Research Article
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Antibacterial Effect of Purchased Pomegranate Juice and Its Sinergistic Effect With Some Antibiotics

Year 2018, Volume: 8 Issue: 3, 131 - 135, 30.09.2018

Merve Arı Nurcan Erbil

https://doi.org/10.21597/jist.458611
Cited By: 1

Abstract

Pomegranate juice is a fruit juice that we consume in our daily life, and it is known that the pomegranate

is very useful for health. In this study, it was aimed to determine the antibacterial activity of pomegranate juice

which is commercially purchased and consumed against different Gr (+) and Gr (-) bacteria and its potential

synergistic effect when it is used together with antibiotics. For this purpose, pomegranate juice branded “meySu”,

which was purchased commercially, was used. According to results, Ampicillin, Gentamicin and pomegranate

juice exhibited different antibacterial effects against test bacteria (7.64-9.23, 22.26-22.98 and 19.07-20.14 mm,

respectively). It was observed that pomegranate juice had the higher antibacterial effect than Ampicillin. When

pomegranate juice and Ampicillin were applied together, it was seen that they formed the zone diameter between

20.11-21.14 mm. When ponegranate juice and Gentamicin were applied together, they exhibited the inhibition

zones between 26.36-28.94 mm. These results showed that pomegranate juice exhibited the synergistic effect with

both of the standard antibiotics. The results of this study demostrated that pomegranate juice exhibited the high

antibacterial activity against test bacteria used in this study. In addition, it is also important that pomegranate juice

showed a synergistic effect when used with antibiotics tested in this study.

Keywords

Antimicrobial effect bacteria pomegranate juice synergistic effect

References

  • Aviram M, Rosenblat M, 2012. Pomegranate protection against cardiovascular diseases. Evidence-Based Complementary and Alternative Medicine, doi:10.1155/2012/382763.
  • Aviram M, Volkova N, Coleman R, Dreher M, Reddy MK., Ferreira D, Rosenblat M, 2008. Pomegranate phenolics from the peels, arils, and flowers are antiatherogenic: studies in vivo in atherosclerotic apolipoprotein E-deficient (E-o) mice and in vitro in cultured macrophages and upoproteins. Journal of Agricultural and Food Chemistry, 56: 1148–1157.
  • Collins CH, Lyne PM, Grange JM, 1989. Microbiological Methods. London, 410s.
  • Dağcı EK, Dığrak M, 2005. Bazı Meyve Ekstraktlarının antibakteriyal ve antifungal aktiviteleri. KSÜ Fen ve Mühendislik Dergisi, 8(2): 1-7.
  • Elmanama AA, Alyazji AA, Abu NA, 2011. Antibacterial, antifungal and synergistic effect of Lawsonia inermis, Punica granatum and Hibiscus sabdariffa. Annals of Alquds Medicine, 7: 33-41.
  • Glazer I, Masaphy S, Marciano P, Bar-Ilan I, Holland D, Kerem Z, Amir R, 2012. Partial identification of bioactive compounds having antifungal activities from Punica granatum peel extracts. Journal of Agricultural and Food Chemistry, 60(19): 4841–4848.
  • Hama AA, Taha Y, Qadir SA, 2014. The antimicrobial activity of pomegranate (Punica granatum) juice. International Journal of Scientific & Engineering Research, 5(10): 796-798.
  • Jayaprakasha G, Jena B, Negi P, 2006. Antimicrobial activities of pomegranate. Seeram NP, Schulman RN, Heber D (Ed.). Pomegranates: Ancient Roots to Modern Medicine. CRC Press, 167–183 p.
  • Langley P, 2000. Why a pomegranate. British Medical Journal, 321: 1153–1154.
  • Neurath AR, Strick N, Li YY, Debnath AK, 2005. Punica granatum (pomegranate) juice provides an HIV-1 entry inhibitor and candidate topical microbicide. Annals of The New York Academy of Sciences, 1056: 311–327.
  • Orak HH, Demirci AŞ, Gümüş T, 2011. Antibacterial and antifungal activity of pomegranate (Punica granatum L. CV.) peel. Electronic Journal of Environmental Agricultural and Food Chemistry, 10(3): 1958-1969.
  • Özçelik S, 1992. Gıda Mikrobiyolojisi Laboratuar Kılavuzu. F.Ü. Fen-Edebiyat Fakültesi Yayınları, Yayın No: 1, Elazığ, 135s.
  • Quideau S, Deffieux D, Douat-Casassus C, Pouysegu L, 2011. Plant polyphenols: chemical properties biological activities, and synthesis. Angewandte Chemie International Edition in English, 50: 586–621
  • Seeram NP, Adams LS, Henning SM, Niu Y, Zhang Y, Nair MG, Heber D, 2005. In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice. The Journal of Nutritional Biochemistry, 16: 360–367.
  • Seeram NP, Zhang Y, Reed JD, Krueger CG, Vaya J, 2006. Pomegranate phytochemicals. Seeram NP, Schulman RN, Heber D (Ed.). Pomegranates Ancient Roots to Modern Medicine. CRC Press, 3–29 p.
  • Zarei M, Azizi M, Zeinolabedin BS, 2011. Evaluation of Physicochemical Characteristics of Pomegranate (Punica granatum L.) Fruit during Ripening. Fruits, 66: 121-129.

