Araştırma Makalesi
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Yıl 2021, Cilt: 11 Sayı: 1, 73 - 86, 30.06.2021
https://doi.org/10.37094/adyujsci.782874

Öz

Kaynakça

  • [1] Pistrick, K., Mansfeld’s Encyclopedia of Agricultural and Horticultural Crops. 1st ed, 2001.
  • [2] Erten, H., Tanguler, H., Canbaş, A., A traditional Turkish lactic acid fermented beverage: shalgam (salgam), Food Reviews International, 24(3), 352–359, 2008.
  • [3] Montilla, E.C., Arzaba, M.R., Hillebrand, S. et al., Anthocyanin composition of black carrot (daucus carota ssp sativus var atrorubens alef) cultivars Antonina, Beta Sweet, Deep Purple, and Purple Haze, Journal of Agricultural and Food Chemistry, 59(7), 3385–3390, 2011.
  • [4] Kırca, A., Özkan, M., Cemeroglu, B., Stability of black carrot anthocyanins in various fruit juices and nectars, Food Chemistry, 97(4), 598–605, 2006.
  • [5] Kaur, A., Singh Sogi, D., Influence of development stages on the physicochemical properties of black carrots (Daucus carota L), Cogent Food & Agriculture, 6(1), 1841358, 2020.
  • [6] Yildiz, E., Guldas, M., Gurbuz, O., Determination of in-vitro phenolics, antioxidant capacity and bio-accessibility of Kombucha tea produced from black carrot varieties grown in Turkey, Food Science and Technology, 2020.
  • [7] Nouri, M., Khaki, A., Azar, F.F. et al., The protective effects of carrot seed extract on spermatogenesis and cauda epididymal sperm reserves in gentamicin treated rats, Yakhteh, 11(3), 327–333, 2009.
  • [8] Yakubu, M.T., Opakunle, F.K., Salimon, S.S., Effects of the ethanolic extract of Daucus carota L seeds on acetaminophen-induced uremia and antiandrogenicity in male rats, Tropical Journal of Health Sciences, 24(3), 33–40, 2017.
  • [9] Goodson, A., Robin, H., Summerfield, W. et al., Migration of bisphenol A from can coatings—effects of damage, storage conditions and heating, Food Additives and Contaminants, 21(10), 1015–1026, 2004.
  • [10] Geens, T., Aerts, D., Berthot, C. et al., A review of dietary and non-dietary exposure to bisphenol-A, Food and Chemical Toxicology, 50(10), 3725–3740, 2012.
  • [11] vom Saal, F.S., Akingbemi, B.T., Belcher, S.M. et al., Chapel Hill bisphenol A expert panel consensus statement: Integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure, Reproductive Toxicology, 24(2), 131–138, 2007.
  • [12] Cariati, F., D’Uonno, N., Borrillo, F. et al., Bisphenol A: an emerging threat to male fertility, Reproductive Biology and Endocrinology, 17(1), 6, 2019.
  • [13] Manfo, F.P.T., Jubendradass, R., Nantia, E.A. et al., Adverse effects of bisphenol A on male reproductive function, Reviews of environmental contamination and toxicology, 228, 57–82, 2014.
  • [14] Aitken, R.J., Roman, S.D., Antioxidant systems and oxidative stress in the testes, Oxidative Medicine and Cellular Longevity, 1(1), 15–24, 2008.
  • [15] Doreswamy, K., Muralidhara, Genotoxic consequences associated with oxidative damage in testis of mice subjected to iron intoxication, Toxicology, 206(1), 169–178, 2005.
  • [16] Nahar, M.S., Kim, J.H., Sartor, M.A. et al., Bisphenol A-associated alterations in the expression and epigenetic regulation of genes encoding xenobiotic metabolizing enzymes in human fetal liver, Environmental and Molecular Mutagenesis, 55(3), 184–195, 2014.
  • [17] Mikhailov, A.T., Torrado, M., Carboxylesterase overexpression in the male reproductive tract: a universal safeguarding mechanism, Reproduction, Fertility and Development, 11(3), 133, 1999.
  • [18] Balasubramaniam, P., Pari, L., Menon, V.P., Protective effect of carrot (daucus carota L) against lindane - induced hepatotoxicity in rats, Phytotherapy Research, 12(6), 434–436, 1998.
  • [19] Bindhumol, V., Chitra, K.C., Mathur, P.P., Bisphenol A induces reactive oxygen species generation in the liver of male rats, Toxicology, 188(2–3), 117–124, 2003.
  • [20] Ozkaya, A., Sahin, Z., Kuzu, M. et al., Role of geraniol against lead acetate-mediated hepatic damage and their interaction with liver carboxylesterase activity in rats, Archives of Physiology and Biochemistry, 124(1), 80–87, 2018.
