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Trombosit Kitle İndeksi, Plt/Mpv Oranı ve Diğer Hemogram Parametrelerinin Acil Servise Başvuran Covıd-19 Hatalarında Tanısal Değeri

Year 2021, Volume: 13 Issue: 1, 101 - 107, 11.03.2021
https://doi.org/10.18521/ktd.826613

Abstract

Amaç: Bu çalışmanın amacı, trombosit kitle indeksi, trombosit sayısı / ortalama trombosit hacmi oranı ve diğer hemogram parametrelerini koronavirüs (COVID-19) hastaları ve kontrol grubu arasında kıyaslamak ve COVID-19 hastaları ile COVID-19 olmayan sağlıklı kontrol hastaları ayırımının yapılmasında anlamlı olan parametrelerin saptanmasıdır.

Yöntem: Hastanemizin acil servisine COVID-19’u düşündüren semptomlarla başvuran ve polimeraz zincir reaksiyonu (PCR) pozitif olan 80 hasta ile PCR (-) olan 80 kontrol birey retrospektif olarak incelenmiştir. Hastaların beyaz kan hücresi (WBC), nötrofil sayısı, lenfosit sayısı, monosit sayısı, trombosit sayısı, nötrofil/lenfosit oranı NLR), lenfosit/monosit oranı (LMR), trombosit sayısı, trombosit/lenfosit oranı (PLR), ortalama trombosit hacmi (MPV), kırmızı hücre dağılım genişliği (RDW), trombosit kitle indeksi (PMI), kırmızı kan hücresi dağılım genişliği / ortalama trombosit hacmi (RDW / MPV) ve trombosit sayısı/ ortalama trombosit hacmi (PLT / MPV) oranları analiz edilmiştir. Aynı zamanda kontrol ve COVID-19’u ayırmada anlamlı parametrelerin belirlenmesi için Receiver Operating Characteristic (ROC) analizi yapıldı.

Bulgular: Çalışmamızda WBC, lenfosit, monosit nötrofil, LMR, trombosit, PMI ve PLT/MPV değerleri COVID-19 hastalarında düşmüş, PLR ve MPV değerleri ise yükselmiştir. LMR, PLR, PMI ve PLT/MPV’nin eğri altında kalan alanları anlamlıdır. İncelenen parametreler için en iyi cut-off noktaları; LMR için <2.91, PLR için 117.95, PMI için 2167.65 ve PLT/MPV için <25.13’tür.

Sonuç: Çalışmamızda COVID-19 hastalarında WBC, lenfosit, monosit, nötrofil, trombosit, PMI ve PLT/MPV düzeylerinin azaldığı, PLR ve MPV değerlerinin ise azaldığı saptanmıştır. Bu parametreler COVID-19 hastalarının prognozunun izlenmesinde ve bu hastaların, COVID-19 bulunmayan sağlıklıkişilerden ayırt edilmesinde yardımcı olabileceğini düşünmekteyiz.

References

  • 1. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020;395:497–506. doi: 10.1016/S0140-6736(20)30183-5.
  • 2. Li K, Wu J, Wu F, Guo D, Chen L, Fang Z, et al. The Clinical and Chest CT Features Associated With Severe and Critical COVID-19 Pneumonia. Invest Radiol 2020;55:327–31. doi: 10.1097/RLI.0000000000000672.

Diagnostic Value of Platelet Mass Index, Plt/Mpv Ratio and Other Hemogram Parameters in Covid-19 Patients Who Presented to Emergency Department

Year 2021, Volume: 13 Issue: 1, 101 - 107, 11.03.2021
https://doi.org/10.18521/ktd.826613

Abstract

Objective: The objective of this study was to compare PMI, PLT/MPV, and other hemogram parameters between COVID-19 patients and a control group and to determine the parameters that are significant in discrimination between COVID-19 and non-COVID 19.

Methods: Data of a total of 80 patients who presented to the emergency department of our hospital with the symptoms suggesting COVID-19 with PCR (+) result and 80 healthy controls with a PCR (-) test results were retrospectively analyzed. Patients’ laboratory parameters including white blood cells (WBC), neutrophils count, lymphocytes count, monocytes count, neutrophils to lymphocytes ratio (NLR), lymphocytes to monocytes ratio (LMR), platelets (PLT), platelets to lymphocytes ratio (PLR), mean platelet volume (MPV), red blood cell distribution width (RDW), platelet mass index (PMI), RDW/MPV and PLT/MPV ratios were analyzed. At the same time, a ROC analysis was performed for determining laboratory indicators in distinguishing control and COVID-19 positive cases from each other.

