Araştırma Makalesi
Yıl 2023,
Cilt: 33 Sayı: 4, 426 - 429, 31.08.2023
Öz
Amaç: Literatürde östrojen ve reseptörlerinin, hastalığın seyri, şiddeti ve pik dönemlerindeki cinsiyet farklılıkları nedeniyle bipolar bozukluğun etiyopatogenezinde önemli rol oynadığına dair artan kanıtlar bulunmaktadır. Bu bağlamda üreme sisteminin yanı sıra sinir sistemi, endokrin sistem ve kardiyovasküler sistemde de tanımlanan ve östradiolün nörolojik faydalarına aracılık eden GPER’in bu hastalıktaki rolünü daha iyi anlamak önemlidir.
Yöntemler: Bu çalışmada, ötimik dönemdeki bipolar bozukluk hastaları ile yaş, cinsiyet ve vücut kitle indeksi açısından eşleştirilmiş sağlıklı kontrollerde serum GPER düzeylerini karşılaştırmayı amaçladık.
Sonuçlar: Bu çalışmada hasta gruplarında kontrol gruplarına göre her iki cinsiyette ayrı ayrı ve toplamda serum GPER düzeylerinin düşük olduğunu saptadık.
Tartışma: Sonuçlarımız ön çalışma olarak değerlendirilmeli ve daha büyük örneklemlerle daha homojen gruplarda tekrarlanmalıdır. Ek olarak, G1'in depresif dönemdeki bipolar hastalarda terapötik etkinliği konusunda daha fazla araştırma yapılması gerektiğine inanıyoruz.
Anahtar Kelimeler
Kaynakça
- Diflorio, A. and I. Jones, Is sex important? Gender differences in bipolar disorder. International review of psychiatry, 2010. 22(5): p. 437-452.
- Gogos, A., et al., Sex differences in schizophrenia, bipolar disorder, and post‐traumatic stress disorder: Are gonadal hormones the link? British Journal of Pharmacology, 2019. 176(21): p. 4119-4135.
- Meinhard, N., L.V. Kessing, and M. Vinberg, The role of estrogen in bipolar disorder, a review. Nordic Journal of Psychiatry, 2014. 68(2): p. 81-87.
- Munk-Olsen, T., et al., New parents and mental disorders: a population-based register study. Jama, 2006. 296(21): p. 2582-2589.
- Payne, J.L., The role of estrogen in mood disorders in women. International Review of Psychiatry, 2003. 15(3): p. 280-290.
- Douma, S., et al., Estrogen-related mood disorders: reproductive life cycle factors. Advances in Nursing Science, 2005. 28(4): p. 364-375.
- Liang, J. and Y. Shang, Estrogen and cancer. Annual review of physiology, 2013. 75: p. 225-240.
- Carroll, J.S. and M. Brown, Estrogen receptor target gene: an evolving concept. Molecular Endocrinology, 2006. 20(8): p. 1707-1714.
- Edwards, D.P., Regulation of signal transduction pathways by estrogen and progesterone. Annu. Rev. Physiol., 2005. 67: p. 335-376.
- Shi, H., S.P.D.S. Kumar, and X. Liu, G protein-coupled estrogen receptor in energy homeostasis and obesity pathogenesis. Progress in Molecular Biology and Translational Science, 2013. 114: p. 193-250.
- Roque, C., et al., The role of G protein-coupled estrogen receptor 1 on neurological disorders. Frontiers in Neuroendocrinology, 2019. 55: p. 100786.
- Hazell, G.G., et al., Localisation of GPR30, a novel G protein-coupled oestrogen receptor, suggests multiple functions in rodent brain and peripheral tissues. The Journal of endocrinology, 2009. 202(2): p. 223.
- Dun, S.L., et al., Expression of estrogen receptor GPR30 in the rat spinal cord and in autonomic and sensory ganglia. Journal of neuroscience research, 2009. 87(7): p. 1610-1619.
- Hwang, W.J., et al., The role of estrogen receptors and their signaling across psychiatric disorders. International journal of molecular sciences, 2020. 22(1): p. 373.
- Einat, H., et al., Protein kinase C inhibition by tamoxifen antagonizes manic-like behavior in rats: implications for the development of novel therapeutics for bipolar disorder. Neuropsychobiology, 2007. 55(3-4): p. 123-131.
- Graae, L., R. Karlsson, and S. Paddock, Significant association of estrogen receptor binding site variation with bipolar disorder in females. PLoS One, 2012. 7(2): p. e32304.
