Case Report
BibTex RIS Cite
Year 2021, Volume: 12 Issue: 2, 41 - 44, 11.06.2021
https://doi.org/10.33706/jemcr.834306

Abstract

References

  • 1. David Josephy P. The molecular toxicology of acetaminophen. Drug metabolism reviews. 2005;37(4):581-94.
  • 2. Papazoglu C, Ang JR, Mandel M, Basak P, Jesmajian S. Acetaminophen overdose associated with double serum concentration peaks. Journal of community hospital internal medicine perspectives. 2015;5(6):29589.
  • 3. Duran L, Sisman B, Dogruel C, Yardan T, Baydin A, Yavuz Y. Parasetamol Zehirlenmesinde Intravenöz N-Asetil Sistein Kullanimi/Use of Intravenous N-Acetyl Systein in Paracetamol Intoxication. Journal of Academic Emergency Medicine. 2011;10(4):145.
  • 4. Lancaster EM, Hiatt JR, Zarrinpar A. Acetaminophen hepatotoxicity: an updated review. Archives of toxicology. 2015;89(2):193-9.
  • 5. Mazer M, Perrone J. Acetaminophen-induced nephrotoxicity: pathophysiology, clinical manifestations, and management. Journal of medical toxicology : official journal of the American College of Medical Toxicology. 2008;4(1):2-6.
  • 6. Zarogiannis SG, Kalomenidis I. Can pharmacologic agents speed the rate of resorption of pleural fluid? Current opinion in pulmonary medicine. 2015;21(4):372-5.
  • 7. Porcel JM, Light RW. Diagnostic approach to pleural effusion in adults. Am Fam Physician. 2006;73(7):1211-20.
  • 8. Moschos C, Kalomenidis I. Drug Related Pleural Disease. TTD Plevra Bülteni. 2010;4(3):8-18.
  • 9. Huggins JT, Sahn SA. Drug-induced pleural disease. Clinics in chest medicine. 2004;25(1):141-53.
  • 10. Kossick MA. Intravenous acetaminophen and intravenous ketorolac for management of pediatric surgical pain: a literature review. AANA journal. 2014;82(1):53.
  • 11. Jones VM. Acetaminophen injection: a review of clinical information. Journal of pain & palliative care pharmacotherapy. 2011;25(4):340-9.
  • 12. Lai-Fook SJ. Pleural mechanics and fluid exchange. Physiological reviews. 2004;84(2):385-410.
  • 13. Kouritas VK, Zisis C, Bellenis I, Gourgoulianis KI, Molyvdas PA, Hatzoglou C. Nonsteroidal anti-inflammatory drugs alter the human mesothelial pleural permeability via ion cellular transportation by inhibiting prostaglandin synthesis. Respiration; international review of thoracic diseases. 2012;84(1):62-8.
  • 14. Kouritas VK, Magkouta S, Zisis C, Psallidas I, Gourgoulianis KI, Kalomenidis I. Paracetamol and ibuprofen block hydrothorax absorption in mice. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. 2015;47(3):426-30; discussion 30.

Paracetamol Overdose May Cause Transudative Pleural Effusion in Adults

Year 2021, Volume: 12 Issue: 2, 41 - 44, 11.06.2021
https://doi.org/10.33706/jemcr.834306

Abstract

Paracetamol is the most widely used and prescribed drug word-wide. It is the most common cause of the poisoning and of the fatality due to the toxic administration throughout the world. A 34-year-old female patient applied to our ED with the complaint of swallowing 33 g of paracetamol. After routine toxicity treatment, on the third day of the hospitalization, dyspnea and pain on the right hemithorax and right flank occurred. Chest X-ray showed blunted right sinus. CT revealed bilateral pleural effusion. With thoracentesis, clear, colorless and odor-free fluid of about 500cc was drained. Laboratory examination of the fluid confirmed it as transudate. We believed pleural effusion is related to high-dose paracetamol intake and it occurred due to decrease in pleural permeability and the consequent decrease of the fluid absorption. In conclusion, high-dose intake of paracetamol might cause transudative pleural effusion as a complication.

