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Bazı Schiff Bazlarının Saccharomyces cerevisiae BY4741 Kültür Ortamlarında Biyokimyasal Parametreler Üzerine Etkileri

Year 2018, Volume: 21 Issue: 2, 131 - 140, 30.04.2018

Ayşe Dilek Özşahin Nesrin Bozhan

Abstract

Yeni
sentezlenmiş bazı Schiff bazlarının kullanılmadan önce canlılar üzerindeki
biyokimyasal etkilerinin incelenmesi gerekir. Bu amaçla Saccharomyces
cerevisiae en önemli hücre modeli içinde yer alır. S. cerevisiae’daki metabolik
özellikler, yüksek yapılı organizmalara benzerlik gösterdiği için elde edilen
sonuçlar da paralellik göstermektedir.



Çalışmada;
yeni sentezlenmiş Schiff bazlarının S. cerevisiae BY4741 kültür ortamlarında lipit
peroksidasyon (MDA), total protein ve glutatyon analizleri yapılmıştır. Bu
amaçla; deneyde kullanılan S. cerevisiae BY4741’in gelişimi ve çoğalması için
YEDP besiyeri ortamı hazırlandı. Uygulama grupları için; schiff bazların her birinden
2ppm, 4 ppm ve 8 ppm olacak şekilde kültür ortamına ilave edildi. Elde edilen
süpernatant ile; GSH,total protein ve MDA analizleri yapıldı.



Lipid
peroksidayon sonuçları kontrol grubu ile karşılaştırıldığında schiff bazı
gruplarının lipid peroksidasyon önleme etkilerinin olmadığı belirlenirken,  yeni sentezlenen schiff bazlarının kontrol
grubuna göre glutatyon ve total protein miktarlarının oldukça
belirgin düzeyde yüksek olduğu saptandı (p<0.0001).



Sonuç
olarak; yeni sentezlemiş Schiff bazlarının S. cerevisiae’nın biyokimyasal ve savunma sistemi
üzerinde farklı etkilere sahip olduğu gözlemlendi. Özellikle antioksidan
savunma sistemi üzerinde açığa çıkan sonuçların diğer canlı modelleri
üzerindeki benzer çalışmalara kaynak olacağı ve in vivo sistemler kullanılarak
yapılacak ileriki çalışmalara destek olarak, literatür bilgisine katkıda
bulunulacağı düşünülmektedir.

