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Endonezya Halk Tıbbında Saga Bitkisi Abrus Precatorius L.'nin Kullanımı

Yıl 2024, Cilt: 4 Sayı: 1, 1 - 8, 31.03.2024

Achmad Yozar Perkasa

https://doi.org/10.59359/maujan.1311263

Öz

Saga ya da Latince adıyla Abrus precatorius L., Fabaceae familyasına ait olup tropikal ve subtropikal bölgelerde yetişen ve aynı zamanda geleneksel tıp uygulamalarında da yaygın olarak kullanılan bir baklagil bitkisidir. Saga'nın doğal özelliklere sahip bir bitki olduğuna inanılıyor ve çeşitli hastalıkları tedavi etmek için ilaç yapmak için bir bileşen kaynağı olarak önemli. Saga'nın anti-diyabetik, anti-doğurganlık, anti-mikrop, anti-kanser vb. Saga bitkisinin yaprak, kök ve tohum şeklindeki kısımları, birçok geleneksel insan tarafından nesiller boyu sürdürülen doğal tıp için kullanılabilir. Yaprak bıçağın bir kısmı triterpen bileşikleri, alkaloidler, glikozitler ve glisirizin içerir. Saga bitkisinin ayrıca insanlar tarafından tüketildiğinde çok tehlikeli toksik etkisi olan abrin bileşiğine sahip olduğu bilinmektedir. Bu makalenin gözden geçirilmesi, destan bitkisi hakkında yararlı bilgiler toplamayı ve böylece insanoğlunun yararına daha iyi kullanılabilmesi ve güçlendirilebilmesini amaçlamaktadır.

Anahtar Kelimeler

Abrus Precatorius L Biyoaktif Bileşikler Endonezya Halk Tıbbı Saga Bitki Kullanımı

