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Drosophila melanogaster Meigen (Diptera: Drosophilidae)'de Kinoa (Chenopodium quinoa Willd.)'nın Total Oksidatif Stres Üzerinde Etkisi

Yıl 2016, Cilt: 19 Sayı: 3, 261 - 267, 29.10.2016

Öz

Tüketimi 2013 yılından beri artan Chenopodium quinoa Willd. temel amino asitler, vitaminler ve mineraller bakımından iyi bir kaynaktır. Bu makalede, Drosophila melanogaster Meigen (Diptera: Drosophilidae) yapay diyetine Kinoa eklenerek beslenen ergin bireylerde total oksidasyon ve antioksidan seviyeleri ve aralarındaki ilişki belirlenmesi amaçlanmıştır. D. melanogaster larvaları ergin evreye kadar Kinoa unu (%0,1-1) ile yetiştirilmiştir. Kinoa konsantrasyonları ile beslenen ergin bireylerde Total antioksidan kapasite (TAS), total oksidan stres (TOS) ve oksidatif stres indeksi (OSI) belirlenmiştir. En düşük konsatrasyonla (%0,1) beslenen böceğin TOS aktivitesinde (11.55 ± 0.07 µmol/l) kontrolle kıyasla önemli derecede artış görülmüştür. Besinsel karışımlara Kinoa eklenmesi oksidasyon seviyesini arttırken, antioksidan seviyeyi değiştirmediği belirlenmiştir. Yüksek miktarda Kinoa tüketimi ise antioksidan aktiviteyi(1.85 ± 0.03 mmol/l) yükseltmiştir. Çevre dostu biyoteknolojik metod olarak Kinoa'nın kullanılması ile çevrenin korunmasında önemli rol oynayabileceği vurgulanmıştır.

Anahtar Kelimeler: Kinoa, Drosophila melanogaster, Beslenme, Oksidatif Stres.

 

The Effect of Quinoa (Chenopodium quinoa  Willd.) on the Total Oxidative Stress Drosophila melanogaster Meigen (Diptera: Drosophilidae)

 

ABSTRACT: Chenopodium quinoa Willd.,the consumption of which has increased since 2013, is a good source for essential amino acids, vitamins and minerals. In this paper, it is aimed to determine the total oxidation and antioxidant levels and the interaction between them for Drosophila melanogaster Meigen (Diptera: Drosophilidae) adults fed with quinoa added artificial diets. D. melanogaster larvae were cultivated with quinoa flour (0.1-1%) until the adult stage. Total antioxidant capacity (TAS), total oxidant stress (TOS) and oxidative stress index (OSI) were determined in adults fed with quinoa concentrations. When compared to control, a significant increase was observed in the TOS acitivity (11.55 ± 0.07 µmol) of the insect fed with the lowest concentration (0.1%). It was detected that while quinoa adding to the nutritional compounds increased the level of oxidation, the level of antioxidant activity unchanged. The consumption of large amounts of quinoa increased antioxidant activity (1.85 ± 0.03 mmol). It is emphasized that the usage of quinoa as an eco-friendly method might play an important role for protection of the enviroment.

