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Anticandidal Activity and Anticandidal Mechanism of Essential Oil of Cuminum cyminum L. and Myrtus communis L. Mixture

Yıl 2022, , 391 - 401, 30.12.2022

Elif Eliuz , Nadire Pelin Bahadırlı

https://doi.org/10.18016/ksutarimdoga.vi.1075012

Öz

C. cyminum (cumin) and M. communis (myrtle) comprise many biologically active molecules. In this study, cumin seed and myrtle leaves were mixed then hydrodistilled and analyzed by GC-MS. The main components of the essential oil were cuminal (50.71%), 1,8 cineole (8.30%), O-cymene (7.88%), β-pinene (7.62%), α-pinene (7.16%), γ-terpinene (6.09%) and α-terpinolene (2.19%). The antifungal activity of the essential oil against C. albicans, C. parapsilosis and C. tropicalis was investigated using spectrophotometric broth microdilution, colorimetric broth microdilution, and agar well diffusion tests. Antimicrobial mechanism of the EO was researched by TTC-dehydrogenase relative activity, protein and DNA leakage analysis. While the MIC values of the oil were 3.29 mg mL-1 for C. albicans, 3.57 mg mL-1 for C. parapsilosis and 3.65 mg mL-1 for C. tropicalis, the 50% cytotoxic concentration values were between 0.17 mg mL-1 and 2.61 mg mL-1 for Candida species. The inhibition values against yeasts in dark and light conditions were found as 42.1 mm on C. parapsilosis and 39 mm on C. tropicalis exposed dark and light, respectively. The inhibition zones of oil in water, glucose, glycerol and salt environment. As a result, the highest IZ was found as 26.6 mm on C. albicans and 26 mm on C. tropicalis in the presence of a 3% glycerol environment. The DNA and protein levels were increased when yeast was exposed to the EO. As a result, the oil of mixed C. cyminum and M. communis preserved its antimicrobial stability in different environmental conditions and should contribute to new antifungal research.

Anahtar Kelimeler

Cumin Myrtle Essential oil Anticandidal Antifungal

Teşekkür

Thanks to Mersin University Advanced Technology Education Research and Application Center for GC-MS analysis.

