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Türkiye'den Glaucium alakirensis, Marrubium bourgaei, and Peucedanum alpinum’un Çeşitli Ekstraktlarının Biyolojik Aktivitelerinin Değerlendirilmesi

Yıl 2024, , 1249 - 1261, 07.11.2024

Eda Delik , Berfin Eroğlu , Mertcan Gülben , Candan Aykurt , Burcu Emine Tefon Öztürk

https://doi.org/10.18016/ksutarimdoga.vi.1388926

Öz

Bitki türleri birçok ikincil metabolit içerir ve içermiş oldukları bu bileşikler türden türe farklılık göstermektedir. Bitkilerin ikincil metabolitlerinin konsantrasyonlarındaki bu farklılıkların sağlık üzerinde farklı etkileri vardır. Bitkilerin antioksidan ve antibakteriyel etkileri üzerine yapılan çalışmalar günümüzde yeniden önem kazanmaktadır. Özellikle mevcut bazı antibiyotiklerin olumsuz etkileri ve sürekli olarak artan bakteriyel direnç, yeni ve doğal antimikrobiyal ajan arayışına neden olmaktadır. Bu çalışmada, Türkiye'de doğal olarak yayılış gösteren Marrubium bourgaei Boiss, Glaucium alakirensis Aykurt, K.Yıldız & A.Özçandır ve Peucedanum alpinum B.L.Burtt & Davis türlerinin toprak üstü kısımlarından metanol, etanol, etil asetat, aseton ve kloroform kullanılarak ekstraktlar elde edilmiştir. Bu ekstraktların antioksidan aktiviteleri DPPH (2,2 Difenil-1-pikrihidrazil) ve ABTS (2,2' azino-bis(3-etilbenz-tiazolin-6-sülfonik-asit)) yöntemleriyle, toplam fenolik madde içerikleri Folin-Ciocalteu yöntemiyle, toplam flavonoid madde içerikleri ise alüminyum klorür kolorimetrik yöntemi ile belirlenmiştir. Ayrıca elde edilen bu bitkisel ekstraktların antibakteriyel aktiviteleri disk difüzyon yöntemi kullanılarak on bakteri için değerlendirilmiştir. Elde edilen sonuçlara göre, bitkilerin metanol, etanol ve aseton ekstraktları diğer ekstraktlarından daha yüksek antioksidan aktivite, toplam fenolik ve flavonoid madde içeriğine sahiptir. Ancak, M. bourgaei'nin toplam flavonoid madde içeriği etil asetat ekstraktında daha yüksek bulunmuştur. Ekstraktların antibakteriyel aktiviteleri değerlendirildiğinde, P. alpinum'da etanol, kloroform ve etil asetat, M. bourgaei'de kloroform, G. alakirensis'de ise metanol, kloroform ve etil asetat ekstraktları diğer ekstraktlara göre daha fazla bakteriye karşı etkilidir. Gerçekleştirilen bu çalışma, kullanılan bu üç bitkinin beş farklı ekstraktının toplam fenolik madde içeriğini, toplam flavonoid madde içeriğini, antioksidan aktivitelerini ve antibakteriyel aktivitelerini değerlendiren ve karşılaştıran ilk çalışmadır.

Anahtar Kelimeler

Antibakteriyel-antioksidan aktivite Glaucium alakirensis Marrubium bourgaei Peucedanum alpinum Fenolik-Flavonoid içerik

