Araştırma Makalesi
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Investigation of Antimicrobial and Antifungal Effects of Some Boron Compounds

Yıl 2023, Cilt: 12 Sayı: 3, 591 - 595, 28.09.2023

F. Çağlar Çelikezen İbrahim Halil Şahin

https://doi.org/10.17798/bitlisfen.1197472

Öz

The importance of boron for human life is increasing day by day, and its usage areas are gradually expanding thanks to the developing science and technology. In the present study, antifungal and antimicrobial effects of ammoniumbiborate, lithiummetaboratedehydrate and potassiumtetraborate were investigated. Disc difussion metod was used for determine antimicrobial and antifungal effects. In the study streptomycin standart discs were used as positive control. Boron compounds were showed antimicrobial and antifungal effects on Enterococcus faecalis (ATCC 29212), Streptococcus pyogenes (ATCC 19615), Pseudomonas aeruginosa (ATCC 27853), Enterobacter aerogenes (ATCC 13048), Escherichia coli (ATCC 35218), Proteus mirabilis (ATCC 7002), Candida tropicalis (ATCC13803), Citrobacter freundii (ATCC 8090), Bacillus subtilis (ATCC6633), Burkholderia Cepacia (ATCC25608). As a conclusion, our results showed that these boron compounds may use as antimicrobial and anti fungal agents.

Anahtar Kelimeler

Boron lithiummetaboratedehydrate ammoniumbiborate potassiumtetraborate antifungal antimicrobial.

Destekleyen Kurum

This study was supported by Bitlis Eren University Scientific Research Projects Unit (BEBAP)

