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Vitiligo Hastalarında Sigara Kullanımının Hastalık Semptom ve Bulguları Üzerinde Etkisi Var Mıdır?

Year 2019, Volume: 5 Issue: 4, 373 - 379, 30.12.2019

Abstract

Amaç:
Kliniğimizde vitiligo nedeniyle takip edilen hastalarda sigara kullanımının
hastalık semptom ve bulguları üzerine etkisi olup olmadığını araştırmayı amaçladık.

Materyal
ve Metod:
Çalışmamızda Sakarya Üniversitesi Tıp Fakültesi
Eğitim ve Araştırma Hastanesi (SÜEAH) Dermatoloji Kliniğinde poliklinik takibi
olan hastaların retrospektif olarak dosyaları taranarak klinik ve laboratuvar
verileri kayıt altına alındı. Hastaların demografik verileri, komorbid
hastalıkları ve hastalıkları ile ilişkili bulguları retrospektif dosya
verilerinden kaydedildi.

Bulgular:
Çalışmaya 217 hasta alındı.  52 hasta sigara
kullanan (grup I) ve 165 hasta sigara kullanmayan grupta (Grup II) idi. Grup I
ile Grup II karşılaştırıldığında sigara kullananların yaş olarak daha büyük ve
erkek baskınlığında olduğu görüldü. Sigara içmeyen grupta Keobner fenomeni,
halo nevüs ve lökotrişi anlamlı derecede fazla saptandı. Repigmentasyon sigara
içenlerde daha az izlendi. HDL düzeyi sigara içen grupta daha düşük bulundu.







Tartışma:
Vitiligo hastalarında sigaranın bırakılması repigmentasyonun sağlanması
açısından önemlidir.

References

  • 1. Alikhan A, Felsten LM, Daly M, Petronic-Rosic V. Vitiligo: a comprehensive overview. Part I. Introduction, epidemiology, quality of life, diagnosis, differential diagnosis, associations, histopathology, etiology, and work-up. J Am Acad Dermatol. 2011; 65:473–91.
  • 2. Jeon IK, Park CJ, Lee MH, Lee DY, et al. A multicenter collaborative study by the Korean society of vitiligo about patients' occupations and the provoking factors of vitiligo. Ann Dermatol. 2014; 26:349–56.
  • 3. Dammak I, Boudaya S, Ben Abdallah F, Turki H, et al. Antioxidant enzymes and lipid peroxidation at the tissue level in patients with stable and active vitiligo. Int J Dermatol. 2009; 48:476–480.
  • 4. Passi S, Grandinetti M, Maggio F, Stancato A, et al. Epidermal oxidative stress in vitiligo. Pigment Cell Res. 1998; 11:81–85.
  • 5. Schallreuter KU, Wood JM, Berger J. Low catalase levels in the epidermis of patients with vitiligo. J Invest Dermatol. 1991; 97:1081–1085.
  • 6. Yildirim M, Baysal V, Inaloz HS, Can M. The role of oxidants and antioxidants in generalized vitiligo at tissue level. J Eur Acad Dermatol Venereol. 2004; 18:683–686.
  • 7. H.H. Park and M.H. Lee. Serum levels of vitamin B12 and folate in Korean patients with vitiligo, Acta Derm Venereol 85(2005), 66-7.
  • 8. Boissy R E & Manga P. On the etiology of contact/occupational vitiligo. Pigment Cell Res 17, 208–214 (2004).
  • 9. Schallreuter KU, Salem MA, Gibbons NC, Martinez A, et al. Blunted epidermal L-tryptophan metabolism in vitiligo affects immune response and ROS scavenging by Fenton chemistry, part 1: Epidermal H2O2/ ONOO (−)-mediated stress abrogates tryptophan hydroxylase and dopa decarboxylase activities, leading to low serotonin and melatonin levels. FASEB J 26, 2457–2470 (2012).
  • 10. Sravani PV, Babu NK, Gopal K, Rama Rao GR, et al. Determination of oxidative stress in vitiligo by measuring superoxide dismutase and catalase levels in vitiliginous and non-vitiliginous skin. Indian J Dermatol Venereol Leprol 75, 268–271 (2009).
  • 11. Zhou Z, Li CY, Li K, Wang T, et al. Decreased methionine sulphoxide reductase A expression renders melanocytes more sensitive to oxidative stress: a possible cause for melanocyte loss in vitiligo. Br J Dermatol 161, 504–509 (2009).
  • 12. Denat L, Kadekaro AL, Marrot L, Leachman SA, et al. Melanocytes as instigators and victims of oxidative stress. J Invest Dermatol 134, 1512–1518 (2014).
  • 13. Laddha NC, Dwivedi M, Mansuri MS, Gani AR, et al. Vitiligo: interplay between oxidative stress and immune system. Exp Dermatol 22, 245–250 (2013).
  • 14. Wang X, Li K, Liu L, Shi Q, et al. AHR promoter variant modulates its transcription and downstream effectors by allele-specific AHR-SP1 interaction functioning as a genetic marker for vitiligo. Sci Rep 5, 13542 (2015).
  • 15. Jian Z, Li K, Song P, Zhu G, et al. Impaired activation of the Nrf2-ARE signaling pathway undermines H2O2-induced oxidative stress response: a possible mechanism for melanocyte degeneration in vitiligo. J Invest Dermatol 134, 2221–2230 (2014).
  • 16. Beckman JS & Koppenol WH. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am J Physiol 271, C1424–1437 (1996).
  • 17. Gill L, Zarbo A, Isedeh P, Jacobsen G, et al. Comorbid autoimmune diseases in patients with vitiligo: A cross-sectional study. J Am Acad Dermatol. 2016 Feb;74(2):295-302.
  • 18. J. P. Ortonne, D. B. Mosher, and T. B. Fitzpatrick. “Vitiligo and other hypomelanoses of hair and skin,” in Topics in Dermatology, J. P. Ortonne, D. B. Mosher, and T. B. Fitzpatrick, Eds., pp. 257–258, Plenum Medical Book, New York, NY, USA, 1983.
  • 19. Ortonne JP, Bahadoran P, Fitzpatrick TB, Mosher DB, et al. Hypomelanoses and hypermelanoses. Fitzpatrick’s Dermatology in General Medicine. Ed. Freedberg IM, Eisen AZ, Wolff K, Goldsmith LA, Katz SI. 6th ed. New York, McGraw Hill, 2003; 836-881.
  • 20. Barona MI, Arrunátegui A, Falabella R, Alzate A. An epidemiologic case-control study in a population with vitiligo. J Am Acad Dermatol. 1995; 33:621–625.

