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Year 2023, Volume: 1 Issue: 3, 123 - 130, 31.12.2023

Feyza Burul Öznur Altunlu Irmak Ferah Okkay Cemil Bayram Fatma Yesilyurt Ufuk Okkay

Abstract

References

  • Abaza, M.-S., Al-Attiyah, R. a., Bhardwaj, R., Abbadi, G., Koyippally, M., & Afzal, M. (2013). Syringic acid from Tamarix aucheriana possesses antimitogenic and chemo-sensitizing activities in human colorectal cancer cells. Pharmaceutical Biology, 51(9), 1110-1124. https://doi.org/10.3109/13880209.2013.781194
  • Ahmed, M. (2020). Colon Cancer: A Clinician's Perspective in 2019. Gastroenterology Res, 13(1), 1-10. https://doi.org/10.14740/gr1239
  • Cikman, O., Soylemez, O., Ozkan, O. F., Kiraz, H. A., Sayar, I., Ademoglu, S., Taysi, S., & Karaayvaz, M. (2015). Antioxidant Activity of Syringic Acid Prevents Oxidative Stress in l-arginine-Induced Acute Pancreatitis: An Experimental Study on Rats. Int Surg, 100(5), 891-896. https://doi.org/10.9738/intsurg-d-14-00170.1
  • Clemente, S. M., Martínez-Costa, O. H., Monsalve, M., & Samhan-Arias, A. K. (2020). Targeting Lipid Peroxidation for Cancer Treatment. Molecules, 25(21), 5144. https://www.mdpi.com/1420-3049/25/21/5144
  • Ferah Okkay, I., Okkay, U., Gundogdu, O. L., Bayram, C., Mendil, A. S., Ertugrul, M. S., & Hacimuftuoglu, A. (2022). Syringic acid protects against thioacetamide-induced hepatic encephalopathy: Behavioral, biochemical, and molecular evidence. Neuroscience Letters, 769, 136385. https://doi.org/https://doi.org/10.1016/j.neulet.2021.136385
  • Gheena, S., & Ezhilarasan, D. (2019). Syringic acid triggers reactive oxygen species–mediated cytotoxicity in HepG2 cells. Human & Experimental Toxicology, 38(6), 694-702. https://doi.org/10.1177/0960327119839173
  • Johdi, N. A., & Sukor, N. F. (2020). Colorectal Cancer Immunotherapy: Options and Strategies. Front Immunol, 11, 1624. https://doi.org/10.3389/fimmu.2020.01624
  • Kuipers, E. J., Grady, W. M., Lieberman, D., Seufferlein, T., Sung, J. J., Boelens, P. G., van de Velde, C. J., & Watanabe, T. (2015). Colorectal cancer. Nat Rev Dis Primers, 1, 15065. https://doi.org/10.1038/nrdp.2015.65
  • Li, J., Ma, X., Chakravarti, D., Shalapour, S., & DePinho, R. A. (2021). Genetic and biological hallmarks of colorectal cancer. Genes Dev, 35(11-12), 787-820. https://doi.org/10.1101/gad.348226.120
  • Lin, S., Li, Y., Zamyatnin, A. A., Jr., Werner, J., & Bazhin, A. V. (2018). Reactive oxygen species and colorectal cancer. J Cell Physiol, 233(7), 5119-5132. https://doi.org/10.1002/jcp.26356
  • Long, A. G., Lundsmith, E. T., & Hamilton, K. E. (2017). Inflammation and Colorectal Cancer. Current Colorectal Cancer Reports, 13(4), 341-351. https://doi.org/10.1007/s11888-017-0373-6
  • Mármol, I., Sánchez-de-Diego, C., Pradilla Dieste, A., Cerrada, E., & Rodriguez Yoldi, M. J. (2017). Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer. Int J Mol Sci, 18(1). https://doi.org/10.3390/ijms18010197
  • Mármol, I., Sánchez-de-Diego, C., Pradilla Dieste, A., Cerrada, E., & Rodriguez Yoldi, M. J. (2017). Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer. International Journal of Molecular Sciences, 18(1), 197. https://www.mdpi.com/1422-0067/18/1/197