Kaynakça

  • Aleksic V, Knezevic P 2014. Antimicrobial and Antioxidative Activity of Extracts and Essential Oils of Myrtus communis L. Microbiological Research 169(4): 240-54.
  • Allaq AA, Sidik NJ, Abdul-Aziz A, Ahmed IA 2020. Cumin (Cuminum cyminum L.): A review of Its Ethnopharmacology, Phytochemistry. Biomed Research and Therapy 7: 4016-4021.
  • Al-Rubaye AF, Kadhim MJ, Hameed IH 2017. Phytochemical Profiles of Methanolic Seeds Extract of Cuminum cyminum Using GC-MS Technique. International Journal of Current Pharmaceutical Research 2017(8): 114-124.
  • Asgarpanah J, Ariamanesh A 2015. Phytochemistry and pharmacological properties of Myrtus communis L. Indian Journal of Traditional Knowledge 1(1): 82-87.
  • Bahadirli NP, Kahramanoğlu İ, Wan C 2021. Exposure to Volatile Essential Oils of Myrtle (Myrtus communis L.) Leaves for Improving the Postharvest Storability of Fresh Loquat Fruits. Journal of Food Quality 2020: 1-10.
  • Bajpai P, Dash V 2012. Hybrid Renewable Energy Systems for Power Generation in Stand-Alone Applications: A Review. Renewable Sustainable Energy Reviews 16: 2926-2939.
  • Bakkali F, Averbeck S, Averbeck D. Idaomar M 2008. Biological Effects of Essential Oils a Review. Food and Chemical Toxicology 46: 446–475.
  • Başer HC, 2009. Uçucu Yağlar ve Aromaterapi. Fitomed 7: 1-8.
  • Bassolé IHN, Juliani HR 2012. Essential Oils in Combination and Their Antimicrobial Properties. Molecules 17: 3989-4006.
  • Bhavya ML, Hebbar HU 2019. Efficacy of Blue LED in Microbial Inactivation: Effect of Photosensitization and Process Parameters. International Jounal of Food Microbiology 2: 290.
  • Bouzabata A, Cabral C, Gonçalves MJ, Cruz MT, Bighelli A, Cavaleiro C, Casanova J, Tomi F, Salgueiro L 2015. Myrtus communis L. as Source of a Bioactive and Safe Essential Oil. Food and Chemical Toxicology 75: 166-172.
  • Bouzabata A, Castola V, Bighelli A, Abed L, Casanova J, Tomi F 2013. Chemical Variability of Algerian Myrtus communis L. Chem Biodiversity, 2013;10, 129-137.
  • Calderone RA, Fonzi WA 2001. Virulence Factors of Candida albicans. Trends in Microbiology 9: 327-335.
  • Cannas S, Molicotti P, Ruggeri M, Cubeddu, M, Sanguýnetti, Marongiu B, Zanetti S 2013. Antimycotic Activity of Myrtus communis L. Towards Candida spp. from Clinical Isolates. Journal of Infection in Developing Countries 7: 295-298.
  • Chalchat JC, Garry RP, Michet A 1998. Essential Oils of Myrtle (Myrtus communis L.) of the Mediterranean Littoral. Journal of Essential Oil Research 10: 613-617.
  • Chaudhary N, Husain SS, Mohammed A 2014. Chemical Composition and Antimicrobial Activity of Volatile Oil of the Seeds of Cuminum cyminum L. World Journal of Pharmaceutical Sciences 3: 1428-1441.
  • Cruz W, Ferraz A, Lima W, Moraes TFS, Ferreira FL 2018. Evaluation of the Activity of Tontelea micrantha Extracts Against Bacteria, Candida and Mayaro virus. Journal of Pharmaceutical Negative Results 9: 21-6.
  • Curini M, Bianchi A, Epifano F, Bruni R, Torta L, Zambonelli A 2003. Composition and In Vitro Antifungal Activity of Essential Oils of Erigeron canadensis and Myrtus communis from France. Chemistry of Natural Compounds 39: 191-194.
  • Ding T, Xuan X-T, Li J, Chen SG, Liu DH, Ye XQ, Si J, Xue SJ 2016. Disinfection Efficacy and Mechanism of Slightly Acidic Electrolyzed Water on Staphylococcus aureus in Pure Culture. Food Control 60: 505-510.
  • Elisa B, Aldo A, Ludovica G 2019. Chemical Composition and Antimycotic Activity of Six Essential Oils (cumin, fennel, manuka, sweet orange, cedar and juniper) Against Different Candida spp. Natural Product Research 1: 1-6.
