Research Article
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Effects of gossypin on acetaminophen-induced hepatotoxicity in mice

Year 2024, Volume: 25 Issue: 1, 81 - 90, 15.04.2024
https://doi.org/10.23902/trkjnat.1410800

Abstract

Liver injury from paracetamol (acetaminophen) (APAP) is common worldwide. To prevent intoxication with a drug with high poisoning, treatment can be made possible with an easily accessible and harmless substance. This study aimed to investigate the hepatoprotective ef-fects of Gossypin (GOS) in mice exposed to an overdose of APAP -the possible mechanism of action. Specifically, serum [alanine aminotransferase (ALT), aspartate transaminase (AST), and hepatic biochemical parameters (glutathione (GSH), malondialdehyde (MDA) and super-oxide dismutase (SOD)] were evaluated. Protein and mRNA levels of inflammatory, apoptot-ic, and cytochrome factors, including TNF-α, IL-1β, IL-6, NF-kB, and CYP2E1, were ana-lyzed using real-time PCR. Pretreatment with GOS significantly reduced APAP-induced he-patic injury via oxidative stress. Along with potent antioxidant activity, GOS promoted APAP hepatic detoxification by regulating AST, ALT, GSH, MDA, and SOD activities and mRNA levels of the cytochrome CYP2E1 gene. The anti-inflammatory activity of GOS in-creases its production. TNF-α, IL-1β and IL-6, through possible NF-kB blockade, are also responsible for its hepatoprotective effect. Taken together, GOS has the potential to be devel-oped as a preventive agent to be administered to patients suffering from APAP overdose.

Ethical Statement

Ethics committee approval was received for this study from the Kafkas University Local Animal Care Committee by the number KAU-HADYEK/2019-071.

