Determination of in Vitro Antioxidant, Antimicrobial Properties and COX-1/COX-2 Enzyme Inhibition Activity of Capparis Sicula

Nağihan Acar; Fatih Çağlar Çelikezen; İbrahim Halil Şahin; Mehmet Fırat; Recep Koçyiğit; Oğuz Ayhan Kireçci

doi:10.18016/ksutarimdoga.vi.1139197

Araştırma Makalesi

Determination of in Vitro Antioxidant, Antimicrobial Properties and COX-1/COX-2 Enzyme Inhibition Activity of Capparis Sicula

Yıl 2023, , 1221 - 1229, 31.12.2023

Nağihan Acar , Fatih Çağlar Çelikezen , İbrahim Halil Şahin , Mehmet Fırat , Recep Koçyiğit , Oğuz Ayhan Kireçci

https://doi.org/10.18016/ksutarimdoga.vi.1139197

Öz

Since synthetic drugs cause many side effects and have a high cost, there has been increasing interest in the development of herbal-based drugs that have fewer side effects and are relatively inexpensive. Capparis sicula is traditionally used in the treatment of some diseases among people. For this purpose, the antioxidant and antimicrobial properties of the methanol extract of the Capparis sicula plant and its inhibitory effects on COX-1 and COX-2 enzymes were investigated. In the study, the antioxidant properties of the Capparis sicula plant were determined by DPPH and CUPRAC methods, while its antimicrobial properties were determined by the disk diffusion method. The effect of Capparis sicula on COX-1 and COX-2 enzymes was determined colorimetrically using commercial kits. The results showed that Capparis sicula had a significant antioxidant effect, but did not have any antimicrobial effect on standard strains of Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Candida albicans. In addition, the inhibitory effect on the COX-1 enzyme was 4.23% for the first time, and the inhibition effect on the COX-2 enzyme was determined as 23.21%. As a result, the pharmaceutical, food and cosmetic industries can use Capparis sicula as an important source of natural raw materials.

Anahtar Kelimeler

Antiinflammatory, Antioxidant, Antimicrobial, Capparis sicula, COX-1

Destekleyen Kurum

Bitlis Eren Üniversitesi BAP

Proje Numarası

2020.07

Teşekkür

This study was produced from Nagihan ACAR's master's thesis with the same name. The present study was supported by Bitlis Eren University Scientific Research Projects Coordinatorship as project numbered BEBAP 2020.07.

Kaynakça

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Abdu-Allah, H.H., Abdelmoez, A.A., Tarazi, H., El-Shorbagi, ANA. & El-Awady, R. (2020). Conjugation of 4-aminosalicylate with thiazolinones afforded non-cytotoxic potent in vitro and in vivo anti-inflammatory hybrids. Bioorg Chem, 94, 103378
Abdu-Allah, H.H., Abdelmoez, A.A., Tarazi, H., El-Shorbagi, ANA. & El-Awady, R. (2020). Conjugation of 4-aminosalicylate with thiazolinones afforded non-cytotoxic potent in vitro and in vivo anti-inflammatory hybrids. Bioorg Chem, 94, 103378
Ageel, A.M., Parmar, N.S., Mossa, J.S., Yahya, M.A.A., Said, M.S.A. & Tariq, M. (1986). Anti-inflammatory activity of some Saudi Arabian medicinal plants. Agents Action, 17, 383-384.
Ageel, A.M., Parmar, N.S., Mossa, J.S., Yahya, M.A.A., Said, M.S.A. & Tariq, M. (1986). Anti-inflammatory activity of some Saudi Arabian medicinal plants. Agents Action, 17, 383-384.
Aichi-Yousfi, H., Meddeb, E., Rouissi, W., Hamrouni, L., Rouz, S., Rejeb, M.N. & Ghrabi-Gammar, Z. (2016). Phenolic composition and antioxidant activity of aqueous andethanolic leaf extracts of six Tunisian species of genus Capparis –Capparaceae. Indus Crop Prod, 92, 218–226.
Al-Said, M.S., Abdelsattar, E.A., Khalifa, S.I. & Al-Feraly, F.S. (1988). Isolation and identification of an anti-inflammatory principle from Capparis spinosa. Die Pharmazie, 43, 640-641. Anjuma, S., Asif, M., Zia, K., Jahan, B., Ashraf, M., Hussainb, S., Hayat, M.Q., Shahd, M.R. & Tahir, M.N. (2020). Biological and phytochemical studies on Capparis decidua (Forssk) Edgew from Cholistan desert. Nat Prod Res, 34(16), 2315–2318.
Apak, R., Güçlü, K., Özyürek, M. & Karademir, S.E. (2004). Novel total antioxidant capacity index for dietary polyphenols and vitamin C and E, using their cupricion reducing capability in the precence of neocuproine: CUPRAC Method. J of Agr and Food Chem, 52, 7970-7981.
Apak, R., Güçlü, K., Özyürek, M. & Karademir, S.E. (2004). Novel total antioxidant capacity index for dietary polyphenols and vitamin C and E, using their cupricion reducing capability in the precence of neocuproine: CUPRAC Method. J of Agr and Food Chem, 52, 7970-7981.
Argentieri, M., Macchia, F., Papadia, P., Fanizzi, F.P. & Avato, P. (2012). Bioactive compounds from Capparis spinosa subsp rupestris. Ind Crop Prod, 36(1), 65-69.
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Arulmozhi, P., Vijayakumar, S., Praseetha, P.K. & Jayanthi, S. (2019a). Extraction methods and computational approaches for evaluation of antimicrobial compounds from Capparis zeylanica L. Anal Biochem, 572, 33-44.
Arulmozhi, P., Vijayakumar, S. & Kumar, T. (2018). Phytochemical analysis and antimicrobial activity of some medicinal plants against selected pathogenic microorganisms. Microbe Pathog, 123, 219-226.
Assadi, S., Shafiee, S.M., Erfani, M. & Akmali, M. (2021). Antioxidative and antidiabetic effects of Capparis spinosa fruit extract on high-fat diet and low-dose streptozotocin-induced type 2 diabetic rats. Biomed Pharmacother, 138, 111391.
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Capparis sicula'nın in vitro Antioksidan, Antimikrobiyal Özellikleri ve COX-1/COX-2 Enzim Inhibisyon Aktivitesinin Belirlenmesi

