3,3-Dimethylcyclohexyl methyl ketone (Herbac®) is a fine fragrance compound used in the cosmetic industry. In this study, the biological derivatisation of the substrate 3,3-dimethylcyclohexyl methyl ketone by 18 fungal cultures was carried out to obtain new derivatives. Among the evaluated, the plant fungus Aspergillus niger ATCC 10549, biotransformed the substrate to the 4-hydroxy derivative in 19% yield. The structure was determined by using NMR and GC-MS spectroscopic methods. In addition, the antimicrobial activity of Herbac® with the metabolite against a panel of pathogenic microbial strains were evaluated using in vitro microdilution. The results showed that the metabolite was relatively more susceptible compared to the substrate Herbac®.
antimicrobial activity Aspergillus niger Biotransformation Fragrance compounds
Scientific and Technological Research Council of Turkey
TEYDEB- 7110249
Financial support from the Scientific and Technological Research Council of Turkey (Grant no: TEYDEB- 7110249) is kindly acknowledged. The authors express their thamks to International Flavors & Fragrances (IFF) Co., USA for providing HERBAC and Badebio Biotechnology Ltd. its infrastructure.
TEYDEB- 7110249
Birincil Dil | İngilizce |
---|---|
Konular | Mühendislik |
Bölüm | Research Article |
Yazarlar | |
Proje Numarası | TEYDEB- 7110249 |
Erken Görünüm Tarihi | 1 Eylül 2022 |
Yayımlanma Tarihi | 1 Ağustos 2022 |
Kabul Tarihi | 14 Mart 2022 |
Yayımlandığı Sayı | Yıl 2022 Cilt: 50 Sayı: 3 |
HACETTEPE JOURNAL OF BIOLOGY AND CHEMİSTRY
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