  • Mihanfar, A., Darband, S. G., Sadighparvar, S., Kaviani, M., Mirza-Aghazadeh-Attari, M., Yousefi, B., & Majidinia, M. (2021). In vitro and in vivo anticancer effects of syringic acid on colorectal cancer: Possible mechanistic view. Chemico-Biological Interactions, 337, 109337. https://doi.org/https://doi.org/10.1016/j.cbi.2020.109337
  • Okkay, U., & Ferah Okkay, I. (2022). In vitro neuroprotective effects of allicin on Alzheimer’s disease model of neuroblastoma cell line. Journal of Surgery and Medicine, 6(2), 209-212. https://doi.org/10.28982/josam.1068336
  • Pacal, I., Karaboga, D., Basturk, A., Akay, B., & Nalbantoglu, U. (2020). A comprehensive review of deep learning in colon cancer. Computers in Biology and Medicine, 126, 104003. https://doi.org/https://doi.org/10.1016/j.compbiomed.2020.104003
  • Pei, J., Velu, P., Zareian, M., Feng, Z., & Vijayalakshmi, A. (2021). Effects of Syringic Acid on Apoptosis, Inflammation, and AKT/mTOR Signaling Pathway in Gastric Cancer Cells. Front Nutr, 8, 788929. https://doi.org/10.3389/fnut.2021.788929
  • Pei, J., Velu, P., Zareian, M., Feng, Z., & Vijayalakshmi, A. (2021). Effects of Syringic Acid on Apoptosis, Inflammation, and AKT/mTOR Signaling Pathway in Gastric Cancer Cells [Original Research]. Frontiers in Nutrition, 8. https://doi.org/10.3389/fnut.2021.788929
  • Sancak, E. B., Akbas, A., Silan, C., Cakir, D. U., Turkon, H., & Ozkanli, S. S. (2016). Protective effect of syringic acid on kidney ischemia-reperfusion injury. Renal Failure, 38(4), 629-635. https://doi.org/10.3109/0886022X.2016.1149868
  • Schmitt, M., & Greten, F. R. (2021). The inflammatory pathogenesis of colorectal cancer. Nat Rev Immunol, 21(10), 653-667. https://doi.org/10.1038/s41577-021-00534-x
  • Sezen, S., Ertuğrul, M. S., Balpınar, Ö., Bayram, C., Özkaraca, M., Okkay, I. F., Hacımüftüoğlu, A., & Güllüce, M. (2023). Assessment of antimicrobial activity and In Vitro wound healing potential of ZnO nanoparticles synthesized with Capparis spinosa extract. Environ Sci Pollut Res Int. https://doi.org/10.1007/s11356-023-30417-8
  • Simon, K. (2016). Colorectal cancer development and advances in screening. Clin Interv Aging, 11, 967-976. https://doi.org/10.2147/cia.S109285
  • Smith, K. M., & Desai, J. (2018). Nivolumab for the treatment of colorectal cancer. Expert Rev Anticancer Ther, 18(7), 611-618. https://doi.org/10.1080/14737140.2018.1480942
  • Srinivasulu, C., Ramgopal, M., Ramanjaneyulu, G., Anuradha, C. M., & Suresh Kumar, C. (2018). Syringic acid (SA) ‒ A Review of Its Occurrence, Biosynthesis, Pharmacological and Industrial Importance. Biomedicine & Pharmacotherapy, 108, 547-557. https://doi.org/https://doi.org/10.1016/j.biopha.2018.09.069
  • Thanikachalam, K., & Khan, G. (2019). Colorectal Cancer and Nutrition. Nutrients, 11(1), 164. https://www.mdpi.com/2072-6643/11/1/164
  • WHO. (2023). Colorectal cancer. Retrieved 02.10 from https://www.who.int/news-room/fact-sheets/detail/colorectal-cancer#:~:text=Colorectal%20cancer%20is%20the%20third,people%20aged%2050%20and%20above.
  • Yücel, A. F., Kemik, O., Kemik, A. S., Purisa, S., & Tüzün, I. S. (2012). Relationship between the levels of oxidative stress in mesenteric and peripheral serum and clinicopathological variables in colorectal cancer. Balkan Med J, 29(2), 144-147. https://doi.org/10.5152/balkanmedj.2011.035

