Araştırma Makalesi
BibTex RIS Kaynak Göster

Yıl 2024, Cilt: 10 Sayı: 2, 157 - 165, 04.03.2024

Songül Çetik Yıldız Cumali Keskin Varol Şahintürk Adnan Ayhancı

https://doi.org/10.18621/eurj.1373134

Öz

Kaynakça

  • 1. Abdel-Latif GA, Elwahab AHA, Hasan RA, et al. A novel protective role of sacubitril/valsartan in cyclophosphamide induced lung injury in rats: impact of miRNA-150-3p on NF-κB/MAPK signaling trajectories. Sci Rep. 2020;10(1):13045. doi: 10.1038/s41598-020-69810-5.
  • 2. Saghir SA, Alharbi SA, Al-Garadi MA, et al. Curcumin prevents cyclophosphamide-induced lung injury in rats by suppressing oxidative stress and apoptosis. Processes. 2020;8(2):127. doi: 10.3390/pr8020127.
  • 3. Ab Abd El-Ghafar OAM, Hassanein EHM, Sayed AM, Rashwan EK, Shalkami AS, Mahmoud AM. Acetovanillone prevents cyclophosphamide-induced acute lung injury by modulating PI3K/Akt/mTOR and Nrf2 signaling in rats. Phytother Res. 2021;35(8):4499-4510. doi: 10.1002/ptr.7153.
  • 4. Badawi MS. The protective effect of β-cryptoxanthin against cyclophosphamide-induced lung injury in adult male albino rats. Bull Natl Res Cent. 2022;46:1-9. doi: 10.1186/s42269-022-00792-2.
  • 5. Cengiz M, Cetik Yildiz S, Demir C, Şahin İK, Teksoy Ö, Ayhanci A. Hepato-preventive and anti-apoptotic role of boric acid against liver injury induced by cyclophosphamide. J Trace Elem Med Biol. 2019;53:1-7. doi: 10.1016/j.jtemb.2019.01.013.
  • 6. Mohamed MT, Zaitone SA, Ahmed A, Mehanna ET, El-Sayed NM. Raspberry ketones attenuate cyclophosphamide-induced pulmonary toxicity in mice through inhibition of oxidative stress and NF-ΚB pathway. Antioxidants (Basel). 2020;9(11):1168. doi: 10.3390/antiox9111168.
  • 7. Cengiz M, Sahinturk V, Yildiz SC, et al. Cyclophosphamide induced oxidative stress, lipid per oxidation, apoptosis and histopathological changes in rats: protective role of boron. J Trace Elem Med Biol. 2020;62:126574. doi: 10.1016/j.jtemb.2020.126574.
  • 8. Das UB, Mallick M, Debnath JM, Ghosh D. Protective effect of ascorbic acid on cyclophosphamide- induced testicular gametogenic and androgenic disorders in male rats. Asian J Androl. 2002;4(3):201-207.
  • 9. Habibi E, Shokrzadeh M, Ahmadi A, et al. Pulmonoprotective action of Zataria multiflora ethanolic extract on cyclophosphamide-induced oxidative lung toxicity in mice. Chin J Integr Med. 2020;26(10):754-761. doi: 10.1007/s11655-018-2984-4.
  • 10. El-Kashef DH. Role of venlafaxine in prevention of cyclophosphamide-induced lung toxicity and airway hyperactivity in rats. Environ Toxicol Pharmacol. 2018;58:70-76. doi: 10.1016/j.etap.2017.12.020.
  • 11. Naraoka T, Sumi T, Keira Y, Nakata H, Chiba H. Epirubicin and cyclophosphamide-induced acute fibrinous and Organizing Pneumonia. Am J Respir Crit Care Med. 2021;204(8):e92-e93. doi: 10.1164/rccm.202101-0020IM.
  • 12. Silva AR, Taofiq O, Ferreira IC, Barros L. Hypericum genus cosmeceutical application–A decade comprehensive review on its multifunctional biological properties. Ind Crops Prod. 2021;159:113053. doi: 10.1016/j.indcrop.2020.113053.
  • 13. Can S, Cetik Yıldız S, Keskin C, et al. Investigation into the protective effects of Hypericum Triquetrifolium Turra seed against cyclophosphamide-induced testicular injury in Sprague Dawley rats. Drug Chem Toxicol. 2022;45(4):1679-1686. doi: 10.1080/01480545.2020.1856130.