Supporting Institution

Science and Technology Research Projects of Kastamonu University

Project Number

KÜ-BAP01/2021-6

References

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  • 2. Babu, B.H., Jayram, H.N., Nair, M.G., Ajaikumar, K.B. & Padikkala, J. 2003. Free radical scavenging, antitumor and anticarcinogenic activity of gossypin. Journal of experimental & clinical cancer research: CR, 22(4): 581-589. https://pubmed.ncbi.nlm.nih.gov/15053300/
  • 3. Bromer, M.Q. & Black, M. 2003. Acetaminophen hepatotoxicity. Clinics in liver disease, 7(2): 351-367. https://doi.org/10.1016/S1089-3261(03)00025-4
  • 4. Bunchorntavakul, C. & Reddy, K.R. 2013. Acetaminophen-related hepatotoxicity. Clinics in liver disease, 17(4): 587-607. https://doi.org/10.1016/j.cld.2013.07.005
  • 5. Cadirci, E., Ugan, R.A., Dincer, B., Gundogdu, B., Cinar, I., Akpinar, E. & Halici, Z. 2019. Urotensin receptors as a new target for CLP induced septic lung injury in mice. Naunyn-Schmiedeberg's archives of pharmacology, 392(2): 135-145. https://doi.org/10.1007/s00210-018-1571-8
  • 6. Cinar, I. 2021. Apoptosis-Inducing Activity and Antiproliferative Effect of Gossypin on PC-3 Prostate Cancer Cells. Anti-cancer agents in medicinal chemistry, 21(4): 445-450. https://doi.org/10.2174/1871520620666200721103422
  • 7. Cinar, I., Sirin, B., Aydin, P., Toktay, E., Cadirci, E., Halici, I. & Halici, Z. 2019. Ameliorative effect of gossypin against acute lung injury in experimental sepsis model of rats. Life sciences, 221: 327-334. https://doi.org/10.1016/j.lfs.2019.02.039
  • 8. Cinar, I., Yayla, M., Tavaci, T., Toktay, E., Ugan, R.A., Bayram, P. & Halici, H. 2022. In Vivo and In Vitro Cardioprotective Effect of Gossypin Against Isoproterenol-Induced Myocardial Infarction Injury. Cardiovascular toxicology, 22(1): 52-62. https://doi.org/.1007/s12012-021-09698-3
  • 9. Dincer, B., Cinar, I., Yayla, M. & Toktay, E. 2022. Evaluation of the protective effects of gossypin for ischemia/reperfusion injury in ovary tissue. The journal of obstetrics and gynaecology research, 48(3): 748-756. https://doi.org/10.1111/jog.15127
  • 10. Dong, D., Xu, L., Han, X., Qi, Y., Xu, Y., Yin, L., Liu, K. & Peng, J. 2014. Effects of the total saponins from Rosa laevigata Michx fruit against acetaminophen-induced liver damage in mice via induction of autophagy and suppression of inflammation and apoptosis. Molecules, 19(6): 7189-7206. https://doi.org/10.3390/molecules19067189
  • 11. Ferah, I., Halici, Z., Bayir, Y., Demirci, E., Unal, B. & Cadirci, E. 2013. The role of infliximab on paracetamol-induced hepatotoxicity in rats. Immunopharmacology and immunotoxicology, 35(3): 373-381. https://doi.org/10.3109/08923973.2013.775589
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  • 13. Gautam, P. & Flora, S.J. 2010. Oral supplementation of gossypin during lead exposure protects alteration in heme synthesis pathway and brain oxidative stress in rats. Nutrition, 26(5): 563-570. https://doi.org/10.1016/j.nut.2009.06.008
  • 14. Gilroy, D.W., Lawrence, T., Perretti, M. & Rossi, A.G. 2004. Inflammatory resolution: new opportunities for drug discovery. Nature reviews. Drug discovery, 3(5): 401-416. https://doi.org/10.1038/nrd1383
  • 15. Golestan Jahromi, M., Nabavizadeh, F., Vahedian, J., Nahrevanian, H., Dehpour, A.R. & Zare-Mehrjardi, A. 2010. Protective effect of ghrelin on acetaminophen-induced liver injury in rat. Peptides, 31(11): 2114-2117. https://doi.org/10.1016/j.peptides.2010.08.009
  • 16. Holubek, W.J., Kalman, S. & Hoffman, R.S. 2006. Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study. Hepatology, 43(4): 880; author reply 882. https://doi.org/10.1002/hep.21106
  • 17. Karakus, E., Halici, Z., Albayrak, A., Polat, B., Bayir, Y., Kiki, I., Cadirci, E., Topcu, A. & Aksak, S. 2013. Agomelatine: an antidepressant with new potent hepatoprotective effects on paracetamol-induced liver damage in rats. Human & experimental toxicology, 32(8): 846-857. https://doi.org/10.1177/0960327112472994
  • 18. Katary, M. & Salahuddin, A. 2017. Ameliorative effect of gossypin against gentamicin-induced nephrotoxicity in rats. Life sciences, 176: 75-81. https://doi.org/10.1016/j.lfs.2017.03.009
  • 19. Kim, M.S. & Lee, D.Y. 2015. Insulin-like growth factor binding protein-3 enhances etoposide-induced cell growth inhibition by suppressing the NF-kappaB activity in gastric cancer cells. Molecular and cellular biochemistry, 403(1-2): 107-113. https://doi.org/10.3978/j.issn.2304-3881.2014.11.01
