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Pharmacological activities of extracts and isolated compounds of Acalypha Fruticosa Forssk. (Euphorbiaceae)

Yıl 2022, Cilt: 9 Sayı: 3, 290 - 304, 26.09.2022

Vinujan Shanmugalingam Saravanan Vivekanandarajah Sathasivampillai Pholtan Rajeev Sebastian

Öz

Acalypha fruticosa Forssk is a shrub belonging to the family Euphorbiaceae. A. fruticosa has a wide adaptation through traditional medicinal uses to cure several disorders such as dermatitis, diarrhea, dyspepsia, eye infection, inflammations, and stomachache. This article objects to identify, analyze, and document the reported pharmacological activities of A. fruticosa. Electronic databases namely, PubMed, ScienceDirect, Scopus, and Web of Science were employed to identify the related publications from 1900 to August 2021. Compounds such as 1, 2-benzene dicarboxylic acid diisooctyl ester, and eicosyltrichlorosilane were recognized from different parts of this plant species. Until now, only in vivo and in vitro scientific evidence is available for several pharmacological activities for A. fruticosa. Various parts of this plant species have anticancer, antidiabetic, anthelmintic, antibacterial, antileishmanial, and antiplasmodial properties. This work will benefit the investigators on pharmacological and phytochemical investigations of this plant species in the future.

Anahtar Kelimeler

Acalypha fruticosa Anticancer Bioactivity Euphorbiaceae Traditional Medicine

Destekleyen Kurum

Not Applicable

Proje Numarası

Not Applicable

Teşekkür

This work received no funding. The authors are grateful to their family members for their support to deliver this work.

