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The Studies on The endemic Hypericum Species from Turkey

Yıl 2019, Cilt: 9 Sayı: 2, 253 - 268, 25.12.2019

Öz

The genus Hypericum
(Hypericaceae), inclusive about 450 species, has spread in various parts of the
world. The members of this species have been used for centuries as traditional
medicinal plants. Turkey is an important gene center for the genus Hypericum which represented by nearly
100 taxa grouped under 19 sections. Among
them, 45 species are endemic. The
genus is known as “sari kantaron, kantaron, binbirdelik otu, mayasil otu”  and used the treatment of burns, wounds,
haemorroids, diarrhorea and ulcers in Turkish traditional medicine.



Thanks to
this study was collected together the studies on endemic Hypericum species in Turkey.

Kaynakça

  • Akgöz, Y. (2013). Türkiye Florası'na Ait Hypericum L. Cinsinin Tehlike Kategorileri ve Bulunan Yeni Türleri. Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 18(1-2), 62-69.
  • Asan, H. S., Ozen, H. C., Onay, A., & Asan, N. (2015). Effect of BAP on total hypericin production in shoot cultures of Hypericum scabroides: An endemic species in the Eastern Anatolia Region of Turkey. EurAsian Journal of BioSciences, 9, 46-51.
  • Ayan, A. K., & Çirak, C. (2008). Hypericin and Pseudohypericin Contents in Some Hypericum. Species Growing in Turkey. Pharmaceutical biology, 46(4), 288-291.
  • Ayan, A. K., Çirak, C., Kevseroğlu, K., & Sökmen, A. (2005). Effects of explant types and different concentrations of sucrose and phytoharmones on plant regeneration and hypericin content in Hypericum perforatum L. Turkish journal of agriculture and forestry, 29(3), 197-204.
  • Aztopal, N., Erkisa, M., Celikler, S., Ulukaya, E., & Ari, F. (2016). Antigrowth and apoptosis inducing effects of Hypericum olympicum L. and Hypericum adenotrichum Spach. on lung cancer cells in vitro: Involvement of DNA damage. Journal of Food Biochemistry, 40(4), 559-566.
  • Babacan, E. Y., & Bagci, E. (2017). Essential oil composition of Hypericum uniglandulosum Hausskn. ex Bornm. and Hypericum lydium Boiss. from Turkey. International Journal of Nature and Life Sciences, 1(1), 12-16.
  • Bagci, E., & Bekci, F. (2010). Variation in essential oil composition of Hypericum scabrum L. and H. scabroides N. Robson & Poulter (Hypericaceae) aerial parts during its phenological cycle. Acta Botanica Gallica, 157(2), 247-254.
  • Bagci, E., & Yuce, E. (2010). The Essential Oils of the Aerial Parts of Two Hypericum (H. pseudolaeve Robson and H. thymbrifolium Boiss. & Noë)(Guttiferae) Species from Turkey. Journal of Essential Oil Bearing Plants, 13(4), 390-397.
  • Bagci, E., & Yuce, E. (2011). Constituents of the Essential Oils of Two Hypericum capitatum Choisy Varieties (var. capitatum and var. luteum Robson) from Turkey. Journal of Essential Oil Bearing Plants, 14(1), 106-113.
  • Bender, O., Llorent-Martínez, E. J., Zengin, G., Mollica, A., Ceylan, R., Molina-García, L., ... & Atalay, A. (2018). Integration of in vitro and in silico perspectives to explain chemical characterization, biological potential and anticancer effects of Hypericum salsugineum: A pharmacologically active source for functional drug formulations. PloS one, 13(6), e0197815.
