disease. Free Radical Biology and Medicine, 1997. 23, 134–147.
Bioactivities of Hypericum Perforatum L and Equisetum Arvense L fractions obtained with different solvents
Abstract
Bu çalışmada, Hypericum. Perforatum.L (HPL)
ve Equisetum arvense L. (EAL) den elde edilen HPL sulu ekstraktlarının (HPLAE), HPL metanol ekstraktlarının (HPLME), EAL
sulu ekstraktlarının (EALAE) ve EAL
metanol ekstraktlarının (EALME) antikolinesteraz ve antioksidan etkisi
araştırıldı. Asetilkolinesteraz (AChE) üzerine HPLME fraksiyonu, inhibitör
etkisi gösterirken, diğerleri herhangi bir inhibisyon etkisi göstermemiştir. HPL ve EAL'nin farklı fraksiyonunun
antioksidan aktivitesi, Fe3+-Fe2+ indirgeme kapasitesi,
ABTS∙+ radikal giderme kapasitesi, DPPH· serbest radikal giderme kapasitesi ve
kuprak metodunu içeren farklı in vitro yöntemler kullanılarak belirlendi.
Çalışmada bu bitki ekstreleri standart antioksidan olan Butil Hidroksi Toluen (BHT),
Butillenmiş hidroksianisol (BHA) ve troloks ile karşılaştırıldı. Bu
bitkilerden elde edilen fraksiyonlar, standartlara yakın %52 radikal giderme
aktivitesine ve orta derecede metal azaltma aktivitesine sahiptir. Sonuç
olarak, oksidatif stresin neden olduğu birçok hastalığı tedavi etmek için
kullanılan bu şifalı bitkilerin farklı fraksiyonları çeşitli biyoaktivitelere
sahiptir.
Project Number
18240
References
- 1. Işık, M., Beydemir, Ş., Yılmaz, A., Naldan, M. E., Aslan, H. E., & Gülçin, İ. Oxidative stress and mRNA expression of acetylcholinesterase in the leukocytes of ischemic patients. Biomedicine & pharmacotherapy, 2017. 87, 561-567.2. Mukherjee, P. K., Kumar, V., Mal, M., & Houghton, P. J. Acetylcholinesterase inhibitors from plants. Phytomedicine, 2007. 14(4), 289-300.3. Choudhary, M. I. Bioactive natural products as a potential source of new pharmacophores. A theory of memory. Pure and Applied Chemistry, 2001. 73(3), 555-560.4. Chaudière, J., & Ferrari-Iliou, R. Intracellular antioxidants: from chemical to biochemical mechanisms. Food and chemical toxicology, 1999. 37(9-10), 949-962. 5. Göçer, H., Akincioğlu, A., Göksu, S., Gülçin, İ., & Supuran, C. T. Carbonic anhydrase and acetylcholinesterase inhibitory effects of carbamates and sulfamoylcarbamates. Journal of enzyme inhibition and medicinal chemistry, 2015. 30(2), 316-320.6. Işık, M. The Binding Mechanisms and Inhibitory Effect of Intravenous Anesthetics on AChE In Vitro and In Vivo: Kinetic Analysis and Molecular Docking. Neurochemical research, 2019. 44, 2147–2155.7. Gulcin, I.. "Antioxidant activity of food constituents: an overview." Archives of Toxicology, 2012. 86(3): 345-391.8. Pokorny, J. . "Are natural antioxidants better - and safer - than synthetic antioxidants? (vol 109, pg 629, 2007)." European Journal of Lipid Science and Technology, 2007. 109(8): 883-883.9. Heim, K. E., A. R. Tagliaferro and D. J. Bobilya. "Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships." Journal of Nutritional Biochemistry, 2002. 13(10): 572-584.10. Hertog, M. G. L., E. J. M. Feskens, P. C. H. Hollman, M. B. Katan and D. Kromhout . "Dietary Antioxidant Flavonoids and Risk of Coronary Heart-Disease - the Zutphen Elderly Study." Lancet, 1993. 342(8878): 1007-1011.11. Kasper, S. Hypericum perforatum: a review of clinical studies. Pharmacopsychiatry 2001, 34 (Suppl. 