Investigation of the Antitumoral Activity of Syringic Acid on HT-29 Cells: An In Vitro Study

Year 2023, Volume: 1 Issue: 3, 123 - 130, 31.12.2023

Feyza Burul Öznur Altunlu Irmak Ferah Okkay Cemil Bayram Fatma Yesilyurt Ufuk Okkay

Abstract

Abstract
Colorectal cancer (CRC) is one of the most common cancers in the world with high mortality rates, and it is the second leading cause of cancer-related deaths worldwide and it is estimated that more than 930,000 deaths will occur due to CRC. In addition to genetic and environmental factors, oxidative stress, lipid peroxidation and parameter changes in the antioxidant system are among the risk factors. Syringic acid (SA) which contains polyphenolic compounds, has antioxidant, anti-lipid peroxidative and anti-cancer effects. Due to these effects, syringic acid may have a healing effect on HT-29 cells. In our study, we determined the effect of SA on cell viability on HT-29 cells with MTT, and its effects on antioxidant and oxidant parameters with TAC-TOS tests. Syringic acid decreased viability, increased TAC levels and did not cause a significant change in TOS levels in HT-29 cells. These findings may indicate that SA has curative effects on CRC. However, more studies are needed for clinical uses.

Keywords

Anticancer Antioxidant Colorectal cancer HT-29 Cells Syringic acid

References

  • Abaza, M.-S., Al-Attiyah, R. a., Bhardwaj, R., Abbadi, G., Koyippally, M., & Afzal, M. (2013). Syringic acid from Tamarix aucheriana possesses antimitogenic and chemo-sensitizing activities in human colorectal cancer cells. Pharmaceutical Biology, 51(9), 1110-1124. https://doi.org/10.3109/13880209.2013.781194
  • Ahmed, M. (2020). Colon Cancer: A Clinician's Perspective in 2019. Gastroenterology Res, 13(1), 1-10. https://doi.org/10.14740/gr1239
  • Cikman, O., Soylemez, O., Ozkan, O. F., Kiraz, H. A., Sayar, I., Ademoglu, S., Taysi, S., & Karaayvaz, M. (2015). Antioxidant Activity of Syringic Acid Prevents Oxidative Stress in l-arginine-Induced Acute Pancreatitis: An Experimental Study on Rats. Int Surg, 100(5), 891-896. https://doi.org/10.9738/intsurg-d-14-00170.1
  • Clemente, S. M., Martínez-Costa, O. H., Monsalve, M., & Samhan-Arias, A. K. (2020). Targeting Lipid Peroxidation for Cancer Treatment. Molecules, 25(21), 5144. https://www.mdpi.com/1420-3049/25/21/5144
  • Ferah Okkay, I., Okkay, U., Gundogdu, O. L., Bayram, C., Mendil, A. S., Ertugrul, M. S., & Hacimuftuoglu, A. (2022). Syringic acid protects against thioacetamide-induced hepatic encephalopathy: Behavioral, biochemical, and molecular evidence. Neuroscience Letters, 769, 136385. https://doi.org/https://doi.org/10.1016/j.neulet.2021.136385
  • Gheena, S., & Ezhilarasan, D. (2019). Syringic acid triggers reactive oxygen species–mediated cytotoxicity in HepG2 cells. Human & Experimental Toxicology, 38(6), 694-702. https://doi.org/10.1177/0960327119839173
  • Johdi, N. A., & Sukor, N. F. (2020). Colorectal Cancer Immunotherapy: Options and Strategies. Front Immunol, 11, 1624. https://doi.org/10.3389/fimmu.2020.01624
  • Kuipers, E. J., Grady, W. M., Lieberman, D., Seufferlein, T., Sung, J. J., Boelens, P. G., van de Velde, C. J., & Watanabe, T. (2015). Colorectal cancer. Nat Rev Dis Primers, 1, 15065. https://doi.org/10.1038/nrdp.2015.65
  • Li, J., Ma, X., Chakravarti, D., Shalapour, S., & DePinho, R. A. (2021). Genetic and biological hallmarks of colorectal cancer. Genes Dev, 35(11-12), 787-820. https://doi.org/10.1101/gad.348226.120
  • Lin, S., Li, Y., Zamyatnin, A. A., Jr., Werner, J., & Bazhin, A. V. (2018). Reactive oxygen species and colorectal cancer. J Cell Physiol, 233(7), 5119-5132. https://doi.org/10.1002/jcp.26356
  • Long, A. G., Lundsmith, E. T., & Hamilton, K. E. (2017). Inflammation and Colorectal Cancer. Current Colorectal Cancer Reports, 13(4), 341-351. https://doi.org/10.1007/s11888-017-0373-6
  • Mármol, I., Sánchez-de-Diego, C., Pradilla Dieste, A., Cerrada, E., & Rodriguez Yoldi, M. J. (2017). Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer. Int J Mol Sci, 18(1). https://doi.org/10.3390/ijms18010197
  • Mármol, I., Sánchez-de-Diego, C., Pradilla Dieste, A., Cerrada, E., & Rodriguez Yoldi, M. J. (2017). Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer. International Journal of Molecular Sciences, 18(1), 197. https://www.mdpi.com/1422-0067/18/1/197
