Research Article
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Year 2023, Volume: 14 Issue: 49, 140 - 144, 31.08.2023
https://doi.org/10.17944/interdiscip.1352036

Abstract

References

  • Cashman KD. Vitamin D Deficiency: Defining, Prevalence, Causes, and Strategjes of Addressing. Calcif Tissue Int. 2020 Jan;106(1):1 4-29. doi: 10.1007/s00223-0l9-00559-4. Epub 2019 May 8.
  • Sempos CT, Heijboer AC, Bikle DD, Bollerslev J, Bouillon R, Brannon PM, DeLuca HF, Jones G, Munns CF, Bilezikian JP, Giustina A, Binkley N. Vitamin D assays and the definition of hypovitaminosis D: results from the First International Conference on Controversies in Vitamin D. Br J Clin Pharmacol. 2018 Oct;84(10):2194-2207. doi: 10.1111 /bcp.13652. Epub 2018 Jul 17.
  • Börekçi NÖ. Current infonnation on vitamin D deficiency. Jour Tuk Fam Phy 2019;10(1):35-42. doi:10.15511 /jtfp.19.00135
  • Amrein K, Scherkl M, Hoffmann M, Neuwersch-Sommeregger S, Kostenberger M, Tmava Berisha A, Martucci G, Pilz S, Malle O. Vitamin D deficiency 2.0: an update on the current status worldwide. Eur J Clin Nutr. 2020 Nov;74(11): 1498-1513. doi: 10.1038/s41430-020- 0558-y. Epub 2020 Jan 20. PMID: 31959942;
  • CLSI. Defining, Establishing, and Verifying Reference Intervals in the Clinical Laboratory; Approved Guideline-Third Edition. CLSI Document C28-A3. Wayne, PA, USA: Clinical and Laboratory Standards Institute; 2008.
  • Çaycı T, Kurt YG, Honca T, Taş A, Özgürtaş T, Ağıllı M, Aydn FN, Aydın İ. Hastane bilgi sistemindeki kayıtlı hasta sonuçlarından tam kan referans aralıklarının tayini. Gülhane Tıp Derg 2015; 57: I 11-117. doi: 10.5455/gulhane. 167492
  • Aydın İ, Ağıllı M, Aydın FN, Kurt YG, Çaycı T, Taş A, Honca T, Özgürtaş T, Türker Türker, Koçak N. Farklı yaş gruplarında nötrofil/lenfosit oranı referans aralıkları. Gülhane Tıp Derg 2015;57: 414-418. doi: 10.5455/gulhane. 166398
  • Çatak Z. Elazığ Bolgesinin 25 Hidroksivitamin D Düzeylerinin Değerlendirilmesi ve Populasyona Dayalı Yeni Referans Aralıklarının Belirlenmesi. Fırat Tıp Dergisi/Firat Med J 2018; 23 (1): 6-10.
  • Alpdemir M, Alpdemir MF. Determination of reference range with the indirect method of the 25- hydroxyvitamin D3 test in the Balıkesir region, Turkey. Turk J Med Sci (2016)46 :1 512 -1517. doi: 10 .3906/sag-1504-19.
  • Solberg HE. International Federation of Clinical Chemistry (JFCC), Scientific Committee, Clinical Section, Expert Panel on Theory of Reference Values, and International Committee for Standardization in Haematology (JCSH), Standing Committee on Reference Values. Approved recommendation (1986) on the theory of reference values. Part 1. The concept of reference values. J Clin Chem Clin Biochem 1987; 25: 337-342.
  • Öztürk ZA, Gol M, Türkbeyler İH. Prevalence of vitamin D deficiency in otherwise healthy individuals between the ages of 18 and 90 years in southeast Turkey. Wien Klin Wochenschr. 2017 Nov;129(21-22):854-855doi: 10.1007/s00508-017-1241-8. Epub 2017 Jul 27.
  • Buyukuslu N, Esin K, Hizli H, Sunal N, Yigit P, Garipagaoglu M. Clothing preference affects vitamin D status of young women. Nutr Res 2014;34:688-93.
  • Bozkurt S, Alkan BM, Yildiz F, Gumus S, Sezer N, Ardicoglu O, et al. Age, sex, and seasonal variations in the serum vitamin D3 Levels in a local Turkish population. Arch Rheumatol 2014;29:14- 9.
  • Alpdemir M, Alpdemir MF. Vitamin D deficiency status in Turkey: A meta-analysis. Int J Med Biochem 2019;2(3):118-31. DOI: 10.14744/ijmb.2019.04127.
  • Matyar S, Disel NR, Acikalin Akpinar A, Kutnu M, İnal T. Vitamin D levels in Çukurova Region. [Article in Turkish]. Cukurova Med J 2017;42:320-8.
  • Serdar MA, Can BB, Kilercik M, Zeynep A, Durer ZA, Aksungar FB, et al. Analysis of changes in parathyroid hormone and 25 (OH) vitamin D levels with respect to age, gender and season: A Data Mining Study. J Med Biochem 201 7;36:73-83
  • Durmaz ZH, Demir AD, Tiryaki M, Delibaş N. Vitamine D levels of individulas in Amasya region. Bozok med J 2015;5:26-32.
  • Hekimsoy Z, Dinc G, Kafesciler S, Onur E, Guvenc Y, Pala T, et al. Vitamin D status among adults in the Aegean region of Turkey. BMC Public Health 2010;10:782.
  • Ucar F, Taslipinar MY, Soydas AO, Ozcan N. 25-OH vitamin D levels in patients admited to Ankara Etlik Ihtisas Training and Research Hospital. Eur J Basic Med Sci 2012;2:12- 5.