  • 20. Krenkel, O., Mossanen, J.C. & Tacke, F. 2014. Immune mechanisms in acetaminophen-induced acute liver failure. Hepatobiliary surgery and nutrition, 3(6): 331-343. https://doi.org/10.3978/j.issn.2304-3881.2014.11.01
  • 21. La Rosa, F.A., Pierce, J.W. & Sonenshein, G.E. 1994. Differential regulation of the c-myc oncogene promoter by the NF-kappa B rel family of transcription factors. Molecular and cellular biology, 14(2): 1039-1044. https://doi.org/10.1128/mcb.14.2.1039-1044.1994
  • 22. Larsen, F.S. & Wendon, J. 2014. Understanding paracetamol-induced liver failure. Intensive care medicine, 40(6): 888-890. https://doi: 10.1007/s00134-014-3293-9
  • 23. Li, G., Chen, J.B., Wang, C., Xu, Z., Nie, H., Qin, X.Y., Chen, X.M. & Gong, Q. 2013. Curcumin protects against acetaminophen-induced apoptosis in hepatic injury. World journal of gastroenterology, 19(42): 7440-7446. https://doi.org/10.3748/wjg.v19.i42.7440
  • 24. Liang, B., Guo, X.L., Jin, J., Ma, Y.C. & Feng, Z.Q. 2015. Glycyrrhizic acid inhibits apoptosis and fibrosis in carbon-tetrachloride-induced rat liver injury. World journal of gastroenterology, 21(17): 5271-5280. https://doi.org/10.3748/wjg.v21.i17.5271
  • 25. Livak, K.J. & Schmittgen, T.D. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods, 25(4): 402-408. https://doi.org/10.1006/meth.2001.1262
  • 26. Madrigal-Santillan, E., Madrigal-Bujaidar, E., Alvarez-Gonzalez, I., Sumaya-Martinez, M.T., Gutierrez-Salinas, J., Bautista, M., Morales-Gonzalez, A., Garcia-Luna y Gonzalez-Rubio, M., Aguilar-Faisal, J.L. & Morales-Gonzalez, J.A. 2014. Review of natural products with hepatoprotective effects. World journal of gastroenterology, 20(40): 14787-14804. https://doi.org/10.3748/wjg.v20.i40.14787
  • 27. Matic, M.M., Paunovic, M.G., Milosevic, M.D., Ognjanovic, B.I. & Saicic, Z.S. 2021. Hematoprotective effects and antioxidant properties of beta-glucan and vitamin C against acetaminophen-induced toxicity: an experimental study in rats. Drug and chemical toxicology, 44(3): 302-309. https://doi.org/10.1080/01480545.2019.1587451
  • 28. McGill, M.R. & Jaeschke, H. 2013. Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. Pharmaceutical research, 30(9): 2174-2187. https://doi.org/10.1007/s11095-013-1007-6
  • 29. Palabiyik, S.S., Karakus, E., Akpinar, E., Halici, Z., Bayir, Y., Yayla, M. & Kose, D. 2016. The Role of Urotensin Receptors in the Paracetamol-Induced Hepatotoxicity Model in Mice: Ameliorative Potential of Urotensin II Antagonist. Basic & clinical pharmacology & toxicology, 118(2): 150-159. https://doi.org/10.1111/bcpt.12447
  • 30. Raffa, R.B., Pergolizzi, J.V., Jr., Taylor, R., Jr., Decker, J.F. & Patrick, J.T. 2014. Acetaminophen (paracetamol) oral absorption and clinical influences. Pain practice: the official journal of World Institute of Pain, 14(7): 668-677. https://doi.org/10.1111/papr.12130
  • 31. Roomi, M.W., Kalinovsky, T., Ivanov, V., Rath, M. & Niedzwiecki, A. 2008. A nutrient mixture prevents acetaminophen hepatic and renal toxicity in ICR mice. Human & experimental toxicology, 27(3): 223-230. https://doi.org/10.1177/0960327108090276
  • 32. Rotundo, L. & Pyrsopoulos, N. 2020. Liver injury induced by paracetamol and challenges associated with intentional and unintentional use. World journal of hepatology, 12(4): 125-136. https://doi.org/10.4254/wjh.v12.i4.125
  • 33. Song, E., Fu, J., Xia, X., Su, C. & Song, Y. 2014. Bazhen decoction protects against acetaminophen induced acute liver injury by inhibiting oxidative stress, inflammation and apoptosis in mice. PloS one, 9(9): e107405. https://doi.org/10.1371/journal.pone.0107405
  • 34. Toktay, E., Selli, J., Gurbuz, M.A., Tastan, T.B., Ugan, R.A., Un, H. & Halici, Z. 2020. Effects of soy isoflavonoids (genistein and daidzein) on endometrial receptivity. Iranian journal of basic medical sciences, 23(12): 1603-1609. https://doi.org/10.22038/ijbms.2020.48294.11089
  • 35. Ugan, R.A., Cadirci, E., Halici, Z., Toktay, E. & Cinar, I. 2018. The role of urotensin-II and its receptors in sepsis-induced lung injury under diabetic conditions. European journal of pharmacology, 818: 457-469. https://doi.org/10.1016/j.ejphar.2017.11.011
  • 36. Wu, Y.L., Jiang, Y.Z., Jin, X.J., Lian, L.H., Piao, J.Y., Wan, Y., Jin, H.R., Joon Lee, J. & Nan, J.X. 2010. Acanthoic acid, a diterpene in Acanthopanax koreanum, protects acetaminophen-induced hepatic toxicity in mice. Phytomedicine: international journal of phytotherapy and phytopharmacology, 17(6): 475-479. https://doi.org/10.1016/j.phymed.2009.07.011
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Year 2024, Volume: 25 Issue: 1, 81 - 90, 15.04.2024
https://doi.org/10.23902/trkjnat.1410800