Kaynakça

  • Alasbahi, R.H., Safiyeva, S., & Craker, L.E. (1999). Antimicrobial activity of some Yemeni medicinal plants. J. Herbs Spices Med. Plants., 6, 75 83. https://doi.org/10.1300/J044v06n03_07
  • Al-Massarani, S., El-Sayed, M.I.K., & El-Shaibany, A. (2019). Antioxidant and anti-proliferative activities of Acalypha fruticosa: Possible elucidated mechanism. Pak. J. Pharm. Sci., 32, 2041–2050.
  • Alshawsh, M.A., Mothana, R.A., Al-shamahy, H.A., Alsllami, S.F., & Lindequist, U. (2007). Assessment of Antimalarial Activity against Plasmodium falciparum and Phytochemical Screening of Some Yemeni Medicinal Plants. Evid. Based Complement. Alternat. Med., 6, 453–456. https://doi.org/10.1093/ecam/nem148
  • Ambasta, S.P. (1986). The Useful Plants of India. Publication and Information Directorate, CSIR, New Delhi, India, pp. 8.
  • Anonymous. (1988). The Wealth of India- Raw Materials, Vol-1, CSIR, New Delhi, India, pp. 47- 48.
  • Chellappandian, M., Saravanan, M., Pandikumar, P., Harikrishnan, P., Thirugnanasambantham, K., Subramanian, S., Hairul - Islam, V.I., & Ignacimuthu, S. (2018). Traditionally practiced medicinal plant extracts inhibit the ergosterol biosynthesis of clinically isolated dermatophytic pathogens. J. Mycol. Med., 28, 143–149. https://doi.org/10.1016/j.mycmed.2017.11.001
  • Deepaa, C.V., Chalchat, J.C., & John, J.A. (2012). Chemical composition of the essential oil from the leaves of Acalypha fruticosa. J. Essent. Oil-Bear. Plants, 15, 609–613. https://doi.org/10.1080/0972060X.2012.10644095
  • Duraipandiyan, V., Ayyanar, M., & Ignacimuthu, S. (2006). Antimicrobial activity of some ethnomedicinal plants used by Paliyar tribe from Tamil Nadu, India. BMC Complement. Altern. Med., 6, 35. https://doi.org/10.1186/1472-6882-6-35
  • Duraipandiyan, V., & Ignacimuthu, S. (2011). Antifungal activity of traditional medicinal plants from Tamil Nadu, India. Asian Pac. J. Trop. Biomed., 1(SUPPL. 2), S204–S215. https://doi.org/10.1016/S2221-1691(11)60157-3
  • El-Shaibany, A., Al-Habori, M., Al-Massarani, S., Al-Adhl, A., & Michalsen, A. (2015). Hypoglycemic activity of Acalypha fruticosa forssk extracts in normal rabbits. Trop. J. Pharm. Res., 14, 1445–1450. https://doi.org/10.4314/tjpr.v14i8.17
  • Fawzy, G.A., Al-Taweel, A.M., Perveen, S., Shabana, I.K., & Fatma, A.A. (2016). Bioactivity and chemical characterization of Acalypha fruticosa Forssk. growing in Saudi Arabia. Saudi Pharm. J., 25, 104–109. https://doi.org/10.1016/j.jsps.2016.05.004
  • Fleurentin, J., & Pelt, J.M. (1982). Repertory of drugs and medicinal plants of Yemen. J. Ethnopharmacol., 6, 85-108.
  • Gopalakrishnan, S., Saroja, K., & Elizabeth, J.D. (2010). Chemical investigations of aerial parts of Acalypha fruticosa forssk. Der. Pharma. Chem., 2, 383–389.
  • Govindu, S., & Adikay, S. (2014). Evaluation of antiepileptic activity of chloroform extract of Acalypha fruticosa in mice. Pharmacogn. Res., 6, 108–112. https://doi.org/10.4103/0974-8490.128970
  • Kew Science; Plants of the world online, Acalypha fruticosa, (2021). http://www.plantsoftheworldonline.org/taxon/urn:lsid:ipni.org:names:664873-1
  • Khare, C. (2007). Acalypha fruticosa Forsk. In: Khare C. (eds) Indian Medicinal Plants. Springer. https://doi.org/10.1007/978-0-387-70638-2_19
  • Kirtikar, K.R., & Basu, B.D. (2003). Indian Medicinal Plants, Vol. 3, Bishen Singh Mahendra Pal Sing, Dehra Dun, India, pp. 2261.
  • Mothana, R., Al-Musayeib, N., Al-Ajmi, M.F., Cos, P., & Maes, L. (2014). Evaluation of the in vitro antiplasmodial, antileishmanial, and antitrypanosomal activities of selected medicinal plants from the Arabian Peninsula. Planta Medica., 79, PA24. https://doi.org/10.1055/s-0033-1351928
  • Mothana, R.A.A., Abdo, S.A.A., Hasson, S., Althawab, F.M.N., Alaghbari, S.A.Z., & Lindequist, U. (2010). Antimicrobial, antioxidant, and cytotoxic activities and phytochemical screening of some Yemeni medicinal plants. Evid. Based Complement. Alternat. Med., 7, 323–330. https://doi.org/10.1093/ecam/nen004
  • Mothana, R.A.A., Grünert, R., Lindequist, U., & Bednarski, P.J. (2006). Study of the anticancer potential of Yemeni plants used in folk medicine. Pharmazie, 62, 305–307. https://doi.org/10.1691/ph.2007.4.6696
  • Muthukumarasamy, S., Mohan, V.R., Kumaresan, S., & Chelladurai, V.K. (2003). Herbal remedies of paliyar tribe of grizzled giant squirrel wildlife sanctuary, Western Ghats, Srivilliputhur, Tamil Nadu for poisonous bites. J. Econ. Taxon. Bot., 27, 761‑764.
  • Raj, L., Gadamsetty, G., & Sarada, N.C. (2012). Comparative studies on in vitro anthelmintic activity of Gymnema sylvestre and Acalypha fruticosa forssk. Int. J. Pharm., 4, 107–109.
  • Rajkumar, V., Guha, G., & Ashok Kumar, R. (2010) Therapeutic potential of Acalypha fruticosa. Food Chem. Toxicol., 48, 1709–1713. https://doi.org/10.1016/j.fct.2010.03.050
  • Ruffo, C.K., Birnie, A., & Tengnas, B. (2002). Edible wild plants of Tanzania. RELMA Technical Handbook Series 27. Nairobi, Kenya: Regional Land Management Unit (RELMA), Swedish International Development Cooperation Agency (Sida), pp. 80.
  • Schmelzer, G.H. (2007). Acalypha fruticosa Forssk. In: Medicinal plants. Netherlands: PROTA, pp. 11.
  • Senthilkumar, M., Gurumoorthi, P., & Janardhanan, K. (2006). Some medicinal plants used by Irular, the tribal people of Marudhamalai hills, Coimbatore, Tamil Nadu. Nat. Prod. Radiance, 5, 382–388.
  • Sivakumar, T., Murthi, M.N.V., & Kumutha, P. (2010). Evaluation of anti-tumor and anti-oxidant activity of Acalypha fruticosa in Ehrlich’s Ascites Carcinoma bearing Swiss albino mice. Res. J. Pharm. Biol. Chem., 1, 191–199.
  • Thambiraj, J., & Paulsamy, S. (2011). Antimicrobial screening of stem extract of the folklore medicinal plant, Acalypha fruticosa forssk. Int. J. Pharm., 3, 285–287.
  • Thambiraj, J., Paulsamy, S., & Sevukaperumal, R. (2012). Evaluation of in vitro antioxidant activity in the traditional medicinal shrub of western districts of Tamil Nadu, India, Acalypha fruticosa Forssk. (Euphorbiaceae). Asian Pac. J. Trop. Biomed., 2, S127–S130. https://doi.org/10.1016/S2221-1691(12)60142-7