Yıl 2023, , 1221 - 1229, 31.12.2023

Nağihan Acar , Fatih Çağlar Çelikezen , İbrahim Halil Şahin , Mehmet Fırat , Recep Koçyiğit , Oğuz Ayhan Kireçci

https://doi.org/10.18016/ksutarimdoga.vi.1139197

Öz

Sentetik ilaçlar birçok yan etkiye ve yüksek maliyete neden olduğundan daha az yan etkisi olan ve nispeten daha ucuz olan bitkisel bazlı ilaçların geliştirilmesi artan bir ilgi görmüştür. Capparis sicula halk arasında bazı hastalıkların tedavisinde geleneksel olarak kullanılmaktadır. Bu amaçla sunulan çalışmada Capparis sicula bitkisinin metanol ekstraktının antioksidan ve antimikrobiyal özellikleri ile COX-1 ve COX-2 enzimleri üzerindeki inhibisyon etkileri araştırılmıştır. Çalışmada Capparis sicula bitkisinin antioksidan özellikleri DPPH ve CUPRAC yöntemleri ile belirlenirken, antimikrobiyal özellikleri disk difüzyon yöntemi ile belirlenmiştir. Capparis sicula'nın COX-1 ve COX-2 enzimleri üzerindeki etkisi ise, ticari kitler kullanılarak kolorimetrik olarak belirlendi. Sonuçlar, Capparis sicula'nın önemli bir antioksidan etkiye sahip olduğunu, ancak standart Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli ve Candida albicans suşları üzerinde herhangi bir antimikrobiyal etkiye sahip olmadığını gösterdi. Ayrıca COX-1 enzimi üzerindeki inhibisyon etkisi ilk kez %4.23, COX-2 enzimi üzerindeki inhibisyon etkisi ise %23.21 olarak tespit edilmiştir. Sonuç olarak, ilaç, gıda ve kozmetik endüstrileri, Capparis sicula'yı önemli bir doğal hammadde kaynağı olarak kullanabilir.