Does Smoking Have Impact on Symptoms and Signs of Disease in Vitiligo Patients?

Year 2019, Volume: 5 Issue: 4, 373 - 379, 30.12.2019

Abstract

Aim:
We
aimed to investigate whether smoking affects the symptoms and signs of vitiligo
in patients followed up for vitiligo in our clinic.



Materials
and Methods:
In our study, the files of patients who
were followed up in outpatient clinic in Dermatology Clinic of Sakarya
University Medical Faculty Training and Research Hospital (SÜEAH) were
retrospectively scanned and clinical and laboratory data were recorded.
Patients' demographic data, comorbid diseases and their findings related to
their diseases were recorded from retrospective file data.



Results:
Two
hundred and seventeen patients were included in the study. Fifty-two patients
were in smokers group (group I) and 165 patients were in non-smokers group
(Group II). When Group I and Group II were compared, it was seen that smokers
were older and male dominated. Keobner phenomena, halo nevus and leukotrichia
were significantly higher in nonsmoker group. Repigmentation was less frequent
in smokers. HDL levels were lower in the smoker group.



Conclusion:
Smoking
cessation in vitiligo patients is important in terms of repigmentation.

References

  • 1. Alikhan A, Felsten LM, Daly M, Petronic-Rosic V. Vitiligo: a comprehensive overview. Part I. Introduction, epidemiology, quality of life, diagnosis, differential diagnosis, associations, histopathology, etiology, and work-up. J Am Acad Dermatol. 2011; 65:473–91.
  • 2. Jeon IK, Park CJ, Lee MH, Lee DY, et al. A multicenter collaborative study by the Korean society of vitiligo about patients' occupations and the provoking factors of vitiligo. Ann Dermatol. 2014; 26:349–56.
  • 3. Dammak I, Boudaya S, Ben Abdallah F, Turki H, et al. Antioxidant enzymes and lipid peroxidation at the tissue level in patients with stable and active vitiligo. Int J Dermatol. 2009; 48:476–480.
  • 4. Passi S, Grandinetti M, Maggio F, Stancato A, et al. Epidermal oxidative stress in vitiligo. Pigment Cell Res. 1998; 11:81–85.
  • 5. Schallreuter KU, Wood JM, Berger J. Low catalase levels in the epidermis of patients with vitiligo. J Invest Dermatol. 1991; 97:1081–1085.
  • 6. Yildirim M, Baysal V, Inaloz HS, Can M. The role of oxidants and antioxidants in generalized vitiligo at tissue level. J Eur Acad Dermatol Venereol. 2004; 18:683–686.
  • 7. H.H. Park and M.H. Lee. Serum levels of vitamin B12 and folate in Korean patients with vitiligo, Acta Derm Venereol 85(2005), 66-7.
  • 8. Boissy R E & Manga P. On the etiology of contact/occupational vitiligo. Pigment Cell Res 17, 208–214 (2004).
  • 9. Schallreuter KU, Salem MA, Gibbons NC, Martinez A, et al. Blunted epidermal L-tryptophan metabolism in vitiligo affects immune response and ROS scavenging by Fenton chemistry, part 1: Epidermal H2O2/ ONOO (−)-mediated stress abrogates tryptophan hydroxylase and dopa decarboxylase activities, leading to low serotonin and melatonin levels. FASEB J 26, 2457–2470 (2012).
  • 10. Sravani PV, Babu NK, Gopal K, Rama Rao GR, et al. Determination of oxidative stress in vitiligo by measuring superoxide dismutase and catalase levels in vitiliginous and non-vitiliginous skin. Indian J Dermatol Venereol Leprol 75, 268–271 (2009).
  • 11. Zhou Z, Li CY, Li K, Wang T, et al. Decreased methionine sulphoxide reductase A expression renders melanocytes more sensitive to oxidative stress: a possible cause for melanocyte loss in vitiligo. Br J Dermatol 161, 504–509 (2009).