Etik Beyan

Bu makale etik kurul kararı gerektiren çalışmalar içermemektedir

Kaynakça

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  • Arafa, A. M., Mohamed, M. E. S., Eldahmy, S. I. (2016). The aerial parts of yellow horn poppy (Glaucium flavum Cr.) growing in Egypt: Isoquinoline alkaloids and biological activities. Journal of Pharmaceutical Sciences and Research 8(5), 323.
  • Aykurt, C., Yıldız, K., Özçandır, A., Mungan, F., Deniz, G. (2017). Glaucium alakirensis (Papaveraceae), a new species from Southern Anatolia, Turkey. Phytotaxa 295(3), 255-262. Balasundram, N., Sundram, K., Samman, S. (2006). Phenolic compounds in plants and agri-industrial by-products: Antioxidant activity, occurrence, and potential uses. Food Chemistry 99(1), 191-203.
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  • Bardai, S. E., Lyoussi, B., Wibo, M., Morel, N. (2001). Pharmacological evidence of hypotensive activity of Marrubium vulgare and Foeniculum vulgare in spontaneously hypertensive rat. Clinical and experimental hypertension 23(4), 329-343.
  • Bauer, A. W. (1966). Antibiotic susceptibility testing by a standardized single disc method. American Journal of Clinical Pathology 45, 149-158.
  • Boulaaba, M., Kalai, F.Z., Dakhlaoui, S., Ezzine, Y., Selmi, S., Bourgou, S., Smaoui, A., Isoda, H., Ksouri, R. (2019). Antioxidant, antiproliferative and anti-inflammatory effects of Glaucium flavum fractions enriched in phenolic compounds. Medicinal Chemistry Research 28(11), 1995-2001.
  • Bouterfas, K., Mehdadi, Z., Elaoufi, M. M., Latreche, A., Benchiha, W. (2016). Antioxidant activity and total phenolic and flavonoids content variations of leaves extracts of white Horehound (Marrubium vulgare Linné) from three geographical origins. In Annales pharmaceutiques francaises, 74(6), 453-462.
  • Berber, İ., Avsar, C., Çine, N., Bozkurt, N., Elmas, E. (2013). Determination of antibacterial and antifungal activities of methanolic extracts of some plants growing in Sinop. Karaelmas Science and Engineering Journal, 3, 10-16.
  • Chemsa, A. E., Zellagui, A., Öztürk, M., Erol, E., Ceylan, O., Duru, M. E., Gherraf, N. (2016). Antibiofilm formation, antioxidant and anticholinesterase activities of essential oil and methanol extract of Marrubium deserti de Noé.. Journal of Materials and Environmental Science, 7, 993-1000.
  • Danna, C., Bazzicalupo, M., Ingegneri, M., Smeriglio, A., Trombetta, D., Burlando, B., Cornara, L. (2022). Anti-inflammatory and wound healing properties of leaf and rhizome extracts from the medicinal plant Peucedanum ostruthium (L.) WDJ Koch. Molecules, 27(13), 4271.
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  • Fu, Y., Liu, W., Soladoye, O. P. (2021). Towards innovative food processing of flavonoid compounds: Insights into stability and bioactivity. Lebensmittel-Wissenschaft & Technologie, 150, 111968.
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Evaluation of Biological Activities of Various Extracts of Glaucium alakirensis, Marrubium bourgaei, and Peucedanum alpinum from Türkiye

Yıl 2024, , 1249 - 1261, 07.11.2024

Eda Delik , Berfin Eroğlu , Mertcan Gülben , Candan Aykurt , Burcu Emine Tefon Öztürk

https://doi.org/10.18016/ksutarimdoga.vi.1388926

Öz

Plant species contain many secondary metabolites, and these compounds differ from species to species. These differences in the concentrations of these compounds have many health implications. Today, studies on plants' antioxidant and antibacterial effects are gaining importance. In particular, the adverse effects of some existing antibiotics and the constant development of bacterial resistance are leading to the search for new natural antimicrobial agents. In this study, methanol, ethanol, ethyl acetate, acetone, and chloroform extracts were obtained from the aerial parts of Marrubium bourgaei Boiss and Glaucium alakirensis Aykurt, K.Yıldız & A.Özçandır, and Peucedanum alpinum B.L.Burtt & Davis, species which are naturally distributed in Türkiye. The antioxidant activity of the extracts was determined by the DPPH (2,2 Difenil-1-pikrihidrazil) and ABTS (2,2' azino-bis(3-ethylbenz-thiazoline-6-sulfonic-acid)) methods, the total phenolic content by Folin-Ciocalteu method, the total flavonoid content by aluminium chloride colorimetric method, and the antibacterial activity against ten bacteria by the disc diffusion method. According to the results, methanol, ethanol, and acetone extracts had higher antioxidant activity, total phenolic, and total flavonoid contents than other extracts. However, the total flavonoid content of M. bourgaei was higher in the ethyl acetate extract. When evaluated for their antibacterial activity, ethanol, chloroform, and ethyl acetate in P. alpinum, chloroform in M. bourgaei, and methanol, chloroform, and ethyl acetate in G. alakirensis extracts showed antibacterial activity against more bacteria than others. This is the first study to evaluate and compare the total phenolic and flavonoid content, and antioxidant and antibacterial activities of 5 different extracts of these plants.

