Tüberküloz tedavisinde kullanılan antitüberküloz ilaçlar

Nurcihan Biltekin; Mahmut Ülger

Review

Antituberculosis drugs used in the treatment of tuberculosis

Year 2023, Volume: 16 Issue: 3, 525 - 542, 18.12.2023

Nurcihan Biltekin Mahmut Ülger

Abstract

Tuberculosis (TB) is a chronic, granulomatous bacterial disease with different clinical manifestations caused by Mycobacterium tuberculosis (M. tuberculosis). TB continues to be a public health problem that still maintains its importance today. Given the recent years of co-infection with HIV/AIDS and multidrug-resistant (MDR) cases, treatment for TB disease is available in combination with multiple anti-TB drugs for at least six months. Current first-line (primary) treatments for TB, administration of a combination of isoniazid (INH), rifampicin (RIF), pyrazinamide(PZA), and ethambutol(EMB) during the first two months and then based on INH and RIF treatment for a duration of more than four to seven months. In the treatment of TB, with prolonged use of anti-TB drugs, the emergence and spread of MDR and extensive drug-resistant (XDR) M. tuberculosis strains present challenges in treating TB. In this review, it was aimed to mention the general properties of first and second-line anti-TB drugs used in the treatment of TB.

Keywords

Tuberculosis, treatment, anti-tuberculosis drugs

References

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Tüberküloz tedavisinde kullanılan antitüberküloz ilaçlar

Year 2023, Volume: 16 Issue: 3, 525 - 542, 18.12.2023

Nurcihan Biltekin Mahmut Ülger

Abstract

Tüberküloz (TB), Mycobacterium tuberculosis (M. tuberculosis)’in sebep olduğu değişik klinik görünümlere sahip kronik, granülomatöz karakterde bakteriyel bir hastalıktır. TB günümüzde halen önemini koruyan bir halk sağlığı sorunu olmaya devam etmektedir. Son yıllarda HIV/AIDS ile ko-enfeksiyon olması ve çok ilaca dirençli (ÇİD) vakalar göz önüne alındığında TB hastalığında tedavi en az altı ay süre ile çoklu anti-TB ilaçlarla birlikte mevcut tedaviyi oluşturmaktadır. TB için mevcut birinci kuşak (primer) tedaviler, ilk iki ay boyunca izoniazid (INH), rifampisin (RIF), pirazinamid (PZA) ve etambutol (EMB) kombinasyonunun uygulanmasına ve ardından dört ila yedi aydan daha uzun süreli INH ve RIF tedavisine dayanmaktadır. TB tedavisinde, anti-TB ilaçların uzun süre kullanılması ile M. tuberculosis’in ÇİD ve yaygın ilaca dirençli (YİD) suşlarının ortaya çıkması ve yayılması TB’nin tedavisinde zorlukları beraberinde getirmektedir. Bu derlemede TB tedavisinde kullanılan birinci ve ikinci kuşak anti-TB ilaçların genel özelliklerinden bahsedilmesi amaçlanmıştır.

