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Eskişehir’deki Psikiyatrik Hastalarda Folat ve B12 Vitamin Seviyelerinin Değerlendirilmesi

Yıl 2018, Cilt: 3 Sayı: 1, 210 - 213, 29.06.2018

Öz

Majör depresif bozukluk, kişinin sosyal işlevlerini ve
günlük yaşama dair etkinliklerini rahatsız edecek dereceye ulaşmış üzüntü,
melankoli veya keder durumudur. İlaç ile tedavisi ise özellikle kişilerin
tedaviye olumlu yanıt vermesi noktasında yetersiz ve iyileşme sürecinden uzakta
kalmaktadır. Son zamanlarda yapılan çalışmalar insanlarda meydana çıkan bu
depresif bozukluklarda beslenmede yer alan vitamin ve minerallerin önemli bir
rolü olduğuna yönelik kanıtlar ortaya koymaktadır. Merkezi sinir sistemi üzerindeki
etkileri sonucu Folat ve B12 vitamini bu noktada çalışmaların odağı olmaktadır.
Çalışmamızda Eskişehir Osmangazi Üniversitesi psikiyatri servisine başvuran
ayakta tedavi edilen hastaların Folat ve B12 vitamin düzeyleri incelendi. Bu
amaçla 2016 yılında psikiyatri servisine başvuran, B12 vitamin düzeyleri
ölçülen 343 hastanın ve Folat düzeyleri ölçülen 250 hastanın verileri
retrospektif olarak belirlendi. Elde edilen tüm veriler, SPSS 21 paket programı
ile istatistiksel olarak değerlendirildi. Değerlendirme sonucunda, Folat
eksikliğinin prevelansı %15,6, B12 vitamin eksikliğinin pravelansı ise %15,45
olarak bulunmuştur. Literatür ile uyumlu çıkan sonuçlarımız için majör depresif
bozukluk tanı ve tedavi sürecinde rutin olarak B12 vitamininin ve Folat düzeylerinin
takip edilmesi gerektiği söylenebilir. Özellikle antidepresan kullanımının
kısıtlanması ve semptomların giderilmesi noktasında yapılacak vitamin
takviyeleri ile olumlu sonuçlar alınabileceği yorumu yapılabilir.

