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Verbascum kotschyi Boiss. & Hohen. Kullanılarak Sentezlenen Çinko Oksit ve Selenyum Oksit Nanopartiküllerinin Antioksidan ve Antimikrobiyal Özelliklerinin Karşılaştırılması

Yıl 2025, , 9 - 19, 12.02.2025

Leyla Ercan , Cemile Günbegi Çalışkan , Fatma Mungan Kılıç

https://doi.org/10.18016/ksutarimdoga.vi.1404682

Öz

Son yıllarda nanopartiküllerin birbirinden farklı alanlarda kullanımı araştırılmaktadır. Bu çalışmalar içinde özellikle yeşil sentez ile doğa dostu ve sağlığa faydalı nanopartiküllerin sentezi oldukça ilgi çekmektedir. Aynı zamanda bu çalışmalar ile değeri ve pek çok özelliği bilinmeyen çok sayıda bitki türünün önemi de açığa çıkarılmaktadır. Bu nedenle bu bitki türlerinden biri olan ve üzerinde nanopartikül çalışmaları yapılmayan bir tür olan Verbascum kotschyi’den çinko oksit ve selenium nanopartiküller sentezleyip bu nanopartiküllerin antimikrobiyal ve antioksidan özelliklerini belirlemek amaçlanmıştır. Verbascum kotschyi’den sentezlenen nanopartiküllerin SEM, EDX, FTIR analizleri yapıldıktan sonra üç farklı yöntemle (DPPH, CUPRAC ve FRAP) in vitro antioksidan kapasiteleri belirlenmiştir. Ayrıca disk difüzyon yöntemi ile gram-pozitif, gram-negatif bakteriler ve mantar üzerine antimikrobiyal etkisi belirlenmiştir. Sonuç olarak Verbascum kotschyi’den sentezlenen çinko oksit nanaopartiküller selenyum nanopartiküllere kıyasla daha fazla antimikrobiyal özellik sergilemiştir. Ancak selenyum nanaopartiküller çinko oksit nanaopartiküllerden daha etkin antioksidan özellik sergilemiştir. Böylece Verbascum kotschyi’nin nanopartikül sentezi ile oluşturulabilecek ürünleri sayesinde farklı alanlarda kullanılabilecek özelliklere sahip olduğu tespit edildi.

Anahtar Kelimeler

Antimikrobiyal Antioksidan Yeşil sentez Selenyum nanopartikül Verbascum kotschyi

Etik Beyan

Araştırmamız etik kurul onayı gerektirmeyen bir çalışmadır.

