Research Article
BibTex RIS Cite

A research paper on the immunomodulatory and anti-inflammatory activities of olive tree (Olea europaea L.) leaf

Year 2022, Volume: 9 Issue: 3, 348 - 359, 26.09.2022

Seda Beyaz Özlem Gök Abdullah Aslan

https://doi.org/10.21448/ijsm.1075283
Cited By: 1

Abstract

Olive tree (Olea europaea L.) leaf is known to have a number of bioactive properties being antioxidant, antihypertensive, antiatherogenic, anti-inflammatory, antifungal, antiviral and antimicrobial. In this study, the immunomodulatory roles of Olive tree (Olea europaea L.) leaf against oxidative damage caused by carbon tetrachloride (CCl4) in Saccharomyces cerevisiae were investigated. In the study, four groups were formed; namely, (i) Control Group: Yeast only planted group; (ii) CCl4 Group: Group given CCl4 (15 mM); (iii) Olive Tree Leaf Group: The group given olive tree leaf (10%); and (iv) Olive Tree Leaf + CCl4 Group: Olive tree leaf (10%) + CCl4 (15 mM) given group. Cultures of Saccharomyces cerevisiae were grown at 30 °C for 1, 3, 5, and 24 hours. Malondialdehyde (MDA), glutathione levels (GSH), cell growth and catalase (CAT) activity measurements were determined by spectrophotometer. Total protein concentrations were determined by SDS-PAGE electrophoresis and the Bradford protein method. According to the results obtained; compared to the CCl4 group, cell growth (1, 3, 5 and 24 hours), total protein synthesis, and GSH and CAT activities (24 hours) increased in olive tree leaf groups, while MDA level (24 hours) decreased. Thanks to its strong bioactive properties, olive tree leaf has been found to increase cell growth and total protein synthesis by decreasing CCl4 induced oxidative stress in Saccharomyces cerevisiae culture. It has been concluded that if the olive tree leaf is used regularly, it will be beneficial in eliminating many health problems.