Kaynakça

  • Acarkan T, Nazlıkul H. 2017. Depresyona Tamamlayıcı Tıp Yaklaşımı. Journal of Complementary Medicine, Regulation and Neural Therapy 11: 1.
  • Alpert J, Fava M. 1997. Nutrition and depression: the role of folate. Nutr Rev, 55:145–149.
  • Assies J, Pouwer F, Lok A, Mocking, RJ, Bockting CL, Visser I, Schene AH. 2010. Plasma and erythrocyte fatty acid patterns in patients with recurrent depression: A matched case–control study. PLoS ONE, 5: 10635.
  • Bhat RS, Chiu E, Jeste DV. 2005. Beslenme ve geriatrik psikiyatri: ihmal edilmiş bir alan. Curr Opin Psychiatry, 18: 609–14.
  • Bjelland I, Ueland PM, Vollset SE. 2003. Folate and depression. Psychother Psychosom, 72: 59–60.
  • Bolander-Gouaille C, Bottiglieri T. 2007. Homocysteine- Related Vitamins and Neuropsychiatric Disorders. Paris: Springer.
  • Carney MWP, Sheffield BF. 1978. Serum folic acid and B12 in psychiatric in-patients. Psychol Med, 8: 139–144.
  • Chen CN, Wong J, Lee N, Chan-Ho M W, Lau J T F, Fung M. 1993. The Shatin Community Mental Health Survey in Hong Kong. Arch Gen Psychiatry, 50: 125–133.
  • Coppen A, Swade C, Jones S A, Armstrong R A, Blair J A, Leeming RJ. 1989. Depression and tetrahydrobiopterin: the folate connection. J Affect Disord, 16: 103–107.
  • Demet D, Telci Fİ, Dilbaz N, Okay T. 2006. B12 vitamini eksikliğine bağlı psikotik bozukluk. Klinik Psikofarmakoloji Bülteni, 16: 109–113.
  • İnan M. 2017. 10 kişiden 1’i ilaç kullanıyor. http://www.milliyet.com.tr/10-kisiden-1-i-ilac-kullaniyor-gundem, [Son güncelleme: 24.03.2017].
  • Karadima V, Kraniotou C, Bellos G, George T. 2016. Drug-micronutrient interactions: food for thought and thought for action The EPMA Journal, 7: 10.
  • Lazarou C, Kapsou M. 2010. The role of folic acid in prevention and treatment of depression: an overview of existing evidence and implications for practice. Complement Ther Clin Pract, 16: 161–166.
  • Lee S, Chow CC, Shek CC, Wing YK, Chen CN. 1992. Folate concentration in Chinese psychiatric outpatients on long-term lithium treatment. J Affect Disord, 24: 265–270.
  • Lee S, Wing YK, Fong S. 1998. A controlled study of folate levels in Chinese inpatients with major depression in Hong Kong. J Affect Diosord, 49: 73–77.
  • Lerner V, Kanevsky M, Dwolatzky T, Rouach T, Kamin R, Miodownik C. 2006. Vitamin B12 and folat serum levels in newly admitted psychiatric patients. Clin Nutr, 25: 60–67.
  • Penninx BW, Guralnik JM, Ferrucci L, Fried LP, Allen R H, Stabler SP. 2000. Vitamin B12 deficiency and depression in physically disabled older women: epidemiologic evidence from the Women’s health and Aging Study. Am J Psychiatry, 157: 715–721.
  • Prince M, Patel V, Saxena S, Maj M, Maselko J, Phillips MR, Rahman A. 2007. No health without mental health. Lancet, 370: 859–877.
  • Reynolds EH. 2002. Folic acid, ageing, depression and dementia. Br Med J, 324: 1512–515.
  • Rosche J, Uhlman C, Froscher W. 2003. Low serum folate levels as a risk factor for depressive mood in patients with chronic epilepsy. J Neuropsychiatry Clin Neurosci, 15: 64–66.
  • Shorvon S, Carney MWP, Chanarin I, Reynolds E. 1980. The neuropsychiatry of megaloblastic anaemia. Br Med J, 281: 1036–1038.
  • Simon N, Young J. 2007. Folate and depression a neglected problem. Psychiatry Neurosci, 32: 80–82.
  • Tufan AE, Bilici R, Usta G, Erdoğan A. 2012. Mood disorder with mixed, psychotic features due to vitamin B12 deficiency in an adolescent: case report. Child and Adolescent Psychiatry and Mental Health, 6: 25.
  • Weissman MM, Bland RC, Canino GJ, Faravelli C, Greenwald S, Hwu HG, Joyce PR, Karam EG, Lee CK, Lellouch J, Lepine JP, Newman SC, Rubic-Stipec M, Wells JE, Wickramaratne PJ, Wittchen HU, Yeh EK. 1996. Cross-national epidemiology of major depression and bipolar disorder. JAMA, 276: 293–299.
  • Yener G, Van Loon P. 2009. Vitamin B12 Status in Patients of Turkish and Dutch Descent with Depression: A Comparative Cross-Sectional Study. Ann General Psychiatry, 8: 18.

Evaluation of Folate and B12 Vitamin Levels in Psychiatric Patients in Eskişehir

Yıl 2018, Cilt: 3 Sayı: 1, 210 - 213, 29.06.2018

Öz

Major depressive disorder is sadness, melancholy, or
grief, which has reached a degree of disturbance for one's social functions and
activities of daily living. Drug treatment is inadequate at the situation where
people respond positively to treatment, and is far from the recovery process.
Recent studies have shown evidence that vitamins and minerals in the diet play
an important role in these depressive disorders that occur in humans. The
effects on the central nervous system are the resultant Folate and B12
vitamins. In our study, Folate and vitamin B12 levels of outpatients treated
with Eskişehir Osmangazi University psychiatric department were examined. For
this purpose, 343 patients with vitamin B12 levels and 250 patients with Folate
levels who were referred to a psychiatric service in 2016 were retrospectively
determined. All the data obtained were evaluated statistically by SPSS 21
package program. As a result of the evaluation, the prevalence of folate
deficiency was found to be 15.6% and that of vitamin B12 deficiency was found
to be 15.45%. For our results consistent with the literature, it can be said
that vitamin B12 and folate levels should be routinely monitored during the
diagnosis and treatment of major depressive disorder. Especially, antidepressant
use restriction and relieving symptoms can be interpreted as positive results
with vitamin supplements.

