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A theoretical study of oleuropein derivatives as drugs

Year 2022, Volume: 6 Issue: 2, 18 - 21, 15.12.2022

Faik Gökalp Ramazan Erenler

https://doi.org/10.33435/tcandtc.977727

Abstract

Oleuropein is a natural product revealing a large variety of biological activity. The natural products are functionalized to increase the activity in the pharmaceutical industry. Theoretical calculations were carried out for oleuropein derivatives to display the target compound exhibiting the most biological effects. Hence, synthetic chemists are able to get inspired to synthesize the most active oleuropein derivatives. The chemical properties of oleuropein derivatives have been investigated theoretically. Gaussian method was used for quantum calculations of these compounds. The properties of compounds were presented and the utilization of these compounds in pharmaceutical industries was investigated. The quantum calculations revealed that 2H-oleuropein (3) and 4-aminobutyl-2-oleuropein (2) were unstable and were prone to react to the radical compounds.

Keywords

Oleuropein Gaussian 2H-oleuropein

References

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  • [2]. Elmastas, M.; Erenler, R.; Isnac, B.; Aksit, H.; Sen, O.; Genc, N.; Demirtas, I. Natural Product Research 2016, 30, 299-304.
  • [3]. Elmastas, M.; Ozturk, L.; Gokce, I.; Erenler, R.; Aboul-Enein, H. Y. Analytical Letters 2004, 37, 1859-1869.
  • [4]. Erenler, R.; Meral, B.; Sen, O.; Elmastas, M.; Aydin, A.; Eminagaoglu, O.; Topcu, G. Pharmaceutical Biology 2017, 55, 1646-1653.
  • [5]. Erenler, R.; Sen, O.; Aksit, H.; Demirtas, I.; Yaglioglu, A. S.; Elmastas, M.; Telci, İ. Journal of the Science of Food and Agriculture 2016, 96, 822-836.
  • [6]. Aksit, H.; Celik, S. M.; Sen, O.; Erenler, R.; Demirtas, I.; Telci, I.; Elmastas, M. Records of Natural Products 2014, 8, 277-280.
  • [7]. Erenler, R.; Sen, O.; Yaglioglu, A. S.; Demirtas, I. Comb Chem High Throughput Screen 2016, 19, 66-72.
  • [8]. Erenler, R.; Sen, O.; Yildiz, I.; Aydin, A. Records of Natural Products 2016, 10, 766-770.
  • [9]. Psaltopoulou, T.; Kosti, R. I.; Haidopoulos, D.; Dimopoulos, M.; Panagiotakos, D. B. Lipids in health and disease 2011, 10, 127.
  • [10].Pelucchi, C.; Bosetti, C.; Negri, E.; Lipworth, L.; La Vecchia, C. Current pharmaceutical design 2011, 17, 805-812.
  • [11]. Schwingshackl, L.; Hoffmann, G. Current nutrition reports 2016, 5, 9-17.
  • [12]. Servili, M.; Esposto, S.; Fabiani, R.; Urbani, S.; Taticchi, A.; Mariucci, F.; Selvaggini, R.; Montedoro, G. Inflammopharmacology 2009, 17, 76-84.
  • [13]. Omar, S. H. Scientia pharmaceutica 2010, 78, 133-154.
  • [14]. Fabiani, R.; Rosignoli, P.; De Bartolomeo, A.; Fuccelli, R.; Servili, M.; Montedoro, G. F.; Morozzi, G. The Journal of Nutrition 2008, 138, 1411-1416.
  • [15]. Piroddi, M.; Albini, A.; Fabiani, R.; Giovannelli, L.; Luceri, C.; Natella, F.; Rosignoli, P.; Rossi, T.; Taticchi, A.; Servili, M. Biofactors 2017, 43, 17-41.
  • [16]. Musa, A. Y.; Kadhum, A. A. H.; Mohamad, A. B.; Rahoma, A. A. B.; Mesmari, H. Journal of Molecular Structure: Theochem 2010, 969, 233-237.
  • [17]. Geerlings, P.; De Proft, F.; Langenaeker, W. Chemical reviews 2003, 103, 1793-1874.
  • [18]. Tanak, H. Journal of Molecular Structure: Theochem 2010, 950, 5-12.
  • [19]. Gökalp,F.,.Journal of Food and Drug Analysis,2018,26,657-661.
  • [20]. Gökalp,F., Nutrition and Cancer, 2021,doi: 10.1080/01635581.2021.1895233.