Kaynakça

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  • Akintelu, S. A., & Folorunso, A. S. (2020). A Review on Green Synthesis of Zinc Oxide Nanoparticles Using Plant Extracts and Its Biomedical Applications. BioNanoScience, 10(4), 848–863. https://doi.org/10.1007/S12668-020-00774-6/METRICS
  • Al-Dhabi, N. A., & Arasu, M. V. (2018). Environmentally-Friendly Green Approach for the Production of Zinc Oxide Nanoparticles and Their Anti-Fungal, Ovicidal, and Larvicidal Properties. Nanomaterials (Basel, Switzerland), 8(7), 500. https://doi.org/10.3390/NANO8070500
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  • Dinakarkumar, Y., Masi, C., Rajabathar, J. R., Ramakrishnan, G., Ninawe, R., Al-Lohedan, H., & Veera, H. M. (2024). Phytoconstituents of a traditional herb, Verbascum sinaiticum Benth mediated zinc-ferric bimetallic nanoparticle synthesis and bioactive properties for sustainable application. Journal of Molecular Structure, 1310, 138307. https://doi.org/10.1016/J.MOLSTRUC.2024.138307
  • Dole, B. N., Mote, V. D., Huse, V. R., Purushotham, Y., Lande, M. K., Jadhav, K. M., & Shah, S. S. (2011). Structural studies of Mn doped ZnO nanoparticles. Current Applied Physics, 11(3), 762–766. https://doi.org/10.1016/J.CAP.2010.11.050
  • Donn, P., Barciela, P., Perez-Vazquez, A., Cassani, L., Simal-Gandara, J., & Prieto, M. A. (2023). Bioactive Compounds of Verbascum sinuatum L.: Health Benefits and Potential as New Ingredients for Industrial Applications. Biomolecules, 13(3), 427. https://doi.org/10.3390/BIOM13030427
  • Dülger, B., Kirmizi, S., Arslan, H., & Güleryüz, G. (2002). Antimicrobial Activity of Three Endemic Verbascum Species. Pharmaceutical Biology, 40(8), 587–589. https://doi.org/10.1076/PHBI.40.8.587.14657
  • Eksik, C. (2020). Ethnobotanic study of some Villages of Artuklu, Ömerli, Yeşilli District in Mardin Province. Harran University, Natural and Applied Sciences, Department of Biology, Master's thesis.
  • Elemike, E. E., Onwudiwe, D. C., & Mkhize, Z. (2016). Eco-friendly synthesis of AgNPs using Verbascum thapsus extract and its photocatalytic activity. Materials Letters, 185, 452–455. https://doi.org/ 10.1016/J.MATLET.2016.09.026
  • Emsen, B., Çinar, İ., & Doğan, M. (2023). Detoxification Efficiency of Micropropagated Alternanthera reineckii Briq. against Zinc Oxide Nanoparticles in Human Keratinocyte Cells. Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, 26(5), 1066–1074. https://doi.org/10.18016/ksutarimdoga.vi.1241907
  • Ercan, L., Gunbegi Caliskan, C., Kilic, M., Comparison of chemical and antimicrobial properties of different nanoparticles synthesized from Verbascum x calcicolum Hub.-Mor. Hybrid. Journal of the Indian Chemical Society 101(2024), 101133 https://doi.org/10.1016/j.jics.2024.101133
  • Fakhari, S., Jamzad, M., & Kabiri Fard, H. (2019). Green synthesis of zinc oxide nanoparticles: a comparison. Green Chemistry Letters and Reviews, 12(1), 19–24. https://doi.org/10.1080/17518253.2018.1547925
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Comparison of Antioxidant and Antimicrobial Properties of Zinc oxide and Selenium oxide Nanoparticles using Verbascum kotschyi Boiss. & Hohen.

Yıl 2025, , 9 - 19, 12.02.2025

Leyla Ercan , Cemile Günbegi Çalışkan , Fatma Mungan Kılıç

https://doi.org/10.18016/ksutarimdoga.vi.1404682

Öz

Nanoparticle applications have been studied in many fields in recent years. Among these studies, the synthesis of nature-friendly and health-friendly nanoparticles through green synthesis attracts much attention. These investigations also highlight the significance of several plant species, many of whose worth and traits remain unknown. The goal of this work is to create zinc oxide and selenium nanoparticles from Verbascum kotschyi Boiss. & Hohen., a plant species that hasn't received much attention, and to ascertain the antioxidant and antibacterial qualities of these nanoparticles. To accomplish this, three distinct techniques (DPPH, CUPRAC, and FRAP) were used to assess the produced nanoparticles' in vitro antioxidant capabilities after SEM, EDX, and FTIR analyses. Furthermore, the disk diffusion technique was utilized to ascertain the antibacterial efficacy of these nanoparticles against both gram-positive and gram-negative bacteria and fungus In conclusion, V. kotschyi-derived zinc oxide nanoparticles outperformed selenium nanoparticles in terms of antibacterial activity. But when it came to antioxidant activity, selenium nanoparticles outperformed zinc oxide nanoparticles. Thus, it was determined that the products created by nanoparticle synthesis from Verbascum kotschyi have properties that can be used in different fields.

Anahtar Kelimeler

Antimicrobial Antioxidant Green synthesis Selenium nanoparticles Verbascum kotschyi