  • Bingol, U., Cosge, B., & Gurbuz, B. (2011). Hypericum species in flora of Turkey. Hypericum. Medicinal and aromatic plant science and biotechnology, 5, 86-90.
  • Boga, M., Ertas, A., Eroglu-Ozkan, E., Kizil, M., Ceken, B., & Topcu, G. (2016). Phytochemical analysis, antioxidant, antimicrobial, anticholinesterase and DNA protective effects of Hypericum capitatum var. capitatum extracts. South African Journal of Botany, 104, 249-257.Bombardelli E, Morazzoni P (1995). Hypericum perforatum. Fitoterapia 66:43-68.
  • Boran, R. (2018). Investigations of anti-aging potential of Hypericum origanifolium Willd. for skincare formulations. Industrial Crops and Products, 118, 290-295.
  • Bruneton J (1995). Pharmacognosy, Phytochemistry, Medicinal Plants. Lavoisier Publishing, Paris 367-370.
  • Cakir, A., Kordali, S., Zengin, H., Izumi, S., & Hirata, T. (2004). Composition and antifungal activity of essential oils isolated from Hypericum hyssopifolium and Hypericum heterophyllum. Flavour and Fragrance Journal, 19(1), 62-68.
  • Camas, N., Radusiene, J., Ivanauskas, L., Jakstas, V., Kayikci, S., & Cirak, C. (2014b). Chemical composition of Hypericum species from the Taeniocarpium and Drosanthe sections. Plant systematics and evolution, 300(5), 953-960.
  • Camas, N., Radusiene, J., Stanius, Z., Caliskan, O., & Cirak, C. (2012). Secondary metabolites of Hypericum leptophyllum Hochst., an endemic Turkish species. The Scientific World Journal, 2012.
  • Cellarova, E., Kimakova, K., & Brutovska, R. (1992). Multiple shoot formation in Hypericum perforatum L. and variability of R0. Biol Plant, 34(suppl), 536.
  • Cirak, C., & Bertoli, A. (2013). Aromatic profiling of wild and rare species growing in Turkey: Hypericum aviculariifolium Jaub. and Spach subsp. depilatum (Freyn and Bornm.) Robson var. depilatum and Hypericum pruinatum Boiss. and Bal. Natural product research, 27(2), 100-107.
  • Cirak, C., Radusiene, J., Camas, N., Caliskan, O., & Odabas, M. S. (2013). Changes in the contents of main secondary metabolites in two Turkish Hypericum species during plant development. Pharmaceutical Biology, 51(3), 391-399.
  • Cirak, C., Radusiene, J., Jakstas, V., Ivanauskas, L., Seyis, F., & Yayla, F. (2016a). Secondary metabolites of seven Hypericum species growing in Turkey. Pharmaceutical biology, 54(10), 2244-2253.
  • Cirak, C., Radusiene, J., Jakstas, V., Ivanauskas, L., Yayla, F., Seyis, F., & Camas, N. (2016b). Secondary metabolites of Hypericum species from the Drosanthe and Olympia sections. South African Journal of Botany, 104, 82-90.
  • Çirak, C., Ivanauskas, L., Janulis, V., & Radušienė, J. (2009). Chemical constituents of Hypericum adenotrichum Spach, an endemic Turkish species. Natural product research, 23(13), 1189-1195.
  • Çirak, C., Radušiene, J., Janulis, V., Ivanauskas, L., & Arslan, B. (2007d). Chemical Constituents of SomeHypericum Species Growing in Turkey. Journal of Plant Biology, 50(6), 632.
  • Çirak, C., Sağlam, B., Ayan, A. K., & Kevseroğlu, K. (2006). Morphogenetic and diurnal variation of hypericin in some Hypericum species from Turkey during the course of ontogenesis. Biochemical Systematics and Ecology, 34(1), 1-13.
  • Davis PH, Cullen J, Coode MJE (1967) Flora of Turkey and the East Aegean Islands, (Vol 2), Edinburgh University Press, Edinburgh, 581 pp