Determination of 25 hydroxyvitamin D reference ranges in Hatay region by indirect method

Year 2023, Volume: 14 Issue: 49, 140 - 144, 31.08.2023
https://doi.org/10.17944/interdiscip.1352036

Abstract

Objective: The aim of this study is to determine the reference ranges of 25 hydroxyvitamin D (25(OH)D) levels from the serum 25(OH)D results of the patients and to investigate variations across age and gender groups.

Methods: The patients (n=26829) who applied to Hatay Mustafa Kemal University Hospital between January 2018 and December 2019 and whose 25(OH)D levels were studied were included in this retrospective study. Serum 25(OH)D levels were studied by the chemiluminescence immunoassay method. The hospital information management system was used to obtain the test results and patient data. The indirect method was used to determine the reference ranges.

Results: The prevalence of 25(OH)D deficiency in the patients participating in this study was 60.9% in the general population, 54.9% in men, and 67.5% in women. It has been observed that 25(OH)D deficiency is more common in women than in men. The reference ranges determined in this study were lower than the reference ranges provided by the manufacturer.

Conclusion: In this study, 25(OH)D levels and reference ranges of Hatay Region were determined in a very large population. It can be said that the results of our region will contribute to the studies to be carried out on the determination of 25(OH)D levels and reference ranges throughout the country.