Keywords: Quinoa, Drosophila melanogaster, Nutrition, Oxidative Stress

Kaynakça

  • Adler, M.I., Bonduriansky, R. 2014. Why do the well-fed appear to die young?: a new evolutionary hypothesis for the effect of dietary restriction on lifespan. Bioessays, 36: 439-450.
  • Ahmad, S. 1992. Biochemical Defence of Pro-Oxidant Plant Allelochemicals by Herbivorous Insects. Biochemical Ecology System, 20: 269-296.
  • Altun Çolak, D. 2013. Dioksinlerin Toksik Etkilerinin Drosophila Kanat Benek Testi ve Biyokimyasal Yöntemlerle Belirlenmesi ve Bu Etkilerin Farklı Antioksidanlar ile Giderilmesi Üzerine Araştırmalar. AÜ.Fen Bil. Ens., Biyoloji ABD, Doktora Tezi, 171 s.
  • Bahadorani, S., Bahadorani P., Philips J.P., Hilliker A.J. 2008. The Effects of Vitamin Supplementation on Drosophila Life Span Under Normoxia and Under Oxidative Stress. Journal of Gerontology. Biological Sciences, 63A(1): 35-42.
  • Bahadorani, S., Hilliker, A. J. 2008. Cocoa Confers Life Span Extension in Drosophila melanogaster. Nutrition Research, 28: 377-382.
  • Barbehenn, R.V., Stannard, J. 2004. Antioxidant Defense of The Midgut Epithelium by The Peritrophic Envelope in Caterpillars. Journal of Insect Physiology, 50: 783-790.
  • Bruce, K. D., Hoxha, S., Carvalho, G. B., Yamada, R., Wang, H. D., Karayan, P., .....William, W. J. 2013. High Carbohydrate-Low Protein Consumption Maximizes Drosophila lifespan. Journal of Experimental Gerontolog, 48: 1129-1135.
  • Chapman, T., Partridge, L. 1996. Female fitness in Drosophila melanogaster:an Interaction Between The Effect of Nutrition and of Encounter Rate With Males. Proceeding of the Royal Society of London Series B Biological Sciences, 263: 755-759.
  • Clark, A.M., Rockstein, M. 1964. Aging in Insect. Physiology of insecta, 1: 227-281.
  • Çobanoğlu, S. 2011. Deneysel Ateroskleroz Oluşturulmuş Sıçanlarda L-Argininin TAS, TOS ve Oksidatif Stres İndeksine Etkisi. TÜ.Sağlık Bil. Ens., Tıbbi Biyokimya ABD, Yüksek Lisans Tezi,93 s.
  • Cui, X., Dai, X.G., Li, W.B., Zhang, B.L., Fang, Y.Z. 1999. Effects of Lu-Duo-Wei Capsule on Prolonging Life Span of Housefly and Drosophila melanogaster. American Journal of Chinese Medicine, 27: 407.
  • De Moed, G.H., Kruitwagen, C.L.J.J., De Jong, G., Scharloo, W. 1999. Critical Weight for the Induction of Pupariation in Drosophila melanogaster: Genetic and Environmental Variation. Journal of Evolutionary Biology, 852-858.
  • Demir, E., Kaya, B., Marcos, R., Kocaoğlu Cenkci, S., Çetin H. 2013. Investigation of the Genotoxic and Antigenotoxic Properties of Essential Oils Obtained From TwoOriganum species by Drosophila wing SMART assay.Turkish Journal of Biology, 37: 129-138.
  • Driver, C.J., Cosopodiotis, G. 1979. The Effect Of Dietary Fat On Longevity of Drosophila melanogaster. Journal of Experimental Gerontolog, 14: 95-100.
  • Ekmekçi, İ. 2014. Glutensiz Ekşi Maya Ekmeği Üretimi Için Starter Kültür Oluşturulması. EÜ. Fen Bil. Ens., Gıda Mühendisiliği ABD, Yüksek lisans Tezi, 84 s.