  • 14. Chen L, Liu Y, Tang Z, et al. Improvements in estrogen deficiency-induced hypercholesterolemia by Hypericum perforatum L. extract are associated with gut microbiota and related metabolites in ovariectomized (OVX) rats. Biomed Pharmacother. 2021;135:111131. doi: 10.1016/j.biopha.2020.111131.
  • 15. Ibaokurgil F, Yildirim BA, Yildirim S. Effects of Hypericum scabrum L. essential oil on wound healing in streptozotocin-induced diabetic rats. Cutan Ocul Toxicol. 2022;41(2):137-144. doi: 10.1080/15569527.2022.2052890.
  • 16. Manzullo EF, Escalante CP. Research into fatigue. Hematol Oncol Clin North Am. 2002;16(3):619-628. doi: 10.1016/s0889-8588(02)00012-6.
  • 17. Toker Z. Variation of total hypericin, phenolic and flavonoid compounds in Hypericum triquetrifolium during its phenological cycle. Pharm Biol. 2009;47(4):285-288. doi: 10.1080/13880200802578983.
  • 18. Alzoubi KH, Abdel-Hafiz L, Khabour OF, El-Elimat T, Alzubi MA, Alali FQ. Evaluation of the Effect of Hypericum triquetrifolium Turra on memory impairment induced by chronic psychosocial stress in rats: role of BDNF. Drug Des Devel Ther. 2020;14:5299-5314. doi: 10.2147/DDDT.S278153.
  • 19. Mustafa YS, Maulood KA. Protective effect of Hypericum triquetrifolium aqueous extract on biochemical and histopathological parameters in hyperlipidemic male rats. Kirkuk University Journal for Scientific Studies. 2019;14(4):63-88. doi: 10.32894/kujss.2019.14.4.5.
  • 20. Suvarna KS, Layton C, Bancroft JD. Bancroft's Theory and Practice of Histological Techniques. E-Book, 8th ed., Elsevier Health Sciences. 2018.
  • 21. Liu J, Huang X, Hu S, He H, Meng Z. Dexmedetomidine attenuates lipopolysaccharide induced acute lung injury in rats by inhibition of caveolin-1 downstream signaling. Biomed Pharmacother. 2019;118:109314. doi: 10.1016/j.biopha.2019.109314.
  • 22. Şengül E, Gelen V, Gedikli S, et al. The protective effect of quercetin on cyclophosphamide-Induced lung toxicity in rats. Biomed Pharmacother. 2017;92:303-307. doi: 10.1016/j.biopha.2017.05.047.
  • 23. Gozuoglu G, Yıldız SC. Myeloprotective and hematoprotective role of kefir on cyclophosphamide toxicity in rats. Arch Clin Exp Med. 2021;6(2):77-82. doi: 10.25000/acem.903843.
  • 24. Faraji N, Ganji A, Heshami N, et al. Hypolipidemic effects of Hypericum Scabrum extract on the serum lipid profile and obesity in high-fat diet fed rats. Hum Antibodies. 2021;29(1):55-61. doi: 10.3233/HAB-200430.
  • 25. Timraz NZ, El-Bassossy HM, Ibrahim SR, El-Halawany AM, Aljohani OS, Abdallah HM. Vasodilating effect of Hypericum revolutum (Vahl)(Clusiaceae) methanol extract in rats. Trop J Pharm Res. 2021;20:1003-1007. doi: 10.4314/tjpr.v20i5.17.
  • 26. Yildiz SC, Keskin C, Şahintürk V, Ayhanci A. Cardioprotective effects of Hypericum triquetrifolium Turra. against cyclophosphamide related cardiotoxicity in rats. Marmara Pharm J. 2018;22(3):374-385. doi: 10.12991/jrp.2018.77.
  • 27. Abd El-Ghafar OAM, Hassanein EHM, Sayed AM, Rashwan EK, Shalkami AS, Mahmoud AM. Acetovanillone prevents cyclophosphamide-induced acute lung injury by modulating PI3K/Akt/mTOR and Nrf2 signaling in rats. Phytother Res. 2021;35(8):4499-4510. doi: 10.1002/ptr.7153.
  • 28. Yildiz SC, Keskin C, Sahintürk V, Ayhanci A. A histopathological, immunohistochemical and biochemical investigation on the in vitro antioxidant, myeloprotective, hematoprotective and hepatoprotective effects of Hypericum triquetrifolium seed extract against cyclophosphamide-induced toxicity. Braz Arch Biol Technol. 2019;62:e19180345. doi: 10.1590/1678-4324-2019180345.