  • Dogan, G., Yilmaz, A., Bagci, E., & Kaya, Z. (2017). Molecular Phylogeny Of Sectıon Drosanthe (Spach) Endl.(Hyperıcum L.) Inferred From Chloroplast Genome. Pak. J. Bot, 49(6), 2235-2242.
  • Dulger, B., & Gonuz, A. (2005). Antibacterial activity of the endemic Hypericum kazdaghensis. Fitoterapia, 76(2), 237-239
  • Dulger, B., & Hacioglu, N. (2009). Antibacterial activity of three endemic Hypericum species used in folkloric medicine against methicilin-resistant Staphylococcus aureus. Biotechnology & Biotechnological Equipment, 23(sup1), 763-765.
  • Dulger, B., Gonuz, A., Bilen, S., & Jäger, A. K. (2005). Antimicrobial studies on three Hypericum species from Turkey. South African Journal of Botany, 71(1), 100-103.
  • Dulger, G., & Dulger, B. (2014). Antifungal activity of Hypericum havvae against some medical Candida yeast and Cryptococcus species. Tropical Journal of Pharmaceutical Research, 13(3), 405-408.
  • Dulger, G., & Dulger, B. (2014). Antifungal activity of Hypericum havvae against some medical Candida yeast and Cryptococcus species. Tropical Journal of Pharmaceutical Research, 13(3), 405-408.
  • Dulger, G., Dulger, B., & Aki, C. (2010). Antibacterial activity of two endemic Hypericum (H. kazdaghensis and H. havvae) against Methicillin-Resistant Staphylococcus aureus. Asian Journal of Chemistry, 22(9), 7083.
  • Ekim T, Koyuncu M, Vural M, Duman H, Aytaç Z, Adıgüzel N (2000) Red Data Book of Turkish Plants (Pteridophyta and Spermatophyta), Türkiye Tabiatını Koruma Dernegi & Van 100. Yıl Üniversitesi, Barıçcan Ofset, Ankara, 246 pp
  • Erken, S., Malyer, H., Demirci, F., Demirci, B., & Baser, K. H. C. (2001). Chemical investigations on some Hypericum species growing in Turkey-I. Chemistry of Natural Compounds, 37(5), 434-438.
  • Fu, P., Zhang, W. D., Liu, R. H., Li, T. Z., Shen, Y. H., Li, H. L., ..& Chen, H. S. (2006). Two new xanthones from Hypericum japonicum. Natural product research, 20(13), 1237-1240.
  • Ozkan, E. E., Nurten, O., Ozhan, G., Celik, B. O., & Mat, A. (2013a). Chemical Compositions and Biological Activities of Hypericum neurocalycinum an Endemic Species of Turkey. Planta Medica, 79(13), PJ14.
  • Ozkan, E. E., Ozden, T. Y., Ozsoy, N., & Mat, A. (2018). Evaluation of chemical composition, antioxidant and anti-acetylcholinesterase activities of Hypericum neurocalycinum and Hypericum malatyanum. South African Journal of Botany, 114, 104-110.
  • Ozkan, E. E., Ozsoy, N., Ozden, T. Y., Ozhan, G., & Mat, A. (2018b). Evaluation of Chemical Composition and In-vitro Biological Activities of Three Endemic Hypericum Species from Anatolia (H. thymbrifolium, H. spectabile and H. pseudolaeve). Iranian journal of pharmaceutical research: IJPR, 17(3), 1036.
  • Öcal, A., & Eroğlu, H. E. (2012). In vitro cytogenetic effects of Hypericum heterophyllum in human peripheral blood l Maltas ymphocytes. Bangladesh Journal of Pharmacology, 7(1), 36-41.
  • Özhatay, F. N., Kültür, Ş., & Gürdal, M. B. (2011). Check-list of additional taxa to the supplement Flora of Turkey V. Turkish Journal of Botany, 35(5), 589-624.
  • Özkan, A. M. G., Demirci, B., & Başer, K. H. C. (2009). Essential oil composition of Hypericum thymopsis Boiss. Journal of Essential Oil Research, 21(2), 149-153.
  • Özkan, E. E., Özsoy, N., Özhan, G., Celik, B. Ö., & Mat, A. (2013b). Chemical composition and biological activities of Hypericum pamphylicum. Industrial crops and products, 50, 182-189.