Anahtar Kelimeler

Antibacterial-antioxidant activity Glaucium alakirensis Marrubium bourgaei Peucedanum alpinum Phenolic-flavonoid content

Etik Beyan

Not required

Kaynakça

  • Abozed, S. S., El-Kalyoubi, M., Abdelrashid, A., & Salama, M. F. (2014). Total phenolic contents and antioxidant activities of various solvent extracts from whole wheat and bran. Annals of Agricultural Sciences, 59(1), 63-67.
  • Al, M.K., Kuıate Jr, M.R., Ra, N.N., Ml, K.M., Rm, E.E., Bıyıtı, L., Ph, A.Z. (2012). Antibacterial and antioxidant properties of the methanolic extract of the leaves of Peucedanum Zenkeri (Apiaceae). Sciences, Technologie & Développement. 13(1), 36-47.
  • Alali, F.Q., Tawaha, K., El-Elimat, T., Syouf, M., El-Fayad, M., Abulaila, K., Nielsen, S.J., Wheaton, W.D., Falkinham III, J.O., Oberlies, N.H. (2007). Antioxidant activity and total phenolic content of aqueous and methanolic extracts of Jordanian plants: an ICBG project. Natural Product Research 21(12), 1121-1131.
  • Arafa, A. M., Mohamed, M. E. S., Eldahmy, S. I. (2016). The aerial parts of yellow horn poppy (Glaucium flavum Cr.) growing in Egypt: Isoquinoline alkaloids and biological activities. Journal of Pharmaceutical Sciences and Research 8(5), 323.
  • Aykurt, C., Yıldız, K., Özçandır, A., Mungan, F., Deniz, G. (2017). Glaucium alakirensis (Papaveraceae), a new species from Southern Anatolia, Turkey. Phytotaxa 295(3), 255-262. Balasundram, N., Sundram, K., Samman, S. (2006). Phenolic compounds in plants and agri-industrial by-products: Antioxidant activity, occurrence, and potential uses. Food Chemistry 99(1), 191-203.
  • Balick, M. J., Cox, P. A. (1996). Plants, people, and culture: The Sciense of ethobotany. by Scientific American Library. First printing, 65-66.
  • Bardai, S. E., Lyoussi, B., Wibo, M., Morel, N. (2001). Pharmacological evidence of hypotensive activity of Marrubium vulgare and Foeniculum vulgare in spontaneously hypertensive rat. Clinical and experimental hypertension 23(4), 329-343.
  • Bauer, A. W. (1966). Antibiotic susceptibility testing by a standardized single disc method. American Journal of Clinical Pathology 45, 149-158.
  • Boulaaba, M., Kalai, F.Z., Dakhlaoui, S., Ezzine, Y., Selmi, S., Bourgou, S., Smaoui, A., Isoda, H., Ksouri, R. (2019). Antioxidant, antiproliferative and anti-inflammatory effects of Glaucium flavum fractions enriched in phenolic compounds. Medicinal Chemistry Research 28(11), 1995-2001.
  • Bouterfas, K., Mehdadi, Z., Elaoufi, M. M., Latreche, A., Benchiha, W. (2016). Antioxidant activity and total phenolic and flavonoids content variations of leaves extracts of white Horehound (Marrubium vulgare Linné) from three geographical origins. In Annales pharmaceutiques francaises, 74(6), 453-462.
  • Berber, İ., Avsar, C., Çine, N., Bozkurt, N., Elmas, E. (2013). Determination of antibacterial and antifungal activities of methanolic extracts of some plants growing in Sinop. Karaelmas Science and Engineering Journal, 3, 10-16.
  • Chemsa, A. E., Zellagui, A., Öztürk, M., Erol, E., Ceylan, O., Duru, M. E., Gherraf, N. (2016). Antibiofilm formation, antioxidant and anticholinesterase activities of essential oil and methanol extract of Marrubium deserti de Noé.. Journal of Materials and Environmental Science, 7, 993-1000.
  • Danna, C., Bazzicalupo, M., Ingegneri, M., Smeriglio, A., Trombetta, D., Burlando, B., Cornara, L. (2022). Anti-inflammatory and wound healing properties of leaf and rhizome extracts from the medicinal plant Peucedanum ostruthium (L.) WDJ Koch. Molecules, 27(13), 4271.