The protective and antiapoptotic effects of Hypericum triquetrifolium Turra against cyclophosphamide-induced lung injury in rats: in vitro evaluation

Yıl 2024, Cilt: 10 Sayı: 2, 157 - 165, 04.03.2024

Songül Çetik Yıldız Cumali Keskin Varol Şahintürk Adnan Ayhancı

https://doi.org/10.18621/eurj.1373134

Öz

Objectives: Hypericum triquetrifolium Turra (HTT) has been traditionally used in medical treatments due to its sedative, antiseptic, antiinflammatory, and anthelmintic properties. The present study aims to investigate the lung-protective and antiapoptotic effects of HTT against cyclophosphamide (CP)-induced lung injury in rats.

Methods: Thirty-five Sprague Dawley rats were categorized into 5 groups, each consisting of seven members. Phenolic acid and flavonoid contents of this plant were determined. The lung tissue samples cultivated from the rats were examined in histopathological and immunohistochemically for the apoptosis markers of Caspase-3, Bax, and Bcl-2.

Results: Histopathological results indicated that structural defects, bleeding areas, and edema had occurred in the lungs of the CP-Alone Group. Besides, Caspase-3 and Bax positivity of the lung cells had also increased while Bcl-2 positivity had decreased. On the other hand, in the HTT+CP Group, HTT was shown to have reversed the aforementioned changes positively.

Conclusion: Based on in vivo results, HTT could be a strong protective candidate for CP-induced lung injury and apoptosis