  • Erdoğan Eliuz EA 2020. Indifferent Effect in Combinations of Mentha piperita Essential Oil and Fluconazole against C. albicans. Romanian Bitechnological Letters 25: 1709-1715.
  • Erdoğan Eliuz EA, Ayas D, Goksen G 2017. In Vitro Phototoxicity and Antimicrobial Activity of Volatile Oil Obtained from Some Aromatic Plants. Journal of Essential Oil Bearing Plants 20: 758-768.
  • Ersoy ZG, Barisci S, Dinc O 2019. Mechanisms of the Escherichia coli and Enterococcus faecalis Inactivation by Ozone. LWT Food Science and Technology 100: 306-313.
  • Gachkar L, Yadegari D, Razaei MB, Taghizadeh M, Astaneh A, Rasooli I 2007. Chemical and Biological Characteristics of Cuminum cyminum and Rosmarinus officinalis Essential Oils. Food Chemistry 102: 898-904.
  • Gardeli C, Vassiliki P, Athanasios M, Kibouris T, Komaitis M 2008. Essential Oil Composition of Pistacia lentiscus L. and Myrtus communis L.: Evaluation of Antioxidant Capacity of Methanolic Extracts. Food Chemistry 7: 1120-1130.
  • Gutierrez J, Barry-Ryan C, Bourke P 2008. The Antimicrobial Efficacy of Plant Essential Oil Combinations and Interactions with Food Ingredients. International Journal of Food Microbiology 124: 91-97.
  • Hussein HKA, Kadhem NH, Abbod ZH 2006. Study of the Biological Activity of Aqueous Extract of Cuminum cyminum L. and Hibiscus sabdariffa L. and Detection of Some Active Groups in Them. Journal of Kerbala University 5: 65-72.
  • Jamoussi B, Romdhane M, Abderraba A, Hassine BB, Gadri AE 2005. Effect of Harvest Time on Yield and Composition of Tunisian Myrtle Oils. Flavour and Fragrance Journal 20: 27-47.
  • Johri JR 2011. Cuminum cyminum and Carum carvi. Pharmacognosy Reviews, 5, 63-72.
  • Kırıcı S, Bayram E, Tansı S, Arabacı O, Baydar H, Telci İ, İnan M, Kaya DA, Özel A 2020. Tıbbi ve Aromatik Bitkilerin Üretiminde Mmevcut Durum ve Ggelecek. Türkiye Ziraat Mühendisliği IX. Teknik Kongresi, 505-528, Ankara.
  • Li R, Jiang ZT 2004. Chemical Composition of the Essential Oil of Cuminum cyminum L. from China. Flavour and Fragrance Journal 19: 311-313.
  • Mahboubi M, Bidgoli FG 2010. In vitro Synergistic Efficacy of Combination of Amphotericin B with Myrtus communis Essential Oil Against Clinical Isolates of Candida albicans. Phytomedicine 17: 771-774.
  • Mahdavi OS, Esmaeilzadeh S, Rahmani Z 2010. Laboratory Study of Anticandidal Activity of Thyme, Ppennyroyal and Lemon Essential Oils by Micro Dilution Method. Jundishapur Journal of Microbiology 3: 161-167.
  • Miguel LGS, Cobo J, Otheo E, Sánchez-Sousa A, Abraira V, Moreno S 2005. Secular Trends of Candidemia in a Large Tertiary-Care Hospital from 1988 to 2000: Emergence of Candida parapsilosis. Infection Control Hospital Epidemiology 26: 548-52.
  • Minooeianhaghighi MH, Sepehrian L, Shokri H 2017. Antifungal Eeffects of Lavandula binaludensis and Cuminum cyminum Essential Oils Against Candida albicans Strains Isolated from Patients with Recurrent Vulvovaginal Candidiasis. Journal of Medical Mycology 27: 65-71.
  • Morton JF 1976. Herbs and Spices (Golden Press, New York), 160.
  • Naeini A, Naderi NJ, Shokri H 2014. Analysis and In Vitro Anti-Candida Antifungal Activity of Cuminum cyminum and Salvadora persica Herbs Extracts Against Pathogenic Candida Strains, Journal of Medical Mycology 24: 13–18.
  • NCCLS 1997. National Committee for Clinical Laboratory Standards Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts. Approved standard M27-A. National Committee for Clinical Laboratory Standards, Wayne, Pa.
