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Yıl 2014, Cilt: 24 Sayı: 1, 38 - 52, 30.06.2014

Öz

There are 482 Hypericum species which grow naturally in different geographic origins of the world from equator zone to Scandinavian Countries. Those species have been used as folk remedy in world-wide in treatments of neuralgia, menstural disorders, sciatica, arthritis and stomach diseases for centuries. Of all Hypericum, the most popular and common one is Hypericum perforatum L. It has been studied extensively in clinical trials for the last three decades and used popularly in treatment of depression. Our country is an important centre for Hypericum species which are known as “kantaron, binbirdelik otu, kan otu, kılıç otu, yaraotu, kuzukıran”. There are 89 Hypericum species in our flora of which 43 are endemic. On the contrary of world literature, hovewer, there are only few scientific studies on those species, conducted in our contry. Besides, those species have been collected extensively from natural flora for commercial purposes. In this review, it was aimed to remark Hypericum species which are an inactive source currently for our country and to present detailed information to the relevants

Kaynakça

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Önemli Tıbbi Bitkiler Olarak Hypericum Türleri​

Yıl 2014, Cilt: 24 Sayı: 1, 38 - 52, 30.06.2014

Öz

Ekvator kuşağından kuzeyde İskandinav ülkelerine kadar dünyanın farklı coğrafyalarında yayılış gösteren 482 Hypericum türü bulunmaktadır. Bu türler dünya genelinde halk ilacı olarak yüzyıllardan bu yana sinir hastalıkları, adet krampları, siyatik, eklem iltihabı ve midevi rahatsızlıklardan kaynaklanan ağrıların giderilmesinde ve bazı cilt hastalıklarının tedavisinde kullanılmaktadır. Hypericum türleri içerisinde en yaygın ve popüler olanı Hypericum perforatum L.’dur. Bu tür son 30 yıldan beri bitki klinik ve laboratuar şartlarında yoğun olarak çalışılmakta olup günümüzde bilhassa depresyon tedavisinde yoğun olarak kullanılmaktadır. Ülkemiz kantaron, binbirdelik otu, kan otu, kılıç otu, yaraotu, kuzukıran gibi yöresel adlarla bilinen Hypericum türleri bakımından önemli bir merkezdir ve mevcut 96 türün 46’sı endemiktir. Ancak dünya literatürünün aksine bu türler ile ilgili ülkemiz şartlarında yürütülen çalışmaların sayısı oldukça azdır. Ayrıca bu bitkiler tür ayrımı gözetmeksizin doğal floradan ihraç maksadıyla yoğun bir şekilde toplanmaktadır. Bu derlemede ülkemiz için atıl bir kaynak durumunda olan Hypericum türlerine dikkat çekmek ve konuyla ilgilenenler için derli toplu ve detaylı bilgi sunmak amaçlanmıştır