Results: In our study, WBC, lymphocytes, monocytes, neutrophils, LMR, platelets, PMI, and PLT/MPV levels decreased, while PLR and MPV values increased in COVID-19 patients. According to ROC analysis, among the parameters examined in terms of discriminating between COVID-19 and control groups, LMR, PLR, PMI, and PLT/MPV parameters had significant areas under the curve. The best cut-off points of the parameter were found as <2.91 for LMR, 117.95 for PLR, 2167.65 for PMI, and <25.13 for PLT/MPV

Conclusion: Regular control visits are necessary for monitoring possible changes in hemogram parameters and to assess potential complications in future. For this purpose, blood parameters could provide practical methods.

References

  • 1. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020;395:497–506. doi: 10.1016/S0140-6736(20)30183-5.
  • 2. Li K, Wu J, Wu F, Guo D, Chen L, Fang Z, et al. The Clinical and Chest CT Features Associated With Severe and Critical COVID-19 Pneumonia. Invest Radiol 2020;55:327–31. doi: 10.1097/RLI.0000000000000672.
There are 2 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Articles
Authors

Eyyup Sabri Şeyhanlı 0000-0002-1800-1357

İbrahim Halil Yasak 0000-0002-6399-7755

Publication Date March 11, 2021
Acceptance Date February 25, 2021
Published in Issue Year 2021 Volume: 13 Issue: 1

Cite

APA Şeyhanlı, E. S., & Yasak, İ. H. (2021). Diagnostic Value of Platelet Mass Index, Plt/Mpv Ratio and Other Hemogram Parameters in Covid-19 Patients Who Presented to Emergency Department. Konuralp Medical Journal, 13(1), 101-107. https://doi.org/10.18521/ktd.826613
AMA Şeyhanlı ES, Yasak İH. Diagnostic Value of Platelet Mass Index, Plt/Mpv Ratio and Other Hemogram Parameters in Covid-19 Patients Who Presented to Emergency Department. Konuralp Medical Journal. March 2021;13(1):101-107. doi:10.18521/ktd.826613
Chicago Şeyhanlı, Eyyup Sabri, and İbrahim Halil Yasak. “Diagnostic Value of Platelet Mass Index, Plt/Mpv Ratio and Other Hemogram Parameters in Covid-19 Patients Who Presented to Emergency Department”. Konuralp Medical Journal 13, no. 1 (March 2021): 101-7. https://doi.org/10.18521/ktd.826613.
EndNote Şeyhanlı ES, Yasak İH (March 1, 2021) Diagnostic Value of Platelet Mass Index, Plt/Mpv Ratio and Other Hemogram Parameters in Covid-19 Patients Who Presented to Emergency Department. Konuralp Medical Journal 13 1 101–107.
IEEE E. S. Şeyhanlı and İ. H. Yasak, “Diagnostic Value of Platelet Mass Index, Plt/Mpv Ratio and Other Hemogram Parameters in Covid-19 Patients Who Presented to Emergency Department”, Konuralp Medical Journal, vol. 13, no. 1, pp. 101–107, 2021, doi: 10.18521/ktd.826613.
ISNAD Şeyhanlı, Eyyup Sabri - Yasak, İbrahim Halil. “Diagnostic Value of Platelet Mass Index, Plt/Mpv Ratio and Other Hemogram Parameters in Covid-19 Patients Who Presented to Emergency Department”. Konuralp Medical Journal 13/1 (March 2021), 101-107. https://doi.org/10.18521/ktd.826613.
JAMA Şeyhanlı ES, Yasak İH. Diagnostic Value of Platelet Mass Index, Plt/Mpv Ratio and Other Hemogram Parameters in Covid-19 Patients Who Presented to Emergency Department. Konuralp Medical Journal. 2021;13:101–107.
MLA Şeyhanlı, Eyyup Sabri and İbrahim Halil Yasak. “Diagnostic Value of Platelet Mass Index, Plt/Mpv Ratio and Other Hemogram Parameters in Covid-19 Patients Who Presented to Emergency Department”. Konuralp Medical Journal, vol. 13, no. 1, 2021, pp. 101-7, doi:10.18521/ktd.826613.
Vancouver Şeyhanlı ES, Yasak İH. Diagnostic Value of Platelet Mass Index, Plt/Mpv Ratio and Other Hemogram Parameters in Covid-19 Patients Who Presented to Emergency Department. Konuralp Medical Journal. 2021;13(1):101-7.