Keywords

Schiff bazı Saccharomyces cerevisiae MDA GSH Toplam Protein

References

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  • Akkuş İ 1995. Serbest radikaller ve fizyopatolojik etkileri. 1. Baskı, Mimoza Yayınları, Konya, 3-10s.
  • Amirkhanov VM, Bundya EA, Trush VA, Ovchynnikov VA, Zaitsev VN 1999. Coordination compounds of Co (II), Ni(II), Mn(II), and Zn(II) with new representative of carbacylamidophosphates–potential anticancer drugs. 5th International symposium on applied bioinorganic chemistry, Greece.
  • Bakkali F, Averbeck S, Averbeck D, Zhiri A, Baudoux D, Idaomar M 2006. Antigenotoxic effects of three essential oils in diploid yeast (Saccharomyces cerevisiae) after treatments with UVC radiation, 8-MOP plus UVA and MMS. Mutation Research, 606: 27-38.
  • Bergman LW 2001. Growth and Maintenance of Yeast. 2001. Methods in Molecular Biology, Vol. 177, Two-Hybrid Systems: Methods and Protocols Edited by: P. N. MacDonald © Humana Press Inc., Totowa, NJ.
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  • Braconi D, Bernardini G, Santucci A 2015. Saccharomyces cerevisiae as a model in ecotoxicological studies: A post-genomics perspective. Journal of Proteomics, 137:19-34.
  • Ceyhan G, Çelik C, Uruş S, Demirtaş İ, Elmastaş M, Tümer M 2011. Antioxidant, electrochemical, thermal, antimicrobial and alkane oxidation properties of tridentate Schiff base ligands and their metal complexes. Spectrochimica Acta Part A, 81: 184– 198.
  • Chavan VL, Mehta BH 2011. X-ray, Thermal and biological studies of Ru (III), Rh(III) and Pd(II) schiff base metal complexes. Research Journal of Chemistry and Environment, 15: 57-61.
  • Cheeseman KH, Slater TF 1993. An in production to free radical biochemistry. British Medical Bulletin, 49 (3): 481-93.
  • Chohan ZH, Praveen M 2001. Synthesis, characterization, coordination and antibacterial properties of novel asymmetric 1,1′-disubstituted ferrocene-derived Schiff-base ligands and their Co(II), Cu(II) Ni(II) and Zn(II) complexes. Applied Organometalic Chemistry, 15: 617-625.
  • Chu Z, Huang W 2007. Syntheses and structures of two new bis-N,O-bidentate schiff base ligands and their respective copper(II) complexes with dinuclear double-helical configuration. Journal of Molecular Structure, 837: 15-22.
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  • Dominguez-Vera JM, Galvez N, Moreno JM, Colacio E 1998. Copper (II) complexes of two new oxamidate bis-tetradentate schiff-base ligands. Polyhedron, 17: 2713-2718.
  • Ellman GI 1959. Tissue sulfhydryl groups. Archives of Biochemistry and Biophysics, 70-77.
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  • Kim C, Yoong-He L 1992. Synthesis and evaluation of uracil-6-carboxaldehyde Schiff bases as potential antitumor agents. Korean Journal of Medicinal Chemistry, 2(1).
  • Kirecci OA 2017. Saccharomyces cerevisiae’nın gelişme ortamına ilave edilen ağır metallerin (Mn, Mg, Cd, Fe) bazı biyokimyasal parametrelere etkileri. KSU Doğa Bilimleri Dergisi, 20(3): 175-184.
  • Klayman DL, Scovill JP, Bartosevich JF, Bruce J 1983. 2-Acetylpyridine thiosemicarbazones.1-[l-(2-Pyridyl) ethyl]-3-thiosemicarbazides as potential antimalarial agents. Journal of Medicinal Chemistry, 26-35.
  • Kuduk J, Trynda L 1994. Impact of K 2 PtCl 6 on the structure of human serum albumin and its binding ability of heme and bilirubin. Journal of Inorganic Biochemistry, 53: 4, 249-260.
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  • Li-Juan C, Fu-Ming M, Guang-Xing L 2009. Co (II) Schiff base complexes on silica by sol–gel method as heterogeneous catalysts for oxidative carbonylation of aniline. Catalysis Communication, 10: 981-985.
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  • Mathur S, Tabassum S 2006. New homodi- and heterotrinuclear metal complexes of Schiff base compartmental ligand: Interaction studies of copper complexes with calf thymus DNA. Central European Journal of Chemistry, 4: 502–522.
  • Metzler CM, Cahill A, Metzler DE 1980. Equilibriums and absorption spectra of Schiff bases. Journal of The American Chemical Society, 102(19): 6075-6082.
  • Mirabelli CK, Hill DT, Faucette LF, McCabe FL, Girard GR, Bryan DB, Sutton BM, Bartus JO, Crooke ST, Johnson RK 1987. Antitumor activity of bis(diphenylphosphino)alkanes, their gold(I) coordination complexes, and related compounds. Journal of Medicinal Chemistry, 30: 2181-90
  • Mounika K, Anupama B, Pragathi J, Gyanakumari C 2010. Synthesis¸ characterization and biological activity of a Schiff base derived from 3-ethoxy salicylaldehyde and 2-amino benzoic acid and its transition metal complexes. Journal of Scientific Research, 2: 513-524.
  • Mukherjee S, Samanta, S, Roy, B. C, Bhaumik, A 2006. Efficient allylic oxidation of cyclohexene catalyzed by immobilized Schiff base complex using peroxides as oxidants. Applied Catalaysis A: General, 301: 79-88.
  • Niederhoffer EC, Timmons JH, Martel AG 1984. Thermodynamics of oxygen binding in natural and synthetic dioxygen complexes. Chemical Reviews, 84-137.
  • Ohkawa H, Ohishi N, Yagi K 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry, 95: 351.
  • Patel VK, Vasanwala AM, Jejurkar CR 1989. Synthesis of mixed Schiff base complexes of Cu (II) and Ni (II) and their spectral, magnetik and antifungal studies. Indian Journal of Chemistry, 28A: 719-721.
  • Penninckx M 2000. A short review on the role of glutathione in the response of yeasts to nutritional, environmental, and oxidative stresses. Enzyme and Microbial Technology, 26: 737-742.
  • Peralta RA, Neves A, Bortoluzzi AJ, dos Anjos A, Xavier FR, Szpoganicz B, Terenzi H, Oliveira MCB, Castellano E, GR, Friedermann, Mangrich, AS, Novak MA 2006. New unsymmetric dinuclear Cu (II)Cu(II) complexes and their relevance to copper(II) containing metalloenzymes and DNA cleavage. Journal of Inorganic Biochemistry, 100: 992-1004.
  • Prashanthi Y, Raj S 2010. Synthesis and characterization of transition metal complexes with N,O; N,N and S,N-donor Schifff base ligands. Journal of Scientific Research, 2: 114-126.
  • Raman N, Muthuraj V, Ravichandran S, Kulandaisamy, A 2003. Synthesis, characterization and electrochemical behavior of Cu (II), Co(II), Ni(II) and Zn(II) complexes derived from acetylacetone and p-anisidine and their antimicrobial activity. Proceedings of the Indian Academy of Science, 115-161.
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The Effects of Some Schiff Bases on Biochemical Parameters in Saccharomyces cerevisiae BY4741 Cultural Environments