  • Mihanfar, A., Darband, S. G., Sadighparvar, S., Kaviani, M., Mirza-Aghazadeh-Attari, M., Yousefi, B., & Majidinia, M. (2021). In vitro and in vivo anticancer effects of syringic acid on colorectal cancer: Possible mechanistic view. Chemico-Biological Interactions, 337, 109337. https://doi.org/https://doi.org/10.1016/j.cbi.2020.109337
  • Okkay, U., & Ferah Okkay, I. (2022). In vitro neuroprotective effects of allicin on Alzheimer’s disease model of neuroblastoma cell line. Journal of Surgery and Medicine, 6(2), 209-212. https://doi.org/10.28982/josam.1068336
  • Pacal, I., Karaboga, D., Basturk, A., Akay, B., & Nalbantoglu, U. (2020). A comprehensive review of deep learning in colon cancer. Computers in Biology and Medicine, 126, 104003. https://doi.org/https://doi.org/10.1016/j.compbiomed.2020.104003
  • Pei, J., Velu, P., Zareian, M., Feng, Z., & Vijayalakshmi, A. (2021). Effects of Syringic Acid on Apoptosis, Inflammation, and AKT/mTOR Signaling Pathway in Gastric Cancer Cells. Front Nutr, 8, 788929. https://doi.org/10.3389/fnut.2021.788929
  • Pei, J., Velu, P., Zareian, M., Feng, Z., & Vijayalakshmi, A. (2021). Effects of Syringic Acid on Apoptosis, Inflammation, and AKT/mTOR Signaling Pathway in Gastric Cancer Cells [Original Research]. Frontiers in Nutrition, 8. https://doi.org/10.3389/fnut.2021.788929
  • Sancak, E. B., Akbas, A., Silan, C., Cakir, D. U., Turkon, H., & Ozkanli, S. S. (2016). Protective effect of syringic acid on kidney ischemia-reperfusion injury. Renal Failure, 38(4), 629-635. https://doi.org/10.3109/0886022X.2016.1149868
  • Schmitt, M., & Greten, F. R. (2021). The inflammatory pathogenesis of colorectal cancer. Nat Rev Immunol, 21(10), 653-667. https://doi.org/10.1038/s41577-021-00534-x
  • Sezen, S., Ertuğrul, M. S., Balpınar, Ö., Bayram, C., Özkaraca, M., Okkay, I. F., Hacımüftüoğlu, A., & Güllüce, M. (2023). Assessment of antimicrobial activity and In Vitro wound healing potential of ZnO nanoparticles synthesized with Capparis spinosa extract. Environ Sci Pollut Res Int. https://doi.org/10.1007/s11356-023-30417-8
  • Simon, K. (2016). Colorectal cancer development and advances in screening. Clin Interv Aging, 11, 967-976. https://doi.org/10.2147/cia.S109285
  • Smith, K. M., & Desai, J. (2018). Nivolumab for the treatment of colorectal cancer. Expert Rev Anticancer Ther, 18(7), 611-618. https://doi.org/10.1080/14737140.2018.1480942
  • Srinivasulu, C., Ramgopal, M., Ramanjaneyulu, G., Anuradha, C. M., & Suresh Kumar, C. (2018). Syringic acid (SA) ‒ A Review of Its Occurrence, Biosynthesis, Pharmacological and Industrial Importance. Biomedicine & Pharmacotherapy, 108, 547-557. https://doi.org/https://doi.org/10.1016/j.biopha.2018.09.069
  • Thanikachalam, K., & Khan, G. (2019). Colorectal Cancer and Nutrition. Nutrients, 11(1), 164. https://www.mdpi.com/2072-6643/11/1/164
  • WHO. (2023). Colorectal cancer. Retrieved 02.10 from https://www.who.int/news-room/fact-sheets/detail/colorectal-cancer#:~:text=Colorectal%20cancer%20is%20the%20third,people%20aged%2050%20and%20above.
  • Yücel, A. F., Kemik, O., Kemik, A. S., Purisa, S., & Tüzün, I. S. (2012). Relationship between the levels of oxidative stress in mesenteric and peripheral serum and clinicopathological variables in colorectal cancer. Balkan Med J, 29(2), 144-147. https://doi.org/10.5152/balkanmedj.2011.035
There are 27 citations in total.

Details

Primary Language English
Subjects Medical Pharmacology
Journal Section Research Articles
Authors

Feyza Burul 0009-0002-2193-1106

Öznur Altunlu 0000-0003-3192-3118

Irmak Ferah Okkay 0000-0001-8836-9547

Cemil Bayram 0000-0001-8940-8560

Fatma Yesilyurt 0000-0002-1336-6322

Ufuk Okkay 0000-0002-2871-0712

Early Pub Date December 29, 2023
Publication Date December 31, 2023
Submission Date December 11, 2023
Acceptance Date December 28, 2023
Published in Issue Year 2023 Volume: 1 Issue: 3

Cite

APA Burul, F., Altunlu, Ö., Ferah Okkay, I., Bayram, C., et al. (2023). Investigation of the Antitumoral Activity of Syringic Acid on HT-29 Cells: An In Vitro Study. Recent Trends in Pharmacology, 1(3), 123-130.
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