Anahtar Kelimeler

Cyclophosphamide Hypericum triquetrifolium immunohistochemical apoptosis rats

Kaynakça

  • 1. Abdel-Latif GA, Elwahab AHA, Hasan RA, et al. A novel protective role of sacubitril/valsartan in cyclophosphamide induced lung injury in rats: impact of miRNA-150-3p on NF-κB/MAPK signaling trajectories. Sci Rep. 2020;10(1):13045. doi: 10.1038/s41598-020-69810-5.
  • 2. Saghir SA, Alharbi SA, Al-Garadi MA, et al. Curcumin prevents cyclophosphamide-induced lung injury in rats by suppressing oxidative stress and apoptosis. Processes. 2020;8(2):127. doi: 10.3390/pr8020127.
  • 3. Ab Abd El-Ghafar OAM, Hassanein EHM, Sayed AM, Rashwan EK, Shalkami AS, Mahmoud AM. Acetovanillone prevents cyclophosphamide-induced acute lung injury by modulating PI3K/Akt/mTOR and Nrf2 signaling in rats. Phytother Res. 2021;35(8):4499-4510. doi: 10.1002/ptr.7153.
  • 4. Badawi MS. The protective effect of β-cryptoxanthin against cyclophosphamide-induced lung injury in adult male albino rats. Bull Natl Res Cent. 2022;46:1-9. doi: 10.1186/s42269-022-00792-2.
  • 5. Cengiz M, Cetik Yildiz S, Demir C, Şahin İK, Teksoy Ö, Ayhanci A. Hepato-preventive and anti-apoptotic role of boric acid against liver injury induced by cyclophosphamide. J Trace Elem Med Biol. 2019;53:1-7. doi: 10.1016/j.jtemb.2019.01.013.
  • 6. Mohamed MT, Zaitone SA, Ahmed A, Mehanna ET, El-Sayed NM. Raspberry ketones attenuate cyclophosphamide-induced pulmonary toxicity in mice through inhibition of oxidative stress and NF-ΚB pathway. Antioxidants (Basel). 2020;9(11):1168. doi: 10.3390/antiox9111168.
  • 7. Cengiz M, Sahinturk V, Yildiz SC, et al. Cyclophosphamide induced oxidative stress, lipid per oxidation, apoptosis and histopathological changes in rats: protective role of boron. J Trace Elem Med Biol. 2020;62:126574. doi: 10.1016/j.jtemb.2020.126574.
  • 8. Das UB, Mallick M, Debnath JM, Ghosh D. Protective effect of ascorbic acid on cyclophosphamide- induced testicular gametogenic and androgenic disorders in male rats. Asian J Androl. 2002;4(3):201-207.
  • 9. Habibi E, Shokrzadeh M, Ahmadi A, et al. Pulmonoprotective action of Zataria multiflora ethanolic extract on cyclophosphamide-induced oxidative lung toxicity in mice. Chin J Integr Med. 2020;26(10):754-761. doi: 10.1007/s11655-018-2984-4.
  • 10. El-Kashef DH. Role of venlafaxine in prevention of cyclophosphamide-induced lung toxicity and airway hyperactivity in rats. Environ Toxicol Pharmacol. 2018;58:70-76. doi: 10.1016/j.etap.2017.12.020.
  • 11. Naraoka T, Sumi T, Keira Y, Nakata H, Chiba H. Epirubicin and cyclophosphamide-induced acute fibrinous and Organizing Pneumonia. Am J Respir Crit Care Med. 2021;204(8):e92-e93. doi: 10.1164/rccm.202101-0020IM.
  • 12. Silva AR, Taofiq O, Ferreira IC, Barros L. Hypericum genus cosmeceutical application–A decade comprehensive review on its multifunctional biological properties. Ind Crops Prod. 2021;159:113053. doi: 10.1016/j.indcrop.2020.113053.
  • 13. Can S, Cetik Yıldız S, Keskin C, et al. Investigation into the protective effects of Hypericum Triquetrifolium Turra seed against cyclophosphamide-induced testicular injury in Sprague Dawley rats. Drug Chem Toxicol. 2022;45(4):1679-1686. doi: 10.1080/01480545.2020.1856130.
  • 14. Chen L, Liu Y, Tang Z, et al. Improvements in estrogen deficiency-induced hypercholesterolemia by Hypericum perforatum L. extract are associated with gut microbiota and related metabolites in ovariectomized (OVX) rats. Biomed Pharmacother. 2021;135:111131. doi: 10.1016/j.biopha.2020.111131.
  • 15. Ibaokurgil F, Yildirim BA, Yildirim S. Effects of Hypericum scabrum L. essential oil on wound healing in streptozotocin-induced diabetic rats. Cutan Ocul Toxicol. 2022;41(2):137-144. doi: 10.1080/15569527.2022.2052890.
  • 16. Manzullo EF, Escalante CP. Research into fatigue. Hematol Oncol Clin North Am. 2002;16(3):619-628. doi: 10.1016/s0889-8588(02)00012-6.