  • Özek T, Demirci B, Baser KHC 2000. Chemical Composition of Turkish Myrtle Oil. Journal of Essential Oil Research 12: 541-544.
  • Pappas PG, Kauffman CA, Andes DR, David R, Clancy C, Marr KA, Ostrosky L, Reboli AC, Schuster MG, Vazquez JA, Walsh TJ, Zaoutis TE, Sobel JD 2015. Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America. Clinical Infectious Diseases 62: 1-50.
  • Petretto GL, Fancello F, Bakhy K, Faiz CAL, Sibawayh Z, Chessa M, Zara S, Sanna ML, Maldini M, Rourke JP, Pintone G 2018. Chemical Composition and Antimicrobial Activity of Essential oils from Cuminum cyminum L. Collected in Different Areas of Morocco. Food Bioscience 22: 50–58.
  • Qi H, Hung YC, 2019. Inactivation Mechanism of Ferrous and Alkaline Activated Persulfate on Escherichia coli O157:H7 and Listeria monocytogenes. LWT Food Science and Technology 111: 62-68.
  • Sahana K, Nagarajan S, Mohan Rao LJ 2011. Cumin (Cuminum cyminum L.) Seed Volatile Oil: Chemistry and Role in Health and Disease Prevention, In: Nuts and Seeds in Health and Disease Prevention, edited by V R Preedy, R R Watson & VB Patel, (Academic Pres Elsevier), 417-427.
  • Silva S, Negri M, Henriques M, Oliveira R, Williams DW, Azeredo J 2012. Candida glabrata, Candida parapsilosis and Candida tropicalis: Biology, Epidemiology, Pathogenicity and Antifungal Resistance. FEMS Microbiology Reviews 36: 288-305.
  • Sumbul S, Aftab Ahmad M, Asif M, Akhtar M 2011. Myrtus communis Linn.: A review. Indian Journal of Natural Products and Resources 2: 395-402.
  • Thippeswamy NB, Naidu KA 2005. Antioxidant potency of cumin varieties—cumin, black cumin and bitter cumin—on antioxidant systems. European Food Research and Technology. 220(5): 472-476.
  • Trofa D, Gacser A, Nosanchuk JD 2008. Candida parapsilosis, an Emerging Fungal Pathogen. Clinical Microbiology Reviews 21: 606-625.
  • VanderJagt TJ, Ghattas R, VanderJagt DJ, Crossey M, Glew RH 2002. Comparison of the Total Antioxidant Content of 30 Widely Used Medicinal Plants of New Mexico. Life Science 70: 1035-1040.
  • Vieira JN, Gonçalves CL, Villarreal JPV, Gonçalves VM, Lund RG, Freitag RA, Silva AF, Nascente PS 2019. Chemical Composition of Essential Oils from the Apiaceae Family, Cytotoxicity, and Their Antifungal Activity In Vitro Against Candida Species from Oral Cavity. Brazilian Journal of Biology 79: 432-437.
  • Wang H, Cheng H, Wang F, Wei D, Wang X 2010. An Improved 3-(4,5-dimethylthiazol-2-yl)-2,5-Diphenyl Tetrazolium Bromide (MTT) Reduction Assay for Evaluating the Viability of Escherichia coli Cells. Journal of Microbiological Methods 82: 330-333.
  • Whaley SG, Berkow EL, Rybak JM, Nishimoto AT, Barker KS, Rogers PD 2017. Azole Antifungal Resistance in Candida albicans and Emerging Non-Albicans Candida Species. Frontiers in Microbiology 7: 1–12.
  • Wisplinghoff H, Bischoff T, Tallent SM, Seifert H, Wenzel RP, Edmond MB 2004. Nosocomial Bloodstream Infections in US Hospitals: Analysis of 24,179 Cases from a Prospective Nationwide Surveillance Study. Clinical Infectious Diseases 39: 309-317.
  • Yadegarinia D, Gachkar L, Rezaei MB, Taghizadeh M, Astaneh SA, Rasooli I 2006. Biochemical Activities of Iranian Mentha piperita L. and Myrtus communis L. Essential Oils. Phytochemistry 67: 1249-1255.
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Cuminum cyminum L. ve Myrtus communis L. Karışım Uçucu Yağının Antikandidal Aktivitesi ve Antikandidal Mekanizmasının Belirlenmesi