- Dias, R.S., et al., Longitudinal follow-up of bipolar disorder in women with premenstrual exacerbation: findings from STEP-BD. American Journal of Psychiatry, 2011. 168(4): p. 386-394.
- Orhan, F.Ö., et al., Serum levels of GPER-1 in euthymic bipolar patients. Neuropsychiatric Disease and Treatment, 2018: p. 855-862.
- Hursitoglu, O., et al., Evaluation serum levels of g protein-coupled estrogen receptor and its diagnostic value in patients with schizophrenia. memory, 2020. 33: p. 34.
- Davis, K.E., et al., Sexually dimorphic role of G protein-coupled estrogen receptor (GPER) in modulating energy homeostasis. Hormones and behavior, 2014. 66(1): p. 196-207.
- Brailoiu, E., et al., Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system. Journal of endocrinology, 2007. 193(2): p. 311.
- Alexander, A., A.J. Irving, and J. Harvey, Emerging roles for the novel estrogen-sensing receptor GPER1 in the CNS. Neuropharmacology, 2017. 113: p. 652-660.
- Dennis, M.K., et al., In vivo effects of a GPR30 antagonist. Nature chemical biology, 2009. 5(6): p. 421-427.
- Xu, H., et al., Extra-nuclear estrogen receptor GPR30 regulates serotonin function in rat hypothalamus. Neuroscience, 2009. 158(4): p. 1599-1607.
- McAllister, C.E., et al., GPR30 is necessary for estradiol-induced desensitization of 5-HT1A receptor signaling in the paraventricular nucleus of the rat hypothalamus. Psychoneuroendocrinology, 2012. 37(8): p. 1248-1260.
- Benmansour, S., et al., Effects of long-term treatment with estradiol and estrogen receptor subtype agonists on serotonergic function in ovariectomized rats. Neuroendocrinology, 2016. 103(3-4): p. 269-281.
- Lu, C.L. and C. Herndon, New roles for neuronal estrogen receptors. Neurogastroenterology & Motility, 2017. 29(7): p. e13121.
- Ervin, K.S.J., et al., Activation of the G protein-coupled estrogen receptor, but not estrogen receptor α or β, rapidly enhances social learning. Psychoneuroendocrinology, 2015. 58: p. 51-66.
- Van Rheenen, T.E., et al., Current understandings of the trajectory and emerging correlates of cognitive impairment in bipolar disorder: An overview of evidence. Bipolar disorders, 2020. 22(1): p. 13-27.
Yıl 2023,
Cilt: 33 Sayı: 4, 426 - 429, 31.08.2023
Öz
Objectives: There is increasing evidence in the literature that estrogen and its receptors play an important role in the etiopathogenesis of bipolar disorder due to gender differences in the course, severity and peak periods of the disease. In this context, GPER, which is defined in the reproductive system as well as the nervous system, endocrine system and cardiovascular system, and mediates the neurological benefits of estradiol; It is important to better understand its role in this disease.
Method: In this study, we aimed to compare serum GPER levels in euthymic bipolar disorder and healthy controls matched for age, sex and body mass index.
Results: In this study, we found decreased serum GPER levels in both genders separately and in total in the patient groups compared to the control groups.
Conclusion: Our results should be considered preliminary and should be repeated in more homogeneous groups with larger samples. In addition, we believe that further studies should be conducted on the therapeutic efficacy of G1 in depressive bipolar patients.
Anahtar Kelimeler
Kaynakça
- Diflorio, A. and I. Jones, Is sex important? Gender differences in bipolar disorder. International review of psychiatry, 2010. 22(5): p. 437-452.
- Gogos, A., et al., Sex differences in schizophrenia, bipolar disorder, and post‐traumatic stress disorder: Are gonadal hormones the link? British Journal of Pharmacology, 2019. 176(21): p. 4119-4135.
- Meinhard, N., L.V. Kessing, and M. Vinberg, The role of estrogen in bipolar disorder, a review. Nordic Journal of Psychiatry, 2014. 68(2): p. 81-87.
- Munk-Olsen, T., et al., New parents and mental disorders: a population-based register study. Jama, 2006. 296(21): p. 2582-2589.
- Payne, J.L., The role of estrogen in mood disorders in women. International Review of Psychiatry, 2003. 15(3): p. 280-290.
- Douma, S., et al., Estrogen-related mood disorders: reproductive life cycle factors. Advances in Nursing Science, 2005. 28(4): p. 364-375.
- Liang, J. and Y. Shang, Estrogen and cancer. Annual review of physiology, 2013. 75: p. 225-240.