  • Dubick, M. A. (1986). Historical perspectives on the use of herbal preparations to promote health. The Journal of Nutrition, 116(7), 1348-1354.
  • Fu, Y., Liu, W., Soladoye, O. P. (2021). Towards innovative food processing of flavonoid compounds: Insights into stability and bioactivity. Lebensmittel-Wissenschaft & Technologie, 150, 111968.
  • Ghasemi, K., Ghasemi, Y., Ebrahimzadeh, M. A. (2009). Antioxidant activity, phenol and flavonoid contents of 13 citrus species peels and tissues. Pakistan Journal of Pharmaceutical Sciences, 22(3), 277-281.
  • Gonelimali, F. D., Lin, J., Miao, W., Xuan, J., Charles, F., Chen, M., Hatab, S. R. (2018). Antimicrobial properties and mechanism of action of some plant extracts against food pathogens and spoilage microorganisms. Frontiers in microbiology, 9, 1639.
  • Golmakani, H., Rabbani Nasab, H., Sharifan, M., Kamali, H., Yadollahi, A. (2016). The essential oil composition and antibacterial activity of Marrubium duabense murata from north khorassan province, Iran. Journal of Essential Oil-Bearing Plants, 19(4), 963-971.
  • Hamedeyazdan, S., Sharifi, S., Nazemiyeh, H., Fathiazad, F. (2014). Evaluating antiproliferative and antioxidant activity of Marrubium crassidens. Advanced pharmaceutical bulletin, 4(Suppl 1), 459.
  • Hayat, J., Akodad, M., Moumen, A., Baghour, M., Skalli, A., Ezrari, S., Belmalha, S. (2020). Phytochemical screening, polyphenols, flavonoids and tannin content, antioxidant activities and FTIR characterization of Marrubium vulgare L. from 2 different localities of Northeast of Morocco. Heliyon, 6(11), e05609.
  • Hughes, D., Andersson, D. I. (2017). Evolutionary trajectories to antibiotic resistance. Annual Review of Microbiology, 71, 579-596. Johns, T. (1990). With bitter herbs they shall eat it: chemical ecology and the origins of human diet and medicine. University of Arizona Press.
  • Kang, C. G., Hah, D. S., Kim, C. H., Kim, Y. H., Kim, E., Kim, J. S. (2011). Evaluation of antimicrobial activity of the methanol extracts from 8 traditional medicinal plants. Toxicological research, 27, 31-36
  • Karaman, H. T., Küskü, D. Y., Söylemezoğlu, G., Çelik, H. (2022) Vitis labrusca L. Genotiplerinin Fenolik Bileşik ve Antioksidan Kapasite İçerikleri. Tekirdağ Ziraat Fakültesi Dergisi 19 (2), 318-331.
  • Kim, D. O., Lee, K. W., Lee, H. J., Lee, C. Y. (2002). Vitamin C equivalent antioxidant capacity (VCEAC) of phenolic phytochemicals. Journal of Agricultural and food chemistry, 50(13), 3713-3717.
  • Kim, M., Seo, K. S., Yun, W. (2018). Antimicrobial and Antioxidant Activity of Saposhnikovia divaricata, Peucedanum japonicum and Glehnia littoralis. Indian Journal of Pharmaceutical Sciences, 80(3), 560-565.
  • Kocanci, F., Hamamcioglu, B., Aslım, B. (2017). The anti-AChE and anti-proliferative Activities of Glaucium acutidentatum and Glaucium corniculatum Alkaloid Extracts. Journal of Applied Pharmaceutical Science, 7(8), 191-200.
  • Koné, W. M., Atindehou, K. K., Terreaux, C., Hostettmann, K., Traore, D., Dosso, M. (2004). Traditional medicine in North Côte-d’Ivoire: screening of 50 medicinal plants for antibacterial activity. Journal of ethnopharmacology, 93(1), 43-49.
  • Kumoro, A. C., Hasan, M., Singh, H. (2009). Effects of solvent properties on the Soxhlet extraction of diterpenoid lactones from Andrographis paniculata leaves. Science Asia, 35(1), 306-309.