Year 2018, Volume: 21 Issue: 2, 131 - 140, 30.04.2018

Ayşe Dilek Özşahin Nesrin Bozhan

Abstract



Biochemical
effects of newly synthesized some Schiff bases on living creatures need to be
investigated before using them.  For this
purpose, Saccharomyces cerevisiae is involved in the most important cell model.
Because metabolic properties of S. cerevisiae are similar to the highly
organized organisms, the results show parallelism, as well. 




In
the present study; lipid peroxidation (MDA), total protein, and glutathione
analyses of newly synthesized Schiff bases were conducted in S. cerevisiae
BY4741 culture media. For this purpose, YEDP medium was prepared for
development and growth of S. cerevisiae BY4741 used in the experiment. 2ppm, 4
ppm, and 8 ppm from each of Schiff bases were added in to culture medium for
application groups. GSH, total protein and MDA analyses were carried out with
the obtained supernatant. 




When
the results of lipid peroxidation were compared with the control group, it was
determined that the schiff base groups had no lipid peroxidation inhibition
effects, and the newly synthesized schiff bases were found to have
significantly higher amounts of glutathione and total protein than the control
group (p<0.0001).




As
a result, newly synthesized Schiff bases were determined to have different
effects on biochemical and defense system of S. cerevisiae.  In particular, the results of the antioxidant
defense system will be a source for similar studies on other living models and
will contribute to the knowledge of the literature as support for future studies
using in vivo systems.



The data obtained was
then evaluated in ThermaCAM software program. The results show that thermal
camera imaging technique offers prospects as a practical method for assessing
the aerobic stability of silages on farm.