- Carroll, J.S. and M. Brown, Estrogen receptor target gene: an evolving concept. Molecular Endocrinology, 2006. 20(8): p. 1707-1714.
- Edwards, D.P., Regulation of signal transduction pathways by estrogen and progesterone. Annu. Rev. Physiol., 2005. 67: p. 335-376.
- Shi, H., S.P.D.S. Kumar, and X. Liu, G protein-coupled estrogen receptor in energy homeostasis and obesity pathogenesis. Progress in Molecular Biology and Translational Science, 2013. 114: p. 193-250.
- Roque, C., et al., The role of G protein-coupled estrogen receptor 1 on neurological disorders. Frontiers in Neuroendocrinology, 2019. 55: p. 100786.
- Hazell, G.G., et al., Localisation of GPR30, a novel G protein-coupled oestrogen receptor, suggests multiple functions in rodent brain and peripheral tissues. The Journal of endocrinology, 2009. 202(2): p. 223.
- Dun, S.L., et al., Expression of estrogen receptor GPR30 in the rat spinal cord and in autonomic and sensory ganglia. Journal of neuroscience research, 2009. 87(7): p. 1610-1619.
- Hwang, W.J., et al., The role of estrogen receptors and their signaling across psychiatric disorders. International journal of molecular sciences, 2020. 22(1): p. 373.
- Einat, H., et al., Protein kinase C inhibition by tamoxifen antagonizes manic-like behavior in rats: implications for the development of novel therapeutics for bipolar disorder. Neuropsychobiology, 2007. 55(3-4): p. 123-131.
- Graae, L., R. Karlsson, and S. Paddock, Significant association of estrogen receptor binding site variation with bipolar disorder in females. PLoS One, 2012. 7(2): p. e32304.
- Dias, R.S., et al., Longitudinal follow-up of bipolar disorder in women with premenstrual exacerbation: findings from STEP-BD. American Journal of Psychiatry, 2011. 168(4): p. 386-394.
- Orhan, F.Ö., et al., Serum levels of GPER-1 in euthymic bipolar patients. Neuropsychiatric Disease and Treatment, 2018: p. 855-862.
- Hursitoglu, O., et al., Evaluation serum levels of g protein-coupled estrogen receptor and its diagnostic value in patients with schizophrenia. memory, 2020. 33: p. 34.
- Davis, K.E., et al., Sexually dimorphic role of G protein-coupled estrogen receptor (GPER) in modulating energy homeostasis. Hormones and behavior, 2014. 66(1): p. 196-207.
- Brailoiu, E., et al., Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system. Journal of endocrinology, 2007. 193(2): p. 311.
- Alexander, A., A.J. Irving, and J. Harvey, Emerging roles for the novel estrogen-sensing receptor GPER1 in the CNS. Neuropharmacology, 2017. 113: p. 652-660.
- Dennis, M.K., et al., In vivo effects of a GPR30 antagonist. Nature chemical biology, 2009. 5(6): p. 421-427.
- Xu, H., et al., Extra-nuclear estrogen receptor GPR30 regulates serotonin function in rat hypothalamus. Neuroscience, 2009. 158(4): p. 1599-1607.
- McAllister, C.E., et al., GPR30 is necessary for estradiol-induced desensitization of 5-HT1A receptor signaling in the paraventricular nucleus of the rat hypothalamus. Psychoneuroendocrinology, 2012. 37(8): p. 1248-1260.
- Benmansour, S., et al., Effects of long-term treatment with estradiol and estrogen receptor subtype agonists on serotonergic function in ovariectomized rats. Neuroendocrinology, 2016. 103(3-4): p. 269-281.
- Lu, C.L. and C. Herndon, New roles for neuronal estrogen receptors. Neurogastroenterology & Motility, 2017. 29(7): p. e13121.
- Ervin, K.S.J., et al., Activation of the G protein-coupled estrogen receptor, but not estrogen receptor α or β, rapidly enhances social learning. Psychoneuroendocrinology, 2015. 58: p. 51-66.
- Van Rheenen, T.E., et al., Current understandings of the trajectory and emerging correlates of cognitive impairment in bipolar disorder: An overview of evidence. Bipolar disorders, 2020. 22(1): p. 13-27.
Toplam 29 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Klinik Tıp Bilimleri |
| Bölüm | Original Article |
| Yazarlar | |
| Erken Görünüm Tarihi | 29 Ağustos 2023 |
| Yayımlanma Tarihi | 31 Ağustos 2023 |
| Gönderilme Tarihi | 28 Mart 2023 |
| Yayımlandığı Sayı | Yıl 2023 Cilt: 33 Sayı: 4 |
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