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GENOTOXIC EFFECTS OF SILICON DIOXIDE NANOPARTICLES IN ALLIUM CEPA

Yıl 2017, Cilt: Volume 2 Sayı: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology, 189 - 189, 16.02.2017

Öz

Silicon dioxide
nanoparticles-SiO2 NPs, are widely used in many nanotechnological products. So
the production, usage, and release of these nanoparticles to the environment
are increasing every day. It is reported that nanoparticles may have toxic,
particularly genotoxic effects. The aim of this study was to investigate the
genotoxic potential of SiO2 NPs by using root cells of Allium cepa which is an
indicator organism. Roots were treated with 50, 250, 500 and 1000 μg/ml for 24,
48 and 72 h. SiO2 NPs decreased the mitotic index in Allium cepa however, this
decrease was significant at 50 and 1000 μg/ml at 24 h, 1000 μg/ml at 48 h, and
50 μg/ml at 72 h treatment, compared to the control. Moreover, SiO2 NPs
increased the frequency of chromosomal abnormalities at all the concentrations
and treatment times compared to the control. C-metaphase, sticky chromosomes,
disturbed pro-meta-ana-telophase, chromosomal break, asynchron division,
multipolarity, lagging and vagrant chromosomes, star anaphase, micronuclei, and
loss of genetic material were observed under light microscopy. Transmission
electron microscopy analyses showed internalization of NPs inside the cell. On
entering the cells, the nanoparticles are transported from one cell to other
through plasmadesmata. NPs can reach to the cell wall, cytoplasm, cell nucleus,
mitochondria and some other structures like vacuole. These observations are
verified by the cytotoxic and clastogenic/genotoxic effect of SiO2 NPs detected
by light microscopy. These findings also suggest that Allium cepa can be used
for the genotoxicity monitoring of novel nanomaterials that are used in many
consumer products. 

Kaynakça

  • Özlem ÇALBAY, Fatma ÜNAL, Zekiye SULUDERE, Deniz YÜZBAŞIOĞLU
  • Gazi University, Science Faculty, Department of Biology, Genetic Toxicology Laboratory, 06500, Ankara, TURKEY
Yıl 2017, Cilt: Volume 2 Sayı: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology, 189 - 189, 16.02.2017

Öz

Kaynakça

  • Özlem ÇALBAY, Fatma ÜNAL, Zekiye SULUDERE, Deniz YÜZBAŞIOĞLU
  • Gazi University, Science Faculty, Department of Biology, Genetic Toxicology Laboratory, 06500, Ankara, TURKEY
Toplam 2 adet kaynakça vardır.

Ayrıntılar

Bölüm Articles
Yazarlar

Özlem Çalbay Bu kişi benim

Fatma Ünal

Zekiye Suludere Bu kişi benim

Deniz Yüzbaşıoğlu Bu kişi benim

Yayımlanma Tarihi 16 Şubat 2017
Yayımlandığı Sayı Yıl 2017 Cilt: Volume 2 Sayı: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology

Kaynak Göster

APA Çalbay, Ö., Ünal, F., Suludere, Z., Yüzbaşıoğlu, D. (2017). GENOTOXIC EFFECTS OF SILICON DIOXIDE NANOPARTICLES IN ALLIUM CEPA. The Turkish Journal Of Occupational / Environmental Medicine and Safety, Volume 2(İssue 1 (1), 189-189.
AMA Çalbay Ö, Ünal F, Suludere Z, Yüzbaşıoğlu D. GENOTOXIC EFFECTS OF SILICON DIOXIDE NANOPARTICLES IN ALLIUM CEPA. turjoem. Şubat 2017;Volume 2(İssue 1 (1):189-189.
Chicago Çalbay, Özlem, Fatma Ünal, Zekiye Suludere, ve Deniz Yüzbaşıoğlu. “GENOTOXIC EFFECTS OF SILICON DIOXIDE NANOPARTICLES IN ALLIUM CEPA”. The Turkish Journal Of Occupational / Environmental Medicine and Safety Volume 2, sy. İssue 1 (1) (Şubat 2017): 189-89.
EndNote Çalbay Ö, Ünal F, Suludere Z, Yüzbaşıoğlu D (01 Şubat 2017) GENOTOXIC EFFECTS OF SILICON DIOXIDE NANOPARTICLES IN ALLIUM CEPA. The Turkish Journal Of Occupational / Environmental Medicine and Safety Volume 2 İssue 1 (1) 189–189.
IEEE Ö. Çalbay, F. Ünal, Z. Suludere, ve D. Yüzbaşıoğlu, “GENOTOXIC EFFECTS OF SILICON DIOXIDE NANOPARTICLES IN ALLIUM CEPA”, turjoem, c. Volume 2, sy. İssue 1 (1), ss. 189–189, 2017.
ISNAD Çalbay, Özlem vd. “GENOTOXIC EFFECTS OF SILICON DIOXIDE NANOPARTICLES IN ALLIUM CEPA”. The Turkish Journal Of Occupational / Environmental Medicine and Safety VOLUME 2/İssue 1 (1) (Şubat 2017), 189-189.
JAMA Çalbay Ö, Ünal F, Suludere Z, Yüzbaşıoğlu D. GENOTOXIC EFFECTS OF SILICON DIOXIDE NANOPARTICLES IN ALLIUM CEPA. turjoem. 2017;Volume 2:189–189.
MLA Çalbay, Özlem vd. “GENOTOXIC EFFECTS OF SILICON DIOXIDE NANOPARTICLES IN ALLIUM CEPA”. The Turkish Journal Of Occupational / Environmental Medicine and Safety, c. Volume 2, sy. İssue 1 (1), 2017, ss. 189-.
Vancouver Çalbay Ö, Ünal F, Suludere Z, Yüzbaşıoğlu D. GENOTOXIC EFFECTS OF SILICON DIOXIDE NANOPARTICLES IN ALLIUM CEPA. turjoem. 2017;Volume 2(İssue 1 (1):189-.