Keywords

Tüberküloz, Tedavi, Anti-tüberküloz ilaçlar

References

Knechel NA. Tuberculosis: pathophysiology, clinical features, and diagnosis. Critical care nurse. 2009;29(2):34-43. https://doi.org/10.4037/ccn2009968
Sia JK, Rengarajan J. Immunology of Mycobacterium tuberculosis infections. Microbiology spectrum. 2019;7(4):7-4. https://doi.org/10.1128/microbiolspec.GPP3-0022-2018
Bañuls AL, Sanou A, Nguyen TVA, Godreul S. Mycobacterium tuberculosis: Ecology and Evolution of a Human Bacterium. Journal of Medical Microbiology. 2015;64(11):1261-1269. https://doi.org/10.1099/jmm.0.000171
World Health Organization (WHO). Global Tuberculosis Report 2021. Geneva: World Health Organization; 2021. https://www.who.int/publications/i/item/9789240037021. 10 Ekim 2022 de erişildi.
T.C. Sağlık Bakanlığı, Halk Sağlığı Genel Müdürlüğü, Türkiye’de Verem Savaşı 2020 Raporu Ankara. https://hsgm.saglik.gov.tr/depo/kurumsal/yayinlarimiz/Raporlar/Turkiyede_Verem_Savasi_2020_Raporu.pdf. 15 Kasım 2022’de erişildi.
Jhun BW, Koh WJ. Treatment of isoniazid-resistant pulmonary tuberculosis. Tuberculosis and Respiratory Diseases, 2020;83(1):20-30. https://doi.org/10.4046/trd.2019.0065
Prasad R, Gupta N, Banka A. Multidrug-resistant tuberculosis/rifampicin-resistant tuberculosis: Principles of management. Lung India: official organ of Indian chest society. 2018;35(1): 78-81. https://doi.org/10.4103/lungindia.lungindia_98_17
An Q, Li C, Chen Y, Deng Y, Yang T, Luo Y. Repurposed drug candidates for antituberculosis therapy. European journal of medicinal chemistry. 2020;192:112175. https://doi.org/10.1016/j.ejmech.2020.112175
Almedia da Silva P, Aínsa JA. Drug and drug interactions. İçinde: Palomino JC, Leão SC, Ritacco V, ed. Tuberculosis 2007 From basic science to patient care. 1st Ed. Bourcillier Kamps, 2007:593-611.
Hopewell PC. Treatment of Tuberculosis. İçinde: Raviglione MC, Ed. Tuberculosis: the Essentials (Vol. 237). 4.Baskı. Informa Healthcare USA, Inc;2016:113-122.
Mitchison DA. The action of antituberculosis drugs in shortcourse therapy. Tubercle 1985;66:219-25.
Otkun M. Tüberküloz tedavisinde Temel ilkeler ve direnç sorunu. Klimik dergisi. 2001;14(2):71-82.
Janin YL. Antituberculosis drugs: ten years of research. Bioorganic & medicinal chemistry. 2007;15(7):2479-2513.
Blumberg HM, Burman WJ, Chaisson RE, Daley CL. American thoracic society/centers for disease control and prevention/infectious diseases society of America: treatment of tuberculosis. American journal of respiratory and critical care medicine. 2003; 167(4):603.
Hoagland DT, Liu J, Lee RB, Lee RE. New agents for the treatment of drug-resistant Mycobacterium tuberculosis. Advanced drug delivery reviews. 2016;102:55-72. https://doi.org/10.1016/j.addr.2016.04.026
T.C. Sağlık Bakanlığı, Halk Sağlığı Genel Müdürlüğü, Tüberküloz Tanı ve Tedavi Rehberi. 2 Baskı. 2019. https://hsgm.saglik.gov.tr/depo/birimler/tuberkuloz_db/haberler/Tuberkuloz_Tani_Ve_Tedavi_Rehberi_/Tuberkuloz_Tani_ve_Tedavi_Rehberi.pdf 1 Mart 2023’de erişildi.
Zhang Y, Amzel L. Tuberculosis drug targets. Curr Drug Targets. 2002;3(2):131-154.
Bansal R, Sharma D, Singh R. Tuberculosis and its treatment: an overview. Mini Reviews in Medicinal Chemistry. 2018;18(1):58-71. https://doi.org/10.2174/1389557516666160823160010
Cheng S, Hide M, Pheng SH, et al. Resistance to second-line anti-TB drugs in cambodia: a phenotypic and genetic study. Infection and Drug Resistance. 2021;1089-1104. doi: 10.2147/IDR.S289907
Brausch LM, Bass JB Jr. The treatment of tuberculosis. Medical Clinic of North America. 1993;77:1277-88.
Kocabaş A, Kuleci S. Antimikobakteriyel ajanlar. İçinde: Sarıca Y, İnal TC, Canataroğlu A, Güvenç B, Horoz M, Sağlıker Özkaynak P, ed. Harrison İç Hastalıklar Prensibleri. 1.Cilt. Nobel Tıp Kitabevleri, İstanbul; 2004: 1017-23.
Özkara Ş. Tüberküloz kliniği, tanı ve tedavisine genel bakış. İçinde: Şimşek H, Gülhan M, İlhan Tarhan A, ed. Her Yönüyle Tüberküloz. 1.Baskı. Hipokrat Kitabevi, Ankara; 2019: 93-105.
Vilchèze C, Jacobs Jr WR. The isoniazid paradigm of killing, resistance, and persistence in Mycobacterium tuberculosis. Journal of molecular biology. 2019;431(18):3450-61. https://doi.org/10.1016/j.jmb.2019.02.016