  • Erel, O. 2004. A Novel Automated Direct Measurement Method for Total Antioxidant Capacity Using A New Generation, More Stable ABTS Radical Cation. Clinical Biochemistry, 37(4): 277-285.
  • Erel, O. 2005. A New Automated Colorimetric Method For Measuring Total Oxidant Status. Clinical Biochemistry, 38: 1103-1111.
  • Fanson, B.G., Taylor, P.W. 2012. Protein:carbohydrate ratios explain life span patterns found in Queensl and fruit fly on diets varying in yeast:sugar ratios. Age (Dordr), 34: 1361-1368.
  • Felton, G.W., Summers, C.B. 1995. Antioxidant Systems in Insects. Archives of Insect Biochemistry and Physiology, 9: 187-197.
  • Fidan, A.F. 2007. Deneysel Diyabet Oluşturulmuş Ratlarda Diyete Katilan Farklı Yapılardaki Saponin Içerikli Bitkilerin Dna Hasari, Protein Oksidasyonu ve Lipid Peroksidasyonu ile Bazi Biyokimyasal Parametrelere Etkilerinin Araştirilmasi. AKÜ. Sağ Bil. Ens., Biyokimya ABD, Doktora Tezi, 138 s.
  • Ghiselli, A., Serafini, M., Natella, F., Scaccini, C. 2000. Total Antioxidant Capacity as A Tool to Assess Redox Status: Critical View and Experimental Data. Free Radical Biology and Medicine, 29(11): 1106-1114.
  • Güneş, E. 2015. Drosophila melanogaster'de Yulaf Unu (Avena sativa L.)'nun Total Oksidatif Stres Üzerinde Etkisi. Anadolu Doğa Bilimleri Dergisi, 6(2): 134-140.
  • Guzmán, B., Tenorio, R., Cruz, D.L., Espinal, C., Alvarado, J.A., Mollinedo, P. 2015. Saponins from chenopodium quinoa willd and chenopodium pallidicaule aellen as biocontrollers of phytopathogen fungi and hemolysis agents. Revista Boliviana De Química,32 (1): 8-14.
  • Halliwell, B. 1994. Free Radicals, Antioxidant, And Human Disease: Curiosity. Cause or Consequence. Lancet, 344: 721-724.
  • Heinle, H., Betz, E. 1994. Effects of Dietary Garlic Supplemantation in Rat Model of Atherosclerosis. Arznei-for, 44: 614-617.
  • Heinrichsen, E.T., Zhang, H., Robinson, J.E.,Ngo, J., Diop, S., Bodmer, R., Joiner, W.J., Metallo, C.M., Haddad, G.G. 2013. Metabolic and Transcriptional Response to A High-Fat DietinDrosophila melanogaster. Molecular Metabolism, 3: 42-54.
  • Ja, W.W., Carvalho, G.B., Zid, B.M., Mak, E.M., Brummel, T., et al. 2009. Water- And Nutrient-Dependent Effects of Dietary Restriction on Drosophila lifespan. Proceedings of the National Academy of Sciences, 106: 18633-18637.
  • Jancurová, M., Minarovičová, L., Dandár, A. 2009. Quinoa. Czech Journal of Food Science, 27(2): 71-79.
  • Jordens, R.G., Berry, M.D., Gillott, C., Boulton A.A. 1999. Prolongation of Life in an Experimental Model of Ageing in Drosophila melanogaster. Neurochemical Research. 24(2): 227-233.
  • Kaya, B., Yanıkoglu, A., Creus, A., Marcos, R.2000. The Use of The Drosophila Wing Spot Test inThe Genotoxicity Testing of Different Herbicides. Environmental and Molecular Mutagenesis, 36: 40-46.
  • Kaya, B., Creus, A., Velazquez, A., Yanikoglu, A. 2002. Marcos R Genotoxicity is Modulated ByAscorbic Acid - Studies Using The Wing Spot Test in Drosophila.Mutation Research,520(1-2): 93-101.