  • Özmen, A., Bauer, S., Gridling, M., Singhuber, J., Krasteva, S., Madlener, S., ...& Szekeres, T. (2009). In vitro anti-neoplastic activity of the ethno-pharmaceutical plant Hypericum adenotrichum Spach endemic to Western Turkey. Oncology reports, 22(4), 845-852.
  • Pretto, F. R., & Santarém, E. R. (2000). Callus formation and plant regeneration from Hypericum perforatum leaves. Plant Cell, Tissue and Organ Culture, 62(2), 107-113.
  • Santarém, E. R., & Astarita, L. V. (2003). Multiple shoot formation in Hypericum perforatum L. and hypericin production. Brazilian journal of plant physiology, 15(1), 43-47.
  • Sarimahmut, M., Balikci, N., Celikler, S., Ari, F., Ulukaya, E., Guleryuz, G., & Ozel, M. Z. (2016). Evaluation of genotoxic and apoptotic potential of Hypericum adenotrichum Spach. in vitro. Regulatory Toxicology and Pharmacology, 74, 137-146.
  • Sezik, E., Yeşilada, E., Honda, G., Takaishi, Y., Takeda, Y., & Tanaka, T. (2001). Traditional medicine in Turkey X. Folk medicine in central Anatolia. Journal of ethnopharmacology, 75(2-3), 95-115.
  • Smelcerovic, A., Zuehlke, S., Spiteller, M., Raabe, N., & Özen, T. (2008). Phenolic constituents of 17 Hypericum species from Turkey. Biochemical Systematics and Ecology, 4(36), 316-319.
  • Solomon, D., Adams, J., & Graves, N. (2013). Economic evaluation of St. John's wort (Hypericum perforatum) for the treatment of mild to moderate depression. Journal of affective disorders, 148(2-3), 228-234.
  • Tala, M. F., Tchakam, P. D., Wabo, H. K., Talontsi, F. M., Tane, P., Kuiate, J. R., & Laatsch, H. (2013). Chemical constituents, antimicrobial and cytotoxic activities of Hypericum riparium (Guttiferae). Records of Natural Products, 7(1), 65.
  • Tekin, M. (2017). Pharmacobotanical study of Hypericum thymopsis. Revista Brasileira de Farmacognosia, 27(2), 143-152.
  • Turkoglu, S., Turkoglu, I., Celik, S., Bahsi, M., Gur, S., & Parlak, A. E. (2015). Some biological compounds, antioxidant and antimicrobial activities of endemic Hypericum uniglandulosum. Chemistry of natural compounds, 51(4), 615-619
  • Uzun, F. (2009). Ontogenic changes in hypericin content of some Hypericum species in natural pastureland of Turkey. Bangladesh J. Bot, 38, 13-18.
  • Yamaner, O., & Erdag, B. (2013). Effects of sucrose and polyethylene glycol on hypericins content in Hypericum adenotrichum. Eurasian Journal of Biosciences, 7.
  • Yamaner, Ö., Erdağ, B., & Gökbulut, C. (2013). Stimulation of the production of hypericins in in vitro seedlings of Hypericum adenotrichum by some biotic elicitors. Turkish Journal of Botany, 37(1), 153-159.
  • Yuce, E. (2009). Hypericum L.(Hypericaceae) cinsine ait Drosanthe (Spach) Endl. seksiyonunun biyosistematigi. Doktora Tezi, Fırat Üniversitesi, Fen Bilimleri Enstitüsü.
  • Yuce, E., & Bagci, E. (2012). The essential oils of the aerial parts of two Hypericum taxa (Hypericum triquetrifolium and Hypericum aviculariifolium subsp. depilatum var. depilatum (Clusiaceae)) from Turkey. Natural product research, 26(21), 1985-1990.
  • Zobayed, S. M. A., Murch, S. J., Rupasinghe, H. P. V., & Saxena, P. K. (2004). In vitro production and chemical characterization of St. John’s wort (Hypericum perforatum L. cv ‘New Stem’). Plant Science, 166(2), 333-340.