Pharmacological activities of extracts and isolated compounds of Acalypha Fruticosa Forssk. (Euphorbiaceae)

Yıl 2022, Cilt: 9 Sayı: 3, 290 - 304, 26.09.2022

Vinujan Shanmugalingam Saravanan Vivekanandarajah Sathasivampillai Pholtan Rajeev Sebastian

Öz

Acalypha fruticosa Forssk is a shrub belonging to the family Euphorbiaceae. A. fruticosa has a wide adaptation through traditional medicinal uses to cure several disorders such as dermatitis, diarrhea, dyspepsia, eye infection, inflammations, and stomachache. This article objects to identify, analyze, and document the reported pharmacological activities of A. fruticosa. Electronic databases namely, PubMed, ScienceDirect, Scopus, and Web of Science were employed to identify the related publications from 1900 to August 2021. Compounds such as 1, 2-benzene dicarboxylic acid diisooctyl ester, and eicosyltrichlorosilane were recognized from different parts of this plant species. Until now, only in vivo and in vitro scientific evidence is available for several pharmacological activities for A. fruticosa. Various parts of this plant species have anticancer, antidiabetic, anthelmintic, antibacterial, antileishmanial, and antiplasmodial properties. This work will benefit the investigators on pharmacological and phytochemical investigations of this plant species in the future.