Keywords

Schiff base Saccharomyces cerevisiae MDA GSH Total Protein

References

  • Ahmed HJ, Ezer N 2008. Prunella L. türlerinin kimyasal bileşikleri ve biyolojik aktiviteleri. Hacettepe Üniversitesi Eczacılık Fakültesi Dergisi, 28: 93-113.
  • Akkuş İ 1995. Serbest radikaller ve fizyopatolojik etkileri. 1. Baskı, Mimoza Yayınları, Konya, 3-10s.
  • Amirkhanov VM, Bundya EA, Trush VA, Ovchynnikov VA, Zaitsev VN 1999. Coordination compounds of Co (II), Ni(II), Mn(II), and Zn(II) with new representative of carbacylamidophosphates–potential anticancer drugs. 5th International symposium on applied bioinorganic chemistry, Greece.
  • Bakkali F, Averbeck S, Averbeck D, Zhiri A, Baudoux D, Idaomar M 2006. Antigenotoxic effects of three essential oils in diploid yeast (Saccharomyces cerevisiae) after treatments with UVC radiation, 8-MOP plus UVA and MMS. Mutation Research, 606: 27-38.
  • Bergman LW 2001. Growth and Maintenance of Yeast. 2001. Methods in Molecular Biology, Vol. 177, Two-Hybrid Systems: Methods and Protocols Edited by: P. N. MacDonald © Humana Press Inc., Totowa, NJ.
  • Braconi D, Sotgi M, Millucci L, Paffetti A, Tasso F, Alisi C, Martini S, Rappuoli R, Lusini P, Rosa A, Rossi C, Santucci A 2006. Comparative analysis of the effects of locally used herbicides and their active ingredients on a wild-type wine (Saccharomyces cerevisiae) strain. Journal of Agricural and Food Chemistry, 54: 31633172.
  • Braconi D, Bernardini G, Santucci A 2015. Saccharomyces cerevisiae as a model in ecotoxicological studies: A post-genomics perspective. Journal of Proteomics, 137:19-34.
  • Ceyhan G, Çelik C, Uruş S, Demirtaş İ, Elmastaş M, Tümer M 2011. Antioxidant, electrochemical, thermal, antimicrobial and alkane oxidation properties of tridentate Schiff base ligands and their metal complexes. Spectrochimica Acta Part A, 81: 184– 198.
  • Chavan VL, Mehta BH 2011. X-ray, Thermal and biological studies of Ru (III), Rh(III) and Pd(II) schiff base metal complexes. Research Journal of Chemistry and Environment, 15: 57-61.
  • Cheeseman KH, Slater TF 1993. An in production to free radical biochemistry. British Medical Bulletin, 49 (3): 481-93.
  • Chohan ZH, Praveen M 2001. Synthesis, characterization, coordination and antibacterial properties of novel asymmetric 1,1′-disubstituted ferrocene-derived Schiff-base ligands and their Co(II), Cu(II) Ni(II) and Zn(II) complexes. Applied Organometalic Chemistry, 15: 617-625.
  • Chu Z, Huang W 2007. Syntheses and structures of two new bis-N,O-bidentate schiff base ligands and their respective copper(II) complexes with dinuclear double-helical configuration. Journal of Molecular Structure, 837: 15-22.
  • Dikci İ 1999. Akut viral hepatitlerle interferon tedavisi görmüs kronik viral hepatitlerde oksidatif stresin arastırılması. Selçuk Üni. Tıp Fak. Biyokimya Anabilim Dalı, Uzmanlık Tezi, 73s.
  • Dolaz M, McKee V, Uruş S, Demir N, Sabik AE, Golcu A, Tumer M 2010. Synthesis, structural characterization, catalytic, thermal and electrochemical investigations of bidentate Schiff base ligand and its metal complexes. Spectrochimica Acta A, 76: 174-181.
  • Dominguez-Vera JM, Galvez N, Moreno JM, Colacio E 1998. Copper (II) complexes of two new oxamidate bis-tetradentate schiff-base ligands. Polyhedron, 17: 2713-2718.
  • Ellman GI 1959. Tissue sulfhydryl groups. Archives of Biochemistry and Biophysics, 70-77.