Türkiye’den Endemik Hypericum Türleri Üzerinde Çalışmalar

Yıl 2019, Cilt: 9 Sayı: 2, 253 - 268, 25.12.2019

Öz

Yaklaşık 450 tür içeren Hypericum (Hypericaceae) cinsi, dünyanın çeşitli
bölgelerine yayılmıştır. Bu türün üyeleri yüzyıllardır geleneksel şifalı
bitkiler olarak kullanılmaktadır. Türkiye, 19 bölüm altında gruplanmış yaklaşık
100 taksonun temsil ettiği Hypericum (Hypericaceae) cinsi için önemli bir gen
merkezidir. Bunlar arasında 45 tür endemiktir. Bu bitki cinsi, “sari kantaron,
kantaron, binbirdelik otu, mayasil otu” olarak bilinir ve Türk geleneksel
tıbbında yanıklar, yaralar, hemorroidler, diyare ve ülserlerin tedavisinde
kullanılır.



Bu çalışma sayesinde Türkiye'deki endemik Hypericum türleri ile ilgili
çalışmalar bir araya toplanmıştır.

Kaynakça

  • Akgöz, Y. (2013). Türkiye Florası'na Ait Hypericum L. Cinsinin Tehlike Kategorileri ve Bulunan Yeni Türleri. Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 18(1-2), 62-69.
  • Asan, H. S., Ozen, H. C., Onay, A., & Asan, N. (2015). Effect of BAP on total hypericin production in shoot cultures of Hypericum scabroides: An endemic species in the Eastern Anatolia Region of Turkey. EurAsian Journal of BioSciences, 9, 46-51.
  • Ayan, A. K., & Çirak, C. (2008). Hypericin and Pseudohypericin Contents in Some Hypericum. Species Growing in Turkey. Pharmaceutical biology, 46(4), 288-291.
  • Ayan, A. K., Çirak, C., Kevseroğlu, K., & Sökmen, A. (2005). Effects of explant types and different concentrations of sucrose and phytoharmones on plant regeneration and hypericin content in Hypericum perforatum L. Turkish journal of agriculture and forestry, 29(3), 197-204.
  • Aztopal, N., Erkisa, M., Celikler, S., Ulukaya, E., & Ari, F. (2016). Antigrowth and apoptosis inducing effects of Hypericum olympicum L. and Hypericum adenotrichum Spach. on lung cancer cells in vitro: Involvement of DNA damage. Journal of Food Biochemistry, 40(4), 559-566.
  • Babacan, E. Y., & Bagci, E. (2017). Essential oil composition of Hypericum uniglandulosum Hausskn. ex Bornm. and Hypericum lydium Boiss. from Turkey. International Journal of Nature and Life Sciences, 1(1), 12-16.
  • Bagci, E., & Bekci, F. (2010). Variation in essential oil composition of Hypericum scabrum L. and H. scabroides N. Robson & Poulter (Hypericaceae) aerial parts during its phenological cycle. Acta Botanica Gallica, 157(2), 247-254.
  • Bagci, E., & Yuce, E. (2010). The Essential Oils of the Aerial Parts of Two Hypericum (H. pseudolaeve Robson and H. thymbrifolium Boiss. & Noë)(Guttiferae) Species from Turkey. Journal of Essential Oil Bearing Plants, 13(4), 390-397.
  • Bagci, E., & Yuce, E. (2011). Constituents of the Essential Oils of Two Hypericum capitatum Choisy Varieties (var. capitatum and var. luteum Robson) from Turkey. Journal of Essential Oil Bearing Plants, 14(1), 106-113.
  • Bender, O., Llorent-Martínez, E. J., Zengin, G., Mollica, A., Ceylan, R., Molina-García, L., ... & Atalay, A. (2018). Integration of in vitro and in silico perspectives to explain chemical characterization, biological potential and anticancer effects of Hypericum salsugineum: A pharmacologically active source for functional drug formulations. PloS one, 13(6), e0197815.
  • Bingol, U., Cosge, B., & Gurbuz, B. (2011). Hypericum species in flora of Turkey. Hypericum. Medicinal and aromatic plant science and biotechnology, 5, 86-90.