Kaynakça

  • Akram, M., Hamid, A., Khalil, A., Ghaffar, A., Tayyaba, N., Saeed, A., Ali, M. and Naveed, A. 2014. Review on medicinal uses, pharmacological, phytochemistry and immunomodulatory activity of plants. International Journal of Immunopathology and Pharmacology, 27(3): 313-319.
  • Backer, C. A and Van den Brink, B. 1965. Flora of Java. NVP Nordhoff-Groningen The Netherlands II. 622 p.
  • Barrows. W. 1968. Text book of Microbiology 19th Edition. W. B. Saunders Co:187-207.
  • Bhatia, M., Siddiqui, N. A. and Gupta, S. 2013. Abrus precatorius (L.) :An evaluation of traditional herb. Indo American Journal of Pharmaceutical Research, 3(4): 3295-3315.
  • Bhakta, S., and Das S. K. 2020. The medicinal values of Abrus precatorius: a review study. J Adv Biotechnol Exp Ther, 3(2):84-91. https://doi.org/10.5455/jabet.2020.d111
  • Bahrami, Y. and Franco, C. M. M. 2016. Acetylated triterpene glycosides and their biological activity from holothuroidea reported in the past six decades. Mar Drugs, 14(8):147. https://doi.org/10.3390/md14080147
  • Burkill, I. A. 1935. Dictionary of Economic Prodacts of Malay Peninsula Known Agent for the Colonies. London II. 4-9.
  • Das, A., Jain, V. and Mishra A. A. 2016. Brief review on a traditional herb: Abrus precatorius (L.). Int J Forensic Med Toxicol Sci, 1(1):1-10. https://doi.org/10.18231/j.ijfmts.2016.001
  • Departemen Kesehatan R.I. 1979. Farmakope Indonesia Edisi III. Direktorat Jenderal Pengawasan Obat dan Makanan. Jakarta. 781-782.
  • Diningrat O. U. S. 1987. Plasma Nutfah Tanaman Saga Pengembangan penelitian Plasma Nutfah Tanaman Rempah dan Obat. Edisi Khusus Littro III. (1) 74-77.
  • Dwijoseputro. R. 1989. Dasar-dasar Mikrobiologi. Penerbit Djambatan, Malang: 113 118.
  • Eriani, K., Ainsyah, Rosnizar, Yunita, Ichsan dan Azhar, A. 2018. Uji efek imunostimulan ekstrak metanol daun flamboyan [Delonix regia (Boj. ex Hook.) Raf.] terhadap peningkatan sel-sel imun pada mencit strain swiss-webster. Jurnal Natural, 18(1): 44-48.
  • Emmyzar, Taryono. 1990. Peningkatan Mutu Lingkungan Hidup Melalui TOGA. Makalah Pertemuan PIA Ardhia Garini Halim Perdanakusumah. Jakarta.
  • Garaniya, N. and Bapodra, A. 2014. Ethno botanical and Phytophrmacological potential of Abrus precatorius L.: A review. Asian Pac J Trop Biomed. 4:S27-34. https://doi.org/10.12980/APJTB.4.2014C1069
  • Gatler, R. J. 1991. Pengantar Kromatografi Edisi II. Penerbit ITB, Bandung,107-109.
  • Hadioetomo, R. S. 1985. Mikrobiologi Dasar dalam Praktek. Penerbit PT. Gramedia. Jakarta: 53-56, 149-151.
  • Helliwel, B. and Gutteridge, J. M. C. 1999. Free Radical in Biology and Medicine. 3rd ed. Oxford University Press, 1999, p. 23-31, 105-115.
  • Herrmann, M. S. and Behnke, W. D. 1981. A characterization of abrin a from the seeds of the Abrus precatorius plant. Biochim Biophys Acta (BBA)-Protein Struct. 667(2):397-410. https://doi.org/10.1016/0005-2795(81)90206-3
  • Heyne, K. 1987. Tumbuhan Berguna Indonesia. Jilid II. Badan Penelitian dan Pengembangan Kehutanan, Jakarta.
  • Karpurashetti, N. B., Hiremath, S. K. and Manjulabai, K. H. K. S. 2014. A review of gunja (Abrus precatorius. linn) on both aspect of medicine as well as poison. Asian J Pharm Res Dev. 2(1):66-7.
  • Keputusan Menteri Kesehatan Republik Indonesia. 2017. No. Hk.01.07/ Menkes/2017. Tentang formularium ramuan obat tradisional Indonesia. Menkes RI.
  • Juniarti, Osmeli, D., dan Yuhemita. 2010. Kandungan senyawa kimia, uji toksisitas (Brine shrimp lethality test) dan antioksidan (1,1-diphenyl-2-pikrilhydrazyl) dari ekstrak daun saga (Abrus precatorius L.). Makara Journal of Science, 13(1): 50-54.
  • Kardinan, A, 2005. Peptisida Nabati Ramuan Dan Aplikasi. Penebar Swadaya, Jakarta.
  • Meyer, B. N., Feerigni, N. R., Putnam, J. E., Jacobson, L. B., Nicholas, D. E. and McLaughlin, J. L. 1982. Planta Medica 45, 31-34.
  • Nenov, V. D, Marinov, P., Sabeva, J. and Nenov, D. S. 2003. Current applications of plasmapheresis in clinical toxicology. Nephrol Dial Transplant. 18(suppl_5):v56-8. https://doi.org/10.1093/ndt/gfg1049
  • Qian, H., Wang, L., Li, Y., Wang, B., Li, C., Fang, L. and Tang, L. 2022. The traditional uses, phytochemistry and pharmacology of Abrus precatorius L.: A comprehensive review, Journal of Ethnopharmacology, Volume 296, 115463 https://doi.org/10.1016/j.jep.2022.115463.
  • Pal, R. S., Ariharasivakumar, G., Girhepunjhe, K. and Upadhay, A. 2009. In-vitro antioxidative activity of phenolic and flavonoid compounds extracted from seeds of Abrus precatorius. Int J Pharm Pharm Sci. 1(2):136-40.
  • Patil, M. M., Patil, S. V., Akki, A. S. and Lakhkar, B. B. S. 2016. An arrow poison (Abrus precatorius) causing fatal poisoning in a child. J Clin diagnostic Res JCDR. 10(3):SD03-4. https://doi.org/10.7860/JCDR/2016/18234.7439
  • Raddish, F. 1961. Antiseptic, Desinfectans, Fungicides and Chemical and Physical Stenlization 2th Edition. Lea and Philadelphia USA. 98-99.
  • Ross, A. I., 2003. Abrusprecatorius L., Medicinal Plants of the World, vol. 1: Chemical Constituents, Traditional and Modern Medicinal Uses, 2nd edition. 506.
  • Rosrta, S. M. D., Rostiana, O., Wahid, P. dan Sitepu, D. 1991. Program dan Perkembangan Penelitian Tumbuhan Obat Indonesia. Prosiding Pelestarian Pemanfaatan Tumbuhan Obat dan Hujan Tropis Indonesia. 137-158.
  • Tam, C. C., Henderson, T. D., Stanker, L. H. and He, X. C. L. W. 2017. Abrin toxicity and bioavailability after temperature and ph treatment. Toxins (Basel). 9(10):320. https://doi.org/10.3390/toxins9100320
  • Verma, S. 2016. Phytochemical and pharmacological study on Abrus precatorius. Asian J Plant Sci Res. 6(2):24-6.
  • Verma, D, Tiwari, S. S., Srivastava, S. and Rawat, A. K. S. 2011. Pharmacognostical evaluation and phytochemical standardization of Abrus precatorius L. seeds. Nat Prod Sci. 17(1):51-7.
  • Wooten, J. V., Pittman, C. T., Blake, T. A., Thomas, J. D., Devlin, J. J., Higgerson, R. A., et al. 2014. A case of abrin toxin poisoning, confirmed via quantitation of L-abrine (N-methyl-L-tryptophan) biomarker. J Med Toxicol. 10(4):392-4. https://doi.org/10.1007/s13181-013-0377-9
  • Widiyanti, H. 2005. Sejarah perkembangan industri jamu tradisional dan pengaruhnya terhadap kehidupan sosial masyarakat gentasari kecamatan kroya kabupaten cilacap tahun 1990-2002. Perpustakaan Universitas Semarang. Semarang.
  • Yonemoto R, Shimada, M., Gunawan-Puteri, M. D. P. T., Kato, E. and Kawabata, J. 2014. α-Amylase inhibitory triterpene from Abrus precatorius leaves. J Agric Food Chem. 62(33):8411-4. https://doi.org/10.1021/jf502667z
  • Wang, Z. Y., Cheng, S. J., Zhou, Z. C., Athar, M., Khan, W. A., Bickers, D. R., and Mukhtar, H. 1989. Mutat. Res, 223 273-285.