1), S51-S55.12. Barnes, J.; Anderson, L. A.; Phillipson, J. D. St John’s wort (Hypericum perforatum L.): a review of its chemistry, pharmacology, and clinical properties. J. Pharm. Pharmacol. 2001, 53,583-600.13. Linde K.. St. John’s wort–an overview, Complementary Medicine Research, 2009. 16(3): 146-155.14. Hunt, E. J., Lester, C. E., Lester, E. A., & Tackett, R. L.. Effect of St. John’s wort on free radical production. Life Sciences, 2001. 69, 181–190.15. Hostettmann K., Wolfender J.L. St. John’s Wort and its Active Principles in Depression and Anxiety, Phytochemistry, 2005. 5-20.16. Kozak, A., Bernath, J., Zeitschrift Für Arznei- Und Gewürzpflanzenbau, 11, No. 1, 2006. P. 3417. Pallag, A., Botanicã Farmaceuticã, Sistematica, Cormobionta, Editura Universitatii Din Oradea, 2015. P 29-31.18. Grieve, M.. Horsetails. In:A Modern Herbal. New York: DoverPublishers. 1971; Available from: http://www.botanical.com/botanical/mgmh/mgmh.html (accessed 7 June 2006).19. Veit, M., Beckert, C., Hohne, C., Bauer, K. & Geiger, H.. Interspecific and intraspecific variation of phenolics in the Equisetum.Phytochemistry, 1995. 38, 881–891.20. Asgarpanah, J., Roohı, E., Journal Of Medicinal Plant Research, 2012. 6, No. 21, p. 3689. 21. Hoffman Martins Do Monte, F., Guilherme dos Santos, J. Jr, Russi,M., Nascimento Bispo Lanziotti, V.M., Almeida Moreira Leal,L.K.M. & de Andrade Cunha, G.M. (2004).22. Oh, H., Kim, D.-H., Cho, J.-H. & Kim, Y.-C.. Hepatoprotec-tive and free radical scavenging activities of phenolic petrosins andflavonoids isolated from Equisetum arvense L. Journal of Ethno-pharmacology, 2005. 95, 421–424.23. Beckert, C., Horn, C., Schnitzler, J.-P., Lehning, A., Heller, W. & Veit,M.. Styrylpyrone biosynthesis inEquisetum arvense. Phyto-chemistry, 1997. 44, 275–283.24. Oyaizu, M.. Studies on products of browning reaction: antioxidative activity of products of browning reaction. Jpn. J. Nutr, 1986. 44(6), 307-315.25. Bursal, E., Köksal, E., & Gülçin, I.. In vitro Antioxidant Properties and Phenolic Content of Ginger (Zingiber officinale Rosc) Root. Department of Chemistry, 2012. 86-93.26. Işık, M., Demir, Y., Kırıcı, M., Demir, R., Şimşek, F., & Beydemir, Ş. . Changes in the anti-oxidant system in adult epilepsy patients receiving anti-epileptic drugs. Archives of physiology and biochemistry, 2015. 121(3), 97-102. 27. Blois, M. S.. Antioxidant determinations by the use of a stable free radical. Nature, 1985. 181(4617), 1199.28. Gülçin, İ., Elias, R., Gepdiremen, A., & Boyer, L.. Antioxidant activity of lignans from fringe tree (Chionanthus virginicus L.). European Food Research and Technology, 2006. 223(6), 75929. Ak, T., & Gülçin, İ.. Antioxidant and radical scavenging properties of curcumin. Chemico-biological interactions, 2008. 174(1), 27-37.30. Ellman GL, Courtney KD, Andres V, Featherstone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 1961; 7: 88-95.31. Gülçın, İlhami, et al. Sage (Salvia pilifera): determination of its polyphenol contents, anticholinergic, antidiabetic and antioxidant activities. Journal of Food Measurement and Characterization, 2019, 1-13.32. Chaudière, J., & Ferrari-Iliou, R.. Intracellular antioxidants: from chemical to biochemical mechanisms. Food and chemical toxicology, 1999. 