Yıl 2022, , 391 - 401, 30.12.2022

Elif Eliuz , Nadire Pelin Bahadırlı

https://doi.org/10.18016/ksutarimdoga.vi.1075012

Öz

C. cyminum (kimyon) ve M. communis (murt) pek çok aktif bileşeni olan özellikle antimikrobiyal, antioksidan ve antidiyabetik özellikleriyle bilinmektedirler. Bu çalışmada, ilk kez olarak, kimyon tohumları ve murt bitkisinin yaprakları birlikte su distilasyonuna tab tutulmuş ve elde edilen uçucu yağın bileşenleri GC-MS cihazıyla belirlenmiştir. Uçucu yağın temel bileşenleri cuminal (%50.71), 1,8 sineol (%8.30), osimen (%7.88), β-pinen (%7.62), α-pinen (%7.16), γ-terpinen (6.09%) ve α-terpinolen (%2.19) olarak belirlenmiştir. Antifungal aktiviteyi belirlemek amacıyla uçucu yağın C. albicans, C. parapsilosis and C. tropicalis mantarlarına karşı Spektrofotometrik Broth Mikrodilüsyon, Kolorimetrik Broth Mikrodilüsyon ve Agar Well Difğzyon metodlarıyla etkileri belirlenmiştir. Uçucu yağın animikrobiyal etkisini belirlemek amacıyla TTC-dehidrogenaz aktivite, protein kaçağı ve DNA aktiviteleri incelenmiştir. Yağlarin MIC değerleri C. albicans için 3.29 mg mL-1, C. parapsilosis için 3.57 mg mL-1 ve C. tropicalis için 3.65 mg mL-1, CC50 (%50 sitotoksisite konsantrasyonu) değerleri ise çalışılan kandidalar için 0.17 mg mL-1 ve 2.61 mg mL-1 olarak belirlenmiştir. Yağların mayalara karşı karanlık ve ışık (standart LED ışık) koşullarında etkilerinin de belirlendiği çalışmada en yüksek inhibisyon 42.1 mm ile C. parapsilosis ve 39 mm ile C. tropicalis’de sırasıyla karanlık ve ışıkta bulunmuştur. Çalışmada ayrıca yağların su, glikoz, gliserol ve tuz koşullarında inhibisyon bölgeleri (IZ) 26.6 mm ile C. albicans ve 26 mm ile C. tropicalis’de %3 gliserol koşullarında bulunmuştur. Mayaların DNA ve protein seviyelerinde yağa maruz kalma durumlarına göre artış tespit edilmiştir. Sonuç olarak, kimyon ve murt birlikte distile uçucu yağının antimikrobiyal stabilite gösterdiği ileri çalışmalar yapılması gerektiği tespit edilmiştir.

