The Investigation of Anti-Proliferative Effects of [Ag2(sac)2(dap)2] Complex on Different Types of Cancer
Abstract
Objective: Cytotoxic features of silver and saccharine compounds have taken attention due to the fact that most of them have showed a cytotoxic effect against tumor cells. In this study, it is aimed to investigate anti-proliferative effects of [Ag2(sac)2(dap)2] complex on different types of cancer cell lines.
Methods: HeLa (cervical cancer), PC-3 (prostate cancer), DU-145 (prostate cancer), A549 (non-small cell lung cancer), K562 (chronic myeloid leukemia) and MRC-5 (normal lung fibroblast) cell lines were grown in plates. In order to determine anti-proliferative effects, IC 50 values of [Ag2(sac)2(dap)2] and cisplatin on these cell lines were determined by MTT method.
Results: IC 50 value of [Ag2(sac)2(dap)2] complex was 19.53 ± 1.74 μM for HeLa cell line, 17.14 ± 1.41 μM for PC-3 cell line, 18.56 ± 4.04 for DU 145 cell line, 17.93 ± 1.06 μM for A549 cell line, 3.18 ± 0.04 μM for K562 cell line and 7.25 ± 1.00 μM for MRC-5 cell line. Also, IC 50 value of cisplatin was 4.00 ± 0.47 μM for HeLa cell line, 12.29 ± 1.60 μM for PC-3 cell line, 5.05 ± 0.65 for DU 145 cell line, 12.74 ± 1.26 μM for A549 cell line, 5.90 ± 0.59 μM for K562 cell line and 5.91 ± 0.32 μM for MRC-5 cell line. Only in K562 cell line, IC 50 of [Ag2(sac)2(dap)2] complex was lower than IC 50 of cisplatin.
Conclusion: Anti-proliferative activity of [Ag2(sac)2(dap)2] complex is more than cisplatin on chronic myeloid leukemia cells so this complex may be possible to be used as a treatment option especially for chronic myeloid leukemia.
Supporting Institution
Scientific Research Projects Commission of Ordu University
Project Number
A-1842
Thanks
.
References
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- Kalinowska-Lis U, Felczak A, Checinska L, Szabłowska-Gadomska I, Patyna E, Malecki M, et al. Antibacterial activity and cytotoxicity of silver (I) complexes of pyridine and (Benz) imidazole derivatives. X-ray crystal structure of [Ag (2, 6-di (CH2OH) py) 2] NO3. Molecules 2016; 21(2): 87.
- Mourino V, Cattalini JP, Boccaccini AR. Metallic ions as therapeutic agents in tissue engineering scaffolds: an overview of their biological applications and strategies for new developments. J R Soc Interface 2012; 9(68): 401-419.
- Ndagi U, Mhlongo N, Soliman ME. Metal complexes in cancer therapy–an update from drug design perspective. Drug Des Dev Ther 2017; 11: 599.
- Siciliano TJ, Deblock MC, Hindi KM, Durmus S, Panzner MJ, Tessier CA, Youngs WJ. Synthesis and anticancer properties of gold (I) and silver (I) N-heterocyclic carbene complexes. J Organomet Chem 2011; 696(5): 1066-1071.
- Yilmaz VT, Icsel C, Turgut OR, Aygun M, Erkisa M, Turkdemir MH, Ulukaya E. Synthesis, structures and anticancer potentials of platinum (II) saccharinate complexes of tertiary phosphines with phenyl and cyclohexyl groups targeting mitochondria and DNA. Eur J Med Chem 2018; 155: 609-622.
Abstract
Project Number
A-1842
References
- Ali KA, Abd-Elzaher MM and Mahmoud K. Synthesis and anticancer properties of silver (I) complexes containing 2, 6-Bis (substituted) pyridine derivatives. Int J Med Chem 2013; 256836.
- Ari F, Aztopal N, Icsel C, Yilmaz VT, Guney E, Buyukgungor O, Ulukaya E. Synthesis, structural characterization and cell death-inducing effect of novel palladium (II) and platinum (II) saccharinate complexes with 2-(hydroxymethyl) pyridine and 2-(2-hydroxyethyl) pyridine on cancer cells in vitro. Bioorgan Med Chem 2013;21(21): 6427-6434.
- Baran EJ, Yilmaz VT. Metal complexes of saccharin. Coordin Chem Rev 2006; 250(15-16): 1980-1999.
- Benedetti BT, Peterson EJ, Kabolizadeh P, Martínez A, Kipping R, Farrell NP. Effects of noncovalent platinum drug–protein interactions on drug efficacy: use of fluorescent conjugates as probes for drug metabolism. Mol Pharmaceut 2011; 8(3): 940-948.
- Florea AM, Büsselberg D. Cisplatin as an anti-tumor drug: cellular mechanisms of activity, drug resistance and induced side effects. Cancers 2011; 3(1): 1351-1371.
- Henderson W, Nicholson BK, McCaffrey LJ. Platinum (II) and palladium (II) saccharinate complexes. Inorg Chim Acta 1999; 285(1): 145-148.
- Kalinowska-Lis U, Felczak A, Checinska L, Szabłowska-Gadomska I, Patyna E, Malecki M, et al. Antibacterial activity and cytotoxicity of silver (I) complexes of pyridine and (Benz) imidazole derivatives. X-ray crystal structure of [Ag (2, 6-di (CH2OH) py) 2] NO3. Molecules 2016; 21(2): 87.
- Mourino V, Cattalini JP, Boccaccini AR. Metallic ions as therapeutic agents in tissue engineering scaffolds: an overview of their biological applications and strategies for new developments. J R Soc Interface 2012; 9(68): 401-419.
- Ndagi U, Mhlongo N, Soliman ME. Metal complexes in cancer therapy–an update from drug design perspective. Drug Des Dev Ther 2017; 11: 599.
- Siciliano TJ, Deblock MC, Hindi KM, Durmus S, Panzner MJ, Tessier CA, Youngs WJ. Synthesis and anticancer properties of gold (I) and silver (I) N-heterocyclic carbene complexes. J Organomet Chem 2011; 696(5): 1066-1071.
- Yilmaz VT, Icsel C, Turgut OR, Aygun M, Erkisa M, Turkdemir MH, Ulukaya E. Synthesis, structures and anticancer potentials of platinum (II) saccharinate complexes of tertiary phosphines with phenyl and cyclohexyl groups targeting mitochondria and DNA. Eur J Med Chem 2018; 155: 609-622.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Research articles |
| Authors | |
| Project Number | A-1842 |
| Publication Date | April 30, 2020 |
| Published in Issue | Year 2020 Volume: 6 Issue: 1 |
e-ISSN 2149-7796