Kaynakça

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  • Öztürk Y, Aydin S, Beis R, Başer KHC, Berberoğlu H. 1996. Effects of Hypericum perforatum L. And Hypericum calycinum L. extracts on the Central Nervous System in mice. Phytomedicine. 3: 139-146.
  • Öztürk, N., Korkmaz, S., Öztürk, Y., 2007. Wound-healing activity of St. John’s Wort (L.)onchicken embryonic fibroblasts. Journal of Ethnopharmacology 111, 33–39.
  • Pabuçcuoglu, A, Konyalıoglu S, Baş M, Meral GE. 2003. The in vitro effects of Hypericum species on human leukocyte myeloperoxidase activity. Journal of Ethnopharmacology. 87: 89-92.
  • Panossian, A.G., Gabrielian, E., Manvelian, V., Jurcic, K., Wagner, H., 1996. Immunosuppressive effects of hypericin on stimulated human leukocytes: inhibition of the arachidonic acid release, leukotriene B4 and interleukin-1 alpha production, and activation of nitric oxide formation. Phytomedicine 3, 19–28.
  • Papakostas, G.I., Crawford, C.M., Scalia, M.J., Fava, M., 2007. Timing of clinical improvement and symptom resolution in the treatment of major depressive disorder. A replication of findings with the use of a double-blind, placebo-controlled trial of Hypericumperforatum versus fluoxetine. Neuropsychobiology 56, 132–137
  • Peeva-Naumovska, V., Panovski, N., Grdanovska, T., Fredro- Kumbaradzi, E., 2010. Formulations of St. John’s Wort oil ointment and evaluation of its antibacterial effect. Available from: www.amapseec.org/cmapseec. 1/Papers/pap p067.htm
  • Philipp, M., Kohnen, R., Hiller, K.O., 1999. Hypericumextract versus imipramine or placebo in patients with moderate depression: randomised multicenter study of treatment for eight weeks. BMJ 319, 1534–1538.
  • Qu, L., Widrlechner, M.P., Rigby, S.M. 2010. Analysis of breeding systems, ploidy, and the role of hexaploids in three Hypericum perforatum L. populations. Industrial Crops and Products. 32:1-6.
  • Rahimi, R., Nikfar, S., Abdollahi, M., 2009. Efficacy and tolerability of Hypericumperforatum in major depressive disorder in comparison with selective serotonin reuptake inhibitors: a meta-analysis. Prog. Neuropsychopharmacol. Biol. Psychiatry 33, 118–127.
  • Robson, N. K. B. 1981. Studies in the genus Hypericum L.(Guttiferae) 2. Characters of the genus. Bulletin of the British Museum (Natural History) Botany Series, 8, 55-226.
  • Robson, N. K. B., Adams, P., 1968. Chromosome number in Hypericum and related genera. Brittonia. 20:95-106.
  • Röder, C., Schaefer, M., Leucht, S., 2004. Meta-analysis of effectiveness and tolerability of treatment of mild to moderate depression with St. John's Wort. Fortschr Neurol Psychiatr. 72: 330-43.
  • Saljic, J,. 1975. Ointment for the treatment of burns, Ger. Offen. 2,406,452 (CL. A61K), 21 Aug 1975 (CA 83: 197797).
  • Sanchez-Mateo, CC, C.X. Bonkanka, M. Hernández-Pérez, R.M. Rabanal. 2006. Evaluation of the analgesic and topical anti-inflammatory effects of Hypericum reflexum L. fil.. Journal of Ethnopharmacology 107: 1- 6.
  • Tanaka, N., Takaishi, Y., 2006. Xanthones from Hypericum
  • Saroglou, V., Marin, P.D., Rancic, A., Veljic, M., Skaltsa, H., 2007. Composition and antimicrobial activity of the essential oil of six Hypericum species from Serbia. Biochemical Systematics and Ecology 35, 146-152.
  • Sarrell, E.M., Cohen, H.A., Kahan, E., 2003. Naturopathic treatment for ear pain in children. Pediatrics 111: 574- 579.
  • Schempp, C.M., Kirkin, V., Simon-Haarhaus, B., Kersten, A., Kiss, J., Termeer, C.C., Gilb, B., Kaufmann, T., Borner, C., Sleeman, J.P., Simon, J.C., 2002. Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John’s Wort that acts by induction of apoptosis. Oncogene 21, 1242–1250.
  • Schempp, C.M., Windeck, T., Hezel, S., Simon, J.C., 2003. Topical treatment of atopic dermatitis with St. John’s Wort cream – a randomized, placebo controlled, double blind half-side comparison. Phytomedicine 10, 31–37.
  • Schmitt, A.C., Ravazzolo, A.P., Von Poser, G.L., 2001. Investigation of some Hypericumspecies native to Southern of Brazil for antiviral activity. Journal of Ethnopharmacology. 77: 239–245.
  • Sezik, E., Yeşilada, E., Honda, G., Takaishi, Y., Takeda, Y., Tanaka, T., 2001. Traditional medicine in Turkey 10: Folk medicine in central Anatolia. Journal of Ethnopharmacology. Vol:75. P:95-115.
  • Smelcerovic, A., Zuehlke, S., Spiteller, M., Raabe, N., Özen, T., 2008. Phenolic constituents of 17 Hypericum species from Turkey. Biochem Syst Ecol 36: 316-319.
  • Solomon, D., Adams, J., Graves, N., 2013. Economic evaluation of St. John’s wort (Hypericum perforatum) for the treatment of mild to moderate depression. Journal of Affective Disorders 148: 228-234.
  • Sparenberg, B.L., Demisch, J., Holzl, J., 1993. Untersuchungen uber die antidepressiven Wirkstoffe von Johanniskraut. Pharm Ztg Wiss. 138, 239–254.
  • Süntar, I.P., Akkol, E.K., Yılmazer, D., Baykal, T., Kırmızıbekmez, H., Alper, M., Yesilada, E., 2010. Investigations on the in vivo wound healing potential of Ethnopharmacology 127: 468-477.
  • Szegedi, A., Kohnen, R., Dienel, A., Kieser, M., 2005. Acute treatment of moderate to severe depression with Hypericumextract WS 5570 (St John's wort): randomised controlled double blind non-inferiority trial versus paroxetine. BMJ 330, 503.
  • Şerbetci, T., Özsoy, N., Demirci, B., Can, A., Kültür, Ş., Baser, K.H.C., 2012. Chemical composition of the essential oil and antioxidant activity of methanolic extracts from fruits and flowers of Hypericum lydium Boiss. Industrial Crops and Products 36: 599-606. chinense. Phytochemistry. 67: 2146-51.
  • Toker, Z., Kızıl, G., Özen, H.Ç., Kızıl, M., Ertekin, S., 2006. Compositions and antimicrobial activities of the essential oils of two Hypericum species from Turkey. Fitoterapia. 77: 57-60.
  • Tolkunova, N.N., Cheuva, E.N., Bidyuk, A.Ya., 2002. Effect of medicinal plant extracts on microorganism development. Pishchevaya Promyshlennost 8, 70–71.
  • Van Gurp, G., Meterissian, G.B., Haiek, L.N., McCusker, J., Bellavance, F., 2002. St John's wort or sertraline Randomized controlled trial in primary care. Can. Fam. Physician 48, 905–912.
  • Uzun, F. 2009. Ontogenic changes in hypericin content of some Hypericum species in natural pastureland of Turkey. Bangladesh J. Bot. 38: 13-18.
  • Verotta, L., Appendino, G., Bombardelli, E., Brun, R., 2007. In vitro antimalarial activity of hyperforin, a prenylated acylphloroglucinol. A structure–activity study. Bioorganic & Medicinal Chemistry Letters 17, 1544–1548.
  • Vlietinck, A.J., De Bruyne, T., Apers, S., Pieters, L.A., 1998. Plant derived leading compounds chemotherapy of human immunodeficiency virus (HIV-1) infection. Planta Medica 64, 97–109.
  • Vorbach, E.U., Hubner, W.D., Arnoldt, K.H., 1994. Effectiveness and tolerance of the Hypericumextract LI 160 in comparison with imipramine: randomized double-blind study with 135 outpatients. J. Geriatr. Psychiatry Neurol. 7 (Suppl 1), S19–S23.
  • Westerhoff, K., Kaunzinger, A., Wurglics, M., Dressman, J., Schubert-Zsilavecz, M., 2002. Biorelevant dissolution testing of St John's wort products. J. Pharm. Pharmacol. 54, 1615–1621.
  • Wheatley, D., 1997. LI 160, an extract of St. John's wort, versus amitriptyline in mildly to moderately depressed outpatients—a controlled 6-week clinical trial. Pharmacopsychiatry 30 (Suppl 2), 77–80.
  • WHO,1999. World Health Organization Monographs on Selected Medicinal Plants, vol. 2, Geneva.
  • Withering, W., 1796. An arrangement of British plants third ed. Published by Swinney, London.
  • Woelk, H., 2000. Comparison of St John's wort and imipramine for treating depression: randomised controlled trial. BMJ 321, 536–539.
  • Xie, X., J.B. Hudson, E.S. Guns, 2001. Tumor-specific and photodependent cytotoxicity of hypericin in the human LNCaP prostate tumor model, Photochem. Photobiol. 74: 221–225.
  • Yesilada, E., Gürbüz, I., 1998. Evaluation of the anti- ulcerogenic effect of the flowering herbs of Hypericum perforatum. Journal of Faculty of Pharmacy of Gazi University 15, 25–31.
  • Yesilada, E., Honda, G., Sezik, E., Tabata, M., Fujita, T., Tanaka, T., Takeda, Y., Takaishi, Y., 1995. Traditional medicine in Turkey. V. Folk medicine in the inner Taurus Mountains. Journal of Ethnopharmacology 46, 133–152
Toplam 141 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Makaleler
Yazarlar