Year 2022, Volume: 6 Issue: 2, 18 - 21, 15.12.2022

Faik Gökalp Ramazan Erenler

https://doi.org/10.33435/tcandtc.977727

Abstract

References

  • [1]. Demirtas, I.; Erenler, R.; Elmastas, M.; Goktasoglu, A. Food Chemistry 2013, 136, 34-40.
  • [2]. Elmastas, M.; Erenler, R.; Isnac, B.; Aksit, H.; Sen, O.; Genc, N.; Demirtas, I. Natural Product Research 2016, 30, 299-304.
  • [3]. Elmastas, M.; Ozturk, L.; Gokce, I.; Erenler, R.; Aboul-Enein, H. Y. Analytical Letters 2004, 37, 1859-1869.
  • [4]. Erenler, R.; Meral, B.; Sen, O.; Elmastas, M.; Aydin, A.; Eminagaoglu, O.; Topcu, G. Pharmaceutical Biology 2017, 55, 1646-1653.
  • [5]. Erenler, R.; Sen, O.; Aksit, H.; Demirtas, I.; Yaglioglu, A. S.; Elmastas, M.; Telci, İ. Journal of the Science of Food and Agriculture 2016, 96, 822-836.
  • [6]. Aksit, H.; Celik, S. M.; Sen, O.; Erenler, R.; Demirtas, I.; Telci, I.; Elmastas, M. Records of Natural Products 2014, 8, 277-280.
  • [7]. Erenler, R.; Sen, O.; Yaglioglu, A. S.; Demirtas, I. Comb Chem High Throughput Screen 2016, 19, 66-72.
  • [8]. Erenler, R.; Sen, O.; Yildiz, I.; Aydin, A. Records of Natural Products 2016, 10, 766-770.
  • [9]. Psaltopoulou, T.; Kosti, R. I.; Haidopoulos, D.; Dimopoulos, M.; Panagiotakos, D. B. Lipids in health and disease 2011, 10, 127.
  • [10].Pelucchi, C.; Bosetti, C.; Negri, E.; Lipworth, L.; La Vecchia, C. Current pharmaceutical design 2011, 17, 805-812.
  • [11]. Schwingshackl, L.; Hoffmann, G. Current nutrition reports 2016, 5, 9-17.
  • [12]. Servili, M.; Esposto, S.; Fabiani, R.; Urbani, S.; Taticchi, A.; Mariucci, F.; Selvaggini, R.; Montedoro, G. Inflammopharmacology 2009, 17, 76-84.
  • [13]. Omar, S. H. Scientia pharmaceutica 2010, 78, 133-154.
  • [14]. Fabiani, R.; Rosignoli, P.; De Bartolomeo, A.; Fuccelli, R.; Servili, M.; Montedoro, G. F.; Morozzi, G. The Journal of Nutrition 2008, 138, 1411-1416.
  • [15]. Piroddi, M.; Albini, A.; Fabiani, R.; Giovannelli, L.; Luceri, C.; Natella, F.; Rosignoli, P.; Rossi, T.; Taticchi, A.; Servili, M. Biofactors 2017, 43, 17-41.
  • [16]. Musa, A. Y.; Kadhum, A. A. H.; Mohamad, A. B.; Rahoma, A. A. B.; Mesmari, H. Journal of Molecular Structure: Theochem 2010, 969, 233-237.
  • [17]. Geerlings, P.; De Proft, F.; Langenaeker, W. Chemical reviews 2003, 103, 1793-1874.
  • [18]. Tanak, H. Journal of Molecular Structure: Theochem 2010, 950, 5-12.
  • [19]. Gökalp,F.,.Journal of Food and Drug Analysis,2018,26,657-661.
  • [20]. Gökalp,F., Nutrition and Cancer, 2021,doi: 10.1080/01635581.2021.1895233.
There are 20 citations in total.

Details

Primary Language English
Subjects Chemical Engineering
Journal Section Research Article
Authors

Faik Gökalp 0000-0003-4363-3839

Ramazan Erenler 0000-0002-0505-3190

Early Pub Date March 18, 2022
Publication Date December 15, 2022
Submission Date August 2, 2021
Published in Issue Year 2022 Volume: 6 Issue: 2

Cite

APA Gökalp, F., & Erenler, R. (2022). A theoretical study of oleuropein derivatives as drugs. Turkish Computational and Theoretical Chemistry, 6(2), 18-21. https://doi.org/10.33435/tcandtc.977727
AMA Gökalp F, Erenler R. A theoretical study of oleuropein derivatives as drugs. Turkish Comp Theo Chem (TC&TC). December 2022;6(2):18-21. doi:10.33435/tcandtc.977727
Chicago Gökalp, Faik, and Ramazan Erenler. “A Theoretical Study of Oleuropein Derivatives As Drugs”. Turkish Computational and Theoretical Chemistry 6, no. 2 (December 2022): 18-21. https://doi.org/10.33435/tcandtc.977727.
EndNote Gökalp F, Erenler R (December 1, 2022) A theoretical study of oleuropein derivatives as drugs. Turkish Computational and Theoretical Chemistry 6 2 18–21.
IEEE F. Gökalp and R. Erenler, “A theoretical study of oleuropein derivatives as drugs”, Turkish Comp Theo Chem (TC&TC), vol. 6, no. 2, pp. 18–21, 2022, doi: 10.33435/tcandtc.977727.
ISNAD Gökalp, Faik - Erenler, Ramazan. “A Theoretical Study of Oleuropein Derivatives As Drugs”. Turkish Computational and Theoretical Chemistry 6/2 (December 2022), 18-21. https://doi.org/10.33435/tcandtc.977727.
JAMA Gökalp F, Erenler R. A theoretical study of oleuropein derivatives as drugs. Turkish Comp Theo Chem (TC&TC). 2022;6:18–21.
MLA Gökalp, Faik and Ramazan Erenler. “A Theoretical Study of Oleuropein Derivatives As Drugs”. Turkish Computational and Theoretical Chemistry, vol. 6, no. 2, 2022, pp. 18-21, doi:10.33435/tcandtc.977727.
Vancouver Gökalp F, Erenler R. A theoretical study of oleuropein derivatives as drugs. Turkish Comp Theo Chem (TC&TC). 2022;6(2):18-21.

Journal Full Title: Turkish Computational and Theoretical Chemistry


Journal Abbreviated Title: Turkish Comp Theo Chem (TC&TC)