Kaynakça

  • Acarkan T, Nazlıkul H. 2017. Depresyona Tamamlayıcı Tıp Yaklaşımı. Journal of Complementary Medicine, Regulation and Neural Therapy 11: 1.
  • Alpert J, Fava M. 1997. Nutrition and depression: the role of folate. Nutr Rev, 55:145–149.
  • Assies J, Pouwer F, Lok A, Mocking, RJ, Bockting CL, Visser I, Schene AH. 2010. Plasma and erythrocyte fatty acid patterns in patients with recurrent depression: A matched case–control study. PLoS ONE, 5: 10635.
  • Bhat RS, Chiu E, Jeste DV. 2005. Beslenme ve geriatrik psikiyatri: ihmal edilmiş bir alan. Curr Opin Psychiatry, 18: 609–14.
  • Bjelland I, Ueland PM, Vollset SE. 2003. Folate and depression. Psychother Psychosom, 72: 59–60.
  • Bolander-Gouaille C, Bottiglieri T. 2007. Homocysteine- Related Vitamins and Neuropsychiatric Disorders. Paris: Springer.
  • Carney MWP, Sheffield BF. 1978. Serum folic acid and B12 in psychiatric in-patients. Psychol Med, 8: 139–144.
  • Chen CN, Wong J, Lee N, Chan-Ho M W, Lau J T F, Fung M. 1993. The Shatin Community Mental Health Survey in Hong Kong. Arch Gen Psychiatry, 50: 125–133.
  • Coppen A, Swade C, Jones S A, Armstrong R A, Blair J A, Leeming RJ. 1989. Depression and tetrahydrobiopterin: the folate connection. J Affect Disord, 16: 103–107.
  • Demet D, Telci Fİ, Dilbaz N, Okay T. 2006. B12 vitamini eksikliğine bağlı psikotik bozukluk. Klinik Psikofarmakoloji Bülteni, 16: 109–113.
  • İnan M. 2017. 10 kişiden 1’i ilaç kullanıyor. http://www.milliyet.com.tr/10-kisiden-1-i-ilac-kullaniyor-gundem, [Son güncelleme: 24.03.2017].
  • Karadima V, Kraniotou C, Bellos G, George T. 2016. Drug-micronutrient interactions: food for thought and thought for action The EPMA Journal, 7: 10.
  • Lazarou C, Kapsou M. 2010. The role of folic acid in prevention and treatment of depression: an overview of existing evidence and implications for practice. Complement Ther Clin Pract, 16: 161–166.
  • Lee S, Chow CC, Shek CC, Wing YK, Chen CN. 1992. Folate concentration in Chinese psychiatric outpatients on long-term lithium treatment. J Affect Disord, 24: 265–270.
  • Lee S, Wing YK, Fong S. 1998. A controlled study of folate levels in Chinese inpatients with major depression in Hong Kong. J Affect Diosord, 49: 73–77.
  • Lerner V, Kanevsky M, Dwolatzky T, Rouach T, Kamin R, Miodownik C. 2006. Vitamin B12 and folat serum levels in newly admitted psychiatric patients. Clin Nutr, 25: 60–67.
  • Penninx BW, Guralnik JM, Ferrucci L, Fried LP, Allen R H, Stabler SP. 2000. Vitamin B12 deficiency and depression in physically disabled older women: epidemiologic evidence from the Women’s health and Aging Study. Am J Psychiatry, 157: 715–721.
  • Prince M, Patel V, Saxena S, Maj M, Maselko J, Phillips MR, Rahman A. 2007. No health without mental health. Lancet, 370: 859–877.
  • Reynolds EH. 2002. Folic acid, ageing, depression and dementia. Br Med J, 324: 1512–515.
  • Rosche J, Uhlman C, Froscher W. 2003. Low serum folate levels as a risk factor for depressive mood in patients with chronic epilepsy. J Neuropsychiatry Clin Neurosci, 15: 64–66.
  • Shorvon S, Carney MWP, Chanarin I, Reynolds E. 1980. The neuropsychiatry of megaloblastic anaemia. Br Med J, 281: 1036–1038.
  • Simon N, Young J. 2007. Folate and depression a neglected problem. Psychiatry Neurosci, 32: 80–82.
  • Tufan AE, Bilici R, Usta G, Erdoğan A. 2012. Mood disorder with mixed, psychotic features due to vitamin B12 deficiency in an adolescent: case report. Child and Adolescent Psychiatry and Mental Health, 6: 25.
  • Weissman MM, Bland RC, Canino GJ, Faravelli C, Greenwald S, Hwu HG, Joyce PR, Karam EG, Lee CK, Lellouch J, Lepine JP, Newman SC, Rubic-Stipec M, Wells JE, Wickramaratne PJ, Wittchen HU, Yeh EK. 1996. Cross-national epidemiology of major depression and bipolar disorder. JAMA, 276: 293–299.
  • Yener G, Van Loon P. 2009. Vitamin B12 Status in Patients of Turkish and Dutch Descent with Depression: A Comparative Cross-Sectional Study. Ann General Psychiatry, 8: 18.
Toplam 25 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm 2018-Makaleler
Yazarlar