Proje Numarası

BEBAP 2013.02

Kaynakça

  • [1] C.D. Hunt, “Biochemical effects of physiological amounts of dietary boron,” J Trace Elem Med Biol vol. 9, pp. 185–213, 1996
  • [2] H. Turkez, F. Geyikoglu, A. Tatar, M.S. Keles, I Kaplan, “The effects of some boron compounds against heavy metal toxicity in human blood, ” Exp Toxicol Pathol vol. 64, pp. 93-101, 2012.
  • [3] N. Yenmez, “The importance of boron minerals in Turkey as a strategic mine,” İstanbul Üniversitesi Edebiyat Fakültesi Coğrafya Bölümü Coğrafya Dergisi, vol. 19, pp.59-94, 2010.
  • [4] T.A. Devirian, S.L. Volpe, “The physiological effects of dietary boron,” Crit Rev Food Sci Nutr, vol. 43, pp. 219–231, 2003.
  • [5] T.A. Armstrong, J.W. Spears, K.E. Lloyd, “Inflammatory response, growth, and thyroid hormone concentrations are affected by long-term boron supplementation in gilts,” JAS, 79, pp. 1549–1556, 2001.
  • [6] M. Eren, G.B. Kocaoglu, F. Uyanik, N. Karabulut, “The effects of dietary boron supplementation on performance, carcass composition and serum lipids in Japanese quails,” J. Vet. Adv, vol. 5, pp. 1105–1108, 2006.
  • [7] F.Ç. Çelikezen, H. Türkez, E. Aydın, “The antioxidant and genotoxic activities of Na2B4O7.10H2O in vitro,” Fresenius environmental bulletin vol. 24, no. 3, pp. 947-953, 2015.
  • [8] R.F. Barth, J.A. Coderre, M.G. Vicente, T.H. Blue, “Boron neutron capture therapy of cancer: current status and prospects,” Clin. Cancer Res. Vol. 11, pp. 3987-4002, 2005.
  • [9] T. Rezanka and K. Sigler, “Biologically active compounds of semi-metals,” Phytochemistry, vol. 69, pp. 585-606, 2008.
  • [10] R. Hutter, W. Keller-Schierlein, F. Kneusel, V. Prelog, G.C. Jr Rodgers, P. Suter, G. Vogel, W. Voser, H, “Zahner Stoffwechselprodukte von Mikroorganismen,” Helv. Chim. Acta vol. 50, pp.1533-1539, 1967.
  • [11] J. Kohno, T. Kawahata, T. Otake, M. Morimoto, H. Mori, N. Ueba, A. Kinumaki, S. Komatsubara, K. Kawashima, “Boromycin, an anti-HIV antibiotic,” Biosci. Biotechnol. Biochem., vol. 60, pp. 1036-1037, 1996.
  • [12] W. Pache, H. Zahner, “Metabolic products of microorganisms. 77. Studies on the mechanism of action of boromycin,” Arch. Microbiol, vol. 67, pp. 156-65,1969.
  • [13] D.H. Davies, G.L.F. Norris, “Growth promotion,” US Patent, vol. 4, pp. 225-593,1980.
  • [14] P. Lewer, E.L. Chapin, P.R. Graupner, J.R. Gilbert, C. Peacock, 2003. “Tartrolone C: a novel insecticidal macrodiolide produced by Streptomyces sp. CP1130,” J. Nat. Prod., vol. 66, pp. 143-145, 2003.
  • [15] F.Ç. Çelikezen, H. Turkez, B. Togar, M.S. Izgi, “DNA damaging and biochemical effects of potassium tetraborate,” EXCLI J, vol. 30, 446-450, 2014.
  • [16] F.Ç. Çelikezen, B. Toğar, F.B. Özgeriş, M.S.İzgi, Türkez H, “Cytogenetic and oxidative alterations after exposure of cultured human whole blood cells to lithium metaborate dehydrate,” Cytotechnology, vol.68, 821–827, 2016.
  • [17] F.Ç. Çelikezen, H. Turkez, E. Aydin, M.S. Izgi, B. Çelikezen, “Potent antioxidant and genotoxic effects of ammonium tetraborate in vitro,” Nat. Sci. Disc., vol.1, pp. 45-49, 2015
  • [18] I. Aibinu, T. Adenipekun, T. Adelowotan, T. Ogunsanya, T, “Odugbemi Evaluation of the antimicrobial properties of different parts of Citrus aurantifolia (lime fruit) as used locally,” Afr J Tradit Complement Altern Med, vol.13, no. 4(2), pp.185-90, 2006.