Unissa AN, Subbian S, Hanna LE, Selvakumar N. Overview on mechanisms of isoniazid action and resistance in Mycobacterium tuberculosis. Infection, Genetics Evolution. 2016;45:474-492. doi: 10.1016/j.meegid.2016.09.004
Miotto P, Zhang Y, Cirillo DM, Yam WC. Drug resistance mechanisms and drug susceptibility testing for tuberculosis. Respirology. 2018;23(12):1098-1113. https://doi.org/10.1111/resp.13393
Grobbelaar M, Louw GE, Sampson SL, van Helden PD, Donald PR, Warren RM. Evolution of rifampicin treatment for tuberculosis. Infection, Genetics and Evolution. 2019;74:103937. https://doi.org/10.1016/j.meegid.2019.103937
Zaw MT, Emran NA, Lin Z. Mutations inside rifampicin-resistance determining region of rpoB gene associated with rifampicin-resistance in Mycobacterium tuberculosis. Journal of infection and public health. 2018;11(5):605-10. https://doi.org/10.1016/j.jiph.2018.04.005
Palomino JC, Martin A. Drug resistance mechanisms in Mycobacterium tuberculosis. Antibiotics. 2014;3(3):317-40. https://doi.org/10.3390/antibiotics3030317
Goldstein BP. Resistance to rifampicin: a review. The Journal of antibiotics. 2014;67(9):625-30.
Waters M, Tadi P. Streptomycin. In:StatPearls. StatPearls Publishing, Treasure Island (FL). 2022. PMID: 32310346.
Sreevatsan S, Pan X, Stockbauer KE, Williams DL, Kreiswirth BN, Musser JM. Characterization of rpsL and rrs mutations in streptomycin-resistant Mycobacterium tuberculosis isolates from diverse geographic localities. Antimicrobial agents and chemotherapy. 1996;40(4):1024-26.
Smittipat N, Juthayothin T, Billamas P, et al. Mutations in rrs, rpsL and gidB in streptomycin-resistant Mycobacterium tuberculosis isolates from Thailand. Journal of global antimicrobial resistance. 2016; 4:5-10. https://doi.org/10.1016/j.jgar.2015.11.009
Sharma D, Bisht D. Secretory proteome analysis of streptomycin-resistant Mycobacterium tuberculosis clinical isolates. SLAS DISCOVERY:Advancing Life Sciences R&D. 2017; 22(10):1229-38. https://doi.org/10.1177/2472555217698428
Lee N, Nguyen H. Ethambutol. In: StatPearls. StatPearls Publishing, Treasure Island (FL); 2022. PMID: 32644476.
Mohammadi B, Ramazanzadeh R, Nouri B, Rouhi S. Frequency of codon 306 mutations in embB gene of Mycobacterium tuberculosis resistant to ethambutol: a systematic review and meta-analysis. International Journal of Preventive Medicine. 2020;11:112. https://doi.org/10.4103/ijpvm.IJPVM_114_19
Zhang N, Savic RM, Boeree MJ. Optimising pyrazinamide for the treatment of tuberculosis. European Respiratory Journal. 2021;58(1):2002013. doi: 10.1183/13993003.02013-2020.
Zhang Y, Mitchison D. The curious characteristics of pyrazinamide: a review. The international journal of tuberculosis and lung disease. 2003;7(1):6-21.
De Jong BC, Onipede A, Pym AS, Gagneux S, Aga RS, DeRiemer K, Small PM. Does resistance to pyrazinamide accurately indicate the presence of Mycobacterium bovis?. Journal of clinical microbiology. 2005; 43(7):3530-32.
Njire M, Tan Y, Mugwer, J, et al. Pyrazinamide resistance in Mycobacterium tuberculosis: Review and update. Advances in Medical Sciences. 2016;61(1): 63-71. https://doi.org/10.1016/j.advms.2015.09.007
Chen J, Zhang S, Cui P, Shi W, Zhang W, Zhang Y. Identification of novel mutations associated with cycloserine resistance in Mycobacterium tuberculosis. J Antimicrob Chemother.2017;72(12):3272-76. doi: 10.1093/jac/dkx316.
Ushtanit A, Kulagina E, Mikhailova Y, Makarova M, Safonova S, Zimenkov D. Molecular determinants of Ethionamide resistance in clinical isolates of mycobacterium tuberculosis. Antibiotics. 2022;11(2):133. https://doi.org/10.3390/antibiotics11020133
Vilchèze C, Jacobs Jr WR. Resistance to isoniazid and ethionamide in Mycobacterium tuberculosis:genes, mutations, and causalities. Microbiology spectrum. 2014;2(4):2-4. https://doi.org/10.1128/microbiolspec.MGM2-0014-2013
Bashir KM, Cho MG. The Effect of Kanamycin and Tetracycline on Growth and Photosynthetic Activity of Two Chlorophyte Algae. Biomed Res Int. 2016;2016:5656304. doi: 10.1155/2016/5656304.
Hotta K, Kondo S. Kanamycin and its derivative, arbekacin: significance and impact. J Antibiot (Tokyo). 2018;71(4):417-24. doi: 10.1038/s41429-017-0017-8.
Ramirez MS, Tolmasky ME. Amikacin: Uses, Resistance, and Prospects for Inhibition. Molecules. 2017;22(12):2267. doi: 10.3390/molecules22122267.
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Details