  • Keser, D. 2010. Aspirin ve Asetaldehitin Drosophila melanogaster’in Bazı Gelişimsel Özellikleri Üzerine Etkileri. KÜ. Fen Bil. Ens., Biyoloji ABD, Yüksek Lisans Tezi, 68 s.
  • Kono, Y., Shishido,T. 1992. Distribution of Glutathione S-Transferase Activity in Insect Tissues. Applied Entomology and Zoology, 27: 391-397.
  • Kosecik, M., Erel, O., Sevinc, E., Selek, S. 2005. Increased Oxidative Stress in Children Exposed to Passive Smoking. The International Journal of Cardiology, 100(1): 61-4.
  • Lee, K. P., Simpson, S. J., Clissold, F. J., Brooks, R., Ballard, J. W. O., Taylor, P. W., … Raubenheimer, D. 2008. Lifespan and Reproduction in Drosophila: New Insights From Nutritional Geometry. Proceedings of the National Academy of Sciences, 105: 2498-2503.
  • Lesch, C., Goto, A., Lindgren, M., Bidla, G., Dushay, M.S. ,Theopold, U. 2007. A Role for Hemolectin in Coagulation and Immunity in Drosophila melanogaster. Developmental and Comparative Immunology, 31: 1255-1263.
  • Li, Y.M., Chan, H.Y.E., Huang, Y., Chen, Z.Y. 2007. Green Tea Catechins Upregulate Superoxide Dismutase and Catalase in Fruit Flies. Molecular Nutriotion and Food Research, 51(5): 546-554.
  • Missirlis, F., Rahlfs, S., Dimopoulos, N., Bauer, H., Becker, K., Hilliker, A., Phillips, J.P. 2003. A Putative Glutathione Peroxidase of Drosophila Encodes Thioredoxin Peroxidase That Provides Resistance Against Oxidative Stress But Fails to Complement A Lack of Catalase Activity. The Journal of Biological Chemistry, 384(3): 463-472.
  • Moskovitz, J., Berlett, B.S., Poston, J.M., Stadtman, E.R. 1997. The Yeast Peptidemethionine Sulfoxide Reductase Functions as on Antioxidant In Vivo. Proceedings of the National Academy of Sciences of the United States of America, 94: 9585-9589.
  • Nsimba, R.Y., Kikuzaki, H., Konishi, Y. 2008. Antioxidant Activity of Various Extracts and Fractions of Chenopodium quinoa and Amaranthus spp. seeds. Food Chemistry, 106: 760-766.
  • Özgün, E., Özgün, G.S., Eskiocak, S., Yalçın, Ö., Gökmen, S.S. 2013. Deneysel Kolitte L-Karnitinin Serum Paraoksonaz, Arilesteraz ve Laktonaz Aktivitelerine ve Oksidatif Duruma Etkisi. Türk Biyokimya Dergisi, 38(2): 145-153.
  • Paredes, L.E.B. 2010.Determinacion De La Activided Insecticida De La Saponina De Quinoa (Chenopodium quinoa) Hidrolizada Y No Hidrolizada Sobre Drosophila melanogaster. Esuela Superior Politecnica De Chimborazo, Faculted De Ciencias, Tesis De Grado, 127 p.
  • Piper, M.D.W , Mair, W., Partridge, L. 2005. Counting the Calories: The Role of Specific Nutrients in Extension of Life Span by Food Restriction. Journal of Gerontolog, 60A(5): 549-555.
  • Rogina, B., Reenan, R.A., Nilsen, S.P., Helfand, S.L. 2000. Extended Life-Span Conferred by Cotransporter Gene Mutations in Drosophila. Biogerontology Science, 290: 2137-2140.
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Yıl 2016, Cilt: 19 Sayı: 3, 261 - 267, 29.10.2016