  • Boga, M., Ertas, A., Eroglu-Ozkan, E., Kizil, M., Ceken, B., & Topcu, G. (2016). Phytochemical analysis, antioxidant, antimicrobial, anticholinesterase and DNA protective effects of Hypericum capitatum var. capitatum extracts. South African Journal of Botany, 104, 249-257.Bombardelli E, Morazzoni P (1995). Hypericum perforatum. Fitoterapia 66:43-68.
  • Boran, R. (2018). Investigations of anti-aging potential of Hypericum origanifolium Willd. for skincare formulations. Industrial Crops and Products, 118, 290-295.
  • Bruneton J (1995). Pharmacognosy, Phytochemistry, Medicinal Plants. Lavoisier Publishing, Paris 367-370.
  • Cakir, A., Kordali, S., Zengin, H., Izumi, S., & Hirata, T. (2004). Composition and antifungal activity of essential oils isolated from Hypericum hyssopifolium and Hypericum heterophyllum. Flavour and Fragrance Journal, 19(1), 62-68.
  • Camas, N., Radusiene, J., Ivanauskas, L., Jakstas, V., Kayikci, S., & Cirak, C. (2014b). Chemical composition of Hypericum species from the Taeniocarpium and Drosanthe sections. Plant systematics and evolution, 300(5), 953-960.
  • Camas, N., Radusiene, J., Stanius, Z., Caliskan, O., & Cirak, C. (2012). Secondary metabolites of Hypericum leptophyllum Hochst., an endemic Turkish species. The Scientific World Journal, 2012.
  • Cellarova, E., Kimakova, K., & Brutovska, R. (1992). Multiple shoot formation in Hypericum perforatum L. and variability of R0. Biol Plant, 34(suppl), 536.
  • Cirak, C., & Bertoli, A. (2013). Aromatic profiling of wild and rare species growing in Turkey: Hypericum aviculariifolium Jaub. and Spach subsp. depilatum (Freyn and Bornm.) Robson var. depilatum and Hypericum pruinatum Boiss. and Bal. Natural product research, 27(2), 100-107.
  • Cirak, C., Radusiene, J., Camas, N., Caliskan, O., & Odabas, M. S. (2013). Changes in the contents of main secondary metabolites in two Turkish Hypericum species during plant development. Pharmaceutical Biology, 51(3), 391-399.
  • Cirak, C., Radusiene, J., Jakstas, V., Ivanauskas, L., Seyis, F., & Yayla, F. (2016a). Secondary metabolites of seven Hypericum species growing in Turkey. Pharmaceutical biology, 54(10), 2244-2253.
  • Cirak, C., Radusiene, J., Jakstas, V., Ivanauskas, L., Yayla, F., Seyis, F., & Camas, N. (2016b). Secondary metabolites of Hypericum species from the Drosanthe and Olympia sections. South African Journal of Botany, 104, 82-90.
  • Çirak, C., Ivanauskas, L., Janulis, V., & Radušienė, J. (2009). Chemical constituents of Hypericum adenotrichum Spach, an endemic Turkish species. Natural product research, 23(13), 1189-1195.
  • Çirak, C., Radušiene, J., Janulis, V., Ivanauskas, L., & Arslan, B. (2007d). Chemical Constituents of SomeHypericum Species Growing in Turkey. Journal of Plant Biology, 50(6), 632.
  • Çirak, C., Sağlam, B., Ayan, A. K., & Kevseroğlu, K. (2006). Morphogenetic and diurnal variation of hypericin in some Hypericum species from Turkey during the course of ontogenesis. Biochemical Systematics and Ecology, 34(1), 1-13.
  • Davis PH, Cullen J, Coode MJE (1967) Flora of Turkey and the East Aegean Islands, (Vol 2), Edinburgh University Press, Edinburgh, 581 pp
  • Dogan, G., Yilmaz, A., Bagci, E., & Kaya, Z. (2017). Molecular Phylogeny Of Sectıon Drosanthe (Spach) Endl.(Hyperıcum L.) Inferred From Chloroplast Genome. Pak. J. Bot, 49(6), 2235-2242.
  • Dulger, B., & Gonuz, A. (2005). Antibacterial activity of the endemic Hypericum kazdaghensis. Fitoterapia, 76(2), 237-239