Keywords

Olive tree leaf Oleuropein Oxidative stress Polyphenol Saccharomyces cerevisiae

References

  • Aebi, H. (1974). Catalase. In: Bergmeyer U, Ed. methods of enzymatic analysis. New York: Academic Press, 673–684.
  • Ahmed, H.A., Ali, H.A., & Mutar, T.F. (2021). Protective effects of olive leaf extract against reproductive toxicity of the lead acetate in rats. Environ. Sci. Pollut. Res. Int., 28(44), 63102-63110.
  • Araki, R., Fujie, K., Yuine, N., Watabe, Y., Nakata, Y., Suzuki, H., Isoda, H., & Hashimoto, K. (2019). Olive leaf tea is beneficial for lipid metabolism in adults with prediabetes: An exploratory randomized controlled trial. Nutr. Res., 67, 60-66.
  • Aslan, A. (2021). The protective effects of goji berry against oxidative damage caused by chromium (K2Cr2O7) in Saccharomyces cerevisiae. Bitlis Eren Univ. J. Sci., 10, 784-795.
  • Aslan, A., Beyaz, S., & Gok, O. (2019a). The protective effect of tomato extract against to chromium-induced damage in Saccharomyces cerevisiae. Erzincan Uni. J. Sci. Institute., 12(2), 1048-1055.
  • Aslan, A., Gok, O., & Beyaz, S. (2019b). The protective effect of grape seed extract against to hydrogen peroxide-induced damage in Saccharomyces cerevisiae. Igdır Uni. J. Sci. Techno., 9(4), 2216-2224.
  • Beyaz, S., Dalkılıç, L.K., Gok, O., & Aslan, A. (2020). Effect of black mulberry (Morus nigra L.) and Cranberry (Cornus mas L.) on some molecular biological and biochemical parameters against oxidative damage caused by hydrogen peroxide in Saccharomyces cerevisiae. Bitlis Eren Univ. J. Sci., 9(3), 1134-1144.
  • Beyaz, S., Gok, O., & Aslan, A. (2021a). The determination of the effect of Curcumin on Saccharomyces cerevisiae totally protein expression changes and cell growth. Prog. Nutr., 23(1), 1-10.
  • Beyaz, S., Gok, O., Can, M.I., & Aslan, A. (2021b). The protective effects of epigallocatechin-3-gallate (EGCG) on hydrogen peroxide-induced oxidative damages in Saccharomyces cerevisiae. Prog. Nutr., 23(2), 1-11.
  • Bock, M., Derraik, J.G, Brennan, C.M., Biggs, J.B., Morgan, P.E., Hodgkinson, S.C., Hofman, P.L., & Cutfield, W.S. (2013). Olive ( Olea europaea L.) leaf polyphenols improve insulin sensitivity in middle-aged overweight men: A randomized, placebo-controlled, crossover trial. PloS One, 8(3), e57622.
  • Bradford, M.M., (1796). A rapid and sensitive methof for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248–254.
  • Borjan, D., Leitgeb, M., Knez, Z., & Hrncic, M.K. (2020). Microbiological and antioxidant activity of phenolic compounds in olive leaf extract. Molecules, 25(24), 5946.
  • Chen, Y., Cheng, L., Zhang, X., Cao, J., Wu, Z., & Zheng, X. (2019). Transcriptomic and proteomic effects of (-)-epigallocatechin 3-o-(3-o-methyl) gallate (EGCG3”Me) treatment on ethanol-stressed Saccharomyces cerevisiae cells. Food Res. Int., 119, 67-75.
  • Cicco, P., Maisto, M., Tenore, G.C., & Ianaro, A. (2020). Olive leaf extract, from Olea europaea L., reduces palmitate-induced inflammation via regulation of murine macrophages polarization. Nutrients., 12(12), 3663.
  • Duina, A.A., Miller, M.E., & Keeney, J.B. (2014). Budding yeast for budding geneticists: A primer on the Saccharomyces cerevisiae model system. Genetics., 197(1), 33-48.
  • Elkafrawy, N., Younes, K., Naguib, A., Badr, H., Kamal Zewain, S., Kamel, M., Raoof, G.F.A, El-Desoky, A.M., Mohamed, S. (2020). Antihypertensive efficacy and safety of a standardized herbal medicinal product of Hibiscus sabdariffa and Olea europaea extracts (NW Roselle): A phase‐ii, randomized, double‐blind, captopril‐controlled clinical trial. Phytother. Res., 34(12), 3379-3387.
  • Ferdousi, F., Araki, R., Hashimoto, K., & Isoda, H. (2019). Olive leaf tea may have hematological health benefit over green tea. Clin. Nutr., 38(6), 2952-2955.
  • Gok, O., Beyaz, S., & Aslan, A. (2021b). Biological and oxidative effect of ellagic acid on Saccharomyces cerevisiae: A new way for culture developing. Brazilian Arch. Biol. Techno., 64, 1-11.
  • Gok, O., Beyaz, S., Erman, F., & Aslan, A. (2021a). Does persimmon leaf have a protective effect against oxidative damage caused by chromium in Saccharomyces cerevisiae?. Prog. Nutr., 23(2), 1-8.
  • Gokce, Z. (2020). The protective effect of Pistacia vera L. (Pistachio) against to carbon tetrachloride (CCl4)-induced damage in Saccharomyces cerevisiae. Prog. Nutr., 22, e2020077.
  • Gorzynik-Debicka, M., Przychodzen, P., Cappello, F., Kuban-Jankowska, A., Marino Gammazza, A., Knap, N., Wozniak, M., & Gorska-Ponikowska, M. (2018). Potential health benefits of olive oil and plant polyphenols. Int. J. Mol. Sci., 19(3), 686.
  • Gutteridge, J.M. (1995). Lipid peroxidation and antioxidants as biomarkers of tissue damage. Clin. Chem., 41, 1819-1828.
  • Hashmi, M.A., Khan, A., Hanif, M., Farooq, U., & Perveen, S. (2015). Traditional uses, phytochemistry and pharmacology of Olea europaea (Olive). Evid. Based. Complement. Alternat. Med., 1-29.