Öz

Kaynakça

  • Adler, M.I., Bonduriansky, R. 2014. Why do the well-fed appear to die young?: a new evolutionary hypothesis for the effect of dietary restriction on lifespan. Bioessays, 36: 439-450.
  • Ahmad, S. 1992. Biochemical Defence of Pro-Oxidant Plant Allelochemicals by Herbivorous Insects. Biochemical Ecology System, 20: 269-296.
  • Altun Çolak, D. 2013. Dioksinlerin Toksik Etkilerinin Drosophila Kanat Benek Testi ve Biyokimyasal Yöntemlerle Belirlenmesi ve Bu Etkilerin Farklı Antioksidanlar ile Giderilmesi Üzerine Araştırmalar. AÜ.Fen Bil. Ens., Biyoloji ABD, Doktora Tezi, 171 s.
  • Bahadorani, S., Bahadorani P., Philips J.P., Hilliker A.J. 2008. The Effects of Vitamin Supplementation on Drosophila Life Span Under Normoxia and Under Oxidative Stress. Journal of Gerontology. Biological Sciences, 63A(1): 35-42.
  • Bahadorani, S., Hilliker, A. J. 2008. Cocoa Confers Life Span Extension in Drosophila melanogaster. Nutrition Research, 28: 377-382.
  • Barbehenn, R.V., Stannard, J. 2004. Antioxidant Defense of The Midgut Epithelium by The Peritrophic Envelope in Caterpillars. Journal of Insect Physiology, 50: 783-790.
  • Bruce, K. D., Hoxha, S., Carvalho, G. B., Yamada, R., Wang, H. D., Karayan, P., .....William, W. J. 2013. High Carbohydrate-Low Protein Consumption Maximizes Drosophila lifespan. Journal of Experimental Gerontolog, 48: 1129-1135.
  • Chapman, T., Partridge, L. 1996. Female fitness in Drosophila melanogaster:an Interaction Between The Effect of Nutrition and of Encounter Rate With Males. Proceeding of the Royal Society of London Series B Biological Sciences, 263: 755-759.
  • Clark, A.M., Rockstein, M. 1964. Aging in Insect. Physiology of insecta, 1: 227-281.
  • Çobanoğlu, S. 2011. Deneysel Ateroskleroz Oluşturulmuş Sıçanlarda L-Argininin TAS, TOS ve Oksidatif Stres İndeksine Etkisi. TÜ.Sağlık Bil. Ens., Tıbbi Biyokimya ABD, Yüksek Lisans Tezi,93 s.
  • Cui, X., Dai, X.G., Li, W.B., Zhang, B.L., Fang, Y.Z. 1999. Effects of Lu-Duo-Wei Capsule on Prolonging Life Span of Housefly and Drosophila melanogaster. American Journal of Chinese Medicine, 27: 407.
  • De Moed, G.H., Kruitwagen, C.L.J.J., De Jong, G., Scharloo, W. 1999. Critical Weight for the Induction of Pupariation in Drosophila melanogaster: Genetic and Environmental Variation. Journal of Evolutionary Biology, 852-858.
  • Demir, E., Kaya, B., Marcos, R., Kocaoğlu Cenkci, S., Çetin H. 2013. Investigation of the Genotoxic and Antigenotoxic Properties of Essential Oils Obtained From TwoOriganum species by Drosophila wing SMART assay.Turkish Journal of Biology, 37: 129-138.
  • Driver, C.J., Cosopodiotis, G. 1979. The Effect Of Dietary Fat On Longevity of Drosophila melanogaster. Journal of Experimental Gerontolog, 14: 95-100.
  • Ekmekçi, İ. 2014. Glutensiz Ekşi Maya Ekmeği Üretimi Için Starter Kültür Oluşturulması. EÜ. Fen Bil. Ens., Gıda Mühendisiliği ABD, Yüksek lisans Tezi, 84 s.
  • Erel, O. 2004. A Novel Automated Direct Measurement Method for Total Antioxidant Capacity Using A New Generation, More Stable ABTS Radical Cation. Clinical Biochemistry, 37(4): 277-285.
  • Erel, O. 2005. A New Automated Colorimetric Method For Measuring Total Oxidant Status. Clinical Biochemistry, 38: 1103-1111.
  • Fanson, B.G., Taylor, P.W. 2012. Protein:carbohydrate ratios explain life span patterns found in Queensl and fruit fly on diets varying in yeast:sugar ratios. Age (Dordr), 34: 1361-1368.
  • Felton, G.W., Summers, C.B. 1995. Antioxidant Systems in Insects. Archives of Insect Biochemistry and Physiology, 9: 187-197.
  • Fidan, A.F. 2007. Deneysel Diyabet Oluşturulmuş Ratlarda Diyete Katilan Farklı Yapılardaki Saponin Içerikli Bitkilerin Dna Hasari, Protein Oksidasyonu ve Lipid Peroksidasyonu ile Bazi Biyokimyasal Parametrelere Etkilerinin Araştirilmasi. AKÜ. Sağ Bil. Ens., Biyokimya ABD, Doktora Tezi, 138 s.