Anahtar Kelimeler

Acalypha fruticosa Anticancer Bioactivity Euphorbiaceae Traditional Medicine

Proje Numarası

Not Applicable

Kaynakça

  • Alasbahi, R.H., Safiyeva, S., & Craker, L.E. (1999). Antimicrobial activity of some Yemeni medicinal plants. J. Herbs Spices Med. Plants., 6, 75 83. https://doi.org/10.1300/J044v06n03_07
  • Al-Massarani, S., El-Sayed, M.I.K., & El-Shaibany, A. (2019). Antioxidant and anti-proliferative activities of Acalypha fruticosa: Possible elucidated mechanism. Pak. J. Pharm. Sci., 32, 2041–2050.
  • Alshawsh, M.A., Mothana, R.A., Al-shamahy, H.A., Alsllami, S.F., & Lindequist, U. (2007). Assessment of Antimalarial Activity against Plasmodium falciparum and Phytochemical Screening of Some Yemeni Medicinal Plants. Evid. Based Complement. Alternat. Med., 6, 453–456. https://doi.org/10.1093/ecam/nem148
  • Ambasta, S.P. (1986). The Useful Plants of India. Publication and Information Directorate, CSIR, New Delhi, India, pp. 8.
  • Anonymous. (1988). The Wealth of India- Raw Materials, Vol-1, CSIR, New Delhi, India, pp. 47- 48.
  • Chellappandian, M., Saravanan, M., Pandikumar, P., Harikrishnan, P., Thirugnanasambantham, K., Subramanian, S., Hairul - Islam, V.I., & Ignacimuthu, S. (2018). Traditionally practiced medicinal plant extracts inhibit the ergosterol biosynthesis of clinically isolated dermatophytic pathogens. J. Mycol. Med., 28, 143–149. https://doi.org/10.1016/j.mycmed.2017.11.001
  • Deepaa, C.V., Chalchat, J.C., & John, J.A. (2012). Chemical composition of the essential oil from the leaves of Acalypha fruticosa. J. Essent. Oil-Bear. Plants, 15, 609–613. https://doi.org/10.1080/0972060X.2012.10644095
  • Duraipandiyan, V., Ayyanar, M., & Ignacimuthu, S. (2006). Antimicrobial activity of some ethnomedicinal plants used by Paliyar tribe from Tamil Nadu, India. BMC Complement. Altern. Med., 6, 35. https://doi.org/10.1186/1472-6882-6-35
  • Duraipandiyan, V., & Ignacimuthu, S. (2011). Antifungal activity of traditional medicinal plants from Tamil Nadu, India. Asian Pac. J. Trop. Biomed., 1(SUPPL. 2), S204–S215. https://doi.org/10.1016/S2221-1691(11)60157-3
  • El-Shaibany, A., Al-Habori, M., Al-Massarani, S., Al-Adhl, A., & Michalsen, A. (2015). Hypoglycemic activity of Acalypha fruticosa forssk extracts in normal rabbits. Trop. J. Pharm. Res., 14, 1445–1450. https://doi.org/10.4314/tjpr.v14i8.17
  • Fawzy, G.A., Al-Taweel, A.M., Perveen, S., Shabana, I.K., & Fatma, A.A. (2016). Bioactivity and chemical characterization of Acalypha fruticosa Forssk. growing in Saudi Arabia. Saudi Pharm. J., 25, 104–109. https://doi.org/10.1016/j.jsps.2016.05.004
  • Fleurentin, J., & Pelt, J.M. (1982). Repertory of drugs and medicinal plants of Yemen. J. Ethnopharmacol., 6, 85-108.
  • Gopalakrishnan, S., Saroja, K., & Elizabeth, J.D. (2010). Chemical investigations of aerial parts of Acalypha fruticosa forssk. Der. Pharma. Chem., 2, 383–389.
  • Govindu, S., & Adikay, S. (2014). Evaluation of antiepileptic activity of chloroform extract of Acalypha fruticosa in mice. Pharmacogn. Res., 6, 108–112. https://doi.org/10.4103/0974-8490.128970
  • Kew Science; Plants of the world online, Acalypha fruticosa, (2021). http://www.plantsoftheworldonline.org/taxon/urn:lsid:ipni.org:names:664873-1
  • Khare, C. (2007). Acalypha fruticosa Forsk. In: Khare C. (eds) Indian Medicinal Plants. Springer. https://doi.org/10.1007/978-0-387-70638-2_19
  • Kirtikar, K.R., & Basu, B.D. (2003). Indian Medicinal Plants, Vol. 3, Bishen Singh Mahendra Pal Sing, Dehra Dun, India, pp. 2261.