References

  • Cashman KD. Vitamin D Deficiency: Defining, Prevalence, Causes, and Strategjes of Addressing. Calcif Tissue Int. 2020 Jan;106(1):1 4-29. doi: 10.1007/s00223-0l9-00559-4. Epub 2019 May 8.
  • Sempos CT, Heijboer AC, Bikle DD, Bollerslev J, Bouillon R, Brannon PM, DeLuca HF, Jones G, Munns CF, Bilezikian JP, Giustina A, Binkley N. Vitamin D assays and the definition of hypovitaminosis D: results from the First International Conference on Controversies in Vitamin D. Br J Clin Pharmacol. 2018 Oct;84(10):2194-2207. doi: 10.1111 /bcp.13652. Epub 2018 Jul 17.
  • Börekçi NÖ. Current infonnation on vitamin D deficiency. Jour Tuk Fam Phy 2019;10(1):35-42. doi:10.15511 /jtfp.19.00135
  • Amrein K, Scherkl M, Hoffmann M, Neuwersch-Sommeregger S, Kostenberger M, Tmava Berisha A, Martucci G, Pilz S, Malle O. Vitamin D deficiency 2.0: an update on the current status worldwide. Eur J Clin Nutr. 2020 Nov;74(11): 1498-1513. doi: 10.1038/s41430-020- 0558-y. Epub 2020 Jan 20. PMID: 31959942;
  • CLSI. Defining, Establishing, and Verifying Reference Intervals in the Clinical Laboratory; Approved Guideline-Third Edition. CLSI Document C28-A3. Wayne, PA, USA: Clinical and Laboratory Standards Institute; 2008.
  • Çaycı T, Kurt YG, Honca T, Taş A, Özgürtaş T, Ağıllı M, Aydn FN, Aydın İ. Hastane bilgi sistemindeki kayıtlı hasta sonuçlarından tam kan referans aralıklarının tayini. Gülhane Tıp Derg 2015; 57: I 11-117. doi: 10.5455/gulhane. 167492
  • Aydın İ, Ağıllı M, Aydın FN, Kurt YG, Çaycı T, Taş A, Honca T, Özgürtaş T, Türker Türker, Koçak N. Farklı yaş gruplarında nötrofil/lenfosit oranı referans aralıkları. Gülhane Tıp Derg 2015;57: 414-418. doi: 10.5455/gulhane. 166398
  • Çatak Z. Elazığ Bolgesinin 25 Hidroksivitamin D Düzeylerinin Değerlendirilmesi ve Populasyona Dayalı Yeni Referans Aralıklarının Belirlenmesi. Fırat Tıp Dergisi/Firat Med J 2018; 23 (1): 6-10.
  • Alpdemir M, Alpdemir MF. Determination of reference range with the indirect method of the 25- hydroxyvitamin D3 test in the Balıkesir region, Turkey. Turk J Med Sci (2016)46 :1 512 -1517. doi: 10 .3906/sag-1504-19.
  • Solberg HE. International Federation of Clinical Chemistry (JFCC), Scientific Committee, Clinical Section, Expert Panel on Theory of Reference Values, and International Committee for Standardization in Haematology (JCSH), Standing Committee on Reference Values. Approved recommendation (1986) on the theory of reference values. Part 1. The concept of reference values. J Clin Chem Clin Biochem 1987; 25: 337-342.
  • Öztürk ZA, Gol M, Türkbeyler İH. Prevalence of vitamin D deficiency in otherwise healthy individuals between the ages of 18 and 90 years in southeast Turkey. Wien Klin Wochenschr. 2017 Nov;129(21-22):854-855doi: 10.1007/s00508-017-1241-8. Epub 2017 Jul 27.
  • Buyukuslu N, Esin K, Hizli H, Sunal N, Yigit P, Garipagaoglu M. Clothing preference affects vitamin D status of young women. Nutr Res 2014;34:688-93.
  • Bozkurt S, Alkan BM, Yildiz F, Gumus S, Sezer N, Ardicoglu O, et al. Age, sex, and seasonal variations in the serum vitamin D3 Levels in a local Turkish population. Arch Rheumatol 2014;29:14- 9.
  • Alpdemir M, Alpdemir MF. Vitamin D deficiency status in Turkey: A meta-analysis. Int J Med Biochem 2019;2(3):118-31. DOI: 10.14744/ijmb.2019.04127.
  • Matyar S, Disel NR, Acikalin Akpinar A, Kutnu M, İnal T. Vitamin D levels in Çukurova Region. [Article in Turkish]. Cukurova Med J 2017;42:320-8.
  • Serdar MA, Can BB, Kilercik M, Zeynep A, Durer ZA, Aksungar FB, et al. Analysis of changes in parathyroid hormone and 25 (OH) vitamin D levels with respect to age, gender and season: A Data Mining Study. J Med Biochem 201 7;36:73-83
  • Durmaz ZH, Demir AD, Tiryaki M, Delibaş N. Vitamine D levels of individulas in Amasya region. Bozok med J 2015;5:26-32.
  • Hekimsoy Z, Dinc G, Kafesciler S, Onur E, Guvenc Y, Pala T, et al. Vitamin D status among adults in the Aegean region of Turkey. BMC Public Health 2010;10:782.
  • Ucar F, Taslipinar MY, Soydas AO, Ozcan N. 25-OH vitamin D levels in patients admited to Ankara Etlik Ihtisas Training and Research Hospital. Eur J Basic Med Sci 2012;2:12- 5.
There are 19 citations in total.

Details

Primary Language English
Subjects Clinical Sciences (Other)
Journal Section Research Articles
Authors

Hamdi Oğuzman 0000-0003-1412-7689

Serdar Doğan 0000-0001-6854-2197

Early Pub Date August 31, 2023
Publication Date August 31, 2023
Submission Date November 11, 2022
Published in Issue Year 2023 Volume: 14 Issue: 49

Cite

Vancouver Oğuzman H, Doğan S. Determination of 25 hydroxyvitamin D reference ranges in Hatay region by indirect method. Interdiscip Med J. 2023;14(49):140-4.