Abstract

Parasetamole (Asetaminofen) (APAP) bağlı karaciğer hasarı dünya çapında yaygındır. Zehir-lenme oranı yüksek bir ilaçla zehirlenmeyi önlemek için kolay ulaşılabilir ve zararsız bir mad-deyle tedavi mümkün kılınabilir. Bu çalışma, aşırı dozda APAP'a maruz kalan farelerde Gossypin (GOS) hepatoprotektif etkilerini (olası etki mekanizması) araştırmayı amaçladı. Spesifik olarak serum [alanin aminotransferaz (ALT), aspartat transaminaz (AST) ve hepatik biyokimyasal parametreler (glutatyon (GSH), malondialdehit (MDA) ve süperoksit dismutaz (SOD)] değerlendirildi. Daha sonra inflamatuar, apoptotik protein ve mRNA seviyeleri değer-lendirildi ve TNF-a, IL-1β, IL-6, NF-kB ve CYP2E1 dahil olmak üzere sitokrom faktörleri, gerçek zamanlı PCR kullanılarak analiz edildi. GOS ile ön tedavi, oksidatif stres ve sentrilo-büler yoluyla APAP'ın neden olduğu karaciğer hasarını önemli ölçüde azalttı. GOS, güçlü antioksidan aktivitesinin yanı sıra, sitokrom CYP2E1 geninin AST, ALT, GSH, MDA ve SOD aktivitelerini ve mRNA seviyelerini düzenleyerek APAP hepatik detoksifikasyonunu destekledi. GOS'in anti-inflamatuar aktivitesi, üretimini artırır. Olası NF-kB blokajı yoluyla TNF-α, IL-1β ve IL-6 da hepatoprotektif etkisinden sorumludur. Birlikte ele alındığında GOS, APAP doz aşımından muzdarip olan hastalara uygulanacak önleyici bir ajan olarak ge-liştirilme potansiyeline sahiptir.