Kaynakça

  • Agarwal, H., & Shanmugam, V. (2020). A review on anti-inflammatory activity of green synthesized zinc oxide nanoparticle: Mechanism-based approach. Bioorganic Chemistry, 94, 103423. https://doi.org/10.1016/ j.bioorg.2019.103423
  • Akintelu, S. A., & Folorunso, A. S. (2020). A Review on Green Synthesis of Zinc Oxide Nanoparticles Using Plant Extracts and Its Biomedical Applications. BioNanoScience, 10(4), 848–863. https://doi.org/10.1007/S12668-020-00774-6/METRICS
  • Al-Dhabi, N. A., & Arasu, M. V. (2018). Environmentally-Friendly Green Approach for the Production of Zinc Oxide Nanoparticles and Their Anti-Fungal, Ovicidal, and Larvicidal Properties. Nanomaterials (Basel, Switzerland), 8(7), 500. https://doi.org/10.3390/NANO8070500
  • Anjum, S., Hashim, M., Asad Malik, S., Khan ,M., Lorenzo, J. M., Haider Abbasi, B., & Hano, C. (2021). Recent Advances in Zinc Oxide Nanoparticles (ZnO NPs) for Cancer Diagnosis, Target Drug Delivery, and Treatment. Cancers, 2021, 13, 4570. https://doi.org/10.3390/cancers13184570
  • Apak, R., Güçlü, K., Demirata, B., Özyürek, M., Çelik, S. E., Bektaşoǧlu, B., Berker, K. I., & Özyurt, D. (2007). Comparative evaluation of various total antioxidant capacity assays applied to phenolic compounds with the CUPRAC assay. Molecules (Basel, Switzerland), 12(7), 1496–1547. https://doi.org/10.3390/12071496
  • Baytop, T. (1999). Türkiyede bitkiler ile Tedavi. Nobel Tıp kitapevleri.
  • Bhuyan, T., Mishra, K., Khanuja, M., Prasad, R., & Varma, A. (2015). Biosynthesis of zinc oxide nanoparticles from Azadirachta indica for antibacterial and photocatalytic applications. Mater. Sci. Semicond. Process. 32, 55–61, https://doi.org/10.1016/j.mssp. 2014.12.053.
  • Dinakarkumar, Y., Masi, C., Rajabathar, J. R., Ramakrishnan, G., Ninawe, R., Al-Lohedan, H., & Veera, H. M. (2024). Phytoconstituents of a traditional herb, Verbascum sinaiticum Benth mediated zinc-ferric bimetallic nanoparticle synthesis and bioactive properties for sustainable application. Journal of Molecular Structure, 1310, 138307. https://doi.org/10.1016/J.MOLSTRUC.2024.138307
  • Dole, B. N., Mote, V. D., Huse, V. R., Purushotham, Y., Lande, M. K., Jadhav, K. M., & Shah, S. S. (2011). Structural studies of Mn doped ZnO nanoparticles. Current Applied Physics, 11(3), 762–766. https://doi.org/10.1016/J.CAP.2010.11.050
  • Donn, P., Barciela, P., Perez-Vazquez, A., Cassani, L., Simal-Gandara, J., & Prieto, M. A. (2023). Bioactive Compounds of Verbascum sinuatum L.: Health Benefits and Potential as New Ingredients for Industrial Applications. Biomolecules, 13(3), 427. https://doi.org/10.3390/BIOM13030427
  • Dülger, B., Kirmizi, S., Arslan, H., & Güleryüz, G. (2002). Antimicrobial Activity of Three Endemic Verbascum Species. Pharmaceutical Biology, 40(8), 587–589. https://doi.org/10.1076/PHBI.40.8.587.14657
  • Eksik, C. (2020). Ethnobotanic study of some Villages of Artuklu, Ömerli, Yeşilli District in Mardin Province. Harran University, Natural and Applied Sciences, Department of Biology, Master's thesis.
  • Elemike, E. E., Onwudiwe, D. C., & Mkhize, Z. (2016). Eco-friendly synthesis of AgNPs using Verbascum thapsus extract and its photocatalytic activity. Materials Letters, 185, 452–455. https://doi.org/ 10.1016/J.MATLET.2016.09.026
  • Emsen, B., Çinar, İ., & Doğan, M. (2023). Detoxification Efficiency of Micropropagated Alternanthera reineckii Briq. against Zinc Oxide Nanoparticles in Human Keratinocyte Cells. Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, 26(5), 1066–1074. https://doi.org/10.18016/ksutarimdoga.vi.1241907