  • Jamnik, P., Goranovič, D., & Raspor, P. (2007). Antioxidative action of royal jelly in the yeast cell. Exp. Gerontol., 42(7), 594-600.
  • Javadi, H., Yaghoobzadeh, H., Esfahani, Z., Memarzadeh, R., & Mirhashemi, M. (2019). Effects of olive leaf extract on metabolic response, liver and kidney functions and inflammatory biomarkers in hypertensive patients. Pak. J. Biol. Sci. PJBS., 22(7), 342-348.
  • Kaeidi, A., Sahamsizadeh, A., Allahtavakoli, M., Fatemi, I., Rahmani, M., Hakimizadeh, E., & Hassanshahi, J. (2020). The effect of oleuropein on unilateral ureteral obstruction induced-kidney injury in rats: The role of oxidative stress, inflammation and apoptosis. Mol. Biol. Rep., 47(2), 1371-1379.
  • Kiruthika, B., & Padma, P.R. (2013). Zea mays leaf extracts protect Saccharomyces cerevisiae cell against oxidative stress-induced cell death. J. Acute Med., 3(3), 83-92.
  • Larussa, T., Oliverio, M., Suraci, E., Greco, M., Placida, R., Gervasi, S., Marasco, R., Imeneo, M., Paolino, D., Tucci, L., Gulletta, E., Massimo, F., Procopio, A., & Luzza, F. (2017). Oleuropein decreases cyclooxygenase-2 and interleukin-17 expression and attenuates inflammatory damage in colonic samples from ulcerative colitis patients. Nutrients, 9(4), 391.
  • Lockyer, S., Rowland, I., Spencer, J.P.E., Yaqoob, P., & Stonehouse, W. (2017). Impact of phenolic-rich olive leaf extract on blood pressure, plasma lipids and inflammatory markers: A randomized controlled trial. Eur. J. Nutr., 56(4), 1421-1432.
  • Mahyoob, W., Alakayleh, Z., Hajar, H.A.A., Al-Mawla, L., Altwaiq, A.M., Al-Remawi, M., & Al-Akayleh, F. (2022). A novel co-processed olive tree leaves biomass for lead adsorption from contaminated water. J. Contam. Hydrol., 248, 104025.
  • Malfa, G.A., Di Giacomo, C., Cardia, L., Sorbara, E.E., Mannucci, C., & Calapai, G. (2021). A standardized extract of Opuntia ficus‐indica (L.) Mill and Olea europaea L. improves gastrointestinal discomfort: A double blinded randomized controlled study. Phytother. Res., 35(7), 3756-3768.
  • Markopoulos, C., Vertzoni, M., Agalias, A., Magiatis, P., & Reppas, C. (2009). Stability of oleuropein in the human proximal gut. J. Pharm. Pharmacol., 61(2), 143-149.
  • Mohsin, N.Y. (2020). Determination of oxidative stress level (malondialdehyde), some antioxidant activities (catalase and reduced glutathione) and IMA (ischemia modified albumin) in gout patients [Master Thesis, Van Yuzuncu Yıl University]. Van, Turkey.
  • Oprea, E., Ruta, L.L., Nicolau, I., Popa, C.V., Neagoe, A.D., & Farcasanu, I.C. (2014). Vaccinium corymbosum L. (blueberry) extracts exhibit protective action against cadmium toxicity in Saccharomyces cerevisiae cells. Food Chem., 152, 516-521.
  • Pereira, A.P., Ferreira, I.C., Marcelino, F., Valentão, P., Andrade, P.B., Seabra, R., Estevinho, L., Bento, A., Pereira, J.A. (2007). Phenolic compounds and antimicrobial activity of olive (Olea europaea L. Cv. Cobrançosa) leaves. Molecules, 12(5), 1153-1162.
  • Perrinjaquet‐Moccetti, T., Busjahn, A., Schmidlin, C., Schmidt, A., Bradl, B., & Aydogan, C. (2008). Food supplementation with an olive ( Olea europaea L.) leaf extract reduces blood pressure in borderline hypertensive monozygotic twins. Phytother. Res., 22(9), 1239-1242.
  • Rocchetti, G., Callegari, M.L., Senizza, A., Giuberti, G., Ruzzolini, J., Romani, A., Urciuoli, S., Nediani, C., & Lucini, L. (2022). Oleuropein from olive leaf extracts and extra-virgin olive oil provides distinctive phenolic profiles and modulation of microbiota in the large intestine. Food Chemistry, 380, 132187.
  • Romani, A., Ieri, F., Urciuoli, S., Noce, A., Marrone, G., Nediani, C., & Bernini, R. (2019). Health effects of phenolic compounds found in extra-virgin olive oil, by products, and leaf of Olea europaea L. Nutrients, 11(8), 1776.
  • Romero-Márquez, J.M., Navarro-Hortal, M.D., Jiménez-Trigo, V., Vera-Ramírez, L., Forbes-Hernández, T.J., Esteban-Muñoz, A., Giampieri, F., Bullon, P., Battino, M., Sanchez-Gonzalez, C., & Quiles, J.L. (2022). An oleuropein rich-olive (Olea europaea L.) leaf extract reduces β-amyloid and tau proteotoxicity through regulation of oxidative-and heat shock-stress responses in caenorhabditis elegans. Food Chem. Toxicol., 162, 112914.
  • Somerville, V., Moore, R., & Braakhuis, A. (2019). The effect of olive leaf extract on upper respiratory illness in high school athletes: A randomized control trial. Nutrients, 11(2), 358.
  • Susalit, E., Agus, N., Effendi, I., Tjandrawinata, R.R., Nofiarny, D., Perrinjaquet-Moccetti, T., & Verbruggen, M. (2011). Olive ( Olea europaea ) leaf extract effective in patients with stage-1 hypertension: Comparison with captopril. Phytomedicine., 18(4), 251-258.
  • Wong, R.H., Garg, M.L., Wood, L.G., & Howe, P.R. (2014). Antihypertensive potential of combined extracts of olive leaf, green coffee bean and beetroot: A randomized, double-blind, placebo-controlled crossover trial. Nutrients, 6(11), 4881-4894.