Cüneyt Çırak Bu kişi benim

Dursun Kurt

Yayımlanma Tarihi 30 Haziran 2014
Gönderilme Tarihi 7 Eylül 2015
Yayımlandığı Sayı Yıl 2014 Cilt: 24 Sayı: 1

Kaynak Göster

APA Çırak, C., & Kurt, D. (2014). Önemli Tıbbi Bitkiler Olarak Hypericum Türleri​. ANADOLU Ege Tarımsal Araştırma Enstitüsü Dergisi, 24(1), 38-52.
AMA Çırak C, Kurt D. Önemli Tıbbi Bitkiler Olarak Hypericum Türleri​. ANADOLU. Haziran 2014;24(1):38-52.
Chicago Çırak, Cüneyt, ve Dursun Kurt. “Önemli Tıbbi Bitkiler Olarak Hypericum Türleri​”. ANADOLU Ege Tarımsal Araştırma Enstitüsü Dergisi 24, sy. 1 (Haziran 2014): 38-52.
EndNote Çırak C, Kurt D (01 Haziran 2014) Önemli Tıbbi Bitkiler Olarak Hypericum Türleri​. ANADOLU Ege Tarımsal Araştırma Enstitüsü Dergisi 24 1 38–52.
IEEE C. Çırak ve D. Kurt, “Önemli Tıbbi Bitkiler Olarak Hypericum Türleri​”, ANADOLU, c. 24, sy. 1, ss. 38–52, 2014.
ISNAD Çırak, Cüneyt - Kurt, Dursun. “Önemli Tıbbi Bitkiler Olarak Hypericum Türleri​”. ANADOLU Ege Tarımsal Araştırma Enstitüsü Dergisi 24/1 (Haziran 2014), 38-52.
JAMA Çırak C, Kurt D. Önemli Tıbbi Bitkiler Olarak Hypericum Türleri​. ANADOLU. 2014;24:38–52.
MLA Çırak, Cüneyt ve Dursun Kurt. “Önemli Tıbbi Bitkiler Olarak Hypericum Türleri​”. ANADOLU Ege Tarımsal Araştırma Enstitüsü Dergisi, c. 24, sy. 1, 2014, ss. 38-52.
Vancouver Çırak C, Kurt D. Önemli Tıbbi Bitkiler Olarak Hypericum Türleri​. ANADOLU. 2014;24(1):38-52.
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