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BibTex RIS Kaynak Göster
Yıl 2018, Cilt: 10 Sayı: 3, 783 - 783, 18.08.2018
https://doi.org/10.37212/jcnos.610103

Öz

Kaynakça

  • Cani PD, Everard A, Duparc T. 2013. Gut microbiota, enteroendocrine functions and metabolism. Curr Opin Pharmacol 13:935-940.
  • Collins SM, Surette M, Bercik P. 2012. The interplay between the intestinal microbiota and the brain. Nat Rev Microbiol. 10:735- 742.
  • Mayer EA, Tillisch K, Gupta A. 2015. Gut/brain axis and the microbiota. J Clin Invest. 125:926-938. Romijn JA, Corssmit EP, Havekes LM, Pijl H. 2008. Gut-brain axis. Curr Opin Clin Nutr Metab Care 11:518-521.

The gut-brain axis: interactions between microbiota and nervous systems

Yıl 2018, Cilt: 10 Sayı: 3, 783 - 783, 18.08.2018
https://doi.org/10.37212/jcnos.610103

Öz

Humans coexist in a mutualistic relationship with the intestinal microbiota, a complex microbial ecosystem that resides largely in the distal bowel. The lower gastrointestinal tract contains almost 100 trillion microorganisms, most of which are bacteria. More than 1,000 bacterial species have been identified in this microbiota. The intestinal microbiota lives in a symbiotic relationship with the host. A bidirectional neurohumoral communication system, known as the gut–brain axis, integrates the host gut and brain activities (Mayer et al. 2015). Communication between the brain and gut occurs along a network of pathways collectively termed the brain-gut axis. The brain-gut axis encompass the CNS, ENS, sympathetic and parasympathetic branches of the autonomic nervous system, neuroendocrine and neuroimmune pathways, and the gut microbiota (Colins et al. 2012). The gut microbiota can signal to the brain via a number of pathways which include: regulating immune activity and the production of roinflammatory cytokines that can either stimulate the HPA axis to produce CRH, ACTH and cortisol, or directly impact on CNS immune activity; through the production of SCFAs such as propionate, butyrate, and acetate; the production of neurotransmitters which may enter circulation and cross the blood brain barrier; by modulating tryptophan metabolism and downstream metabolites, serotonin, kynurenic acid and quinolinic acid. Neuronal and spinal pathways, particularly afferent signaling pathways of the vagus nerve, are critical in mediating the effect of the gut microbiota on brain function and behavior. Microbial produced SCFAs and indole also impact on EC cells of the enteric nervous system (Romijn et al. 2008; Cani et al. 2013). The purpose of this presentation was to summarize our current knowledge regarding the role of microbiota in bottom-up pathways of communication in the gutbrain axis.

Kaynakça

  • Cani PD, Everard A, Duparc T. 2013. Gut microbiota, enteroendocrine functions and metabolism. Curr Opin Pharmacol 13:935-940.
  • Collins SM, Surette M, Bercik P. 2012. The interplay between the intestinal microbiota and the brain. Nat Rev Microbiol. 10:735- 742.
  • Mayer EA, Tillisch K, Gupta A. 2015. Gut/brain axis and the microbiota. J Clin Invest. 125:926-938. Romijn JA, Corssmit EP, Havekes LM, Pijl H. 2008. Gut-brain axis. Curr Opin Clin Nutr Metab Care 11:518-521.
Toplam 3 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm Original Articles
Yazarlar

Orhan Akpınar

Yayımlanma Tarihi 18 Ağustos 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 10 Sayı: 3

Kaynak Göster

APA Akpınar, O. (2018). The gut-brain axis: interactions between microbiota and nervous systems. Journal of Cellular Neuroscience and Oxidative Stress, 10(3), 783-783. https://doi.org/10.37212/jcnos.610103
AMA Akpınar O. The gut-brain axis: interactions between microbiota and nervous systems. J Cell Neurosci Oxid Stress. Ağustos 2018;10(3):783-783. doi:10.37212/jcnos.610103
Chicago Akpınar, Orhan. “The Gut-Brain Axis: Interactions Between Microbiota and Nervous Systems”. Journal of Cellular Neuroscience and Oxidative Stress 10, sy. 3 (Ağustos 2018): 783-83. https://doi.org/10.37212/jcnos.610103.
EndNote Akpınar O (01 Ağustos 2018) The gut-brain axis: interactions between microbiota and nervous systems. Journal of Cellular Neuroscience and Oxidative Stress 10 3 783–783.
IEEE O. Akpınar, “The gut-brain axis: interactions between microbiota and nervous systems”, J Cell Neurosci Oxid Stress, c. 10, sy. 3, ss. 783–783, 2018, doi: 10.37212/jcnos.610103.
ISNAD Akpınar, Orhan. “The Gut-Brain Axis: Interactions Between Microbiota and Nervous Systems”. Journal of Cellular Neuroscience and Oxidative Stress 10/3 (Ağustos 2018), 783-783. https://doi.org/10.37212/jcnos.610103.
JAMA Akpınar O. The gut-brain axis: interactions between microbiota and nervous systems. J Cell Neurosci Oxid Stress. 2018;10:783–783.
MLA Akpınar, Orhan. “The Gut-Brain Axis: Interactions Between Microbiota and Nervous Systems”. Journal of Cellular Neuroscience and Oxidative Stress, c. 10, sy. 3, 2018, ss. 783-, doi:10.37212/jcnos.610103.
Vancouver Akpınar O. The gut-brain axis: interactions between microbiota and nervous systems. J Cell Neurosci Oxid Stress. 2018;10(3):783-.