  • Ghiselli, A., Serafini, M., Natella, F., Scaccini, C. 2000. Total Antioxidant Capacity as A Tool to Assess Redox Status: Critical View and Experimental Data. Free Radical Biology and Medicine, 29(11): 1106-1114.
  • Güneş, E. 2015. Drosophila melanogaster'de Yulaf Unu (Avena sativa L.)'nun Total Oksidatif Stres Üzerinde Etkisi. Anadolu Doğa Bilimleri Dergisi, 6(2): 134-140.
  • Guzmán, B., Tenorio, R., Cruz, D.L., Espinal, C., Alvarado, J.A., Mollinedo, P. 2015. Saponins from chenopodium quinoa willd and chenopodium pallidicaule aellen as biocontrollers of phytopathogen fungi and hemolysis agents. Revista Boliviana De Química,32 (1): 8-14.
  • Halliwell, B. 1994. Free Radicals, Antioxidant, And Human Disease: Curiosity. Cause or Consequence. Lancet, 344: 721-724.
  • Heinle, H., Betz, E. 1994. Effects of Dietary Garlic Supplemantation in Rat Model of Atherosclerosis. Arznei-for, 44: 614-617.
  • Heinrichsen, E.T., Zhang, H., Robinson, J.E.,Ngo, J., Diop, S., Bodmer, R., Joiner, W.J., Metallo, C.M., Haddad, G.G. 2013. Metabolic and Transcriptional Response to A High-Fat DietinDrosophila melanogaster. Molecular Metabolism, 3: 42-54.
  • Ja, W.W., Carvalho, G.B., Zid, B.M., Mak, E.M., Brummel, T., et al. 2009. Water- And Nutrient-Dependent Effects of Dietary Restriction on Drosophila lifespan. Proceedings of the National Academy of Sciences, 106: 18633-18637.
  • Jancurová, M., Minarovičová, L., Dandár, A. 2009. Quinoa. Czech Journal of Food Science, 27(2): 71-79.
  • Jordens, R.G., Berry, M.D., Gillott, C., Boulton A.A. 1999. Prolongation of Life in an Experimental Model of Ageing in Drosophila melanogaster. Neurochemical Research. 24(2): 227-233.
  • Kaya, B., Yanıkoglu, A., Creus, A., Marcos, R.2000. The Use of The Drosophila Wing Spot Test inThe Genotoxicity Testing of Different Herbicides. Environmental and Molecular Mutagenesis, 36: 40-46.
  • Kaya, B., Creus, A., Velazquez, A., Yanikoglu, A. 2002. Marcos R Genotoxicity is Modulated ByAscorbic Acid - Studies Using The Wing Spot Test in Drosophila.Mutation Research,520(1-2): 93-101.
  • Keser, D. 2010. Aspirin ve Asetaldehitin Drosophila melanogaster’in Bazı Gelişimsel Özellikleri Üzerine Etkileri. KÜ. Fen Bil. Ens., Biyoloji ABD, Yüksek Lisans Tezi, 68 s.
  • Kono, Y., Shishido,T. 1992. Distribution of Glutathione S-Transferase Activity in Insect Tissues. Applied Entomology and Zoology, 27: 391-397.
  • Kosecik, M., Erel, O., Sevinc, E., Selek, S. 2005. Increased Oxidative Stress in Children Exposed to Passive Smoking. The International Journal of Cardiology, 100(1): 61-4.
  • Lee, K. P., Simpson, S. J., Clissold, F. J., Brooks, R., Ballard, J. W. O., Taylor, P. W., … Raubenheimer, D. 2008. Lifespan and Reproduction in Drosophila: New Insights From Nutritional Geometry. Proceedings of the National Academy of Sciences, 105: 2498-2503.
  • Lesch, C., Goto, A., Lindgren, M., Bidla, G., Dushay, M.S. ,Theopold, U. 2007. A Role for Hemolectin in Coagulation and Immunity in Drosophila melanogaster. Developmental and Comparative Immunology, 31: 1255-1263.
  • Li, Y.M., Chan, H.Y.E., Huang, Y., Chen, Z.Y. 2007. Green Tea Catechins Upregulate Superoxide Dismutase and Catalase in Fruit Flies. Molecular Nutriotion and Food Research, 51(5): 546-554.
  • Missirlis, F., Rahlfs, S., Dimopoulos, N., Bauer, H., Becker, K., Hilliker, A., Phillips, J.P. 2003. A Putative Glutathione Peroxidase of Drosophila Encodes Thioredoxin Peroxidase That Provides Resistance Against Oxidative Stress But Fails to Complement A Lack of Catalase Activity. The Journal of Biological Chemistry, 384(3): 463-472.
  • Moskovitz, J., Berlett, B.S., Poston, J.M., Stadtman, E.R. 1997. The Yeast Peptidemethionine Sulfoxide Reductase Functions as on Antioxidant In Vivo. Proceedings of the National Academy of Sciences of the United States of America, 94: 9585-9589.