A research paper on the immunomodulatory and anti-inflammatory activities of olive tree (Olea europaea L.) leaf

Year 2022, Volume: 9 Issue: 3, 348 - 359, 26.09.2022

Seda Beyaz Özlem Gök Abdullah Aslan

https://doi.org/10.21448/ijsm.1075283
Cited By: 1

Abstract

Olive tree (Olea europaea L.) leaf is known to have a number of bioactive properties being antioxidant, antihypertensive, antiatherogenic, anti-inflammatory, antifungal, antiviral and antimicrobial. In this study, the immunomodulatory roles of Olive tree (Olea europaea L.) leaf against oxidative damage caused by carbon tetrachloride (CCl4) in Saccharomyces cerevisiae were investigated. In the study, four groups were formed; namely, (i) Control Group: Yeast only planted group; (ii) CCl4 Group: Group given CCl4 (15 mM); (iii) Olive Tree Leaf Group: The group given olive tree leaf (10%); and (iv) Olive Tree Leaf + CCl4 Group: Olive tree leaf (10%) + CCl4 (15 mM) given group. Cultures of Saccharomyces cerevisiae were grown at 30 °C for 1, 3, 5, and 24 hours. Malondialdehyde (MDA), glutathione levels (GSH), cell growth and catalase (CAT) activity measurements were determined by spectrophotometer. Total protein concentrations were determined by SDS-PAGE electrophoresis and the Bradford protein method. According to the results obtained; compared to the CCl4 group, cell growth (1, 3, 5 and 24 hours), total protein synthesis, and GSH and CAT activities (24 hours) increased in olive tree leaf groups, while MDA level (24 hours) decreased. Thanks to its strong bioactive properties, olive tree leaf has been found to increase cell growth and total protein synthesis by decreasing CCl4 induced oxidative stress in Saccharomyces cerevisiae culture. It has been concluded that if the olive tree leaf is used regularly, it will be beneficial in eliminating many health problems.