37(9-10), 949-96233. Mukherjee, P. K., Kumar, V., Mal, M., & Houghton, P. J.. Acetylcholinesterase inhibitors from plants. Phytomedicine, 2007. 14(4), 289-300.34. Shekhar, C., & Kumar, S.. Kinetics of acetylcholinesterase inhibition by an aqueous extract of Mentha longifolia leaves. Int J Pharma Sci Drug Res, 2014. 6, 348-50.35. Vinutha, B., Prashanth, D., Salma, K., Sreeja, S. L., Pratiti, D., Padmaja, R., ... & Deepak, M.. Screening of selected Indian medicinal plants for acetylcholinesterase inhibitory activity. Journal of ethnopharmacology, 2007. 109(2), 359-363.36. Orhan, I., Aslan, S., Kartal, M., Şener, B., & Başer, K. H. C.. Inhibitory effect of Turkish Rosmarinus officinalis L. on acetylcholinesterase and butyrylcholinesterase enzymes. Food Chemistry, 2008. 108(2), 663-668.37. Mir M.Y., Kamili A.N., Hassan Q.P., Rafi S., Parray J.A., Jan S.. In vitro Regeneration and Free Radical Scavenging Assay of Hypericum perforatum L., National Academy Science Letters, 2016. 1-7.38. Rice-Evans, C. A., Miller, N. J., & Paganga, G.. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free radical biology and medicine, 1996. 20(7), 933-95639. Dey, T. B., Chakraborty, S., Jain, K. K., Sharma, A., & Kuhad, R. C.. Antioxidant phenolics and their microbial production by submerged and solid state fermentation process: A review. Trends in Food Science & Technology, 2016. 53, 60-74.40. Dragana D., et al. Antioxidative and antiproliferative activities of different horsetail (Equisetum arvense L.) extracts. Journal of medicinal food, 2010, 13.2: 452-459.41. Nagaı, takeshi; myoda, takao; nagashıma, toshio. antioxidative activities of water extract and ethanol extract from field horsetail (tsukushi) Equisetum arvense L. Food chemistry, 2005, 91.3: 389-394.42. PALLAG, Annamaria, et al. Comparative study of polyphenols, flavonoids and chlorophylls in Equisetum arvense L. populations. Revista de Chimie, 2016, 67.3: 530-533.43. Sılva, Bruno A., et al. Phytochemical and antioxidant characterization of Hypericum perforatum alcoholic extracts. Food chemistry, 2005, 90.1-2: 157-167.44. Lebeau, J., Furman, C., Bernier, J.-L., Duriez, P., Teissier, E., & Cotelle, N.. Antioxidant properties of di-tert -butylhydroxylated flavonoids. Free Radical Biology and Medicine, 2000. 29, 900–91243. Behl, C., & Mosmann, B.. Antioxidant neuroprotection in Alzheimer’s disease as preventive and therapeutic approach. Free Radical Biology and Medicine, 2002. 33, 182–191.44. Foy, C. J., Passmore, A. P., Vahidassr, M. D., Young, I. S., & Lawson, J. T.. Plasma chain-breaking antioxidants in Alzheimer’s disease, vascular dementia, and Parkinson’s disease. QJM Journal of the Association of Physicians, 1999. 92, 39–45.45. Hyun, D. H., Lee, M. H., Halwell, B., & Jenner, P.. Proteasomal dysfunction induced by 4-hydroxy-2,3-trans-nonenal, an end-product of lipid peroxidation: A mechanism contributing to neurodegeneration? Journal of Neurochemistry, 2002. 83, 360–370.46. Markesbery, W. R.. Oxidative stress hypothesis in Alzheimer’s disease. Free Radical Biology and Medicine, 1997. 23, 134–147.
There are 1 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Chemical Engineering |
| Journal Section | Research Articles |
| Authors | |
| Project Number | 18240 |
| Publication Date | December 28, 2019 |
| Published in Issue | Year 2019 Volume: 2 Issue: 3 |