  • Nsimba, R.Y., Kikuzaki, H., Konishi, Y. 2008. Antioxidant Activity of Various Extracts and Fractions of Chenopodium quinoa and Amaranthus spp. seeds. Food Chemistry, 106: 760-766.
  • Özgün, E., Özgün, G.S., Eskiocak, S., Yalçın, Ö., Gökmen, S.S. 2013. Deneysel Kolitte L-Karnitinin Serum Paraoksonaz, Arilesteraz ve Laktonaz Aktivitelerine ve Oksidatif Duruma Etkisi. Türk Biyokimya Dergisi, 38(2): 145-153.
  • Paredes, L.E.B. 2010.Determinacion De La Activided Insecticida De La Saponina De Quinoa (Chenopodium quinoa) Hidrolizada Y No Hidrolizada Sobre Drosophila melanogaster. Esuela Superior Politecnica De Chimborazo, Faculted De Ciencias, Tesis De Grado, 127 p.
  • Piper, M.D.W , Mair, W., Partridge, L. 2005. Counting the Calories: The Role of Specific Nutrients in Extension of Life Span by Food Restriction. Journal of Gerontolog, 60A(5): 549-555.
  • Rogina, B., Reenan, R.A., Nilsen, S.P., Helfand, S.L. 2000. Extended Life-Span Conferred by Cotransporter Gene Mutations in Drosophila. Biogerontology Science, 290: 2137-2140.
  • Sarıkaya, R., K. Erciyas, A.F. Erciyas, S. Ay, M.İ. Kara, Sezer, U. 2012. Antioksidanların (Bor ve Thymoqinone) Antigenotoksik Etkilerinin Drosophila Somatik Mutasyon ve Rekombinasyon Testi İle Araştırılması. Tübitak, Araştırma Projesi, 210T159.
  • Schriner, S. E., Lee, K., Truong, S., Salvadora, K. T., Maler, S., Nam, A., ... …Jafari, M. 2013. Extension of Drosophila Lifespan by Rhodiola rosea through a Mechanism Independent from Dietary Restriction. Plos One,8(5): e63886.
  • Sentinella, A.T., Crean, A.J , Bonduriansky, R. 2013. Dietary Protein Mediates A Trade-Off Between Larval Survival and The Development of Male Secondary Sexual Traits. Functional Ecology, 27: 1134-144.
  • Singh, K.K. 1998. Mitochondrial DNA Mutations in Aging, Disease and Cancer. Springer. New York.
  • Sisodia, S., Singh, B.N. 2012. Experimental Evidence for Nutrition Regulated Stress Resistance in Drosophila ananassae. Plos One, 7(10): 1-9.
  • Sortibrán, A.N.C., Téllez, M.G.O., Arnaiz, R.R. 2015. Assessment of the Genotoxic and Antioxidant Activities of Several Vegetables, Spices and Herbs in Combination with Cyclophosphamide and 4-Nitroquinoline n-Oxide in Drosophila melanogaster. Advance Techniques in Biology and Medicine, 1: 2-9.
  • Tarpey, M.M., Wink, D.A., Grisham, M.B. 2004. Methods for Detection of Reactive Metabolites of Oxygen and Nitrogen: in Vitro And in Vivo Considerations. AJP Regulatory Integrative and Comparative Physiology, 286(3): R431-44.
  • Taşkın, V., K. Küçükakyüz, T. Arslan, B. Çöl, Taşkın Göçmen, B. 2007. The biochemical basis of insecticide resistance and determination of esterase enzyme patterns by using PAGE in field collected populations of Drosophila melanogaster from Muğla province of Turkey. Journal of Cell and Molecular Biology, 6(1): 31-40.
  • Turna, F. 2012. Resveratrol’ün Drosophila melanogaster’de Antigenotoksik Etkilerinin Araştırılması. AÜ. Fen Bil. Ens., Biyoloji ABD, Yüksek Lisans Tezi, 81 s.
  • Unckless, R.L., Rottschaefer, S.M., Lazzaro, B.P. 2015. The Complex Contributions of Genetics and Nutrition to immunity in Drosophila melanogaster. PLOS Genetics, 1-26.
  • Uysal, H., Altun, D., Aslan, A. 2009. Drosophila melanogaster'de Lobaria pulmonaria (L.) Hoffm. Likeninin Ömür Uzunluğu Üzerine Etkisi. TUBAV Bilim Dergisi, 2: 271-276.
  • Valencia-Chamorro, S.A. 2003. Quinoa. In: Caballero B.: Encyclopedia of Food Science and Nutrition. Academic Press, Amsterdam, 8: 4895-4902.
  • Wohlenberg V.C., Lopes-da-Silva, M.2009. Effect of Chenopodium ambrosioides L. (Chenopodiaceae) Aqueous Extract on Reproduction and Life Span of Drosophila melanogaster (Meigen) (Diptera: Drosophilidae). Bioscience Journal, 25(6):129-132.
  • Yıldız, M. 2013. Timol ve Karvakrolün Drosophila melanogaster Asetilkolinesteraz Enzimi Üzerine Etkilerinin Araştırılması. AÜ. Fen Bil. Ens., Moleküler Biyoloji ve Genetik ABD, Yüksek Lisans Tezi, 68 s.
Toplam 58 adet kaynakça vardır.