Fatih Kar

Ceyhan Hacıoğlu

Zeynep Küskü Kiraz

Sema Uslu

Güngör Kanbak

Yayımlanma Tarihi 29 Haziran 2018
Kabul Tarihi 28 Haziran 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 3 Sayı: 1

Kaynak Göster

APA Kar, F., Hacıoğlu, C., Küskü Kiraz, Z., Uslu, S., vd. (2018). Eskişehir’deki Psikiyatrik Hastalarda Folat ve B12 Vitamin Seviyelerinin Değerlendirilmesi. Turkish Journal of Life Sciences, 3(1), 210-213.
AMA Kar F, Hacıoğlu C, Küskü Kiraz Z, Uslu S, Kanbak G. Eskişehir’deki Psikiyatrik Hastalarda Folat ve B12 Vitamin Seviyelerinin Değerlendirilmesi. TJLS. Haziran 2018;3(1):210-213.
Chicago Kar, Fatih, Ceyhan Hacıoğlu, Zeynep Küskü Kiraz, Sema Uslu, ve Güngör Kanbak. “Eskişehir’deki Psikiyatrik Hastalarda Folat Ve B12 Vitamin Seviyelerinin Değerlendirilmesi”. Turkish Journal of Life Sciences 3, sy. 1 (Haziran 2018): 210-13.
EndNote Kar F, Hacıoğlu C, Küskü Kiraz Z, Uslu S, Kanbak G (01 Haziran 2018) Eskişehir’deki Psikiyatrik Hastalarda Folat ve B12 Vitamin Seviyelerinin Değerlendirilmesi. Turkish Journal of Life Sciences 3 1 210–213.
IEEE F. Kar, C. Hacıoğlu, Z. Küskü Kiraz, S. Uslu, ve G. Kanbak, “Eskişehir’deki Psikiyatrik Hastalarda Folat ve B12 Vitamin Seviyelerinin Değerlendirilmesi”, TJLS, c. 3, sy. 1, ss. 210–213, 2018.
ISNAD Kar, Fatih vd. “Eskişehir’deki Psikiyatrik Hastalarda Folat Ve B12 Vitamin Seviyelerinin Değerlendirilmesi”. Turkish Journal of Life Sciences 3/1 (Haziran 2018), 210-213.
JAMA Kar F, Hacıoğlu C, Küskü Kiraz Z, Uslu S, Kanbak G. Eskişehir’deki Psikiyatrik Hastalarda Folat ve B12 Vitamin Seviyelerinin Değerlendirilmesi. TJLS. 2018;3:210–213.
MLA Kar, Fatih vd. “Eskişehir’deki Psikiyatrik Hastalarda Folat Ve B12 Vitamin Seviyelerinin Değerlendirilmesi”. Turkish Journal of Life Sciences, c. 3, sy. 1, 2018, ss. 210-3.
Vancouver Kar F, Hacıoğlu C, Küskü Kiraz Z, Uslu S, Kanbak G. Eskişehir’deki Psikiyatrik Hastalarda Folat ve B12 Vitamin Seviyelerinin Değerlendirilmesi. TJLS. 2018;3(1):210-3.