Project Number

KÜ-BAP01/2021-6

References

  • 1. Aycan, I.O., Tufek, A., Tokgoz, O., Evliyaoglu, O., Firat, U., Kavak, G.O., Turgut, H. & Yuksel, M.U. 2014. Thymoquinone treatment against acetaminophen-induced hepatotoxicity in rats. International journal of surgery, 12(3): 213-218. https://doi.org/10.1016/j.ijsu.2013.12.013
  • 2. Babu, B.H., Jayram, H.N., Nair, M.G., Ajaikumar, K.B. & Padikkala, J. 2003. Free radical scavenging, antitumor and anticarcinogenic activity of gossypin. Journal of experimental & clinical cancer research: CR, 22(4): 581-589. https://pubmed.ncbi.nlm.nih.gov/15053300/
  • 3. Bromer, M.Q. & Black, M. 2003. Acetaminophen hepatotoxicity. Clinics in liver disease, 7(2): 351-367. https://doi.org/10.1016/S1089-3261(03)00025-4
  • 4. Bunchorntavakul, C. & Reddy, K.R. 2013. Acetaminophen-related hepatotoxicity. Clinics in liver disease, 17(4): 587-607. https://doi.org/10.1016/j.cld.2013.07.005
  • 5. Cadirci, E., Ugan, R.A., Dincer, B., Gundogdu, B., Cinar, I., Akpinar, E. & Halici, Z. 2019. Urotensin receptors as a new target for CLP induced septic lung injury in mice. Naunyn-Schmiedeberg's archives of pharmacology, 392(2): 135-145. https://doi.org/10.1007/s00210-018-1571-8
  • 6. Cinar, I. 2021. Apoptosis-Inducing Activity and Antiproliferative Effect of Gossypin on PC-3 Prostate Cancer Cells. Anti-cancer agents in medicinal chemistry, 21(4): 445-450. https://doi.org/10.2174/1871520620666200721103422
  • 7. Cinar, I., Sirin, B., Aydin, P., Toktay, E., Cadirci, E., Halici, I. & Halici, Z. 2019. Ameliorative effect of gossypin against acute lung injury in experimental sepsis model of rats. Life sciences, 221: 327-334. https://doi.org/10.1016/j.lfs.2019.02.039
  • 8. Cinar, I., Yayla, M., Tavaci, T., Toktay, E., Ugan, R.A., Bayram, P. & Halici, H. 2022. In Vivo and In Vitro Cardioprotective Effect of Gossypin Against Isoproterenol-Induced Myocardial Infarction Injury. Cardiovascular toxicology, 22(1): 52-62. https://doi.org/.1007/s12012-021-09698-3
  • 9. Dincer, B., Cinar, I., Yayla, M. & Toktay, E. 2022. Evaluation of the protective effects of gossypin for ischemia/reperfusion injury in ovary tissue. The journal of obstetrics and gynaecology research, 48(3): 748-756. https://doi.org/10.1111/jog.15127
  • 10. Dong, D., Xu, L., Han, X., Qi, Y., Xu, Y., Yin, L., Liu, K. & Peng, J. 2014. Effects of the total saponins from Rosa laevigata Michx fruit against acetaminophen-induced liver damage in mice via induction of autophagy and suppression of inflammation and apoptosis. Molecules, 19(6): 7189-7206. https://doi.org/10.3390/molecules19067189
  • 11. Ferah, I., Halici, Z., Bayir, Y., Demirci, E., Unal, B. & Cadirci, E. 2013. The role of infliximab on paracetamol-induced hepatotoxicity in rats. Immunopharmacology and immunotoxicology, 35(3): 373-381. https://doi.org/10.3109/08923973.2013.775589
  • 12. Ferrucci, L.M., Bell, B.P., Dhotre, K.B., Manos, M.M., Terrault, N.A., Zaman, A., Murphy, R.C., Vanness, G.R., Thomas, A.R., Bialek, S.R., Desai, M.M. & Sofair, A.N. 2010. Complementary and alternative medicine use in chronic liver disease patients. Journal of clinical gastroenterology, 44(2): e40-45. https://doi.org/10.1097/MCG.0b013e3181b766ed
  • 13. Gautam, P. & Flora, S.J. 2010. Oral supplementation of gossypin during lead exposure protects alteration in heme synthesis pathway and brain oxidative stress in rats. Nutrition, 26(5): 563-570. https://doi.org/10.1016/j.nut.2009.06.008
  • 14. Gilroy, D.W., Lawrence, T., Perretti, M. & Rossi, A.G. 2004. Inflammatory resolution: new opportunities for drug discovery. Nature reviews. Drug discovery, 3(5): 401-416. https://doi.org/10.1038/nrd1383
  • 15. Golestan Jahromi, M., Nabavizadeh, F., Vahedian, J., Nahrevanian, H., Dehpour, A.R. & Zare-Mehrjardi, A. 2010. Protective effect of ghrelin on acetaminophen-induced liver injury in rat. Peptides, 31(11): 2114-2117. https://doi.org/10.1016/j.peptides.2010.08.009
  • 16. Holubek, W.J., Kalman, S. & Hoffman, R.S. 2006. Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study. Hepatology, 43(4): 880; author reply 882. https://doi.org/10.1002/hep.21106
  • 17. Karakus, E., Halici, Z., Albayrak, A., Polat, B., Bayir, Y., Kiki, I., Cadirci, E., Topcu, A. & Aksak, S. 2013. Agomelatine: an antidepressant with new potent hepatoprotective effects on paracetamol-induced liver damage in rats. Human & experimental toxicology, 32(8): 846-857. https://doi.org/10.1177/0960327112472994
  • 18. Katary, M. & Salahuddin, A. 2017. Ameliorative effect of gossypin against gentamicin-induced nephrotoxicity in rats. Life sciences, 176: 75-81. https://doi.org/10.1016/j.lfs.2017.03.009