Ayrıntılar

Bölüm Makaleler
Yazarlar

Eda Güneş Bu kişi benim

Yayımlanma Tarihi 29 Ekim 2016
Yayımlandığı Sayı Yıl 2016 Cilt: 19 Sayı: 3

Kaynak Göster

APA Güneş, E. (2016). Drosophila melanogaster Meigen (Diptera: Drosophilidae)’de Kinoa (Chenopodium quinoa Willd.)’nın Total Oksidatif Stres Üzerinde Etkisi. KSÜ Doğa Bilimleri Dergisi, 19(3), 261-267.
AMA Güneş E. Drosophila melanogaster Meigen (Diptera: Drosophilidae)’de Kinoa (Chenopodium quinoa Willd.)’nın Total Oksidatif Stres Üzerinde Etkisi. KSÜ Doğa Bilimleri Dergisi. Ekim 2016;19(3):261-267.
Chicago Güneş, Eda. “Drosophila Melanogaster Meigen (Diptera: Drosophilidae)’de Kinoa (Chenopodium Quinoa Willd.)’nın Total Oksidatif Stres Üzerinde Etkisi”. KSÜ Doğa Bilimleri Dergisi 19, sy. 3 (Ekim 2016): 261-67.
EndNote Güneş E (01 Ekim 2016) Drosophila melanogaster Meigen (Diptera: Drosophilidae)’de Kinoa (Chenopodium quinoa Willd.)’nın Total Oksidatif Stres Üzerinde Etkisi. KSÜ Doğa Bilimleri Dergisi 19 3 261–267.
IEEE E. Güneş, “Drosophila melanogaster Meigen (Diptera: Drosophilidae)’de Kinoa (Chenopodium quinoa Willd.)’nın Total Oksidatif Stres Üzerinde Etkisi”, KSÜ Doğa Bilimleri Dergisi, c. 19, sy. 3, ss. 261–267, 2016.
ISNAD Güneş, Eda. “Drosophila Melanogaster Meigen (Diptera: Drosophilidae)’de Kinoa (Chenopodium Quinoa Willd.)’nın Total Oksidatif Stres Üzerinde Etkisi”. KSÜ Doğa Bilimleri Dergisi 19/3 (Ekim 2016), 261-267.
JAMA Güneş E. Drosophila melanogaster Meigen (Diptera: Drosophilidae)’de Kinoa (Chenopodium quinoa Willd.)’nın Total Oksidatif Stres Üzerinde Etkisi. KSÜ Doğa Bilimleri Dergisi. 2016;19:261–267.
MLA Güneş, Eda. “Drosophila Melanogaster Meigen (Diptera: Drosophilidae)’de Kinoa (Chenopodium Quinoa Willd.)’nın Total Oksidatif Stres Üzerinde Etkisi”. KSÜ Doğa Bilimleri Dergisi, c. 19, sy. 3, 2016, ss. 261-7.
Vancouver Güneş E. Drosophila melanogaster Meigen (Diptera: Drosophilidae)’de Kinoa (Chenopodium quinoa Willd.)’nın Total Oksidatif Stres Üzerinde Etkisi. KSÜ Doğa Bilimleri Dergisi. 2016;19(3):261-7.