  • Laouer, H., Yabrir, B., Djeridane, A., Yousfi, M., Beldovini, N., Lamamra, M. (2009). Composition, antioxidant and antimicrobial activities of the essential oil of Marrubium deserti. Natural product communications, 4(8), 1934578X0900400824.
  • Madumelu, M., Ndukwe, I. G., Ayo, R. G. (2013). Phytochemical and antimicrobial screening of crude methanolic leaf extract of Peucedanum winkleri H. Wolff. Journal of Applied Pharmaceutical Science, 3(12), 129-132.
  • Matejić, J. S., Džamić, A. M., Ćirić, A. D., Krivošej, Z., Ranđelović, L. N., Marin, P. D. (2013). Antioxidant and Antimicrobial Activities Of Extracts of Four Peucedanum L. Species. Digest Journal of Nanomaterials & Biostructures, 8(2), 655 – 665.
  • Mojdeh, H. V., Mina, M., Mojgan, P., Jinous, A., Nahid, R., Saeed, K., & Mohsen, H. (2017). Comparison the antimicrobial effects of the flowering aerial parts of Glaucium vitellinum Boiss. and Buhse and Gaillonia aucheri Jaub. and Spach. Novelty in Biomedicine, 5, 24-29.
  • Morteza-Semnani, K., Saeedi, M., Mahdavi, M. R. (2005). Antibacterial studies on extracts of three species of Glaucium. from Iran. Pharmaceutical biology, 43(3), 234-236.
  • Naveed, M., Hejazi, V., Abbas, M., Kamboh, A.A., Khan, G.J., Shumzaid, M., Ahmad, F., Babazadeh, D., FangFang, X., Modarresi-Ghazani, F., WenHua, L., XiaoHui, Z. (2018). Chlorogenic acid (CGA): A pharmacological review and call for further research. Biomedicine & Pharmacotherapy, 97, 67-74.
  • Okur, M. E., Karakaş, N., Karadağ, A. E., Yılmaz, R., Demirci, F. (2019). In vitro cytotoxicity evaluation of Marrubium vulgare L. methanol extract. Journal of Research in Pharmacy, 23(4), 711-718.
  • Ozsoy, N., Yilmaz-Ozden, T., Aksoy-Sagirli, P., Şahin, H., Sarı, A. (2018). Antioxidant, Anti-acetylcholinesterase, Anti-inflammatory and DNA Protection Activities of Glaucium grandiflorum var. grandiflorum. Iranian Journal of Pharmaceutical Research, 17(2), 677.
  • Özer, C. O., Var, G. B., Demir Özer, E. (2021). Ekstraksiyon koşullarının nar (Punica granatum L.) çiçeği ekstraktlarının antioksidan aktivite ve toplam fenolik içeriği üzerine etkisi. Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, 24(5), 915-920.
  • Özçandır, A., Mohammed, F. S., Sevindik, M., Aykurt, C., Selamoglu, Z., & Akgül, H. (2024). Phenolic composition, total antioxidant, antiradical and antimicrobial potential of endemic Glaucium alakirensis. Sigma Journal of Engineering and Natural Sciences, 42(1), 42-48.
  • Sarikurkcu, C., Tepe, B., Daferera, D., Polissiou, M., Harmandar, M. (2008). Studies on the antioxidant activity of the essential oil and methanol extract of Marrubium globosum subsp. globosum (Lamiaceae) by three different chemical assays. Bioresource Technology, 99(10), 4239-4246.
  • Sarikurkcu, C., Ozer, M. S., Calli, N., Popović-Djordjević, J. (2018). Essential oil composition and antioxidant activity of endemic Marrubium parviflorum subsp. oligodon. Industrial crops and products, 119, 209-213.
  • Sarikurkcu, C., Ozer, M. S., Tlili, N. (2020). Comparison of the influence of the solvent on the extraction of the bioactive compounds from Marrubium lutescens using liquid chromatography–electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). Analytical Letters, 53(14), 2222-2234.
  • Sarkhail, P., Sarkheil, P., Khalighi-Sigaroodi, F., Shafiee, A., Ostad, N. (2013). Tyrosinase inhibitor and radical scavenger fractions and isolated compounds from aerial parts of Peucedanum knappii Bornm. Natural Product Research, 27(10), 896-899.