  • [21] Bradford, M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Analytical Biochemistry, 72(1–2), 248–254, 1976.
  • [22] Nousiainen, U., Törrönen, R., Differentiation of microsomal and cytosolic carboxylesterases in the rat liver by in vivo and in vitro inhibition, General Pharmacology: The Vascular System, 15(3), 223–227, 1984.
  • [23] Placer, Z.A., Cushman, L.L., Johnson, B.C., Estimation of product of lipid peroxidation (malonyl dialdehyde) in biochemical systems, Analytical Biochemistry, 16(2), 359–364, 1966.
  • [24] Moron, M., Depierre, J., Mannervik, B., Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver, Biochimica et Biophysica Acta (BBA) - General Subjects, 582(1), 67–78, 1979.
  • [25] Habig, W.H., Pabst, M.J., Jakoby, W.B., Glutathione S-transferases the first enzymatic step in mercapturic acid formation, The Journal of Biological Chemistry, 249(22), 7130–7139, 1974.
  • [26] Satoh, T., Hosokawa, M., The mammalian carboxylesterases: from molecules to functions, Annual Review of Pharmacology and Toxicology, 38(1), 257–288, 1998.
  • [27] Holmes, R.S., Wright, M.W., Laulederkind, S.J.F. et al., Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins, Mammalian Genome, 21(9–10), 427–441, 2010.
  • [28] Sanghani, S.P., Sanghani, P.C., Schiel, M.A. et al., Human carboxylesterases: an update on CES1, CES2 and CES3, Protein & Peptide Letters, 16(10), 1207–1214, 2009.
  • [29] Zhou, Y.-C., Zhang, Y.-L., Ru, Y.-F. et al., An epididymis-specific carboxyl esterase CES5A is required for sperm capacitation and male fertility in the rat, Asian Journal of Andrology, 17(2), 292, 2015.
  • [30] Jewell, W.T., Miller, M.G., Identification of a carboxylesterase as the major protein bound by molinate, Toxicology and Applied Pharmacology, 149(2), 226–234, 1998.
  • [31] Hess, R.A., Effects of environmental toxicants on the efferent ducts, epididymis and fertility, Journal of Reproduction and Fertility. Supplement, 53, 247–259, 1998.
  • [32] Chapin, R.E., Phelps, J.L., Somkuti, S.G. et al., The interaction of Sertoli and Leydig cells in the testicular toxicity of tri-o-cresyl phosphate, Toxicology and Applied Pharmacology, 104(3), 483–495, 1990.
  • [33] Jiang, X., Li, X., Zhu, C. et al., The target cells of anthocyanins in metabolic syndrome, Critical Reviews in Food Science and Nutrition, 59(6), 921–946, 2019.
  • [34] Cassidy, A., Mukamal, K.J., Liu, L. et al., High anthocyanin intake is associated with a reduced risk of myocardial infarction in young and middle-aged women, Circulation, 127(2), 188–196, 2013.
  • [35] Cassidy, A., Bertoia, M., Chiuve, S. et al., Habitual intake of anthocyanins and flavanones and risk of cardiovascular disease in men, The American Journal of Clinical Nutrition, 104(3), 587–594, 2016.
  • [36] Scotter, M.J., Methods for the determination of European Union-permitted added natural colours in foods: a review, Food Additives & Contaminants: Part A, 28(5), 527–596, 2011.
  • [37] Orororo, O.C., Asagba, S.O., Tonukari, N.J. et al., Hibiscus Sabdarrifa L anthocyanins-induced changes in reproductive hormones of cadmium-exposed rats, International Journal of Scientific and Research Publications (IJSRP), 8(4), 2018.
  • [38] Wallace, T., Slavin, M., Frankenfeld, C., Systematic review of anthocyanins and markers of cardiovascular disease, Nutrients, 8(1), 32, 2016.
  • [39] Gu, X., Zhang, N., Xie, Y. et al., Metarhizium anisopliae CQMa128 regulates antioxidant/detoxification enzymes and exerts acaricidal activity against Psoroptes ovis var cuniculi in rabbits: A preliminary study, Veterinary Parasitology, 279, 109059, 2020.
  • [40] Kong, J.-M., Chia, L.-S., Goh, N.-K. et al., Analysis and biological activities of anthocyanins, Phytochemistry, 64(5), 923–933, 2003.
  • [41] Leong, S.Y., Burritt, D.J., Hocquel, A. et al., The relationship between the anthocyanin and vitamin C contents of red-fleshed sweet cherries and the ability of fruit digests to reduce hydrogen peroxide-induced oxidative stress in Caco-2 cells, Food Chemistry, 227, 404–412, 2017.