  • Dulger, B., & Hacioglu, N. (2009). Antibacterial activity of three endemic Hypericum species used in folkloric medicine against methicilin-resistant Staphylococcus aureus. Biotechnology & Biotechnological Equipment, 23(sup1), 763-765.
  • Dulger, B., Gonuz, A., Bilen, S., & Jäger, A. K. (2005). Antimicrobial studies on three Hypericum species from Turkey. South African Journal of Botany, 71(1), 100-103.
  • Dulger, G., & Dulger, B. (2014). Antifungal activity of Hypericum havvae against some medical Candida yeast and Cryptococcus species. Tropical Journal of Pharmaceutical Research, 13(3), 405-408.
  • Dulger, G., & Dulger, B. (2014). Antifungal activity of Hypericum havvae against some medical Candida yeast and Cryptococcus species. Tropical Journal of Pharmaceutical Research, 13(3), 405-408.
  • Dulger, G., Dulger, B., & Aki, C. (2010). Antibacterial activity of two endemic Hypericum (H. kazdaghensis and H. havvae) against Methicillin-Resistant Staphylococcus aureus. Asian Journal of Chemistry, 22(9), 7083.
  • Ekim T, Koyuncu M, Vural M, Duman H, Aytaç Z, Adıgüzel N (2000) Red Data Book of Turkish Plants (Pteridophyta and Spermatophyta), Türkiye Tabiatını Koruma Dernegi & Van 100. Yıl Üniversitesi, Barıçcan Ofset, Ankara, 246 pp
  • Erken, S., Malyer, H., Demirci, F., Demirci, B., & Baser, K. H. C. (2001). Chemical investigations on some Hypericum species growing in Turkey-I. Chemistry of Natural Compounds, 37(5), 434-438.
  • Fu, P., Zhang, W. D., Liu, R. H., Li, T. Z., Shen, Y. H., Li, H. L., ..& Chen, H. S. (2006). Two new xanthones from Hypericum japonicum. Natural product research, 20(13), 1237-1240.
  • Ozkan, E. E., Nurten, O., Ozhan, G., Celik, B. O., & Mat, A. (2013a). Chemical Compositions and Biological Activities of Hypericum neurocalycinum an Endemic Species of Turkey. Planta Medica, 79(13), PJ14.
  • Ozkan, E. E., Ozden, T. Y., Ozsoy, N., & Mat, A. (2018). Evaluation of chemical composition, antioxidant and anti-acetylcholinesterase activities of Hypericum neurocalycinum and Hypericum malatyanum. South African Journal of Botany, 114, 104-110.
  • Ozkan, E. E., Ozsoy, N., Ozden, T. Y., Ozhan, G., & Mat, A. (2018b). Evaluation of Chemical Composition and In-vitro Biological Activities of Three Endemic Hypericum Species from Anatolia (H. thymbrifolium, H. spectabile and H. pseudolaeve). Iranian journal of pharmaceutical research: IJPR, 17(3), 1036.
  • Öcal, A., & Eroğlu, H. E. (2012). In vitro cytogenetic effects of Hypericum heterophyllum in human peripheral blood l Maltas ymphocytes. Bangladesh Journal of Pharmacology, 7(1), 36-41.
  • Özhatay, F. N., Kültür, Ş., & Gürdal, M. B. (2011). Check-list of additional taxa to the supplement Flora of Turkey V. Turkish Journal of Botany, 35(5), 589-624.
  • Özkan, A. M. G., Demirci, B., & Başer, K. H. C. (2009). Essential oil composition of Hypericum thymopsis Boiss. Journal of Essential Oil Research, 21(2), 149-153.
  • Özkan, E. E., Özsoy, N., Özhan, G., Celik, B. Ö., & Mat, A. (2013b). Chemical composition and biological activities of Hypericum pamphylicum. Industrial crops and products, 50, 182-189.
  • Özmen, A., Bauer, S., Gridling, M., Singhuber, J., Krasteva, S., Madlener, S., ...& Szekeres, T. (2009). In vitro anti-neoplastic activity of the ethno-pharmaceutical plant Hypericum adenotrichum Spach endemic to Western Turkey. Oncology reports, 22(4), 845-852.