Keywords

Olive tree leaf Oleuropein Oxidative stress Polyphenol Saccharomyces cerevisiae

References

  • Aebi, H. (1974). Catalase. In: Bergmeyer U, Ed. methods of enzymatic analysis. New York: Academic Press, 673–684.
  • Ahmed, H.A., Ali, H.A., & Mutar, T.F. (2021). Protective effects of olive leaf extract against reproductive toxicity of the lead acetate in rats. Environ. Sci. Pollut. Res. Int., 28(44), 63102-63110.
  • Araki, R., Fujie, K., Yuine, N., Watabe, Y., Nakata, Y., Suzuki, H., Isoda, H., & Hashimoto, K. (2019). Olive leaf tea is beneficial for lipid metabolism in adults with prediabetes: An exploratory randomized controlled trial. Nutr. Res., 67, 60-66.
  • Aslan, A. (2021). The protective effects of goji berry against oxidative damage caused by chromium (K2Cr2O7) in Saccharomyces cerevisiae. Bitlis Eren Univ. J. Sci., 10, 784-795.
  • Aslan, A., Beyaz, S., & Gok, O. (2019a). The protective effect of tomato extract against to chromium-induced damage in Saccharomyces cerevisiae. Erzincan Uni. J. Sci. Institute., 12(2), 1048-1055.
  • Aslan, A., Gok, O., & Beyaz, S. (2019b). The protective effect of grape seed extract against to hydrogen peroxide-induced damage in Saccharomyces cerevisiae. Igdır Uni. J. Sci. Techno., 9(4), 2216-2224.
  • Beyaz, S., Dalkılıç, L.K., Gok, O., & Aslan, A. (2020). Effect of black mulberry (Morus nigra L.) and Cranberry (Cornus mas L.) on some molecular biological and biochemical parameters against oxidative damage caused by hydrogen peroxide in Saccharomyces cerevisiae. Bitlis Eren Univ. J. Sci., 9(3), 1134-1144.
  • Beyaz, S., Gok, O., & Aslan, A. (2021a). The determination of the effect of Curcumin on Saccharomyces cerevisiae totally protein expression changes and cell growth. Prog. Nutr., 23(1), 1-10.
  • Beyaz, S., Gok, O., Can, M.I., & Aslan, A. (2021b). The protective effects of epigallocatechin-3-gallate (EGCG) on hydrogen peroxide-induced oxidative damages in Saccharomyces cerevisiae. Prog. Nutr., 23(2), 1-11.
  • Bock, M., Derraik, J.G, Brennan, C.M., Biggs, J.B., Morgan, P.E., Hodgkinson, S.C., Hofman, P.L., & Cutfield, W.S. (2013). Olive ( Olea europaea L.) leaf polyphenols improve insulin sensitivity in middle-aged overweight men: A randomized, placebo-controlled, crossover trial. PloS One, 8(3), e57622.
  • Bradford, M.M., (1796). A rapid and sensitive methof for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248–254.
  • Borjan, D., Leitgeb, M., Knez, Z., & Hrncic, M.K. (2020). Microbiological and antioxidant activity of phenolic compounds in olive leaf extract. Molecules, 25(24), 5946.
  • Chen, Y., Cheng, L., Zhang, X., Cao, J., Wu, Z., & Zheng, X. (2019). Transcriptomic and proteomic effects of (-)-epigallocatechin 3-o-(3-o-methyl) gallate (EGCG3”Me) treatment on ethanol-stressed Saccharomyces cerevisiae cells. Food Res. Int., 119, 67-75.
  • Cicco, P., Maisto, M., Tenore, G.C., & Ianaro, A. (2020). Olive leaf extract, from Olea europaea L., reduces palmitate-induced inflammation via regulation of murine macrophages polarization. Nutrients., 12(12), 3663.
  • Duina, A.A., Miller, M.E., & Keeney, J.B. (2014). Budding yeast for budding geneticists: A primer on the Saccharomyces cerevisiae model system. Genetics., 197(1), 33-48.
  • Elkafrawy, N., Younes, K., Naguib, A., Badr, H., Kamal Zewain, S., Kamel, M., Raoof, G.F.A, El-Desoky, A.M., Mohamed, S. (2020). Antihypertensive efficacy and safety of a standardized herbal medicinal product of Hibiscus sabdariffa and Olea europaea extracts (NW Roselle): A phase‐ii, randomized, double‐blind, captopril‐controlled clinical trial. Phytother. Res., 34(12), 3379-3387.