  • [19] National Committee for Clinical Laboratory Standard, “In Performance standards for antimicrobial disk susceptibility test,” 6th approved standard. M2- A6, Wayne, PA, 1997.
  • [20] A.L. Barry, C. Thornsberry, “Susceptibility Tests: Diffusion Test Procedures,” In Lennette EH, Balows A, Hausler WJ, Shadomy HJ (eds) Manual of Clinical Microbiology. Washington, DC: American Society. For Microbiology, pp. 978-987, 1985.
  • [21] M.T. Yılmaz, “Minimum inhibitory and minimum bactericidal concentrations of boron compounds against several bacterial strains,” Turk. J. Med. Sci. Vol. 42, pp. 1423-1429, 2012.
  • [22] N. Surolia, S.P. Ramachandrarao, A. Surolia, “Paradigm shifts in malaria parasite biochemistry and anti-malarial chemotherapy,” Bioessays, vol. 24: pp. 192-196, 2002.
  • [23] S.J. Baker, C.Z. Ding, T. Akama, Y.K. Zhang, V. Hernandez, Y. Xia, “Therapeutics potential of boron-containing compounds,” Future Med. Chem., vol. 1, pp. 1275-1288, 2009.
  • [24] V.M. Dembitsky and M. Srebnik, “Synthesis and biological activity of α-amino boronic acids, amine-carboxy boranes, and their derivatives,” Tetrahedron vol. 59, pp. 579-593, 2003.
  • [25] P.J. Bailey, G. Cousins, G.A. Snow, A.J. White, “Boron-containing antibacterial agents: effects on growth and morphology of bacteria under various culture conditions,” Antimicrob. Agents Chemother., vol. 17, pp. 549-553, 1980
  • [26] E.H. Ochsner, “The prevention and treatment of septic infections of the extremities,” Medical Herald vol. 30, pp. 30-36, 1911.
  • [27] E.H. Ochsner, “Biochemistry of topical applications: Use of boric acid in septic infections,” JAMA vol. 68, pp. 220-223,1917.
  • [28] M. Shubair, B. Larsen, “Growth inhibition of candida albicans and other medically important yeasts by vaginal contraceptive products,” Gynecol. Obstet. Invest. vol. 29, pp. 67-70. 1990.
  • [29] M. Peeters, D. Vanden Berghe, A. Meheus, “Antimicrobial activity of seven metallic compounds against penicillinase-producing and non-penicillinase-producing strains of Neisseria gonorrhoeae,” Genitourin Med, vol. 62, pp. 163-165, 1986.
  • [30] P. Panneerselvam, B.A. Rather, D.R.S. Reddy, N.R. Kumar, “Synthesis and anti-microbial screening of some Schiff bases of 3-amino-6,8 dibromo-2-Phenylquinazolin-4 (3H)-ones,” Eur. J. Med. Chem. vol. 44, pp. 2328-2333, 2009
  • [31] Q. Luan, T. Desta, L. Chehab, V.J. Sanders, J. Plattner, D.T. Graves, “Inhibition of experimental periodontitis by a topical boron-based antimicrobial,” J. Dent. Res vol. 87, pp. 148-152, 2008.
  • [32] S.J. Baker, T. Akama, Y.K. Zhang, V. Sauro, S.M.K. Pandit, J. Khan, J.J. Plattener, S.T. Benkoviç, V. Lee, K.R. Maples, “Identification of a novel boron-containing antibacterial agent (AN0128) with anti-inflammatory activity, for the potential treatment of cutaneous diseases,” Bioorg. Med. Chem. Lett vol.16, pp. 5963-5967, 2006.
  • [33] A.T. Çolak, Y. Sahin, O.Z. Yeşilel, F. Çolak, F. Yılmaz, M. Tas, “Novel boron compounds of 2,3- and 2,5-pyridine dicarboxylic acids,” Inorganica Chim. Acta, vol. 383,pp. 169–177, 2012.