Evaluating Effects of Black Carrot Extract on Testicular Carboxylesterase Activity and Oxidative Stress Parameters in Rats Exposed to Bisphenol A

Yıl 2021, Cilt: 11 Sayı: 1, 73 - 86, 30.06.2021
https://doi.org/10.37094/adyujsci.782874

Öz

We aimed to evaluate the effects of black carrot extract on testicular carboxylesterase (Ces) activity, malondialdehyde (MDA), glutathione S-transferases (GST) and reduced glutathione (GSH) in male rats exposed to bisphenol A (BPA). Adult Wistar albino male rats were divided into 4 groups as follows (n = 7/group): control, BPA, black carrot and BPA+Black carrot. Testicular Ces, MDA, GST and reduced GSH were analyzed by using a spectrophotometer system. Testicular Ces activity was significantly lower only in the BPA group than the control group (p < 0.001). Testicular MDA concentrations were higher only in the BPA group compared with the control group (p < 0.001). Reduced GSH level was higher in the black carrot and BPA+Black carrot groups than the control group (p < 0.05). GST activity was lower in the BPA group in comparison to the control group (p < 0.05). In the black carrot and BPA+Black carrot groups, the GST activities were higher than the control group (p < 0.001). Our results showed BPA suppresses testicular detoxification activity and increases lipid peroxidation in rats. We observed that black carrot extract has a beneficial effect on the toxic and oxidative stress-related parameters caused by BPA exposure.