  • Ferdousi, F., Araki, R., Hashimoto, K., & Isoda, H. (2019). Olive leaf tea may have hematological health benefit over green tea. Clin. Nutr., 38(6), 2952-2955.
  • Gok, O., Beyaz, S., & Aslan, A. (2021b). Biological and oxidative effect of ellagic acid on Saccharomyces cerevisiae: A new way for culture developing. Brazilian Arch. Biol. Techno., 64, 1-11.
  • Gok, O., Beyaz, S., Erman, F., & Aslan, A. (2021a). Does persimmon leaf have a protective effect against oxidative damage caused by chromium in Saccharomyces cerevisiae?. Prog. Nutr., 23(2), 1-8.
  • Gokce, Z. (2020). The protective effect of Pistacia vera L. (Pistachio) against to carbon tetrachloride (CCl4)-induced damage in Saccharomyces cerevisiae. Prog. Nutr., 22, e2020077.
  • Gorzynik-Debicka, M., Przychodzen, P., Cappello, F., Kuban-Jankowska, A., Marino Gammazza, A., Knap, N., Wozniak, M., & Gorska-Ponikowska, M. (2018). Potential health benefits of olive oil and plant polyphenols. Int. J. Mol. Sci., 19(3), 686.
  • Gutteridge, J.M. (1995). Lipid peroxidation and antioxidants as biomarkers of tissue damage. Clin. Chem., 41, 1819-1828.
  • Hashmi, M.A., Khan, A., Hanif, M., Farooq, U., & Perveen, S. (2015). Traditional uses, phytochemistry and pharmacology of Olea europaea (Olive). Evid. Based. Complement. Alternat. Med., 1-29.
  • Jamnik, P., Goranovič, D., & Raspor, P. (2007). Antioxidative action of royal jelly in the yeast cell. Exp. Gerontol., 42(7), 594-600.
  • Javadi, H., Yaghoobzadeh, H., Esfahani, Z., Memarzadeh, R., & Mirhashemi, M. (2019). Effects of olive leaf extract on metabolic response, liver and kidney functions and inflammatory biomarkers in hypertensive patients. Pak. J. Biol. Sci. PJBS., 22(7), 342-348.
  • Kaeidi, A., Sahamsizadeh, A., Allahtavakoli, M., Fatemi, I., Rahmani, M., Hakimizadeh, E., & Hassanshahi, J. (2020). The effect of oleuropein on unilateral ureteral obstruction induced-kidney injury in rats: The role of oxidative stress, inflammation and apoptosis. Mol. Biol. Rep., 47(2), 1371-1379.
  • Kiruthika, B., & Padma, P.R. (2013). Zea mays leaf extracts protect Saccharomyces cerevisiae cell against oxidative stress-induced cell death. J. Acute Med., 3(3), 83-92.
  • Larussa, T., Oliverio, M., Suraci, E., Greco, M., Placida, R., Gervasi, S., Marasco, R., Imeneo, M., Paolino, D., Tucci, L., Gulletta, E., Massimo, F., Procopio, A., & Luzza, F. (2017). Oleuropein decreases cyclooxygenase-2 and interleukin-17 expression and attenuates inflammatory damage in colonic samples from ulcerative colitis patients. Nutrients, 9(4), 391.
  • Lockyer, S., Rowland, I., Spencer, J.P.E., Yaqoob, P., & Stonehouse, W. (2017). Impact of phenolic-rich olive leaf extract on blood pressure, plasma lipids and inflammatory markers: A randomized controlled trial. Eur. J. Nutr., 56(4), 1421-1432.
  • Mahyoob, W., Alakayleh, Z., Hajar, H.A.A., Al-Mawla, L., Altwaiq, A.M., Al-Remawi, M., & Al-Akayleh, F. (2022). A novel co-processed olive tree leaves biomass for lead adsorption from contaminated water. J. Contam. Hydrol., 248, 104025.
  • Malfa, G.A., Di Giacomo, C., Cardia, L., Sorbara, E.E., Mannucci, C., & Calapai, G. (2021). A standardized extract of Opuntia ficus‐indica (L.) Mill and Olea europaea L. improves gastrointestinal discomfort: A double blinded randomized controlled study. Phytother. Res., 35(7), 3756-3768.
  • Markopoulos, C., Vertzoni, M., Agalias, A., Magiatis, P., & Reppas, C. (2009). Stability of oleuropein in the human proximal gut. J. Pharm. Pharmacol., 61(2), 143-149.