Anahtar Kelimeler

Kimyon Uçucu yağ Antikandidal Antifungal Murt

Kaynakça

  • Aleksic V, Knezevic P 2014. Antimicrobial and Antioxidative Activity of Extracts and Essential Oils of Myrtus communis L. Microbiological Research 169(4): 240-54.
  • Allaq AA, Sidik NJ, Abdul-Aziz A, Ahmed IA 2020. Cumin (Cuminum cyminum L.): A review of Its Ethnopharmacology, Phytochemistry. Biomed Research and Therapy 7: 4016-4021.
  • Al-Rubaye AF, Kadhim MJ, Hameed IH 2017. Phytochemical Profiles of Methanolic Seeds Extract of Cuminum cyminum Using GC-MS Technique. International Journal of Current Pharmaceutical Research 2017(8): 114-124.
  • Asgarpanah J, Ariamanesh A 2015. Phytochemistry and pharmacological properties of Myrtus communis L. Indian Journal of Traditional Knowledge 1(1): 82-87.
  • Bahadirli NP, Kahramanoğlu İ, Wan C 2021. Exposure to Volatile Essential Oils of Myrtle (Myrtus communis L.) Leaves for Improving the Postharvest Storability of Fresh Loquat Fruits. Journal of Food Quality 2020: 1-10.
  • Bajpai P, Dash V 2012. Hybrid Renewable Energy Systems for Power Generation in Stand-Alone Applications: A Review. Renewable Sustainable Energy Reviews 16: 2926-2939.
  • Bakkali F, Averbeck S, Averbeck D. Idaomar M 2008. Biological Effects of Essential Oils a Review. Food and Chemical Toxicology 46: 446–475.
  • Başer HC, 2009. Uçucu Yağlar ve Aromaterapi. Fitomed 7: 1-8.
  • Bassolé IHN, Juliani HR 2012. Essential Oils in Combination and Their Antimicrobial Properties. Molecules 17: 3989-4006.
  • Bhavya ML, Hebbar HU 2019. Efficacy of Blue LED in Microbial Inactivation: Effect of Photosensitization and Process Parameters. International Jounal of Food Microbiology 2: 290.
  • Bouzabata A, Cabral C, Gonçalves MJ, Cruz MT, Bighelli A, Cavaleiro C, Casanova J, Tomi F, Salgueiro L 2015. Myrtus communis L. as Source of a Bioactive and Safe Essential Oil. Food and Chemical Toxicology 75: 166-172.
  • Bouzabata A, Castola V, Bighelli A, Abed L, Casanova J, Tomi F 2013. Chemical Variability of Algerian Myrtus communis L. Chem Biodiversity, 2013;10, 129-137.
  • Calderone RA, Fonzi WA 2001. Virulence Factors of Candida albicans. Trends in Microbiology 9: 327-335.
  • Cannas S, Molicotti P, Ruggeri M, Cubeddu, M, Sanguýnetti, Marongiu B, Zanetti S 2013. Antimycotic Activity of Myrtus communis L. Towards Candida spp. from Clinical Isolates. Journal of Infection in Developing Countries 7: 295-298.
  • Chalchat JC, Garry RP, Michet A 1998. Essential Oils of Myrtle (Myrtus communis L.) of the Mediterranean Littoral. Journal of Essential Oil Research 10: 613-617.
  • Chaudhary N, Husain SS, Mohammed A 2014. Chemical Composition and Antimicrobial Activity of Volatile Oil of the Seeds of Cuminum cyminum L. World Journal of Pharmaceutical Sciences 3: 1428-1441.
  • Cruz W, Ferraz A, Lima W, Moraes TFS, Ferreira FL 2018. Evaluation of the Activity of Tontelea micrantha Extracts Against Bacteria, Candida and Mayaro virus. Journal of Pharmaceutical Negative Results 9: 21-6.
  • Curini M, Bianchi A, Epifano F, Bruni R, Torta L, Zambonelli A 2003. Composition and In Vitro Antifungal Activity of Essential Oils of Erigeron canadensis and Myrtus communis from France. Chemistry of Natural Compounds 39: 191-194.
  • Ding T, Xuan X-T, Li J, Chen SG, Liu DH, Ye XQ, Si J, Xue SJ 2016. Disinfection Efficacy and Mechanism of Slightly Acidic Electrolyzed Water on Staphylococcus aureus in Pure Culture. Food Control 60: 505-510.
  • Elisa B, Aldo A, Ludovica G 2019. Chemical Composition and Antimycotic Activity of Six Essential Oils (cumin, fennel, manuka, sweet orange, cedar and juniper) Against Different Candida spp. Natural Product Research 1: 1-6.
  • Erdoğan Eliuz EA 2020. Indifferent Effect in Combinations of Mentha piperita Essential Oil and Fluconazole against C. albicans. Romanian Bitechnological Letters 25: 1709-1715.