  • 12. Denat L, Kadekaro AL, Marrot L, Leachman SA, et al. Melanocytes as instigators and victims of oxidative stress. J Invest Dermatol 134, 1512–1518 (2014).
  • 13. Laddha NC, Dwivedi M, Mansuri MS, Gani AR, et al. Vitiligo: interplay between oxidative stress and immune system. Exp Dermatol 22, 245–250 (2013).
  • 14. Wang X, Li K, Liu L, Shi Q, et al. AHR promoter variant modulates its transcription and downstream effectors by allele-specific AHR-SP1 interaction functioning as a genetic marker for vitiligo. Sci Rep 5, 13542 (2015).
  • 15. Jian Z, Li K, Song P, Zhu G, et al. Impaired activation of the Nrf2-ARE signaling pathway undermines H2O2-induced oxidative stress response: a possible mechanism for melanocyte degeneration in vitiligo. J Invest Dermatol 134, 2221–2230 (2014).
  • 16. Beckman JS & Koppenol WH. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am J Physiol 271, C1424–1437 (1996).
  • 17. Gill L, Zarbo A, Isedeh P, Jacobsen G, et al. Comorbid autoimmune diseases in patients with vitiligo: A cross-sectional study. J Am Acad Dermatol. 2016 Feb;74(2):295-302.
  • 18. J. P. Ortonne, D. B. Mosher, and T. B. Fitzpatrick. “Vitiligo and other hypomelanoses of hair and skin,” in Topics in Dermatology, J. P. Ortonne, D. B. Mosher, and T. B. Fitzpatrick, Eds., pp. 257–258, Plenum Medical Book, New York, NY, USA, 1983.
  • 19. Ortonne JP, Bahadoran P, Fitzpatrick TB, Mosher DB, et al. Hypomelanoses and hypermelanoses. Fitzpatrick’s Dermatology in General Medicine. Ed. Freedberg IM, Eisen AZ, Wolff K, Goldsmith LA, Katz SI. 6th ed. New York, McGraw Hill, 2003; 836-881.
  • 20. Barona MI, Arrunátegui A, Falabella R, Alzate A. An epidemiologic case-control study in a population with vitiligo. J Am Acad Dermatol. 1995; 33:621–625.
There are 20 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Nur Cihan Coşansu 0000-0001-6156-6380

Publication Date December 30, 2019
Submission Date November 5, 2019
Acceptance Date December 23, 2019
Published in Issue Year 2019 Volume: 5 Issue: 4

Cite

APA Coşansu, N. C. (2019). Vitiligo Hastalarında Sigara Kullanımının Hastalık Semptom ve Bulguları Üzerinde Etkisi Var Mıdır?. Journal of Human Rhythm, 5(4), 373-379.
AMA Coşansu NC. Vitiligo Hastalarında Sigara Kullanımının Hastalık Semptom ve Bulguları Üzerinde Etkisi Var Mıdır?. Journal of Human Rhythm. December 2019;5(4):373-379.
Chicago Coşansu, Nur Cihan. “Vitiligo Hastalarında Sigara Kullanımının Hastalık Semptom Ve Bulguları Üzerinde Etkisi Var Mıdır?”. Journal of Human Rhythm 5, no. 4 (December 2019): 373-79.
EndNote Coşansu NC (December 1, 2019) Vitiligo Hastalarında Sigara Kullanımının Hastalık Semptom ve Bulguları Üzerinde Etkisi Var Mıdır?. Journal of Human Rhythm 5 4 373–379.
IEEE N. C. Coşansu, “Vitiligo Hastalarında Sigara Kullanımının Hastalık Semptom ve Bulguları Üzerinde Etkisi Var Mıdır?”, Journal of Human Rhythm, vol. 5, no. 4, pp. 373–379, 2019.
ISNAD Coşansu, Nur Cihan. “Vitiligo Hastalarında Sigara Kullanımının Hastalık Semptom Ve Bulguları Üzerinde Etkisi Var Mıdır?”. Journal of Human Rhythm 5/4 (December 2019), 373-379.
JAMA Coşansu NC. Vitiligo Hastalarında Sigara Kullanımının Hastalık Semptom ve Bulguları Üzerinde Etkisi Var Mıdır?. Journal of Human Rhythm. 2019;5:373–379.
MLA Coşansu, Nur Cihan. “Vitiligo Hastalarında Sigara Kullanımının Hastalık Semptom Ve Bulguları Üzerinde Etkisi Var Mıdır?”. Journal of Human Rhythm, vol. 5, no. 4, 2019, pp. 373-9.
Vancouver Coşansu NC. Vitiligo Hastalarında Sigara Kullanımının Hastalık Semptom ve Bulguları Üzerinde Etkisi Var Mıdır?. Journal of Human Rhythm. 2019;5(4):373-9.