Kaynakça

  • [1] Pistrick, K., Mansfeld’s Encyclopedia of Agricultural and Horticultural Crops. 1st ed, 2001.
  • [2] Erten, H., Tanguler, H., Canbaş, A., A traditional Turkish lactic acid fermented beverage: shalgam (salgam), Food Reviews International, 24(3), 352–359, 2008.
  • [3] Montilla, E.C., Arzaba, M.R., Hillebrand, S. et al., Anthocyanin composition of black carrot (daucus carota ssp sativus var atrorubens alef) cultivars Antonina, Beta Sweet, Deep Purple, and Purple Haze, Journal of Agricultural and Food Chemistry, 59(7), 3385–3390, 2011.
  • [4] Kırca, A., Özkan, M., Cemeroglu, B., Stability of black carrot anthocyanins in various fruit juices and nectars, Food Chemistry, 97(4), 598–605, 2006.
  • [5] Kaur, A., Singh Sogi, D., Influence of development stages on the physicochemical properties of black carrots (Daucus carota L), Cogent Food & Agriculture, 6(1), 1841358, 2020.
  • [6] Yildiz, E., Guldas, M., Gurbuz, O., Determination of in-vitro phenolics, antioxidant capacity and bio-accessibility of Kombucha tea produced from black carrot varieties grown in Turkey, Food Science and Technology, 2020.
  • [7] Nouri, M., Khaki, A., Azar, F.F. et al., The protective effects of carrot seed extract on spermatogenesis and cauda epididymal sperm reserves in gentamicin treated rats, Yakhteh, 11(3), 327–333, 2009.
  • [8] Yakubu, M.T., Opakunle, F.K., Salimon, S.S., Effects of the ethanolic extract of Daucus carota L seeds on acetaminophen-induced uremia and antiandrogenicity in male rats, Tropical Journal of Health Sciences, 24(3), 33–40, 2017.
  • [9] Goodson, A., Robin, H., Summerfield, W. et al., Migration of bisphenol A from can coatings—effects of damage, storage conditions and heating, Food Additives and Contaminants, 21(10), 1015–1026, 2004.
  • [10] Geens, T., Aerts, D., Berthot, C. et al., A review of dietary and non-dietary exposure to bisphenol-A, Food and Chemical Toxicology, 50(10), 3725–3740, 2012.
  • [11] vom Saal, F.S., Akingbemi, B.T., Belcher, S.M. et al., Chapel Hill bisphenol A expert panel consensus statement: Integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure, Reproductive Toxicology, 24(2), 131–138, 2007.
  • [12] Cariati, F., D’Uonno, N., Borrillo, F. et al., Bisphenol A: an emerging threat to male fertility, Reproductive Biology and Endocrinology, 17(1), 6, 2019.
  • [13] Manfo, F.P.T., Jubendradass, R., Nantia, E.A. et al., Adverse effects of bisphenol A on male reproductive function, Reviews of environmental contamination and toxicology, 228, 57–82, 2014.
  • [14] Aitken, R.J., Roman, S.D., Antioxidant systems and oxidative stress in the testes, Oxidative Medicine and Cellular Longevity, 1(1), 15–24, 2008.
  • [15] Doreswamy, K., Muralidhara, Genotoxic consequences associated with oxidative damage in testis of mice subjected to iron intoxication, Toxicology, 206(1), 169–178, 2005.
  • [16] Nahar, M.S., Kim, J.H., Sartor, M.A. et al., Bisphenol A-associated alterations in the expression and epigenetic regulation of genes encoding xenobiotic metabolizing enzymes in human fetal liver, Environmental and Molecular Mutagenesis, 55(3), 184–195, 2014.
  • [17] Mikhailov, A.T., Torrado, M., Carboxylesterase overexpression in the male reproductive tract: a universal safeguarding mechanism, Reproduction, Fertility and Development, 11(3), 133, 1999.
  • [18] Balasubramaniam, P., Pari, L., Menon, V.P., Protective effect of carrot (daucus carota L) against lindane - induced hepatotoxicity in rats, Phytotherapy Research, 12(6), 434–436, 1998.
  • [19] Bindhumol, V., Chitra, K.C., Mathur, P.P., Bisphenol A induces reactive oxygen species generation in the liver of male rats, Toxicology, 188(2–3), 117–124, 2003.
  • [20] Ozkaya, A., Sahin, Z., Kuzu, M. et al., Role of geraniol against lead acetate-mediated hepatic damage and their interaction with liver carboxylesterase activity in rats, Archives of Physiology and Biochemistry, 124(1), 80–87, 2018.
  • [21] Bradford, M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Analytical Biochemistry, 72(1–2), 248–254, 1976.