Ticari Olarak Satın Alınan Nar Suyunun Antibakteriyal ve Bazı Antibiyotiklerle Sinerjistik Etkisi

Year 2018, Volume: 8 Issue: 3, 131 - 135, 30.09.2018

Merve Arı Nurcan Erbil

https://doi.org/10.21597/jist.458611
Cited By: 1

Abstract

Nar suyu günlük hayatamızda tükettiğimiz bir meyve suyu olup, narın sağlık açısından oldukça faydalı
olduğu bilinmektedir. Bu çalışmada ticari olarak satın alınarak tüketilen nar sularının farklı Gram (+) ve Gram (-)
bakteriler üzerinde oluşturduğu antibakteryel aktivitenin ve antibiyotiklerle beraber kullanıldığında oluşabilecek
sinerjistik etkinin belirlenmesi amaçlanmıştır. Bu amaçla ticari olarak satın alınan “meySu” markalı nar suyu
kullanılmıştır. Elde edilen sonuçlar neticesinde tek başına Ampisilin’in 7.64-9.23 mm; Gentamisin’in 22.26-22.98
mm; nar suyunun ise 19.07-20.14 mm arasında zon çapı meydana getirdiği görülmüştür. Bakıldığında tek başına
nar suyunun Ampisilin’den daha yüksek oranda antibakteriyal aktivite sergilediği görülmektedir. Nar suyu ve
Ampicillin beraber uygulandığında 20.11-21.14 mm araasında, nar suyu ve Gentamisin birlikte uygulandığında ise
26.36-28.94 mm araasında zon çapı oluşturduğu görülmektedir. Bu sonuçlar nar suyunun Gentamisin ile daha fazla
olmak üzere her iki antibiyotik ile sinerjistik etki gösterdiğini ortaya koymaktadır. Çalışma sonucunda elde edilen
veriler, nar suyunun test bakterilerine karşı oldukça iyi düzeyde antibakteriyal aktivite sergilediğini göstermektedir.
Ayrıca; nar suyunun test edilen antibiyotiklerle beraber kullanıldığında sinerjistik etki yaratması da ayrıca bir
öneme sahiptir.

Keywords

Antibakteriyal etki bakteri nar suyu sinerjistik etki

References

  • Aviram M, Rosenblat M, 2012. Pomegranate protection against cardiovascular diseases. Evidence-Based Complementary and Alternative Medicine, doi:10.1155/2012/382763.
  • Aviram M, Volkova N, Coleman R, Dreher M, Reddy MK., Ferreira D, Rosenblat M, 2008. Pomegranate phenolics from the peels, arils, and flowers are antiatherogenic: studies in vivo in atherosclerotic apolipoprotein E-deficient (E-o) mice and in vitro in cultured macrophages and upoproteins. Journal of Agricultural and Food Chemistry, 56: 1148–1157.
  • Collins CH, Lyne PM, Grange JM, 1989. Microbiological Methods. London, 410s.
  • Dağcı EK, Dığrak M, 2005. Bazı Meyve Ekstraktlarının antibakteriyal ve antifungal aktiviteleri. KSÜ Fen ve Mühendislik Dergisi, 8(2): 1-7.
  • Elmanama AA, Alyazji AA, Abu NA, 2011. Antibacterial, antifungal and synergistic effect of Lawsonia inermis, Punica granatum and Hibiscus sabdariffa. Annals of Alquds Medicine, 7: 33-41.
  • Glazer I, Masaphy S, Marciano P, Bar-Ilan I, Holland D, Kerem Z, Amir R, 2012. Partial identification of bioactive compounds having antifungal activities from Punica granatum peel extracts. Journal of Agricultural and Food Chemistry, 60(19): 4841–4848.
  • Hama AA, Taha Y, Qadir SA, 2014. The antimicrobial activity of pomegranate (Punica granatum) juice. International Journal of Scientific & Engineering Research, 5(10): 796-798.
  • Jayaprakasha G, Jena B, Negi P, 2006. Antimicrobial activities of pomegranate. Seeram NP, Schulman RN, Heber D (Ed.). Pomegranates: Ancient Roots to Modern Medicine. CRC Press, 167–183 p.
  • Langley P, 2000. Why a pomegranate. British Medical Journal, 321: 1153–1154.
  • Neurath AR, Strick N, Li YY, Debnath AK, 2005. Punica granatum (pomegranate) juice provides an HIV-1 entry inhibitor and candidate topical microbicide. Annals of The New York Academy of Sciences, 1056: 311–327.
  • Orak HH, Demirci AŞ, Gümüş T, 2011. Antibacterial and antifungal activity of pomegranate (Punica granatum L. CV.) peel. Electronic Journal of Environmental Agricultural and Food Chemistry, 10(3): 1958-1969.
  • Özçelik S, 1992. Gıda Mikrobiyolojisi Laboratuar Kılavuzu. F.Ü. Fen-Edebiyat Fakültesi Yayınları, Yayın No: 1, Elazığ, 135s.
  • Quideau S, Deffieux D, Douat-Casassus C, Pouysegu L, 2011. Plant polyphenols: chemical properties biological activities, and synthesis. Angewandte Chemie International Edition in English, 50: 586–621
  • Seeram NP, Adams LS, Henning SM, Niu Y, Zhang Y, Nair MG, Heber D, 2005. In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice. The Journal of Nutritional Biochemistry, 16: 360–367.
  • Seeram NP, Zhang Y, Reed JD, Krueger CG, Vaya J, 2006. Pomegranate phytochemicals. Seeram NP, Schulman RN, Heber D (Ed.). Pomegranates Ancient Roots to Modern Medicine. CRC Press, 3–29 p.
  • Zarei M, Azizi M, Zeinolabedin BS, 2011. Evaluation of Physicochemical Characteristics of Pomegranate (Punica granatum L.) Fruit during Ripening. Fruits, 66: 121-129.
There are 16 citations in total.

