Cilt 17, Sayı 1, Sayfalar 32 - 38 2014-11-19

Transmission of Antibiotic Resistant Enterobacteriaceae between Animals and Humans Gastrointestinal Tract with the Evidence of in vivo Plasmid Transfer

Karwan MAHMOOD [1] , Emel BÜYÜKÜNAL BAL [2]

178 235

Abstract: Recently, the main point of discussion is being undertaken whether the resistance of bacteria and plasmids could have been transmitted to humans from animals. Using antimicrobials in livestock production was previously shown to be followed by the occurrence of the resistant bacteria in the treated animals as well as in humans (caretakers, their family members etc.). Evidences exist that the transmission of resistance might have taken place from animals to humans. Many of these evidences were not direct and were based on the similarities between the resistance profiles of bacteria (among others indicatory E. coli) isolated from animals (poultry, pigs, cattle) and from humans having contact with these animals (farm workers, animal caretakers, their family members). Direct evidences have been based on the molecular methods allowing the detection of either clonally related, resistant zoonotic bacteria in humans and animals or related to resistance of plasmids isolated from humans and animals.

Key words: Enterobacteriaceae, β-lactamase, E. coli, CTX-M

 

Antibiyotik Dirençli Enterobacteriaceae’lerin Hayvan ve İnsan Sindirim Sistemi Arasında in vivo Plazmit Transferinden Kaynaklı Geçişi

Özet: Esas tartışma konusu olan nokta, bakteri ve plazmit kaynaklı bakteri direncinin hayvanlardan insanlara nasıl geçebileceğidir. Antibiyotiklerin çiftlik hayvanlarında kullanımı daha önceleri dirençli bakterilerin tedavi görmüş hayvanlarda ve insanlarda varlığını göstermiştir (hayvan bakıcıları ve çiftlik çalışanları). Direncin geçişinin hayvanlardan insanlara doğru olabileceği şeklinde kanıtlar bulunmaktadır. Bu kanıtların çoğu, direkt olmamakla birlikte hayvanlardan (çiftlik hayvanları) ve bunlarla temas halindeki insanlardan (hayvan bakıcıları ve çiftlik çalışanları) izole edilen bakteriler arasındaki direnç profillerinin benzerliklerine dayanmaktadır. Direkt kanıtlar, birbirleriyle klonal ilişkili insan ve hayvan kaynaklı dirençli zoonotik bakterilerin veya yine bunlardaki dirençle ilgili plazmitlerin moleküler metotlara dayalı olarak saptanması ile olmuştur.

Anahtar kelimeler: Enterobacteriaceae, β-laktamaz, E. coli, CTX-M

Esas tartışma konusu olan nokta, bakteri ve plazmit kaynaklı bakteri direncinin hayvanlardan insanlara nasılgeçebileceğidir. Antibiyotiklerin çiftlik hayvanlarında kullanımı daha önceleri dirençli bakterilerin tedavi görmüşhayvanlarda ve insanlarda varlığını göstermiştir (hayvan bakıcıları ve çiftlik çalışanları). Direncin geçişininhayvanlardan insanlara doğru olabileceği şeklinde kanıtlar bulunmaktadır. Bu kanıtların çoğu, direkt olmamakla birliktehayvanlardan (çiftlik hayvanları) ve bunlarla temas halindeki insanlardan (hayvan bakıcıları ve çiftlik çalışanları) izoleedilen bakteriler arasındaki direnç profillerinin benzerliklerine dayanmaktadır. Direkt kanıtlar, birbirleriyle klonal ilişkiliinsan ve hayvan kaynaklı dirençli zoonotik bakterilerin veya yine bunlardaki dirençle ilgili plazmitlerin molekülermetotlara dayalı olarak saptanması ile olmuştur.
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Birincil Dil en
Konular
Dergi Bölümü MİKROBİYOLOJİ (Microbiology)
Yazarlar

Yazar: Karwan MAHMOOD
E-posta: karwanhmahmood@gmail.com

Yazar: Emel BÜYÜKÜNAL BAL
E-posta: banubal06@gmail.com

Bibtex @ { ksudobil243844, journal = {Kahramanmaraş Sütçü İmam Üniversitesi Doğa Bilimleri Dergisi}, issn = {}, address = {Kahramanmaraş Sütçü İmam Üniversitesi}, year = {2014}, volume = {17}, pages = {32 - 38}, doi = {10.18016/ksujns.71116}, title = {Transmission of Antibiotic Resistant Enterobacteriaceae between Animals and Humans Gastrointestinal Tract with the Evidence of in vivo Plasmid Transfer}, language = {en}, key = {cite}, author = {MAHMOOD, Karwan and BÜYÜKÜNAL BAL, Emel} }
APA MAHMOOD, K , BÜYÜKÜNAL BAL, E . (2014). Transmission of Antibiotic Resistant Enterobacteriaceae between Animals and Humans Gastrointestinal Tract with the Evidence of in vivo Plasmid Transfer. Kahramanmaraş Sütçü İmam Üniversitesi Doğa Bilimleri Dergisi, 17 (1), 32-38. Retrieved from http://dogadergi.ksu.edu.tr/issue/22840/243844
MLA MAHMOOD, K , BÜYÜKÜNAL BAL, E . "Transmission of Antibiotic Resistant Enterobacteriaceae between Animals and Humans Gastrointestinal Tract with the Evidence of in vivo Plasmid Transfer". Kahramanmaraş Sütçü İmam Üniversitesi Doğa Bilimleri Dergisi 17 (2014): 32-38 <http://dogadergi.ksu.edu.tr/issue/22840/243844>
Chicago MAHMOOD, K , BÜYÜKÜNAL BAL, E . "Transmission of Antibiotic Resistant Enterobacteriaceae between Animals and Humans Gastrointestinal Tract with the Evidence of in vivo Plasmid Transfer". Kahramanmaraş Sütçü İmam Üniversitesi Doğa Bilimleri Dergisi 17 (2014): 32-38
RIS TY - JOUR T1 - Transmission of Antibiotic Resistant Enterobacteriaceae between Animals and Humans Gastrointestinal Tract with the Evidence of in vivo Plasmid Transfer AU - Karwan MAHMOOD , Emel BÜYÜKÜNAL BAL Y1 - 2014 PY - 2014 N1 - DO - T2 - Kahramanmaraş Sütçü İmam Üniversitesi Doğa Bilimleri Dergisi JF - Journal JO - JOR SP - 32 EP - 38 VL - 17 IS - 1 SN - -1309-1743 M3 - UR - Y2 - 2017 ER -
EndNote %0 Kahramanmaraş Sütçü İmam Üniversitesi Doğa Bilimleri Dergisi Transmission of Antibiotic Resistant Enterobacteriaceae between Animals and Humans Gastrointestinal Tract with the Evidence of in vivo Plasmid Transfer %A Karwan MAHMOOD , Emel BÜYÜKÜNAL BAL %T Transmission of Antibiotic Resistant Enterobacteriaceae between Animals and Humans Gastrointestinal Tract with the Evidence of in vivo Plasmid Transfer %D 2014 %J Kahramanmaraş Sütçü İmam Üniversitesi Doğa Bilimleri Dergisi %P -1309-1743 %V 17 %N 1 %R %U