References

  • 1. David Josephy P. The molecular toxicology of acetaminophen. Drug metabolism reviews. 2005;37(4):581-94.
  • 2. Papazoglu C, Ang JR, Mandel M, Basak P, Jesmajian S. Acetaminophen overdose associated with double serum concentration peaks. Journal of community hospital internal medicine perspectives. 2015;5(6):29589.
  • 3. Duran L, Sisman B, Dogruel C, Yardan T, Baydin A, Yavuz Y. Parasetamol Zehirlenmesinde Intravenöz N-Asetil Sistein Kullanimi/Use of Intravenous N-Acetyl Systein in Paracetamol Intoxication. Journal of Academic Emergency Medicine. 2011;10(4):145.
  • 4. Lancaster EM, Hiatt JR, Zarrinpar A. Acetaminophen hepatotoxicity: an updated review. Archives of toxicology. 2015;89(2):193-9.
  • 5. Mazer M, Perrone J. Acetaminophen-induced nephrotoxicity: pathophysiology, clinical manifestations, and management. Journal of medical toxicology : official journal of the American College of Medical Toxicology. 2008;4(1):2-6.
  • 6. Zarogiannis SG, Kalomenidis I. Can pharmacologic agents speed the rate of resorption of pleural fluid? Current opinion in pulmonary medicine. 2015;21(4):372-5.
  • 7. Porcel JM, Light RW. Diagnostic approach to pleural effusion in adults. Am Fam Physician. 2006;73(7):1211-20.
  • 8. Moschos C, Kalomenidis I. Drug Related Pleural Disease. TTD Plevra Bülteni. 2010;4(3):8-18.
  • 9. Huggins JT, Sahn SA. Drug-induced pleural disease. Clinics in chest medicine. 2004;25(1):141-53.
  • 10. Kossick MA. Intravenous acetaminophen and intravenous ketorolac for management of pediatric surgical pain: a literature review. AANA journal. 2014;82(1):53.
  • 11. Jones VM. Acetaminophen injection: a review of clinical information. Journal of pain & palliative care pharmacotherapy. 2011;25(4):340-9.
  • 12. Lai-Fook SJ. Pleural mechanics and fluid exchange. Physiological reviews. 2004;84(2):385-410.
  • 13. Kouritas VK, Zisis C, Bellenis I, Gourgoulianis KI, Molyvdas PA, Hatzoglou C. Nonsteroidal anti-inflammatory drugs alter the human mesothelial pleural permeability via ion cellular transportation by inhibiting prostaglandin synthesis. Respiration; international review of thoracic diseases. 2012;84(1):62-8.
  • 14. Kouritas VK, Magkouta S, Zisis C, Psallidas I, Gourgoulianis KI, Kalomenidis I. Paracetamol and ibuprofen block hydrothorax absorption in mice. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. 2015;47(3):426-30; discussion 30.
There are 14 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Case Report
Authors

İlker Akbaş 0000-0001-6676-6517

Abdullah Osman Kocak 0000-0002-1678-4474

Sibel Güçlü Utlu 0000-0001-8635-1562

Sinem Doğruyol 0000-0002-6949-7233

Zeynep Çakır 0000-0002-7991-087X

Publication Date June 11, 2021
Submission Date December 1, 2020
Published in Issue Year 2021 Volume: 12 Issue: 2

Cite

APA Akbaş, İ., Kocak, A. O., Güçlü Utlu, S., Doğruyol, S., et al. (2021). Paracetamol Overdose May Cause Transudative Pleural Effusion in Adults. Journal of Emergency Medicine Case Reports, 12(2), 41-44. https://doi.org/10.33706/jemcr.834306
AMA Akbaş İ, Kocak AO, Güçlü Utlu S, Doğruyol S, Çakır Z. Paracetamol Overdose May Cause Transudative Pleural Effusion in Adults. Journal of Emergency Medicine Case Reports. June 2021;12(2):41-44. doi:10.33706/jemcr.834306
Chicago Akbaş, İlker, Abdullah Osman Kocak, Sibel Güçlü Utlu, Sinem Doğruyol, and Zeynep Çakır. “Paracetamol Overdose May Cause Transudative Pleural Effusion in Adults”. Journal of Emergency Medicine Case Reports 12, no. 2 (June 2021): 41-44. https://doi.org/10.33706/jemcr.834306.
EndNote Akbaş İ, Kocak AO, Güçlü Utlu S, Doğruyol S, Çakır Z (June 1, 2021) Paracetamol Overdose May Cause Transudative Pleural Effusion in Adults. Journal of Emergency Medicine Case Reports 12 2 41–44.
IEEE İ. Akbaş, A. O. Kocak, S. Güçlü Utlu, S. Doğruyol, and Z. Çakır, “Paracetamol Overdose May Cause Transudative Pleural Effusion in Adults”, Journal of Emergency Medicine Case Reports, vol. 12, no. 2, pp. 41–44, 2021, doi: 10.33706/jemcr.834306.
ISNAD Akbaş, İlker et al. “Paracetamol Overdose May Cause Transudative Pleural Effusion in Adults”. Journal of Emergency Medicine Case Reports 12/2 (June 2021), 41-44. https://doi.org/10.33706/jemcr.834306.
JAMA Akbaş İ, Kocak AO, Güçlü Utlu S, Doğruyol S, Çakır Z. Paracetamol Overdose May Cause Transudative Pleural Effusion in Adults. Journal of Emergency Medicine Case Reports. 2021;12:41–44.
MLA Akbaş, İlker et al. “Paracetamol Overdose May Cause Transudative Pleural Effusion in Adults”. Journal of Emergency Medicine Case Reports, vol. 12, no. 2, 2021, pp. 41-44, doi:10.33706/jemcr.834306.
Vancouver Akbaş İ, Kocak AO, Güçlü Utlu S, Doğruyol S, Çakır Z. Paracetamol Overdose May Cause Transudative Pleural Effusion in Adults. Journal of Emergency Medicine Case Reports. 2021;12(2):41-4.