  • Ercan, L., Gunbegi Caliskan, C., Kilic, M., Comparison of chemical and antimicrobial properties of different nanoparticles synthesized from Verbascum x calcicolum Hub.-Mor. Hybrid. Journal of the Indian Chemical Society 101(2024), 101133 https://doi.org/10.1016/j.jics.2024.101133
  • Fakhari, S., Jamzad, M., & Kabiri Fard, H. (2019). Green synthesis of zinc oxide nanoparticles: a comparison. Green Chemistry Letters and Reviews, 12(1), 19–24. https://doi.org/10.1080/17518253.2018.1547925
  • Georgiev, M., Alipieva, K., Orhan, I., Abrashev, R., Denev, P., & Angelova, M. (2011). Antioxidant and cholinesterases inhibitory activities of Verbascum xanthophoeniceum Griseb. and its phenylethanoid glycosides. Food Chemistry, 128(1), 100–105. https://doi.org/10.1016/J.FOODCHEM.2011.02.083
  • Gülçin, I. (2012). Antioxidant activity of food constituents: an overview. Archives of Toxicology, 86(3), 345–391. https://doi.org/10.1007/S00204-011-0774-2
  • Güner, A., Aslan, S., Ekim, T., Vural, M., & Babaç, M. T. (2012). Verbascum L. In Türkiye Bitkileri Listesi (Damarlı Bitkiler). Nezahat Gökyiğit Botanik Bahçesi ve Flora Araştırmaları Derneği Yayını, pp. 850–870.
  • Huber-Morath, A. 1978: Verbascum L., In: Davis, P. H. (ed.), Flora of Turkey and the East Aegean Islands, Edinburgh University Press, Edinburgh, vol. 6, 461–603.
  • Iranifam, M., Fathinia, M., Sadeghi Rad, T., Hanifehpour, Y., Khataee, A. R., & Joo, S. W. (2013). A novel selenium nanoparticles-enhanced chemiluminescence system for determination of dinitrobutylphenol. Talanta, 107, 263–269. https://doi.org/10.1016/J.TALANTA.2012.12.043
  • Jiang, J., Pi, J., & Cai, J. (2018). The Advancing of Zinc Oxide Nanoparticles for Biomedical Applications. Bioinorganic Chemistry and Applications, 2018(1), 1062562. https://doi.org/10.1155/2018/1062562
  • Kalishwaralal, K., Jeyabharathi, S., Sundar, K., & Muthukumaran, A. (2016). A novel one-pot green synthesis of selenium nanoparticles and evaluation of its toxicity in zebrafish embryos. Artificial Cells, Nanomedicine, and Biotechnology, 44(2), 471–477. https://doi.org/10.3109/21691401.2014.962744
  • Khurana, A., Tekula, S., Saifi, M. A., Venkatesh, P., & Godugu, C. (2019). Therapeutic applications of selenium nanoparticles. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 111, 802–812. https://doi.org/10.1016/J.BIOPHA.2018.12.146
  • Kora, A. J., & Rastogi, L. (2016). Biomimetic synthesis of selenium nanoparticles by Pseudomonas aeruginosa ATCC 27853: An approach for conversion of selenite. Journal of Environmental Management, 181, 231–236. https://doi.org/10.1016/J.JENVMAN.2016.06.029
  • Kumar, B., Smita, K., Cumbal, L., & Debut, A. (2014). Green approach for fabrication and applications of zinc oxide nanoparticles. Bioinorganic Chemistry and Applications, 2014, 523869. https://doi.org/10.1155/2014/523869
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  • Makhlouf-Gafsi, I., Krichen, F., Mansour, R. Ben, Mokni, A., Sila, A., Bougatef, A., Blecker, C., Attia, H., & Besbes, S. (2018). Ultrafiltration and thermal processing effects on Maillard reaction products and biological properties of date palm sap syrups (Phoenix dactylifera L.). Food Chemistry, 256, 397–404. https://doi.org/10.1016/J.FOODCHEM.2018.02.145.
  • Mishra, A., Kumar, S., & Pandey, A. K. (2013). Scientific validation of the medicinal efficacy of Tinospora cordifolia. The Scientific World Journal, 2013, 292934. https://doi.org/10.1155/2013/292934
  • Mishra, P. K., Mishra, H., Ekielski, A., Talegaonkar, S., & Vaidya, B. (2017). Zinc oxide nanoparticles: a promising nanomaterial for biomedical applications. Drug Discovery Today, 22(12), 1825–1834. https://doi.org/10.1016/J.DRUDIS.2017.08.006