Utilization of The Saga Plant Abrus Precatorius L. in Indonesian Folk Medicine

Yıl 2024, Cilt: 4 Sayı: 1, 1 - 8, 31.03.2024

Achmad Yozar Perkasa

https://doi.org/10.59359/maujan.1311263

Öz

Saga or known by the Latin name Abrus precatorius L. belongs to the Fabaceae family and is a leguminosae plant that grows in tropical and subtropical regions and has also been widely used for traditional medicinal practices. Saga is believed to be a plant that has natural properties and is important as a source of ingredients for making medicines to treat various diseases. Many pharmacological studies have been carried out which state that saga has various biological activities that can be act as anti-diabetic, anti-fertility, anti-germ, anti-cancer, and so on. Parts of the saga plant in the form of leaves, roots and seeds can be used for natural medicine which has been carried out by many traditional people for generations. Part of the leaf blade contains triterpene compounds, alkaloids, glycosides, and glycyrrhizin. It is known that the saga plant also has an abrin compound which has a very dangerous toxic effect when consumed by humans. The review of this article aims to gather useful information regarding the saga plant so that it can be better utilized and empowered for the benefit of human beings.

Anahtar Kelimeler

Abrus Precatorius L Bioactive Compounds Indonesian Folk Medicine Saga Plant Utilization