  • Erdoğan Eliuz EA, Ayas D, Goksen G 2017. In Vitro Phototoxicity and Antimicrobial Activity of Volatile Oil Obtained from Some Aromatic Plants. Journal of Essential Oil Bearing Plants 20: 758-768.
  • Ersoy ZG, Barisci S, Dinc O 2019. Mechanisms of the Escherichia coli and Enterococcus faecalis Inactivation by Ozone. LWT Food Science and Technology 100: 306-313.
  • Gachkar L, Yadegari D, Razaei MB, Taghizadeh M, Astaneh A, Rasooli I 2007. Chemical and Biological Characteristics of Cuminum cyminum and Rosmarinus officinalis Essential Oils. Food Chemistry 102: 898-904.
  • Gardeli C, Vassiliki P, Athanasios M, Kibouris T, Komaitis M 2008. Essential Oil Composition of Pistacia lentiscus L. and Myrtus communis L.: Evaluation of Antioxidant Capacity of Methanolic Extracts. Food Chemistry 7: 1120-1130.
  • Gutierrez J, Barry-Ryan C, Bourke P 2008. The Antimicrobial Efficacy of Plant Essential Oil Combinations and Interactions with Food Ingredients. International Journal of Food Microbiology 124: 91-97.
  • Hussein HKA, Kadhem NH, Abbod ZH 2006. Study of the Biological Activity of Aqueous Extract of Cuminum cyminum L. and Hibiscus sabdariffa L. and Detection of Some Active Groups in Them. Journal of Kerbala University 5: 65-72.
  • Jamoussi B, Romdhane M, Abderraba A, Hassine BB, Gadri AE 2005. Effect of Harvest Time on Yield and Composition of Tunisian Myrtle Oils. Flavour and Fragrance Journal 20: 27-47.
  • Johri JR 2011. Cuminum cyminum and Carum carvi. Pharmacognosy Reviews, 5, 63-72.
  • Kırıcı S, Bayram E, Tansı S, Arabacı O, Baydar H, Telci İ, İnan M, Kaya DA, Özel A 2020. Tıbbi ve Aromatik Bitkilerin Üretiminde Mmevcut Durum ve Ggelecek. Türkiye Ziraat Mühendisliği IX. Teknik Kongresi, 505-528, Ankara.
  • Li R, Jiang ZT 2004. Chemical Composition of the Essential Oil of Cuminum cyminum L. from China. Flavour and Fragrance Journal 19: 311-313.
  • Mahboubi M, Bidgoli FG 2010. In vitro Synergistic Efficacy of Combination of Amphotericin B with Myrtus communis Essential Oil Against Clinical Isolates of Candida albicans. Phytomedicine 17: 771-774.
  • Mahdavi OS, Esmaeilzadeh S, Rahmani Z 2010. Laboratory Study of Anticandidal Activity of Thyme, Ppennyroyal and Lemon Essential Oils by Micro Dilution Method. Jundishapur Journal of Microbiology 3: 161-167.
  • Miguel LGS, Cobo J, Otheo E, Sánchez-Sousa A, Abraira V, Moreno S 2005. Secular Trends of Candidemia in a Large Tertiary-Care Hospital from 1988 to 2000: Emergence of Candida parapsilosis. Infection Control Hospital Epidemiology 26: 548-52.
  • Minooeianhaghighi MH, Sepehrian L, Shokri H 2017. Antifungal Eeffects of Lavandula binaludensis and Cuminum cyminum Essential Oils Against Candida albicans Strains Isolated from Patients with Recurrent Vulvovaginal Candidiasis. Journal of Medical Mycology 27: 65-71.
  • Morton JF 1976. Herbs and Spices (Golden Press, New York), 160.
  • Naeini A, Naderi NJ, Shokri H 2014. Analysis and In Vitro Anti-Candida Antifungal Activity of Cuminum cyminum and Salvadora persica Herbs Extracts Against Pathogenic Candida Strains, Journal of Medical Mycology 24: 13–18.
  • NCCLS 1997. National Committee for Clinical Laboratory Standards Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts. Approved standard M27-A. National Committee for Clinical Laboratory Standards, Wayne, Pa.
  • Özek T, Demirci B, Baser KHC 2000. Chemical Composition of Turkish Myrtle Oil. Journal of Essential Oil Research 12: 541-544.
  • Pappas PG, Kauffman CA, Andes DR, David R, Clancy C, Marr KA, Ostrosky L, Reboli AC, Schuster MG, Vazquez JA, Walsh TJ, Zaoutis TE, Sobel JD 2015. Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America. Clinical Infectious Diseases 62: 1-50.
  • Petretto GL, Fancello F, Bakhy K, Faiz CAL, Sibawayh Z, Chessa M, Zara S, Sanna ML, Maldini M, Rourke JP, Pintone G 2018. Chemical Composition and Antimicrobial Activity of Essential oils from Cuminum cyminum L. Collected in Different Areas of Morocco. Food Bioscience 22: 50–58.