Anahtar Kelimeler

Antiinflamatuar, Antioksidant, Antimikrobiyal, Capparis sicula, COX-1

Proje Numarası

2020.07

Kaynakça

Abbas, J.A., El-Oglah, A.A. & Mahasneh, A.M. (1992). Herbal plants in the traditionalmedicine of Bahrain. Econ Bot, 46, 158-163.
Abdu-Allah, H.H., Abdelmoez, A.A., Tarazi, H., El-Shorbagi, ANA. & El-Awady, R. (2020). Conjugation of 4-aminosalicylate with thiazolinones afforded non-cytotoxic potent in vitro and in vivo anti-inflammatory hybrids. Bioorg Chem, 94, 103378
Abdu-Allah, H.H., Abdelmoez, A.A., Tarazi, H., El-Shorbagi, ANA. & El-Awady, R. (2020). Conjugation of 4-aminosalicylate with thiazolinones afforded non-cytotoxic potent in vitro and in vivo anti-inflammatory hybrids. Bioorg Chem, 94, 103378
Ageel, A.M., Parmar, N.S., Mossa, J.S., Yahya, M.A.A., Said, M.S.A. & Tariq, M. (1986). Anti-inflammatory activity of some Saudi Arabian medicinal plants. Agents Action, 17, 383-384.
Ageel, A.M., Parmar, N.S., Mossa, J.S., Yahya, M.A.A., Said, M.S.A. & Tariq, M. (1986). Anti-inflammatory activity of some Saudi Arabian medicinal plants. Agents Action, 17, 383-384.
Aichi-Yousfi, H., Meddeb, E., Rouissi, W., Hamrouni, L., Rouz, S., Rejeb, M.N. & Ghrabi-Gammar, Z. (2016). Phenolic composition and antioxidant activity of aqueous andethanolic leaf extracts of six Tunisian species of genus Capparis –Capparaceae. Indus Crop Prod, 92, 218–226.
Al-Said, M.S., Abdelsattar, E.A., Khalifa, S.I. & Al-Feraly, F.S. (1988). Isolation and identification of an anti-inflammatory principle from Capparis spinosa. Die Pharmazie, 43, 640-641. Anjuma, S., Asif, M., Zia, K., Jahan, B., Ashraf, M., Hussainb, S., Hayat, M.Q., Shahd, M.R. & Tahir, M.N. (2020). Biological and phytochemical studies on Capparis decidua (Forssk) Edgew from Cholistan desert. Nat Prod Res, 34(16), 2315–2318.
Apak, R., Güçlü, K., Özyürek, M. & Karademir, S.E. (2004). Novel total antioxidant capacity index for dietary polyphenols and vitamin C and E, using their cupricion reducing capability in the precence of neocuproine: CUPRAC Method. J of Agr and Food Chem, 52, 7970-7981.
Apak, R., Güçlü, K., Özyürek, M. & Karademir, S.E. (2004). Novel total antioxidant capacity index for dietary polyphenols and vitamin C and E, using their cupricion reducing capability in the precence of neocuproine: CUPRAC Method. J of Agr and Food Chem, 52, 7970-7981.
Argentieri, M., Macchia, F., Papadia, P., Fanizzi, F.P. & Avato, P. (2012). Bioactive compounds from Capparis spinosa subsp rupestris. Ind Crop Prod, 36(1), 65-69.
Arslan, R. & Bektas, N. (2010). Antinociceptive effect of methanol extract of Capparis ovata in mice. Pharma Biol, 48(10), 1185- 1190.
Arulmozhi, P., Vijayakumar, S., Praseetha, P.K. & Jayanthi, S. (2019a). Extraction methods and computational approaches for evaluation of antimicrobial compounds from Capparis zeylanica L. Anal Biochem, 572, 33-44.
Arulmozhi, P., Vijayakumar, S., Praseetha, P.K. & Jayanthi, S. (2019a). Extraction methods and computational approaches for evaluation of antimicrobial compounds from Capparis zeylanica L. Anal Biochem, 572, 33-44.
Arulmozhi, P., Vijayakumar, S. & Kumar, T. (2018). Phytochemical analysis and antimicrobial activity of some medicinal plants against selected pathogenic microorganisms. Microbe Pathog, 123, 219-226.
Assadi, S., Shafiee, S.M., Erfani, M. & Akmali, M. (2021). Antioxidative and antidiabetic effects of Capparis spinosa fruit extract on high-fat diet and low-dose streptozotocin-induced type 2 diabetic rats. Biomed Pharmacother, 138, 111391.
Barry, A.L. & Thornsberry, C. (1985). Susceptibility Tests: Diffusion Test Procedures. In: Lennette EH, Balows A, Hausler WJ Jr, Shadomy HJ (ed.) Manual of clinical microbiology, 4th edn, American Society for Microbiology, Washington, D.C. 978-987.
Bektas, N., Arslan, R., Goger, F., Kirimer, N. & Ozturk, Y. (2012a). Investigation for anti-inflammatory and anti-thrombotic activitiesof methanol extract of Capparis ovata buds and fruits. J of Ethnopharm, 142, 48–52.
Bindu, S., Mazumder, S. & Bandyopadhyay, U. (2020). Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: a current perspective. Biochem Pharmacol 180, 114147
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Toplam 70 adet kaynakça vardır.

Ayrıntılar

Birincil Dil	İngilizce
Konular	Bitki Biyokimyası
Bölüm	ARAŞTIRMA MAKALESİ (Research Article)
Yazarlar	Nağihan Acar 0000-0002-8186-9925 Fatih Çağlar Çelikezen 0000-0001-5489-7384 İbrahim Halil Şahin 0000-0001-7667-9310 Mehmet Fırat 0000-0001-5814-614X Recep Koçyiğit 0000-0002-0472-743X Oğuz Ayhan Kireçci 0000-0003-2205-4758
Proje Numarası	2020.07
Erken Görünüm Tarihi	14 Haziran 2023
Yayımlanma Tarihi	31 Aralık 2023
Gönderilme Tarihi	8 Temmuz 2022
Kabul Tarihi	31 Mart 2023
Yayımlandığı Sayı	Yıl 2023

Kaynak Göster

APA	Acar, N., Çelikezen, F. Ç., Şahin, İ. H., Fırat, M., vd. (2023). Determination of in Vitro Antioxidant, Antimicrobial Properties and COX-1/COX-2 Enzyme Inhibition Activity of Capparis Sicula. Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi, 26(6), 1221-1229. https://doi.org/10.18016/ksutarimdoga.vi.1139197