  • 17. Toker Z. Variation of total hypericin, phenolic and flavonoid compounds in Hypericum triquetrifolium during its phenological cycle. Pharm Biol. 2009;47(4):285-288. doi: 10.1080/13880200802578983.
  • 18. Alzoubi KH, Abdel-Hafiz L, Khabour OF, El-Elimat T, Alzubi MA, Alali FQ. Evaluation of the Effect of Hypericum triquetrifolium Turra on memory impairment induced by chronic psychosocial stress in rats: role of BDNF. Drug Des Devel Ther. 2020;14:5299-5314. doi: 10.2147/DDDT.S278153.
  • 19. Mustafa YS, Maulood KA. Protective effect of Hypericum triquetrifolium aqueous extract on biochemical and histopathological parameters in hyperlipidemic male rats. Kirkuk University Journal for Scientific Studies. 2019;14(4):63-88. doi: 10.32894/kujss.2019.14.4.5.
  • 20. Suvarna KS, Layton C, Bancroft JD. Bancroft's Theory and Practice of Histological Techniques. E-Book, 8th ed., Elsevier Health Sciences. 2018.
  • 21. Liu J, Huang X, Hu S, He H, Meng Z. Dexmedetomidine attenuates lipopolysaccharide induced acute lung injury in rats by inhibition of caveolin-1 downstream signaling. Biomed Pharmacother. 2019;118:109314. doi: 10.1016/j.biopha.2019.109314.
  • 22. Şengül E, Gelen V, Gedikli S, et al. The protective effect of quercetin on cyclophosphamide-Induced lung toxicity in rats. Biomed Pharmacother. 2017;92:303-307. doi: 10.1016/j.biopha.2017.05.047.
  • 23. Gozuoglu G, Yıldız SC. Myeloprotective and hematoprotective role of kefir on cyclophosphamide toxicity in rats. Arch Clin Exp Med. 2021;6(2):77-82. doi: 10.25000/acem.903843.
  • 24. Faraji N, Ganji A, Heshami N, et al. Hypolipidemic effects of Hypericum Scabrum extract on the serum lipid profile and obesity in high-fat diet fed rats. Hum Antibodies. 2021;29(1):55-61. doi: 10.3233/HAB-200430.
  • 25. Timraz NZ, El-Bassossy HM, Ibrahim SR, El-Halawany AM, Aljohani OS, Abdallah HM. Vasodilating effect of Hypericum revolutum (Vahl)(Clusiaceae) methanol extract in rats. Trop J Pharm Res. 2021;20:1003-1007. doi: 10.4314/tjpr.v20i5.17.
  • 26. Yildiz SC, Keskin C, Şahintürk V, Ayhanci A. Cardioprotective effects of Hypericum triquetrifolium Turra. against cyclophosphamide related cardiotoxicity in rats. Marmara Pharm J. 2018;22(3):374-385. doi: 10.12991/jrp.2018.77.
  • 27. Abd El-Ghafar OAM, Hassanein EHM, Sayed AM, Rashwan EK, Shalkami AS, Mahmoud AM. Acetovanillone prevents cyclophosphamide-induced acute lung injury by modulating PI3K/Akt/mTOR and Nrf2 signaling in rats. Phytother Res. 2021;35(8):4499-4510. doi: 10.1002/ptr.7153.
  • 28. Yildiz SC, Keskin C, Sahintürk V, Ayhanci A. A histopathological, immunohistochemical and biochemical investigation on the in vitro antioxidant, myeloprotective, hematoprotective and hepatoprotective effects of Hypericum triquetrifolium seed extract against cyclophosphamide-induced toxicity. Braz Arch Biol Technol. 2019;62:e19180345. doi: 10.1590/1678-4324-2019180345.
Toplam 28 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Hücre Metabolizması, Sistem Biyolojisi, Yapısal Biyoloji , Biyokimya ve Hücre Biyolojisi (Diğer)
Bölüm Original Article
Yazarlar

Songül Çetik Yıldız 0000-0002-7855-5343

Cumali Keskin 0000-0003-3758-0654

Varol Şahintürk 0000-0003-2317-3644

Adnan Ayhancı 0000-0003-4866-9814

Erken Görünüm Tarihi 22 Aralık 2023
Yayımlanma Tarihi 4 Mart 2024
Gönderilme Tarihi 9 Ekim 2023
Kabul Tarihi 4 Aralık 2023
Yayımlandığı Sayı Yıl 2024 Cilt: 10 Sayı: 2

Kaynak Göster

AMA Çetik Yıldız S, Keskin C, Şahintürk V, Ayhancı A. The protective and antiapoptotic effects of Hypericum triquetrifolium Turra against cyclophosphamide-induced lung injury in rats: in vitro evaluation. Eur Res J. Mart 2024;10(2):157-165. doi:10.18621/eurj.1373134
 Kapak Resmi İndir

e-ISSN: 2149-3189 


The European Research Journal, hosted by Turkish JournalPark ACADEMIC, is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

by-nc-nd.png

2024