Yıl 2023, Cilt: 12 Sayı: 3, 591 - 595, 28.09.2023

F. Çağlar Çelikezen İbrahim Halil Şahin

https://doi.org/10.17798/bitlisfen.1197472

Öz

Proje Numarası

BEBAP 2013.02

Kaynakça

  • [1] C.D. Hunt, “Biochemical effects of physiological amounts of dietary boron,” J Trace Elem Med Biol vol. 9, pp. 185–213, 1996
  • [2] H. Turkez, F. Geyikoglu, A. Tatar, M.S. Keles, I Kaplan, “The effects of some boron compounds against heavy metal toxicity in human blood, ” Exp Toxicol Pathol vol. 64, pp. 93-101, 2012.
  • [3] N. Yenmez, “The importance of boron minerals in Turkey as a strategic mine,” İstanbul Üniversitesi Edebiyat Fakültesi Coğrafya Bölümü Coğrafya Dergisi, vol. 19, pp.59-94, 2010.
  • [4] T.A. Devirian, S.L. Volpe, “The physiological effects of dietary boron,” Crit Rev Food Sci Nutr, vol. 43, pp. 219–231, 2003.
  • [5] T.A. Armstrong, J.W. Spears, K.E. Lloyd, “Inflammatory response, growth, and thyroid hormone concentrations are affected by long-term boron supplementation in gilts,” JAS, 79, pp. 1549–1556, 2001.
  • [6] M. Eren, G.B. Kocaoglu, F. Uyanik, N. Karabulut, “The effects of dietary boron supplementation on performance, carcass composition and serum lipids in Japanese quails,” J. Vet. Adv, vol. 5, pp. 1105–1108, 2006.
  • [7] F.Ç. Çelikezen, H. Türkez, E. Aydın, “The antioxidant and genotoxic activities of Na2B4O7.10H2O in vitro,” Fresenius environmental bulletin vol. 24, no. 3, pp. 947-953, 2015.
  • [8] R.F. Barth, J.A. Coderre, M.G. Vicente, T.H. Blue, “Boron neutron capture therapy of cancer: current status and prospects,” Clin. Cancer Res. Vol. 11, pp. 3987-4002, 2005.
  • [9] T. Rezanka and K. Sigler, “Biologically active compounds of semi-metals,” Phytochemistry, vol. 69, pp. 585-606, 2008.
  • [10] R. Hutter, W. Keller-Schierlein, F. Kneusel, V. Prelog, G.C. Jr Rodgers, P. Suter, G. Vogel, W. Voser, H, “Zahner Stoffwechselprodukte von Mikroorganismen,” Helv. Chim. Acta vol. 50, pp.1533-1539, 1967.
  • [11] J. Kohno, T. Kawahata, T. Otake, M. Morimoto, H. Mori, N. Ueba, A. Kinumaki, S. Komatsubara, K. Kawashima, “Boromycin, an anti-HIV antibiotic,” Biosci. Biotechnol. Biochem., vol. 60, pp. 1036-1037, 1996.
  • [12] W. Pache, H. Zahner, “Metabolic products of microorganisms. 77. Studies on the mechanism of action of boromycin,” Arch. Microbiol, vol. 67, pp. 156-65,1969.
  • [13] D.H. Davies, G.L.F. Norris, “Growth promotion,” US Patent, vol. 4, pp. 225-593,1980.
  • [14] P. Lewer, E.L. Chapin, P.R. Graupner, J.R. Gilbert, C. Peacock, 2003. “Tartrolone C: a novel insecticidal macrodiolide produced by Streptomyces sp. CP1130,” J. Nat. Prod., vol. 66, pp. 143-145, 2003.
  • [15] F.Ç. Çelikezen, H. Turkez, B. Togar, M.S. Izgi, “DNA damaging and biochemical effects of potassium tetraborate,” EXCLI J, vol. 30, 446-450, 2014.
  • [16] F.Ç. Çelikezen, B. Toğar, F.B. Özgeriş, M.S.İzgi, Türkez H, “Cytogenetic and oxidative alterations after exposure of cultured human whole blood cells to lithium metaborate dehydrate,” Cytotechnology, vol.68, 821–827, 2016.
  • [17] F.Ç. Çelikezen, H. Turkez, E. Aydin, M.S. Izgi, B. Çelikezen, “Potent antioxidant and genotoxic effects of ammonium tetraborate in vitro,” Nat. Sci. Disc., vol.1, pp. 45-49, 2015
  • [18] I. Aibinu, T. Adenipekun, T. Adelowotan, T. Ogunsanya, T, “Odugbemi Evaluation of the antimicrobial properties of different parts of Citrus aurantifolia (lime fruit) as used locally,” Afr J Tradit Complement Altern Med, vol.13, no. 4(2), pp.185-90, 2006.
  • [19] National Committee for Clinical Laboratory Standard, “In Performance standards for antimicrobial disk susceptibility test,” 6th approved standard. M2- A6, Wayne, PA, 1997.