Kaynakça

  • Akram, M., Hamid, A., Khalil, A., Ghaffar, A., Tayyaba, N., Saeed, A., Ali, M. and Naveed, A. 2014. Review on medicinal uses, pharmacological, phytochemistry and immunomodulatory activity of plants. International Journal of Immunopathology and Pharmacology, 27(3): 313-319.
  • Backer, C. A and Van den Brink, B. 1965. Flora of Java. NVP Nordhoff-Groningen The Netherlands II. 622 p.
  • Barrows. W. 1968. Text book of Microbiology 19th Edition. W. B. Saunders Co:187-207.
  • Bhatia, M., Siddiqui, N. A. and Gupta, S. 2013. Abrus precatorius (L.) :An evaluation of traditional herb. Indo American Journal of Pharmaceutical Research, 3(4): 3295-3315.
  • Bhakta, S., and Das S. K. 2020. The medicinal values of Abrus precatorius: a review study. J Adv Biotechnol Exp Ther, 3(2):84-91. https://doi.org/10.5455/jabet.2020.d111
  • Bahrami, Y. and Franco, C. M. M. 2016. Acetylated triterpene glycosides and their biological activity from holothuroidea reported in the past six decades. Mar Drugs, 14(8):147. https://doi.org/10.3390/md14080147
  • Burkill, I. A. 1935. Dictionary of Economic Prodacts of Malay Peninsula Known Agent for the Colonies. London II. 4-9.
  • Das, A., Jain, V. and Mishra A. A. 2016. Brief review on a traditional herb: Abrus precatorius (L.). Int J Forensic Med Toxicol Sci, 1(1):1-10. https://doi.org/10.18231/j.ijfmts.2016.001
  • Departemen Kesehatan R.I. 1979. Farmakope Indonesia Edisi III. Direktorat Jenderal Pengawasan Obat dan Makanan. Jakarta. 781-782.
  • Diningrat O. U. S. 1987. Plasma Nutfah Tanaman Saga Pengembangan penelitian Plasma Nutfah Tanaman Rempah dan Obat. Edisi Khusus Littro III. (1) 74-77.
  • Dwijoseputro. R. 1989. Dasar-dasar Mikrobiologi. Penerbit Djambatan, Malang: 113 118.
  • Eriani, K., Ainsyah, Rosnizar, Yunita, Ichsan dan Azhar, A. 2018. Uji efek imunostimulan ekstrak metanol daun flamboyan [Delonix regia (Boj. ex Hook.) Raf.] terhadap peningkatan sel-sel imun pada mencit strain swiss-webster. Jurnal Natural, 18(1): 44-48.
  • Emmyzar, Taryono. 1990. Peningkatan Mutu Lingkungan Hidup Melalui TOGA. Makalah Pertemuan PIA Ardhia Garini Halim Perdanakusumah. Jakarta.
  • Garaniya, N. and Bapodra, A. 2014. Ethno botanical and Phytophrmacological potential of Abrus precatorius L.: A review. Asian Pac J Trop Biomed. 4:S27-34. https://doi.org/10.12980/APJTB.4.2014C1069
  • Gatler, R. J. 1991. Pengantar Kromatografi Edisi II. Penerbit ITB, Bandung,107-109.
  • Hadioetomo, R. S. 1985. Mikrobiologi Dasar dalam Praktek. Penerbit PT. Gramedia. Jakarta: 53-56, 149-151.
  • Helliwel, B. and Gutteridge, J. M. C. 1999. Free Radical in Biology and Medicine. 3rd ed. Oxford University Press, 1999, p. 23-31, 105-115.
  • Herrmann, M. S. and Behnke, W. D. 1981. A characterization of abrin a from the seeds of the Abrus precatorius plant. Biochim Biophys Acta (BBA)-Protein Struct. 667(2):397-410. https://doi.org/10.1016/0005-2795(81)90206-3
  • Heyne, K. 1987. Tumbuhan Berguna Indonesia. Jilid II. Badan Penelitian dan Pengembangan Kehutanan, Jakarta.
  • Karpurashetti, N. B., Hiremath, S. K. and Manjulabai, K. H. K. S. 2014. A review of gunja (Abrus precatorius. linn) on both aspect of medicine as well as poison. Asian J Pharm Res Dev. 2(1):66-7.
  • Keputusan Menteri Kesehatan Republik Indonesia. 2017. No. Hk.01.07/ Menkes/2017. Tentang formularium ramuan obat tradisional Indonesia. Menkes RI.