  • Mothana, R., Al-Musayeib, N., Al-Ajmi, M.F., Cos, P., & Maes, L. (2014). Evaluation of the in vitro antiplasmodial, antileishmanial, and antitrypanosomal activities of selected medicinal plants from the Arabian Peninsula. Planta Medica., 79, PA24. https://doi.org/10.1055/s-0033-1351928
  • Mothana, R.A.A., Abdo, S.A.A., Hasson, S., Althawab, F.M.N., Alaghbari, S.A.Z., & Lindequist, U. (2010). Antimicrobial, antioxidant, and cytotoxic activities and phytochemical screening of some Yemeni medicinal plants. Evid. Based Complement. Alternat. Med., 7, 323–330. https://doi.org/10.1093/ecam/nen004
  • Mothana, R.A.A., Grünert, R., Lindequist, U., & Bednarski, P.J. (2006). Study of the anticancer potential of Yemeni plants used in folk medicine. Pharmazie, 62, 305–307. https://doi.org/10.1691/ph.2007.4.6696
  • Muthukumarasamy, S., Mohan, V.R., Kumaresan, S., & Chelladurai, V.K. (2003). Herbal remedies of paliyar tribe of grizzled giant squirrel wildlife sanctuary, Western Ghats, Srivilliputhur, Tamil Nadu for poisonous bites. J. Econ. Taxon. Bot., 27, 761‑764.
  • Raj, L., Gadamsetty, G., & Sarada, N.C. (2012). Comparative studies on in vitro anthelmintic activity of Gymnema sylvestre and Acalypha fruticosa forssk. Int. J. Pharm., 4, 107–109.
  • Rajkumar, V., Guha, G., & Ashok Kumar, R. (2010) Therapeutic potential of Acalypha fruticosa. Food Chem. Toxicol., 48, 1709–1713. https://doi.org/10.1016/j.fct.2010.03.050
  • Ruffo, C.K., Birnie, A., & Tengnas, B. (2002). Edible wild plants of Tanzania. RELMA Technical Handbook Series 27. Nairobi, Kenya: Regional Land Management Unit (RELMA), Swedish International Development Cooperation Agency (Sida), pp. 80.
  • Schmelzer, G.H. (2007). Acalypha fruticosa Forssk. In: Medicinal plants. Netherlands: PROTA, pp. 11.
  • Senthilkumar, M., Gurumoorthi, P., & Janardhanan, K. (2006). Some medicinal plants used by Irular, the tribal people of Marudhamalai hills, Coimbatore, Tamil Nadu. Nat. Prod. Radiance, 5, 382–388.
  • Sivakumar, T., Murthi, M.N.V., & Kumutha, P. (2010). Evaluation of anti-tumor and anti-oxidant activity of Acalypha fruticosa in Ehrlich’s Ascites Carcinoma bearing Swiss albino mice. Res. J. Pharm. Biol. Chem., 1, 191–199.
  • Thambiraj, J., & Paulsamy, S. (2011). Antimicrobial screening of stem extract of the folklore medicinal plant, Acalypha fruticosa forssk. Int. J. Pharm., 3, 285–287.
  • Thambiraj, J., Paulsamy, S., & Sevukaperumal, R. (2012). Evaluation of in vitro antioxidant activity in the traditional medicinal shrub of western districts of Tamil Nadu, India, Acalypha fruticosa Forssk. (Euphorbiaceae). Asian Pac. J. Trop. Biomed., 2, S127–S130. https://doi.org/10.1016/S2221-1691(12)60142-7
Toplam 29 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Yapısal Biyoloji , Eczacılık ve İlaç Bilimleri
Bölüm Makaleler
Yazarlar

Vinujan Shanmugalingam 0000-0002-9208-4090

Saravanan Vivekanandarajah Sathasivampillai 0000-0002-5938-0509

Pholtan Rajeev Sebastian 0000-0001-9341-5843

Proje Numarası Not Applicable
Erken Görünüm Tarihi 24 Ağustos 2022
Yayımlanma Tarihi 26 Eylül 2022
Gönderilme Tarihi 8 Ekim 2021
Yayımlandığı Sayı Yıl 2022 Cilt: 9 Sayı: 3

Kaynak Göster

APA Shanmugalingam, V., Vivekanandarajah Sathasivampillai, S., & Sebastian, P. R. (2022). Pharmacological activities of extracts and isolated compounds of Acalypha Fruticosa Forssk. (Euphorbiaceae). International Journal of Secondary Metabolite, 9(3), 290-304.
International Journal of Secondary Metabolite
e-ISSN: 2148-6905