Details

Primary Language Turkish
Subjects Food Engineering
Journal Section Gıda Mühendisliği / Food Engineering
Authors

Merve Arı This is me 0000-0003-2003-4817

Nurcan Erbil 0000-0001-9553-2306

Publication Date September 30, 2018
Submission Date January 23, 2018
Acceptance Date June 1, 2018
Published in Issue Year 2018 Volume: 8 Issue: 3

Cite

APA Arı, M., & Erbil, N. (2018). Ticari Olarak Satın Alınan Nar Suyunun Antibakteriyal ve Bazı Antibiyotiklerle Sinerjistik Etkisi. Journal of the Institute of Science and Technology, 8(3), 131-135. https://doi.org/10.21597/jist.458611
AMA Arı M, Erbil N. Ticari Olarak Satın Alınan Nar Suyunun Antibakteriyal ve Bazı Antibiyotiklerle Sinerjistik Etkisi. J. Inst. Sci. and Tech. September 2018;8(3):131-135. doi:10.21597/jist.458611
Chicago Arı, Merve, and Nurcan Erbil. “Ticari Olarak Satın Alınan Nar Suyunun Antibakteriyal Ve Bazı Antibiyotiklerle Sinerjistik Etkisi”. Journal of the Institute of Science and Technology 8, no. 3 (September 2018): 131-35. https://doi.org/10.21597/jist.458611.
EndNote Arı M, Erbil N (September 1, 2018) Ticari Olarak Satın Alınan Nar Suyunun Antibakteriyal ve Bazı Antibiyotiklerle Sinerjistik Etkisi. Journal of the Institute of Science and Technology 8 3 131–135.
IEEE M. Arı and N. Erbil, “Ticari Olarak Satın Alınan Nar Suyunun Antibakteriyal ve Bazı Antibiyotiklerle Sinerjistik Etkisi”, J. Inst. Sci. and Tech., vol. 8, no. 3, pp. 131–135, 2018, doi: 10.21597/jist.458611.
ISNAD Arı, Merve - Erbil, Nurcan. “Ticari Olarak Satın Alınan Nar Suyunun Antibakteriyal Ve Bazı Antibiyotiklerle Sinerjistik Etkisi”. Journal of the Institute of Science and Technology 8/3 (September 2018), 131-135. https://doi.org/10.21597/jist.458611.
JAMA Arı M, Erbil N. Ticari Olarak Satın Alınan Nar Suyunun Antibakteriyal ve Bazı Antibiyotiklerle Sinerjistik Etkisi. J. Inst. Sci. and Tech. 2018;8:131–135.
MLA Arı, Merve and Nurcan Erbil. “Ticari Olarak Satın Alınan Nar Suyunun Antibakteriyal Ve Bazı Antibiyotiklerle Sinerjistik Etkisi”. Journal of the Institute of Science and Technology, vol. 8, no. 3, 2018, pp. 131-5, doi:10.21597/jist.458611.
Vancouver Arı M, Erbil N. Ticari Olarak Satın Alınan Nar Suyunun Antibakteriyal ve Bazı Antibiyotiklerle Sinerjistik Etkisi. J. Inst. Sci. and Tech. 2018;8(3):131-5.

Cited By

Geleneksel Yöntemlerle Üretilen Nar Ekşisinin Antibakteriyel ve Antimutajenik Etki Potansiyeli
Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi
https://doi.org/10.18185/erzifbed.523767