Lipit raftları (lipit salları), doymuş fosfolipitler, sfingolipitler ve kolesterol bakımından zenginleştirilmiş membran mikro domainleridir. Polarize trafik, sinyal iletimi, endositoz ve ekzositoz, zorunlu hücre içi patojenlerin girişi ve çeşitli hastalıklar ile ilişkili patolojik protein formlarının üretimi dahil olmak üzere çeşitli hücresel süreçlerde yer alırlar. Lipit rafları, çeşitli ve farklı protein bileşimine sahiptirler. Ana lipit raft proteini olan Raftlin (RFTN), B hücrelerinde bulunur ve B hücresi antijen reseptörünün (BCR) sinyal iletiminin düzenlenmesinden sorumludur. Raftlin ayrıca otoimmün yanıtın ve vasküler inflamatuar yanıtın indüklenmesinde önemli rol oynar. Raftlin, inflamatuar hastalıkların tanısını ve immün yanıtı karakterize etmek için vasküler inflamatuar yanıtın patofizyolojisinde kullanılan bir parametredir. Bu derlemede, lipit raftlarının ve bir lipit raft proteini olan Raftlinin yapısı, özelliği ve kullanım alanları ile ilgili bilgilerin aktarılması amaçlanmıştır.
Lipid rafts (lipid rafts) are membrane micro-domains with enriched phospholipids, sphingolipids and contents. Polarized traffic is included in a variety of data, including signaling patterns, endocytosis and exocytosis, the entry of obligate intracellular pathogens, and the production of pathological forms of protein spread by various diseases. The lipid racks bring together various and different groups of proteins. Raftlin (RFTN), the main lipid raft protein, is found in B cells and is responsible for regulating B cell antigen receptor (BCR) signaling. Raftlin also plays an important role in inducing the autoimmune response and the vascular inflammatory response. Raftlin is a parameter used in the pathophysiology of the vascular inflammatory response to diagnose inflammatory diseases and characterize the immune response. In this review, it is aimed to convey information about the structure, properties and usage areas of lipid rafts and Raftlin, a lipid raft protein.
Primary Language | Turkish |
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Subjects | Health Care Administration |
Journal Section | Articles |
Authors | |
Early Pub Date | December 5, 2023 |
Publication Date | December 18, 2023 |
Submission Date | December 1, 2022 |
Acceptance Date | March 6, 2023 |
Published in Issue | Year 2023 Volume: 16 Issue: 3 |
MEU Journal of Health Sciences Assoc was began to the publishing process in 2008 under the supervision of Assoc. Prof. Gönül Aslan, Editor-in-Chief, and affiliated to Mersin University Institute of Health Sciences. In March 2015, Prof. Dr. Caferi Tayyar Şaşmaz undertook the Editor-in Chief position and since then he has been in charge.
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