  • Mishra, R. R., Prajapati, S., Das, J., Dangar, T. K., Das, N., & Thatoi, H. (2011). Reduction of selenite to red elemental selenium by moderately halotolerant Bacillus megaterium strains isolated from Bhitarkanika mangrove soil and characterization of reduced product. Chemosphere, 84(9), 1231–1237. https://doi.org/10.1016/J.CHEMOSPHERE.2011.05.025
  • Mosalam, M., & Marzouk, F. (2013). Effect of gamma radiation on the microbial synthesis of metal nanoparticles, [MSc Thesis].
  • Mungan Kılıç, F., Kılıç, M. (2022). A Review On Verbascum Taxa Distributed In Mardin Province. II. International Siirt Scientific Research Congress 21-23 March 2022, Siirt, Turkey.
  • Nagajyothi, P. C., Minh An, T. N., Sreekanth, T. V. M., Lee, J. Il, Joo, D. L., & Lee, K. D. (2013). Green route biosynthesis: Characterization and catalytic activity of ZnO nanoparticles. Materials Letters, 108, 160–163. https://doi.org/10.1016/J.MATLET.2013.06.095
  • Nayak, V., Singh, K. R., Singh, A. K., & Singh, R. P. (2021). Potentialities of selenium nanoparticles in biomedical science. New Journal of Chemistry, 45(6), 2849–2878. https://doi.org/10.1039/D0NJ05884J
  • Park, Y., Hong, Y. N., Weyers, A., Kim, Y. S., & Linhardt, R. J. (2011). Polysaccharides and phytochemicals: a natural reservoir for the green synthesis of gold and silver nanoparticles. IET Nanobiotechnology, 5(3), 69–78. https://doi.org/10.1049/IET-NBT.2010.0033
  • Pillai, A. M., Sivasankarapillai, V. S., Rahdar, A., Joseph, J., Sadeghfar, F., Anuf A, R., Rajesh, K., & Kyzas, G. Z. (2020). Green synthesis and characterization of zinc oxide nanoparticles with antibacterial and antifungal activity. Journal of Molecular Structure, 1211, 128107. https://doi.org/10.1016/J.MOLSTRUC.2020.128107
  • Rajakumar, G., Thiruvengadam, M., Mydhili, G., Gomathi, T., & Chung, I. M. (2018). Green approach for synthesis of zinc oxide nanoparticles from Andrographis paniculata leaf extract and evaluation of their antioxidant, anti-diabetic, and anti-inflammatory activities. Bioprocess and Biosystems Engineering, 41(1), 21–30. https://doi.org/10.1007/S00449-017-1840-9
  • Ramesh, P., Rajendran, A., & Sundaram, M. (2014). Green Syntheis of Zinc Oxide Nanoparticles Using Flower Extract Cassia Auriculata. Nanotechnology, 2, 41–45.
  • Saleh, M., Isik, Z., Aktas, Y., Arslan, H., Yalvac, M., & Dizge, N. (2021). Green synthesis of zero valent iron nanoparticles using Verbascum thapsus and its Cr (VI) reduction activity. Bioresource Technology Reports, 13, 100637. https://doi.org/10.1016/J.BITEB.2021.100637
  • Salem, S. S., Fouda, M. M. G., Fouda, A., Awad, M. A., Al-Olayan, E. M., Allam, A. A., & Shaheen, T. I. (2021). Antibacterial, Cytotoxicity and Larvicidal Activity of Green Synthesized Selenium Nanoparticles Using Penicillium corylophilum. Journal of Cluster Science, 32(2), 351–361. https://doi.org/10.1007/S10876-020-01794-8/TABLES/1
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Toplam 56 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Bitki Biyokimyası, Bitki Biyoteknolojisi
Bölüm ARAŞTIRMA MAKALESİ (Research Article)
Yazarlar

Leyla Ercan 0000-0002-6570-8128

Cemile Günbegi Çalışkan 0000-0001-8129-4394

Fatma Mungan Kılıç 0000-0001-6858-3458

Erken Görünüm Tarihi 30 Ocak 2025
Yayımlanma Tarihi 12 Şubat 2025
Gönderilme Tarihi 14 Aralık 2023
Kabul Tarihi 7 Kasım 2024
Yayımlandığı Sayı Yıl 2025

Kaynak Göster

APA Ercan, L., Günbegi Çalışkan, C., & Mungan Kılıç, F. (2025). Comparison of Antioxidant and Antimicrobial Properties of Zinc oxide and Selenium oxide Nanoparticles using Verbascum kotschyi Boiss. & Hohen. Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi, 28(1), 9-19. https://doi.org/10.18016/ksutarimdoga.vi.1404682

21082



2022-JIF = 0.500

2022-JCI = 0.170

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