  • Juniarti, Osmeli, D., dan Yuhemita. 2010. Kandungan senyawa kimia, uji toksisitas (Brine shrimp lethality test) dan antioksidan (1,1-diphenyl-2-pikrilhydrazyl) dari ekstrak daun saga (Abrus precatorius L.). Makara Journal of Science, 13(1): 50-54.
  • Kardinan, A, 2005. Peptisida Nabati Ramuan Dan Aplikasi. Penebar Swadaya, Jakarta.
  • Meyer, B. N., Feerigni, N. R., Putnam, J. E., Jacobson, L. B., Nicholas, D. E. and McLaughlin, J. L. 1982. Planta Medica 45, 31-34.
  • Nenov, V. D, Marinov, P., Sabeva, J. and Nenov, D. S. 2003. Current applications of plasmapheresis in clinical toxicology. Nephrol Dial Transplant. 18(suppl_5):v56-8. https://doi.org/10.1093/ndt/gfg1049
  • Qian, H., Wang, L., Li, Y., Wang, B., Li, C., Fang, L. and Tang, L. 2022. The traditional uses, phytochemistry and pharmacology of Abrus precatorius L.: A comprehensive review, Journal of Ethnopharmacology, Volume 296, 115463 https://doi.org/10.1016/j.jep.2022.115463.
  • Pal, R. S., Ariharasivakumar, G., Girhepunjhe, K. and Upadhay, A. 2009. In-vitro antioxidative activity of phenolic and flavonoid compounds extracted from seeds of Abrus precatorius. Int J Pharm Pharm Sci. 1(2):136-40.
  • Patil, M. M., Patil, S. V., Akki, A. S. and Lakhkar, B. B. S. 2016. An arrow poison (Abrus precatorius) causing fatal poisoning in a child. J Clin diagnostic Res JCDR. 10(3):SD03-4. https://doi.org/10.7860/JCDR/2016/18234.7439
  • Raddish, F. 1961. Antiseptic, Desinfectans, Fungicides and Chemical and Physical Stenlization 2th Edition. Lea and Philadelphia USA. 98-99.
  • Ross, A. I., 2003. Abrusprecatorius L., Medicinal Plants of the World, vol. 1: Chemical Constituents, Traditional and Modern Medicinal Uses, 2nd edition. 506.
  • Rosrta, S. M. D., Rostiana, O., Wahid, P. dan Sitepu, D. 1991. Program dan Perkembangan Penelitian Tumbuhan Obat Indonesia. Prosiding Pelestarian Pemanfaatan Tumbuhan Obat dan Hujan Tropis Indonesia. 137-158.
  • Tam, C. C., Henderson, T. D., Stanker, L. H. and He, X. C. L. W. 2017. Abrin toxicity and bioavailability after temperature and ph treatment. Toxins (Basel). 9(10):320. https://doi.org/10.3390/toxins9100320
  • Verma, S. 2016. Phytochemical and pharmacological study on Abrus precatorius. Asian J Plant Sci Res. 6(2):24-6.
  • Verma, D, Tiwari, S. S., Srivastava, S. and Rawat, A. K. S. 2011. Pharmacognostical evaluation and phytochemical standardization of Abrus precatorius L. seeds. Nat Prod Sci. 17(1):51-7.
  • Wooten, J. V., Pittman, C. T., Blake, T. A., Thomas, J. D., Devlin, J. J., Higgerson, R. A., et al. 2014. A case of abrin toxin poisoning, confirmed via quantitation of L-abrine (N-methyl-L-tryptophan) biomarker. J Med Toxicol. 10(4):392-4. https://doi.org/10.1007/s13181-013-0377-9
  • Widiyanti, H. 2005. Sejarah perkembangan industri jamu tradisional dan pengaruhnya terhadap kehidupan sosial masyarakat gentasari kecamatan kroya kabupaten cilacap tahun 1990-2002. Perpustakaan Universitas Semarang. Semarang.
  • Yonemoto R, Shimada, M., Gunawan-Puteri, M. D. P. T., Kato, E. and Kawabata, J. 2014. α-Amylase inhibitory triterpene from Abrus precatorius leaves. J Agric Food Chem. 62(33):8411-4. https://doi.org/10.1021/jf502667z
  • Wang, Z. Y., Cheng, S. J., Zhou, Z. C., Athar, M., Khan, W. A., Bickers, D. R., and Mukhtar, H. 1989. Mutat. Res, 223 273-285.
Toplam 38 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Tıbbi ve Aromatik Bitkiler
Bölüm Derlemeler
Yazarlar

