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Nanopartiküllerin Genotoksik Etkileri

Yıl 2021, Cilt: 2 Sayı: 2, 19 - 38, 01.11.2021
https://doi.org/10.5281/zenodo.5734749

Öz

Nanoteknolojinin amacı, nanopartikül (NP) olarak adlandırılan maddeleri endüstriyel amaçlarla tasarlamak ve sentezlemektir. Ebatları ˂100 nm olan nanopartiküller, küçük boyut ve geniş yüzey alanı, iletkenlik, güç, dayanıklılık ve reaktivite gibi yeni olağanüstü özellikler kazanır. Bu özelliklerinden dolayı NP'ler tıp, eczacılık, kozmetik, elektronik, tekstil, boya, endüstri ve gıda koruma gibi çeşitli alanlarda yaygın olarak kullanılmaktadır. Fakat bu tür özellikler, nanopartiküllerin biyolojik ve toksikolojik özelliklerini de etkilemektedir. NP'ler önemli biyolojik bariyerleri ve zarları kolayca geçebilir ve organlar, hücresel organeller ve genetik materyal ile etkileşime girebilir. NP'ler oksidatif strese, inflamasyona, sitotoksisiteye, genotoksisiteye ve apoptoza neden olabilir. Bu sebeple, nanopartiküllerin olası genotoksik etkileri, Kromozom Anormallikleri (KA), Kardeş Kromatid Değişimi (KKD), Mikronukleus (MN), kuyruklu yıldız/Komet ve Allium testleri kullanılarak incelenmektedir. Bu çalışmanın amacı, yukarıda adı geçen testlerle incelenmiş olan bakır oksit (CuO), çinko oksit (ZnO), demir oksit (Fe2O3), gümüş (Ag), kobalt-krom (CoCr), silikon dioksit (SiO2), titanyum dioksit (TiO2) ve tungsten oksit (WO3) nanopartiküllerinin insan lenfositlerinde ve bazı hücre hatlarında in vitro ve Allium cepa ve Vicia faba’daki in vivo genotoksik etkileri konusundaki bazı makaleleri derlemektir. Ayrıca, nanopartiküllerin genotoksik mekanizmaları konusunda ileri sürülen görüşleri derlemektir.

Kaynakça

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  • [100] Singh, Z., and Singh, I. (2019). CTAB surfactant assisted and high pH nano-formulations of CuO nanoparticles pose greater cytotoxic and genotoxic effects. Scientific Reports, 9(1), 1-13.
  • [101] Çalbay, Ö. (2014). Bakır oksit ve silikon dioksit nanopartiküllerinin Allium cepa’daki genotoksik etkileri. Yüksek Lisans Tezi. Gazi Üniversitesi Fen Bilimleri Enstitüsü. Ankara. 118.
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  • [104] Scherer, M.D., Sposito, J.C.V., Falco, W.F., Grisolia, A.B., Andrade, L.H.C., Lima. S.M., Machado, G., Nascimento, V.A., Gonçalves, D.A., Wender, H., Oliveira, S.L., and Caires, A.R.L. (2019). Cytotoxic and genotoxic effects of silver nanoparticles on meristematic cells of Allium cepa roots: A close analysis of particle size dependence. Science of the Total Environment, 660, 459-467.
  • [105] Atacı, G. Ve Türkoğlu, Ş. (2020). The investigation of toxic, genotoxic and cytotoxic effects of various nanoparticles in Allium cepa and Caenorhabditis elegans test systems. World Journal of Advanced Research and Reviews, 5(1), 016-035.
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  • [107] Demir, E., Kaya, N., Kaya, B. (2014). Genotoxic effects of Zinc oxide and Titanium dioxide nanoparticles on root meristem cells of Allium cepa by comet assay. Turkish Journal of Biology, 38, 31-39.
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  • [109] Filho, R.D.S., Vicari, T., Santos, S.A., Felisbino, K., Mattoso, N., Santos, B., Cestari, M.M., and Leme, D.M. (2019). Genotoxicity of titanium dioxide nanoparticles and triggering of defense mechanisms in Allium cepa. Genetics and Molecular Biology, 42, 2, 425-435.
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  • [113] Mahmoud, H. (2019). Molecular and cytogenetic assessment of Zinc nanoparticles on Vicia faba plant cells. The Egyptian Journal of Experimental Biology (Botany), 15(1), 39-49.
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Toplam 124 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Derlemeler
Yazarlar

Aleyna Halıcı Bu kişi benim 0000-0002-0423-8441

Açelya Seyrek Bu kişi benim 0000-0003-0334-5154

Kübra Aykan Bu kişi benim 0000-0002-9412-8317

Fatma Ünal 0000-0002-7468-6186

Deniz Yüzbaşıoğlu 0000-0003-2756-7712

Yayımlanma Tarihi 1 Kasım 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 2 Sayı: 2

Kaynak Göster

APA Halıcı, A., Seyrek, A., Aykan, K., Ünal, F., vd. (2021). Nanopartiküllerin Genotoksik Etkileri. Gazi Üniversitesi Fen Fakültesi Dergisi, 2(2), 19-38. https://doi.org/10.5281/zenodo.5734749
AMA Halıcı A, Seyrek A, Aykan K, Ünal F, Yüzbaşıoğlu D. Nanopartiküllerin Genotoksik Etkileri. GÜFFD. Kasım 2021;2(2):19-38. doi:10.5281/zenodo.5734749
Chicago Halıcı, Aleyna, Açelya Seyrek, Kübra Aykan, Fatma Ünal, ve Deniz Yüzbaşıoğlu. “Nanopartiküllerin Genotoksik Etkileri”. Gazi Üniversitesi Fen Fakültesi Dergisi 2, sy. 2 (Kasım 2021): 19-38. https://doi.org/10.5281/zenodo.5734749.
EndNote Halıcı A, Seyrek A, Aykan K, Ünal F, Yüzbaşıoğlu D (01 Kasım 2021) Nanopartiküllerin Genotoksik Etkileri. Gazi Üniversitesi Fen Fakültesi Dergisi 2 2 19–38.
IEEE A. Halıcı, A. Seyrek, K. Aykan, F. Ünal, ve D. Yüzbaşıoğlu, “Nanopartiküllerin Genotoksik Etkileri”, GÜFFD, c. 2, sy. 2, ss. 19–38, 2021, doi: 10.5281/zenodo.5734749.
ISNAD Halıcı, Aleyna vd. “Nanopartiküllerin Genotoksik Etkileri”. Gazi Üniversitesi Fen Fakültesi Dergisi 2/2 (Kasım 2021), 19-38. https://doi.org/10.5281/zenodo.5734749.
JAMA Halıcı A, Seyrek A, Aykan K, Ünal F, Yüzbaşıoğlu D. Nanopartiküllerin Genotoksik Etkileri. GÜFFD. 2021;2:19–38.
MLA Halıcı, Aleyna vd. “Nanopartiküllerin Genotoksik Etkileri”. Gazi Üniversitesi Fen Fakültesi Dergisi, c. 2, sy. 2, 2021, ss. 19-38, doi:10.5281/zenodo.5734749.
Vancouver Halıcı A, Seyrek A, Aykan K, Ünal F, Yüzbaşıoğlu D. Nanopartiküllerin Genotoksik Etkileri. GÜFFD. 2021;2(2):19-38.