  • [22] Nousiainen, U., Törrönen, R., Differentiation of microsomal and cytosolic carboxylesterases in the rat liver by in vivo and in vitro inhibition, General Pharmacology: The Vascular System, 15(3), 223–227, 1984.
  • [23] Placer, Z.A., Cushman, L.L., Johnson, B.C., Estimation of product of lipid peroxidation (malonyl dialdehyde) in biochemical systems, Analytical Biochemistry, 16(2), 359–364, 1966.
  • [24] Moron, M., Depierre, J., Mannervik, B., Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver, Biochimica et Biophysica Acta (BBA) - General Subjects, 582(1), 67–78, 1979.
  • [25] Habig, W.H., Pabst, M.J., Jakoby, W.B., Glutathione S-transferases the first enzymatic step in mercapturic acid formation, The Journal of Biological Chemistry, 249(22), 7130–7139, 1974.
  • [26] Satoh, T., Hosokawa, M., The mammalian carboxylesterases: from molecules to functions, Annual Review of Pharmacology and Toxicology, 38(1), 257–288, 1998.
  • [27] Holmes, R.S., Wright, M.W., Laulederkind, S.J.F. et al., Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins, Mammalian Genome, 21(9–10), 427–441, 2010.
  • [28] Sanghani, S.P., Sanghani, P.C., Schiel, M.A. et al., Human carboxylesterases: an update on CES1, CES2 and CES3, Protein & Peptide Letters, 16(10), 1207–1214, 2009.
  • [29] Zhou, Y.-C., Zhang, Y.-L., Ru, Y.-F. et al., An epididymis-specific carboxyl esterase CES5A is required for sperm capacitation and male fertility in the rat, Asian Journal of Andrology, 17(2), 292, 2015.
  • [30] Jewell, W.T., Miller, M.G., Identification of a carboxylesterase as the major protein bound by molinate, Toxicology and Applied Pharmacology, 149(2), 226–234, 1998.
  • [31] Hess, R.A., Effects of environmental toxicants on the efferent ducts, epididymis and fertility, Journal of Reproduction and Fertility. Supplement, 53, 247–259, 1998.
  • [32] Chapin, R.E., Phelps, J.L., Somkuti, S.G. et al., The interaction of Sertoli and Leydig cells in the testicular toxicity of tri-o-cresyl phosphate, Toxicology and Applied Pharmacology, 104(3), 483–495, 1990.
  • [33] Jiang, X., Li, X., Zhu, C. et al., The target cells of anthocyanins in metabolic syndrome, Critical Reviews in Food Science and Nutrition, 59(6), 921–946, 2019.
  • [34] Cassidy, A., Mukamal, K.J., Liu, L. et al., High anthocyanin intake is associated with a reduced risk of myocardial infarction in young and middle-aged women, Circulation, 127(2), 188–196, 2013.
  • [35] Cassidy, A., Bertoia, M., Chiuve, S. et al., Habitual intake of anthocyanins and flavanones and risk of cardiovascular disease in men, The American Journal of Clinical Nutrition, 104(3), 587–594, 2016.
  • [36] Scotter, M.J., Methods for the determination of European Union-permitted added natural colours in foods: a review, Food Additives & Contaminants: Part A, 28(5), 527–596, 2011.
  • [37] Orororo, O.C., Asagba, S.O., Tonukari, N.J. et al., Hibiscus Sabdarrifa L anthocyanins-induced changes in reproductive hormones of cadmium-exposed rats, International Journal of Scientific and Research Publications (IJSRP), 8(4), 2018.
  • [38] Wallace, T., Slavin, M., Frankenfeld, C., Systematic review of anthocyanins and markers of cardiovascular disease, Nutrients, 8(1), 32, 2016.
  • [39] Gu, X., Zhang, N., Xie, Y. et al., Metarhizium anisopliae CQMa128 regulates antioxidant/detoxification enzymes and exerts acaricidal activity against Psoroptes ovis var cuniculi in rabbits: A preliminary study, Veterinary Parasitology, 279, 109059, 2020.
  • [40] Kong, J.-M., Chia, L.-S., Goh, N.-K. et al., Analysis and biological activities of anthocyanins, Phytochemistry, 64(5), 923–933, 2003.
  • [41] Leong, S.Y., Burritt, D.J., Hocquel, A. et al., The relationship between the anthocyanin and vitamin C contents of red-fleshed sweet cherries and the ability of fruit digests to reduce hydrogen peroxide-induced oxidative stress in Caco-2 cells, Food Chemistry, 227, 404–412, 2017.
Toplam 41 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Kimya
Yazarlar