  • Esterbauer H, Gebicki J, Puhl H, Jgens G 1992. The role of lipit peroxidation and antioxidants in oxidative modification of LDL. Free Radical Biology and Medicine, 13: 341-90.
  • Garcia JJ, Reiter RJ, Guerrero JM, Escames G, Yu BP, Oh CS 1997. Melatonin prevents changes in microsomal membrane fluidity during induced lipid peroxidation. FEBS Letters, 408: 297-300.
  • Helmut S, 1976. Metal ions in biological systems, Marcel Dekker Inc, New York, 2-50s.
  • Izawa S, Inoue Y, Kimura, A 1995. Oxidative stress response in yeast: effect of glutathione on adaption to hydrogen peroxide stress in Saccharomyces cerevisia. FEBS Letters, 368: 73-76.
  • Karlin KD, Tyekkerz L 1993. Bioorganic Chemistry of Cupper. Chapman and Hill, NewYork.
  • Kaya B 2003. Anti-genotoxic effect of ascorbic acid on mutagenic dose of three alkylating agents. Turkish Journal of Biology, 27: 241-246.
  • Kelland LR, Barnard CF, Mellish KJ, Jones M, Goddard PM, Valenti M, Bryant A, Murrer BA, Harap KR 1994. A novel trans-platinum coordination complex possessing in vitro and in vivo antitumor activity. Cancer Research, 54: 5618-5622
  • Kim C, Yoong-He L 1992. Synthesis and evaluation of uracil-6-carboxaldehyde Schiff bases as potential antitumor agents. Korean Journal of Medicinal Chemistry, 2(1).
  • Kirecci OA 2017. Saccharomyces cerevisiae’nın gelişme ortamına ilave edilen ağır metallerin (Mn, Mg, Cd, Fe) bazı biyokimyasal parametrelere etkileri. KSU Doğa Bilimleri Dergisi, 20(3): 175-184.
  • Klayman DL, Scovill JP, Bartosevich JF, Bruce J 1983. 2-Acetylpyridine thiosemicarbazones.1-[l-(2-Pyridyl) ethyl]-3-thiosemicarbazides as potential antimalarial agents. Journal of Medicinal Chemistry, 26-35.
  • Kuduk J, Trynda L 1994. Impact of K 2 PtCl 6 on the structure of human serum albumin and its binding ability of heme and bilirubin. Journal of Inorganic Biochemistry, 53: 4, 249-260.
  • Lee JH, Choi IY, Kil IS, Kim SY, Yang ES, Park J 2001. Protective role of superoxide dismutases against ionizing radiation in yeast. Biochimica et Biophysica Acta, 1526: 191–198.
  • Li-Juan C, Fu-Ming M, Guang-Xing L 2009. Co (II) Schiff base complexes on silica by sol–gel method as heterogeneous catalysts for oxidative carbonylation of aniline. Catalysis Communication, 10: 981-985.
  • Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ 1951. Protein measurement with the folin-phenol reagent. The Journal of Biochemistry, 193: 265- 277.
  • Mathur S, Tabassum S 2006. New homodi- and heterotrinuclear metal complexes of Schiff base compartmental ligand: Interaction studies of copper complexes with calf thymus DNA. Central European Journal of Chemistry, 4: 502–522.
  • Metzler CM, Cahill A, Metzler DE 1980. Equilibriums and absorption spectra of Schiff bases. Journal of The American Chemical Society, 102(19): 6075-6082.
  • Mirabelli CK, Hill DT, Faucette LF, McCabe FL, Girard GR, Bryan DB, Sutton BM, Bartus JO, Crooke ST, Johnson RK 1987. Antitumor activity of bis(diphenylphosphino)alkanes, their gold(I) coordination complexes, and related compounds. Journal of Medicinal Chemistry, 30: 2181-90
  • Mounika K, Anupama B, Pragathi J, Gyanakumari C 2010. Synthesis¸ characterization and biological activity of a Schiff base derived from 3-ethoxy salicylaldehyde and 2-amino benzoic acid and its transition metal complexes. Journal of Scientific Research, 2: 513-524.