  • Pretto, F. R., & Santarém, E. R. (2000). Callus formation and plant regeneration from Hypericum perforatum leaves. Plant Cell, Tissue and Organ Culture, 62(2), 107-113.
  • Santarém, E. R., & Astarita, L. V. (2003). Multiple shoot formation in Hypericum perforatum L. and hypericin production. Brazilian journal of plant physiology, 15(1), 43-47.
  • Sarimahmut, M., Balikci, N., Celikler, S., Ari, F., Ulukaya, E., Guleryuz, G., & Ozel, M. Z. (2016). Evaluation of genotoxic and apoptotic potential of Hypericum adenotrichum Spach. in vitro. Regulatory Toxicology and Pharmacology, 74, 137-146.
  • Sezik, E., Yeşilada, E., Honda, G., Takaishi, Y., Takeda, Y., & Tanaka, T. (2001). Traditional medicine in Turkey X. Folk medicine in central Anatolia. Journal of ethnopharmacology, 75(2-3), 95-115.
  • Smelcerovic, A., Zuehlke, S., Spiteller, M., Raabe, N., & Özen, T. (2008). Phenolic constituents of 17 Hypericum species from Turkey. Biochemical Systematics and Ecology, 4(36), 316-319.
  • Solomon, D., Adams, J., & Graves, N. (2013). Economic evaluation of St. John's wort (Hypericum perforatum) for the treatment of mild to moderate depression. Journal of affective disorders, 148(2-3), 228-234.
  • Tala, M. F., Tchakam, P. D., Wabo, H. K., Talontsi, F. M., Tane, P., Kuiate, J. R., & Laatsch, H. (2013). Chemical constituents, antimicrobial and cytotoxic activities of Hypericum riparium (Guttiferae). Records of Natural Products, 7(1), 65.
  • Tekin, M. (2017). Pharmacobotanical study of Hypericum thymopsis. Revista Brasileira de Farmacognosia, 27(2), 143-152.
  • Turkoglu, S., Turkoglu, I., Celik, S., Bahsi, M., Gur, S., & Parlak, A. E. (2015). Some biological compounds, antioxidant and antimicrobial activities of endemic Hypericum uniglandulosum. Chemistry of natural compounds, 51(4), 615-619
  • Uzun, F. (2009). Ontogenic changes in hypericin content of some Hypericum species in natural pastureland of Turkey. Bangladesh J. Bot, 38, 13-18.
  • Yamaner, O., & Erdag, B. (2013). Effects of sucrose and polyethylene glycol on hypericins content in Hypericum adenotrichum. Eurasian Journal of Biosciences, 7.
  • Yamaner, Ö., Erdağ, B., & Gökbulut, C. (2013). Stimulation of the production of hypericins in in vitro seedlings of Hypericum adenotrichum by some biotic elicitors. Turkish Journal of Botany, 37(1), 153-159.
  • Yuce, E. (2009). Hypericum L.(Hypericaceae) cinsine ait Drosanthe (Spach) Endl. seksiyonunun biyosistematigi. Doktora Tezi, Fırat Üniversitesi, Fen Bilimleri Enstitüsü.
  • Yuce, E., & Bagci, E. (2012). The essential oils of the aerial parts of two Hypericum taxa (Hypericum triquetrifolium and Hypericum aviculariifolium subsp. depilatum var. depilatum (Clusiaceae)) from Turkey. Natural product research, 26(21), 1985-1990.
  • Zobayed, S. M. A., Murch, S. J., Rupasinghe, H. P. V., & Saxena, P. K. (2004). In vitro production and chemical characterization of St. John’s wort (Hypericum perforatum L. cv ‘New Stem’). Plant Science, 166(2), 333-340.
Toplam 59 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Derleme Makale
Yazarlar

Hilal Surmuş Asan

Yayımlanma Tarihi 25 Aralık 2019
Gönderilme Tarihi 7 Aralık 2018
Kabul Tarihi 30 Aralık 2019
Yayımlandığı Sayı Yıl 2019 Cilt: 9 Sayı: 2

Kaynak Göster

APA Surmuş Asan, H. (2019). The Studies on The endemic Hypericum Species from Turkey. Batman Üniversitesi Yaşam Bilimleri Dergisi, 9(2), 253-268.