  • Mohsin, N.Y. (2020). Determination of oxidative stress level (malondialdehyde), some antioxidant activities (catalase and reduced glutathione) and IMA (ischemia modified albumin) in gout patients [Master Thesis, Van Yuzuncu Yıl University]. Van, Turkey.
  • Oprea, E., Ruta, L.L., Nicolau, I., Popa, C.V., Neagoe, A.D., & Farcasanu, I.C. (2014). Vaccinium corymbosum L. (blueberry) extracts exhibit protective action against cadmium toxicity in Saccharomyces cerevisiae cells. Food Chem., 152, 516-521.
  • Pereira, A.P., Ferreira, I.C., Marcelino, F., Valentão, P., Andrade, P.B., Seabra, R., Estevinho, L., Bento, A., Pereira, J.A. (2007). Phenolic compounds and antimicrobial activity of olive (Olea europaea L. Cv. Cobrançosa) leaves. Molecules, 12(5), 1153-1162.
  • Perrinjaquet‐Moccetti, T., Busjahn, A., Schmidlin, C., Schmidt, A., Bradl, B., & Aydogan, C. (2008). Food supplementation with an olive ( Olea europaea L.) leaf extract reduces blood pressure in borderline hypertensive monozygotic twins. Phytother. Res., 22(9), 1239-1242.
  • Rocchetti, G., Callegari, M.L., Senizza, A., Giuberti, G., Ruzzolini, J., Romani, A., Urciuoli, S., Nediani, C., & Lucini, L. (2022). Oleuropein from olive leaf extracts and extra-virgin olive oil provides distinctive phenolic profiles and modulation of microbiota in the large intestine. Food Chemistry, 380, 132187.
  • Romani, A., Ieri, F., Urciuoli, S., Noce, A., Marrone, G., Nediani, C., & Bernini, R. (2019). Health effects of phenolic compounds found in extra-virgin olive oil, by products, and leaf of Olea europaea L. Nutrients, 11(8), 1776.
  • Romero-Márquez, J.M., Navarro-Hortal, M.D., Jiménez-Trigo, V., Vera-Ramírez, L., Forbes-Hernández, T.J., Esteban-Muñoz, A., Giampieri, F., Bullon, P., Battino, M., Sanchez-Gonzalez, C., & Quiles, J.L. (2022). An oleuropein rich-olive (Olea europaea L.) leaf extract reduces β-amyloid and tau proteotoxicity through regulation of oxidative-and heat shock-stress responses in caenorhabditis elegans. Food Chem. Toxicol., 162, 112914.
  • Somerville, V., Moore, R., & Braakhuis, A. (2019). The effect of olive leaf extract on upper respiratory illness in high school athletes: A randomized control trial. Nutrients, 11(2), 358.
  • Susalit, E., Agus, N., Effendi, I., Tjandrawinata, R.R., Nofiarny, D., Perrinjaquet-Moccetti, T., & Verbruggen, M. (2011). Olive ( Olea europaea ) leaf extract effective in patients with stage-1 hypertension: Comparison with captopril. Phytomedicine., 18(4), 251-258.
  • Wong, R.H., Garg, M.L., Wood, L.G., & Howe, P.R. (2014). Antihypertensive potential of combined extracts of olive leaf, green coffee bean and beetroot: A randomized, double-blind, placebo-controlled crossover trial. Nutrients, 6(11), 4881-4894.
There are 42 citations in total.

Details

Primary Language English
Subjects Structural Biology
Journal Section Articles
Authors

Seda Beyaz 0000-0003-0436-8112

Özlem Gök 0000-0001-8521-6369

Abdullah Aslan 0000-0002-6243-4221

Early Pub Date August 24, 2022
Publication Date September 26, 2022
Submission Date February 17, 2022
Published in Issue Year 2022 Volume: 9 Issue: 3

Cite

APA Beyaz, S., Gök, Ö., & Aslan, A. (2022). A research paper on the immunomodulatory and anti-inflammatory activities of olive tree (Olea europaea L.) leaf. International Journal of Secondary Metabolite, 9(3), 348-359. https://doi.org/10.21448/ijsm.1075283

Cited By

Nocellara Del Belice (Olea europaea L. Cultivar): Leaf Extract Concentrated in Phenolic Compounds and Its Anti-Inflammatory and Radical Scavenging Activity
Plants
https://doi.org/10.3390/plants12010027
International Journal of Secondary Metabolite

e-ISSN: 2148-6905