  • [20] A.L. Barry, C. Thornsberry, “Susceptibility Tests: Diffusion Test Procedures,” In Lennette EH, Balows A, Hausler WJ, Shadomy HJ (eds) Manual of Clinical Microbiology. Washington, DC: American Society. For Microbiology, pp. 978-987, 1985.
  • [21] M.T. Yılmaz, “Minimum inhibitory and minimum bactericidal concentrations of boron compounds against several bacterial strains,” Turk. J. Med. Sci. Vol. 42, pp. 1423-1429, 2012.
  • [22] N. Surolia, S.P. Ramachandrarao, A. Surolia, “Paradigm shifts in malaria parasite biochemistry and anti-malarial chemotherapy,” Bioessays, vol. 24: pp. 192-196, 2002.
  • [23] S.J. Baker, C.Z. Ding, T. Akama, Y.K. Zhang, V. Hernandez, Y. Xia, “Therapeutics potential of boron-containing compounds,” Future Med. Chem., vol. 1, pp. 1275-1288, 2009.
  • [24] V.M. Dembitsky and M. Srebnik, “Synthesis and biological activity of α-amino boronic acids, amine-carboxy boranes, and their derivatives,” Tetrahedron vol. 59, pp. 579-593, 2003.
  • [25] P.J. Bailey, G. Cousins, G.A. Snow, A.J. White, “Boron-containing antibacterial agents: effects on growth and morphology of bacteria under various culture conditions,” Antimicrob. Agents Chemother., vol. 17, pp. 549-553, 1980
  • [26] E.H. Ochsner, “The prevention and treatment of septic infections of the extremities,” Medical Herald vol. 30, pp. 30-36, 1911.
  • [27] E.H. Ochsner, “Biochemistry of topical applications: Use of boric acid in septic infections,” JAMA vol. 68, pp. 220-223,1917.
  • [28] M. Shubair, B. Larsen, “Growth inhibition of candida albicans and other medically important yeasts by vaginal contraceptive products,” Gynecol. Obstet. Invest. vol. 29, pp. 67-70. 1990.
  • [29] M. Peeters, D. Vanden Berghe, A. Meheus, “Antimicrobial activity of seven metallic compounds against penicillinase-producing and non-penicillinase-producing strains of Neisseria gonorrhoeae,” Genitourin Med, vol. 62, pp. 163-165, 1986.
  • [30] P. Panneerselvam, B.A. Rather, D.R.S. Reddy, N.R. Kumar, “Synthesis and anti-microbial screening of some Schiff bases of 3-amino-6,8 dibromo-2-Phenylquinazolin-4 (3H)-ones,” Eur. J. Med. Chem. vol. 44, pp. 2328-2333, 2009
  • [31] Q. Luan, T. Desta, L. Chehab, V.J. Sanders, J. Plattner, D.T. Graves, “Inhibition of experimental periodontitis by a topical boron-based antimicrobial,” J. Dent. Res vol. 87, pp. 148-152, 2008.
  • [32] S.J. Baker, T. Akama, Y.K. Zhang, V. Sauro, S.M.K. Pandit, J. Khan, J.J. Plattener, S.T. Benkoviç, V. Lee, K.R. Maples, “Identification of a novel boron-containing antibacterial agent (AN0128) with anti-inflammatory activity, for the potential treatment of cutaneous diseases,” Bioorg. Med. Chem. Lett vol.16, pp. 5963-5967, 2006.
  • [33] A.T. Çolak, Y. Sahin, O.Z. Yeşilel, F. Çolak, F. Yılmaz, M. Tas, “Novel boron compounds of 2,3- and 2,5-pyridine dicarboxylic acids,” Inorganica Chim. Acta, vol. 383,pp. 169–177, 2012.
Toplam 33 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Araştırma Makalesi
Yazarlar

F. Çağlar Çelikezen 0000-0001-5489-7384

İbrahim Halil Şahin 0000-0001-7667-9310

Proje Numarası BEBAP 2013.02
Erken Görünüm Tarihi 23 Eylül 2023
Yayımlanma Tarihi 28 Eylül 2023
Gönderilme Tarihi 3 Kasım 2022
Kabul Tarihi 17 Haziran 2023
Yayımlandığı Sayı Yıl 2023 Cilt: 12 Sayı: 3

Kaynak Göster

IEEE F. Ç. Çelikezen ve İ. H. Şahin, “Investigation of Antimicrobial and Antifungal Effects of Some Boron Compounds”, Bitlis Eren Üniversitesi Fen Bilimleri Dergisi, c. 12, sy. 3, ss. 591–595, 2023, doi: 10.17798/bitlisfen.1197472.
 Kapak Resmi İndir



Bitlis Eren Üniversitesi
Fen Bilimleri Dergisi Editörlüğü

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E-posta: fbe@beu.edu.tr