  • Qi H, Hung YC, 2019. Inactivation Mechanism of Ferrous and Alkaline Activated Persulfate on Escherichia coli O157:H7 and Listeria monocytogenes. LWT Food Science and Technology 111: 62-68.
  • Sahana K, Nagarajan S, Mohan Rao LJ 2011. Cumin (Cuminum cyminum L.) Seed Volatile Oil: Chemistry and Role in Health and Disease Prevention, In: Nuts and Seeds in Health and Disease Prevention, edited by V R Preedy, R R Watson & VB Patel, (Academic Pres Elsevier), 417-427.
  • Silva S, Negri M, Henriques M, Oliveira R, Williams DW, Azeredo J 2012. Candida glabrata, Candida parapsilosis and Candida tropicalis: Biology, Epidemiology, Pathogenicity and Antifungal Resistance. FEMS Microbiology Reviews 36: 288-305.
  • Sumbul S, Aftab Ahmad M, Asif M, Akhtar M 2011. Myrtus communis Linn.: A review. Indian Journal of Natural Products and Resources 2: 395-402.
  • Thippeswamy NB, Naidu KA 2005. Antioxidant potency of cumin varieties—cumin, black cumin and bitter cumin—on antioxidant systems. European Food Research and Technology. 220(5): 472-476.
  • Trofa D, Gacser A, Nosanchuk JD 2008. Candida parapsilosis, an Emerging Fungal Pathogen. Clinical Microbiology Reviews 21: 606-625.
  • VanderJagt TJ, Ghattas R, VanderJagt DJ, Crossey M, Glew RH 2002. Comparison of the Total Antioxidant Content of 30 Widely Used Medicinal Plants of New Mexico. Life Science 70: 1035-1040.
  • Vieira JN, Gonçalves CL, Villarreal JPV, Gonçalves VM, Lund RG, Freitag RA, Silva AF, Nascente PS 2019. Chemical Composition of Essential Oils from the Apiaceae Family, Cytotoxicity, and Their Antifungal Activity In Vitro Against Candida Species from Oral Cavity. Brazilian Journal of Biology 79: 432-437.
  • Wang H, Cheng H, Wang F, Wei D, Wang X 2010. An Improved 3-(4,5-dimethylthiazol-2-yl)-2,5-Diphenyl Tetrazolium Bromide (MTT) Reduction Assay for Evaluating the Viability of Escherichia coli Cells. Journal of Microbiological Methods 82: 330-333.
  • Whaley SG, Berkow EL, Rybak JM, Nishimoto AT, Barker KS, Rogers PD 2017. Azole Antifungal Resistance in Candida albicans and Emerging Non-Albicans Candida Species. Frontiers in Microbiology 7: 1–12.
  • Wisplinghoff H, Bischoff T, Tallent SM, Seifert H, Wenzel RP, Edmond MB 2004. Nosocomial Bloodstream Infections in US Hospitals: Analysis of 24,179 Cases from a Prospective Nationwide Surveillance Study. Clinical Infectious Diseases 39: 309-317.
  • Yadegarinia D, Gachkar L, Rezaei MB, Taghizadeh M, Astaneh SA, Rasooli I 2006. Biochemical Activities of Iranian Mentha piperita L. and Myrtus communis L. Essential Oils. Phytochemistry 67: 1249-1255.
  • Yao J, Moellering R 2011. Antibacterial Agents, Versalovic J, Carroll K, Funke G, Jorgensen J, Landry M, Warnock D, 10. (eds), Manual of Clinical Microbiology, ASM Press, Washington.
  • Zomorodian K, Moein M, Lori ZG, Ghasemi Y, Rahimi MJ, Bandegani A, Pakshir K, Bazargani SM, Mirzamohammadi S, Abbasi N 2013. Chemical Composition and Antimicrobial Activities of the Essential Oil from Myrtus communis Leaves, Journal of Essential Oil Bearing Plants 16(1): 76–84.
Toplam 55 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Yapısal Biyoloji , Ziraat, Veterinerlik ve Gıda Bilimleri
Bölüm ARAŞTIRMA MAKALESİ (Research Article)
Yazarlar

Elif Eliuz 0000-0003-4317-3000

Nadire Pelin Bahadırlı 0000-0001-7321-5377

Yayımlanma Tarihi 30 Aralık 2022
Gönderilme Tarihi 17 Şubat 2022
Kabul Tarihi 1 Nisan 2022
Yayımlandığı Sayı Yıl 2022

Kaynak Göster

APA Eliuz, E., & Bahadırlı, N. P. (2022). Anticandidal Activity and Anticandidal Mechanism of Essential Oil of Cuminum cyminum L. and Myrtus communis L. Mixture. Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi, 25(Ek Sayı 2), 391-401. https://doi.org/10.18016/ksutarimdoga.vi.1075012

21082



2022-JIF = 0.500

2022-JCI = 0.170

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