Achmad Yozar Perkasa 0000-0002-8327-1599

Yayımlanma Tarihi 31 Mart 2024
Gönderilme Tarihi 7 Haziran 2023
Yayımlandığı Sayı Yıl 2024 Cilt: 4 Sayı: 1

Kaynak Göster

APA Perkasa, A. Y. (2024). Utilization of The Saga Plant Abrus Precatorius L. in Indonesian Folk Medicine. Muş Alparslan University Journal of Agriculture and Nature, 4(1), 1-8. https://doi.org/10.59359/maujan.1311263
AMA Perkasa AY. Utilization of The Saga Plant Abrus Precatorius L. in Indonesian Folk Medicine. MAÜ Tarım Doğa Derg. Mart 2024;4(1):1-8. doi:10.59359/maujan.1311263
Chicago Perkasa, Achmad Yozar. “Utilization of The Saga Plant Abrus Precatorius L. In Indonesian Folk Medicine”. Muş Alparslan University Journal of Agriculture and Nature 4, sy. 1 (Mart 2024): 1-8. https://doi.org/10.59359/maujan.1311263.
EndNote Perkasa AY (01 Mart 2024) Utilization of The Saga Plant Abrus Precatorius L. in Indonesian Folk Medicine. Muş Alparslan University Journal of Agriculture and Nature 4 1 1–8.
IEEE A. Y. Perkasa, “Utilization of The Saga Plant Abrus Precatorius L. in Indonesian Folk Medicine”, MAÜ Tarım Doğa Derg, c. 4, sy. 1, ss. 1–8, 2024, doi: 10.59359/maujan.1311263.
ISNAD Perkasa, Achmad Yozar. “Utilization of The Saga Plant Abrus Precatorius L. In Indonesian Folk Medicine”. Muş Alparslan University Journal of Agriculture and Nature 4/1 (Mart 2024), 1-8. https://doi.org/10.59359/maujan.1311263.
JAMA Perkasa AY. Utilization of The Saga Plant Abrus Precatorius L. in Indonesian Folk Medicine. MAÜ Tarım Doğa Derg. 2024;4:1–8.
MLA Perkasa, Achmad Yozar. “Utilization of The Saga Plant Abrus Precatorius L. In Indonesian Folk Medicine”. Muş Alparslan University Journal of Agriculture and Nature, c. 4, sy. 1, 2024, ss. 1-8, doi:10.59359/maujan.1311263.
Vancouver Perkasa AY. Utilization of The Saga Plant Abrus Precatorius L. in Indonesian Folk Medicine. MAÜ Tarım Doğa Derg. 2024;4(1):1-8.
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