Ahmet Özkaya 0000-0002-0173-3084

Zafer Şahin 0000-0001-7982-7155

Yunus Şahin Bu kişi benim 0000-0003-3185-5282

Özgür Bulmuş 0000-0001-7736-402X

Miraç Uçkun 0000-0002-9018-8515

Ertan Yoloğlu 0000-0002-9730-9471

Yayımlanma Tarihi 30 Haziran 2021
Gönderilme Tarihi 20 Eylül 2020
Kabul Tarihi 20 Nisan 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 11 Sayı: 1

Kaynak Göster

APA Özkaya, A., Şahin, Z., Şahin, Y., Bulmuş, Ö., vd. (2021). Evaluating Effects of Black Carrot Extract on Testicular Carboxylesterase Activity and Oxidative Stress Parameters in Rats Exposed to Bisphenol A. Adıyaman University Journal of Science, 11(1), 73-86. https://doi.org/10.37094/adyujsci.782874
AMA Özkaya A, Şahin Z, Şahin Y, Bulmuş Ö, Uçkun M, Yoloğlu E. Evaluating Effects of Black Carrot Extract on Testicular Carboxylesterase Activity and Oxidative Stress Parameters in Rats Exposed to Bisphenol A. ADYU J SCI. Haziran 2021;11(1):73-86. doi:10.37094/adyujsci.782874
Chicago Özkaya, Ahmet, Zafer Şahin, Yunus Şahin, Özgür Bulmuş, Miraç Uçkun, ve Ertan Yoloğlu. “Evaluating Effects of Black Carrot Extract on Testicular Carboxylesterase Activity and Oxidative Stress Parameters in Rats Exposed to Bisphenol A”. Adıyaman University Journal of Science 11, sy. 1 (Haziran 2021): 73-86. https://doi.org/10.37094/adyujsci.782874.
EndNote Özkaya A, Şahin Z, Şahin Y, Bulmuş Ö, Uçkun M, Yoloğlu E (01 Haziran 2021) Evaluating Effects of Black Carrot Extract on Testicular Carboxylesterase Activity and Oxidative Stress Parameters in Rats Exposed to Bisphenol A. Adıyaman University Journal of Science 11 1 73–86.
IEEE A. Özkaya, Z. Şahin, Y. Şahin, Ö. Bulmuş, M. Uçkun, ve E. Yoloğlu, “Evaluating Effects of Black Carrot Extract on Testicular Carboxylesterase Activity and Oxidative Stress Parameters in Rats Exposed to Bisphenol A”, ADYU J SCI, c. 11, sy. 1, ss. 73–86, 2021, doi: 10.37094/adyujsci.782874.
ISNAD Özkaya, Ahmet vd. “Evaluating Effects of Black Carrot Extract on Testicular Carboxylesterase Activity and Oxidative Stress Parameters in Rats Exposed to Bisphenol A”. Adıyaman University Journal of Science 11/1 (Haziran 2021), 73-86. https://doi.org/10.37094/adyujsci.782874.
JAMA Özkaya A, Şahin Z, Şahin Y, Bulmuş Ö, Uçkun M, Yoloğlu E. Evaluating Effects of Black Carrot Extract on Testicular Carboxylesterase Activity and Oxidative Stress Parameters in Rats Exposed to Bisphenol A. ADYU J SCI. 2021;11:73–86.
MLA Özkaya, Ahmet vd. “Evaluating Effects of Black Carrot Extract on Testicular Carboxylesterase Activity and Oxidative Stress Parameters in Rats Exposed to Bisphenol A”. Adıyaman University Journal of Science, c. 11, sy. 1, 2021, ss. 73-86, doi:10.37094/adyujsci.782874.
Vancouver Özkaya A, Şahin Z, Şahin Y, Bulmuş Ö, Uçkun M, Yoloğlu E. Evaluating Effects of Black Carrot Extract on Testicular Carboxylesterase Activity and Oxidative Stress Parameters in Rats Exposed to Bisphenol A. ADYU J SCI. 2021;11(1):73-86.

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