  • 19. Kim, M.S. & Lee, D.Y. 2015. Insulin-like growth factor binding protein-3 enhances etoposide-induced cell growth inhibition by suppressing the NF-kappaB activity in gastric cancer cells. Molecular and cellular biochemistry, 403(1-2): 107-113. https://doi.org/10.3978/j.issn.2304-3881.2014.11.01
  • 20. Krenkel, O., Mossanen, J.C. & Tacke, F. 2014. Immune mechanisms in acetaminophen-induced acute liver failure. Hepatobiliary surgery and nutrition, 3(6): 331-343. https://doi.org/10.3978/j.issn.2304-3881.2014.11.01
  • 21. La Rosa, F.A., Pierce, J.W. & Sonenshein, G.E. 1994. Differential regulation of the c-myc oncogene promoter by the NF-kappa B rel family of transcription factors. Molecular and cellular biology, 14(2): 1039-1044. https://doi.org/10.1128/mcb.14.2.1039-1044.1994
  • 22. Larsen, F.S. & Wendon, J. 2014. Understanding paracetamol-induced liver failure. Intensive care medicine, 40(6): 888-890. https://doi: 10.1007/s00134-014-3293-9
  • 23. Li, G., Chen, J.B., Wang, C., Xu, Z., Nie, H., Qin, X.Y., Chen, X.M. & Gong, Q. 2013. Curcumin protects against acetaminophen-induced apoptosis in hepatic injury. World journal of gastroenterology, 19(42): 7440-7446. https://doi.org/10.3748/wjg.v19.i42.7440
  • 24. Liang, B., Guo, X.L., Jin, J., Ma, Y.C. & Feng, Z.Q. 2015. Glycyrrhizic acid inhibits apoptosis and fibrosis in carbon-tetrachloride-induced rat liver injury. World journal of gastroenterology, 21(17): 5271-5280. https://doi.org/10.3748/wjg.v21.i17.5271
  • 25. Livak, K.J. & Schmittgen, T.D. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods, 25(4): 402-408. https://doi.org/10.1006/meth.2001.1262
  • 26. Madrigal-Santillan, E., Madrigal-Bujaidar, E., Alvarez-Gonzalez, I., Sumaya-Martinez, M.T., Gutierrez-Salinas, J., Bautista, M., Morales-Gonzalez, A., Garcia-Luna y Gonzalez-Rubio, M., Aguilar-Faisal, J.L. & Morales-Gonzalez, J.A. 2014. Review of natural products with hepatoprotective effects. World journal of gastroenterology, 20(40): 14787-14804. https://doi.org/10.3748/wjg.v20.i40.14787
  • 27. Matic, M.M., Paunovic, M.G., Milosevic, M.D., Ognjanovic, B.I. & Saicic, Z.S. 2021. Hematoprotective effects and antioxidant properties of beta-glucan and vitamin C against acetaminophen-induced toxicity: an experimental study in rats. Drug and chemical toxicology, 44(3): 302-309. https://doi.org/10.1080/01480545.2019.1587451
  • 28. McGill, M.R. & Jaeschke, H. 2013. Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. Pharmaceutical research, 30(9): 2174-2187. https://doi.org/10.1007/s11095-013-1007-6
  • 29. Palabiyik, S.S., Karakus, E., Akpinar, E., Halici, Z., Bayir, Y., Yayla, M. & Kose, D. 2016. The Role of Urotensin Receptors in the Paracetamol-Induced Hepatotoxicity Model in Mice: Ameliorative Potential of Urotensin II Antagonist. Basic & clinical pharmacology & toxicology, 118(2): 150-159. https://doi.org/10.1111/bcpt.12447
  • 30. Raffa, R.B., Pergolizzi, J.V., Jr., Taylor, R., Jr., Decker, J.F. & Patrick, J.T. 2014. Acetaminophen (paracetamol) oral absorption and clinical influences. Pain practice: the official journal of World Institute of Pain, 14(7): 668-677. https://doi.org/10.1111/papr.12130
  • 31. Roomi, M.W., Kalinovsky, T., Ivanov, V., Rath, M. & Niedzwiecki, A. 2008. A nutrient mixture prevents acetaminophen hepatic and renal toxicity in ICR mice. Human & experimental toxicology, 27(3): 223-230. https://doi.org/10.1177/0960327108090276
  • 32. Rotundo, L. & Pyrsopoulos, N. 2020. Liver injury induced by paracetamol and challenges associated with intentional and unintentional use. World journal of hepatology, 12(4): 125-136. https://doi.org/10.4254/wjh.v12.i4.125
  • 33. Song, E., Fu, J., Xia, X., Su, C. & Song, Y. 2014. Bazhen decoction protects against acetaminophen induced acute liver injury by inhibiting oxidative stress, inflammation and apoptosis in mice. PloS one, 9(9): e107405. https://doi.org/10.1371/journal.pone.0107405
  • 34. Toktay, E., Selli, J., Gurbuz, M.A., Tastan, T.B., Ugan, R.A., Un, H. & Halici, Z. 2020. Effects of soy isoflavonoids (genistein and daidzein) on endometrial receptivity. Iranian journal of basic medical sciences, 23(12): 1603-1609. https://doi.org/10.22038/ijbms.2020.48294.11089
  • 35. Ugan, R.A., Cadirci, E., Halici, Z., Toktay, E. & Cinar, I. 2018. The role of urotensin-II and its receptors in sepsis-induced lung injury under diabetic conditions. European journal of pharmacology, 818: 457-469. https://doi.org/10.1016/j.ejphar.2017.11.011
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There are 37 citations in total.