Primary Language	Turkish
Subjects	Health Care Administration
Journal Section	Articles
Authors	Nurcihan Biltekin 0000-0002-7165-9385 Mahmut Ülger 0000-0001-6649-4195
Early Pub Date	December 5, 2023
Publication Date	December 18, 2023
Submission Date	December 2, 2022
Acceptance Date	March 31, 2023
Published in Issue	Year 2023 Volume: 16 Issue: 3

Cite

APA	Biltekin, N., & Ülger, M. (2023). Tüberküloz tedavisinde kullanılan antitüberküloz ilaçlar. Mersin Üniversitesi Sağlık Bilimleri Dergisi, 16(3), 525-542.
AMA	Biltekin N, Ülger M. Tüberküloz tedavisinde kullanılan antitüberküloz ilaçlar. Mersin Univ Saglık Bilim derg. December 2023;16(3):525-542.
Chicago	Biltekin, Nurcihan, and Mahmut Ülger. “Tüberküloz Tedavisinde kullanılan antitüberküloz ilaçlar”. Mersin Üniversitesi Sağlık Bilimleri Dergisi 16, no. 3 (December 2023): 525-42.
EndNote	Biltekin N, Ülger M (December 1, 2023) Tüberküloz tedavisinde kullanılan antitüberküloz ilaçlar. Mersin Üniversitesi Sağlık Bilimleri Dergisi 16 3 525–542.
IEEE	N. Biltekin and M. Ülger, “Tüberküloz tedavisinde kullanılan antitüberküloz ilaçlar”, Mersin Univ Saglık Bilim derg, vol. 16, no. 3, pp. 525–542, 2023.
ISNAD	Biltekin, Nurcihan - Ülger, Mahmut. “Tüberküloz Tedavisinde kullanılan antitüberküloz ilaçlar”. Mersin Üniversitesi Sağlık Bilimleri Dergisi 16/3 (December 2023), 525-542.
JAMA	Biltekin N, Ülger M. Tüberküloz tedavisinde kullanılan antitüberküloz ilaçlar. Mersin Univ Saglık Bilim derg. 2023;16:525–542.
MLA	Biltekin, Nurcihan and Mahmut Ülger. “Tüberküloz Tedavisinde kullanılan antitüberküloz ilaçlar”. Mersin Üniversitesi Sağlık Bilimleri Dergisi, vol. 16, no. 3, 2023, pp. 525-42.
Vancouver	Biltekin N, Ülger M. Tüberküloz tedavisinde kullanılan antitüberküloz ilaçlar. Mersin Univ Saglık Bilim derg. 2023;16(3):525-42.

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MEU Journal of Health Sciences Assoc was began to the publishing process in 2008 under the supervision of Assoc. Prof. Gönül Aslan, Editor-in-Chief, and affiliated to Mersin University Institute of Health Sciences. In March 2015, Prof. Dr. Caferi Tayyar Şaşmaz undertook the Editor-in Chief position and since then he has been in charge.

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