  • Mukherjee S, Samanta, S, Roy, B. C, Bhaumik, A 2006. Efficient allylic oxidation of cyclohexene catalyzed by immobilized Schiff base complex using peroxides as oxidants. Applied Catalaysis A: General, 301: 79-88.
  • Niederhoffer EC, Timmons JH, Martel AG 1984. Thermodynamics of oxygen binding in natural and synthetic dioxygen complexes. Chemical Reviews, 84-137.
  • Ohkawa H, Ohishi N, Yagi K 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry, 95: 351.
  • Patel VK, Vasanwala AM, Jejurkar CR 1989. Synthesis of mixed Schiff base complexes of Cu (II) and Ni (II) and their spectral, magnetik and antifungal studies. Indian Journal of Chemistry, 28A: 719-721.
  • Penninckx M 2000. A short review on the role of glutathione in the response of yeasts to nutritional, environmental, and oxidative stresses. Enzyme and Microbial Technology, 26: 737-742.
  • Peralta RA, Neves A, Bortoluzzi AJ, dos Anjos A, Xavier FR, Szpoganicz B, Terenzi H, Oliveira MCB, Castellano E, GR, Friedermann, Mangrich, AS, Novak MA 2006. New unsymmetric dinuclear Cu (II)Cu(II) complexes and their relevance to copper(II) containing metalloenzymes and DNA cleavage. Journal of Inorganic Biochemistry, 100: 992-1004.
  • Prashanthi Y, Raj S 2010. Synthesis and characterization of transition metal complexes with N,O; N,N and S,N-donor Schifff base ligands. Journal of Scientific Research, 2: 114-126.
  • Raman N, Muthuraj V, Ravichandran S, Kulandaisamy, A 2003. Synthesis, characterization and electrochemical behavior of Cu (II), Co(II), Ni(II) and Zn(II) complexes derived from acetylacetone and p-anisidine and their antimicrobial activity. Proceedings of the Indian Academy of Science, 115-161.
  • Reiss A, Florea S, Caproiu T, Stanica N 2009. Synthesis, characterization, and antibacterial activity of some transition metals with the Schiff base N-(2-furanylmethylene)-3-aminodibenzofuran. Turkish Journal of Chemistry, 33: 775 – 783.
  • Reddy KH, Reddy PS 2000. Nuclease activity of mixed ligand complexes of copper (II) with heteroaromatic derivatives and Picoline. Transition Metal Chemistry, 25: 505-510.
  • Rho YS, Kim SA, Jung JC, Shin CC, Chang SG 2002. Anticancer cytotoxicity and nephro- toxicity of the new platinum (II) complexes containing diaminocyclohexane and glycolic acid. International Journal of Oncology, 20: 929-35.
  • Sağlam N, Çolak A, Serbest K, Dülger S, Güner S, Karaböcek S, Beldüz AO 2002. Oxidative cleavage of DNA by homo- and heteronuclear Cu(II)-Mn(II) complexes of an oxime-type ligand. Biometals, 15: 357- 365.
  • Scovill JP, Klayman DL, Franchino F 1982. 2-Acetylpyridine thiosemicarbazones. 4. Complexes with transition metals as antimalarial and antileukemic agents. Journal of Medicinal Chemistry, 25: 1261.
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There are 59 citations in total.

Details

Primary Language Turkish
Journal Section RESEARCH ARTICLE
Authors

Ayşe Dilek Özşahin

Nesrin Bozhan

Publication Date April 30, 2018
Submission Date January 20, 2017
Acceptance Date April 27, 2017
Published in Issue Year 2018Volume: 21 Issue: 2

Cite

APA Özşahin, A. D., & Bozhan, N. (2018). Bazı Schiff Bazlarının Saccharomyces cerevisiae BY4741 Kültür Ortamlarında Biyokimyasal Parametreler Üzerine Etkileri. Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi, 21(2), 131-140.
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