Details

Primary Language English
Subjects Toxicology
Journal Section Research Article/Araştırma Makalesi
Authors

İrfan Çınar 0000-0002-9826-2556

Muhammed Yayla 0000-0002-0659-3084

Erdem Toktay 0000-0002-0715-2707

Damla Binnetoğlu 0000-0002-7041-7253

Project Number KÜ-BAP01/2021-6
Early Pub Date March 28, 2024
Publication Date April 15, 2024
Submission Date December 27, 2023
Acceptance Date March 15, 2024
Published in Issue Year 2024 Volume: 25 Issue: 1

Cite

APA Çınar, İ., Yayla, M., Toktay, E., Binnetoğlu, D. (2024). Effects of gossypin on acetaminophen-induced hepatotoxicity in mice. Trakya University Journal of Natural Sciences, 25(1), 81-90. https://doi.org/10.23902/trkjnat.1410800
AMA Çınar İ, Yayla M, Toktay E, Binnetoğlu D. Effects of gossypin on acetaminophen-induced hepatotoxicity in mice. Trakya Univ J Nat Sci. April 2024;25(1):81-90. doi:10.23902/trkjnat.1410800
Chicago Çınar, İrfan, Muhammed Yayla, Erdem Toktay, and Damla Binnetoğlu. “Effects of Gossypin on Acetaminophen-Induced Hepatotoxicity in Mice”. Trakya University Journal of Natural Sciences 25, no. 1 (April 2024): 81-90. https://doi.org/10.23902/trkjnat.1410800.
EndNote Çınar İ, Yayla M, Toktay E, Binnetoğlu D (April 1, 2024) Effects of gossypin on acetaminophen-induced hepatotoxicity in mice. Trakya University Journal of Natural Sciences 25 1 81–90.
IEEE İ. Çınar, M. Yayla, E. Toktay, and D. Binnetoğlu, “Effects of gossypin on acetaminophen-induced hepatotoxicity in mice”, Trakya Univ J Nat Sci, vol. 25, no. 1, pp. 81–90, 2024, doi: 10.23902/trkjnat.1410800.
ISNAD Çınar, İrfan et al. “Effects of Gossypin on Acetaminophen-Induced Hepatotoxicity in Mice”. Trakya University Journal of Natural Sciences 25/1 (April 2024), 81-90. https://doi.org/10.23902/trkjnat.1410800.
JAMA Çınar İ, Yayla M, Toktay E, Binnetoğlu D. Effects of gossypin on acetaminophen-induced hepatotoxicity in mice. Trakya Univ J Nat Sci. 2024;25:81–90.
MLA Çınar, İrfan et al. “Effects of Gossypin on Acetaminophen-Induced Hepatotoxicity in Mice”. Trakya University Journal of Natural Sciences, vol. 25, no. 1, 2024, pp. 81-90, doi:10.23902/trkjnat.1410800.
Vancouver Çınar İ, Yayla M, Toktay E, Binnetoğlu D. Effects of gossypin on acetaminophen-induced hepatotoxicity in mice. Trakya Univ J Nat Sci. 2024;25(1):81-90.

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