  • Sayed-Ahmad, B., Talou, T., Saad, Z., Hijazi, A., Merah, O. (2017). The Apiaceae: Ethnomedicinal family as source for industrial uses. Industrial crops and products, 109, 661-671. Savoia, D. (2012). Plant-derived antimicrobial compounds: alternatives to antibiotics. Future microbiology, 7(8), 979-990.
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  • Shaghaghi, A., Nejad Ebrahimi, S., Sonboli, A. (2019). Study of total phenolic, total flavonoid content and antioxidant potential in various organs of genus Papaver and Glaucium collected from Iran. Journal of Plant Production Research, 26(2), 195-214.
  • Singleton, V. L., Rossi, J. A. (1965). Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. American journal of Enology and Viticulture, 16(3), 144-158.
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  • Subhasree, B., Baskar, R., Keerthana, R. L., Susan, R. L., Rajasekaran, P. (2009). Evaluation of antioxidant potential in selected green leafy vegetables. Food chemistry, 115(4), 1213-1220.
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  • Upadrasta, L., Mukhopadhyay, M., Banerjee, R. (2011). Tannins: Chemistry, biological properties and biodegradation. In Chemistry and Biotechnology of Polyphenols. Cibet Publishers, India: Eds. Sabu A, Roussos S, Aguilar CN) 5–32.
  • Uritu, C. M., Mihai, C. T., Stanciu, G. D., Dodi, G., Alexa-Stratulat, T., Luca, A., Leon-Conctantin, M. M., Stefanescu, R., Bild, V., Melnic, S., Tamba, B. I. (2018). Medicinal plants of the family Lamiaceae in pain therapy: A review. Pain Research and Management, 2018, 1-44.
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  • Xiao, Y., Xing, G., Rui, X., Li, W., Chen, X., Jiang, M., Dong, M. (2014). Enhancement of the antioxidant capacity of chickpeas by solid state fermentation with Cordyceps militaris SN-18. Journal of functional foods, 10, 210-222.
  • Yumrutas, O., Saygideger, S. D. (2010). Determination of in vitro antioxidant activities of different extracts of Marrubium parviflorum Fish et Mey. and Lamium amplexicaule L. from South east of Turkey. Journal of Medicinal Plants Research, 4(20), 2164-2172.
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  • Zlatić, N., Jakovljević, D., & Stanković, M. (2019). Temporal, plant part, and interpopulation variability of secondary metabolites and antioxidant activity of Inula helenium L. Plants, 8(6), 179
Toplam 58 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Bitki Biyokimyası, Mikrobiyoloji (Diğer), Tıbbi ve Aromatik Bitkiler
Bölüm ARAŞTIRMA MAKALESİ (Research Article)
Yazarlar

Eda Delik 0000-0002-9047-2874

Berfin Eroğlu 0000-0002-9099-7603

Mertcan Gülben 0000-0002-0096-7161

Candan Aykurt 0000-0001-8700-3500

Burcu Emine Tefon Öztürk 0000-0003-1690-9879

Erken Görünüm Tarihi 15 Ağustos 2024
Yayımlanma Tarihi 7 Kasım 2024
Gönderilme Tarihi 10 Kasım 2023
Kabul Tarihi 14 Mayıs 2024
Yayımlandığı Sayı Yıl 2024

Kaynak Göster

APA Delik, E., Eroğlu, B., Gülben, M., Aykurt, C., vd. (2024). Evaluation of Biological Activities of Various Extracts of Glaucium alakirensis, Marrubium bourgaei, and Peucedanum alpinum from Türkiye. Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi, 27(6), 1249-1261. https://doi.org/10.18016/ksutarimdoga.vi.1388926

21082



2022-JIF = 0.500

2022-JCI = 0.170

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