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Jurinea brevicaulis'in Biyolojik Aktivitesi; sitotoksisite ve antioksidan aktivitesi

Year 2021, Volume: 24 Issue: 2, 278 - 284, 30.04.2021

Mahmoud Abudayyak , Şeyda Kanbolat Şeyma Batur Reyyan Ergene Rezzan Aliyazıcıoğlu

https://doi.org/10.18016/ksutarimdoga.vi.772989
Cited By: 2

Abstract

Jurinea brevicaulis, Asteraceae familyasına ait çok yıllık otsu bir bitkidir. J. brevicaulis endemik bir cinstir ve Türkiye'de Erzincan ve Gümüşhane illerinde yetişir. Jurinea türleri antikanser, antibakteriyel, antifungal, antioksidan etkiler gösterdiği bilinmektedir. Bu makalede, J. brevicaulis’in antioksidan kapasitesini ve sitotoksik etkilerini değerlendirmek amaçlanmıştır. Sonuçlar, TPC değerlerinin 41.7- 537.5 GAE ug g-1 arasında, FRAP değerlerinin 109.52- 1076.2 uM Troloks eşdeğeri g-1, CUPRAC değerlerinin 231.4- 3083.3 uM Trolox eşdeğer g-1, DPPH tayininde IC50 değerleri 0.0102- 3.4174 mg mL-1 arasında olduğunu göstermektedir. Ekstreler, konsantrasyona bağlı bir biçimde hücre ölümüne neden olmuştur, IC50 değerleri 3.67-10.2 ug mL-1 arasında hesaplanmıştır. Sonuç olarak, kanser hücrelerdeki sitotoksik etkiler ve yüksek antioksidan kapasite, J. brevicaulis'in yeni ilaçların geliştirilmesinde önemli bir bitki olabileceğini göstermektedir.

Keywords

Jurinea brevicaulis Antioksidan Kapasite Sitotoksisite

Project Number

1919B011800561

References

  • Abudayyak M, Özdemir Nath E, Özhan G 2015. Toxic Potentials of Ten Herbs Commonly Used Aphrodisiac Effect in Turkey. Turkish Journal of Medical Sciences 44(3): 496-506.
  • Acıbuca V, Bostan Budak D 2018. Dünya’da ve Türkiye’de Tıbbi ve Aromatik Bitkilerin Yeri ve Önemi. Çukurova Journal of Agricultural and Food Science 33(1): 37-44.
  • Alley MC, Scudiero DA, Monks A, Hursey ML, Czerwinski MJ, Fine DL, Abbott BJ, Mayo JG, Shoemaker RH, Boyd MR 1988. Feasibility of Drug Screening with Panels of Human Tumor Cell Lines Using a Microculture Tetrazolium Assay. Cancer Research 48: 589-601.
  • Apak R, Güçlü K, Özyürek M, Karademir SE, Erçağ E 2006. The Cupric Ion Reducing Antioxidant Capacity and Polyphenolic Content of Some Herbal Teas. International Journal Food Science Nutrition 57(5-6): 292-304.
  • Ayad R, Çakmak YS, Özüsağlam MA, Medjroubi K, Akkal S 2017. In vitro Antioxidant and Antimicrobial Activities of Aerial Parts of Algerian Jurinea humilis DC (Asteraceae). Tropical Journal of Pharmaceutical Research 16(12): 2903-2909.
  • Chahar MK, Sharma N, Dobhal MP, Joshi YC 2011. Flavonoids: A Versatile Source of Anticancer Drugs. Pharmacognosy Reviews 5(9): 1-12.
  • Chan K 2003. Some Aspects of Toxic Contaminants in Herbal Medicines. Chemosphere 52(9): 1361-1371.
  • Davis P 1975. Flora of Turkey and the East Aegean Islands, Volume 5 Edinburgh: Edinburgh University Press, 978-0-8522-42803. 890 pages.
  • Doğan A, Tuzlacı E 2015. Tunceli’nin Bazı Yöresel Bitki Adları. Eurasscience Journal 3(2): 23-33.
  • Doğan B, Duran A, Martin E, Hakkı EE 2011. Karyotype Analyses of the Species of the Genus Jurinea Cass. (Compositae) in Turkey. African Journal of Biotechnology 10(5): 722-729.
  • Doğan B, Duran A, Hakkı EE 2007. Phylogenetic Analysis of Jurinea (Asteraceae) Species from Turkey Based on ISSR Amplification. Annales Botanici Fennici 44: 353-358.
  • Dwivedi SD, Wagay SA 2014. Antimicrobial Activity of Leaf Extracts of Jurinea dolomiaea Plant Against Clinical and Phytopathogenic Bacteria. Chemical and Process Engineering Research 24: 9-13.
  • Faydaoğlu E, Sürücüoğlu MS 2011. Geçmisten Günümüze Tıbbi ve Aromatik Bitkilerin Kullanılması ve Ekonomik Önemi. Kastamonu Üniversitesi Orman Fakültesi Dergisi 11(1): 52-67.
  • Gemici Y, Tam K, Yıldırım H, Gemici M 2008. Helichrysum yurterianum (Asteraceae, Inuleae), A New Species from NE Anatolia, Turkey. Annales Botanici Fennici, 45(3): 223-228.
  • Gupta RK, Patel AK, Shah N, Choudhary AK, Jha UK, Yadav UC, Gupta PK, Pakuwal U 2014. Oxidative Stress and Antioxidants in Disease and Cancer: A Review. Asian Pacific Journal of Cancer Prevention 15(11): 4405-4409.
  • Jiménez N, Carrillo-Hormazaa L, Pujol A, Álzate F, Osorioa E, Lara-Guzmana O 2015. Antioxidant Capacity and Phenolic Content of Commonly Used Anti-Inflammatory Medicinal Plants in Colombia. Industrial Crops and Products 70: 272-279.
  • Kiliç O, Bağcı E 2013. An Ethnobotanical Survey of Some Medicinal Plants in Keban (Elazığ-Turkey). Journal of Medicinal Plants Research 7(23): 1675-1684.
  • Korkmaz M, Kandemir A, Karacan S 2014. A Surway on Determining the Plant of Taxa Zetrin Spice Ussed in Kemaliye District (Erzincan, Turkey). Bothalia 44(3): 101-108.
  • Lau CBS, Ho CY, Kim CF, Leunge KN, Fung KP, Tse TF, Chow MSS 2004. Cytotoxic Activities of Coriolus versicolor (Yunzhi) Extract on Human Leukemia and Lymphoma Cells by Induction of Apoptosis. Life Science Journal 75(7): 797-808.
  • Maiti B, Nagori BP, Singh R, Kumar P 2011, Upadhyay N. Recent Trends in Herbal Drugs: A Review. The International Journal of Drug Research and Technology 1(1): 17-25.
  • Molyneux P 2004. The Use of the Stable Free Radical Diphenylpicrylhydrazyl (DPPH) for Estimating Antioxidant Activity. Songklanakarin Journal of Science and Technology 26(2): 211-219.
  • Zaporozhets OA, Krushynska OA, Lipkovska NA, Barvinchenko VN 2004. A New Test Method for the Evaluation of Total Antioxidant Activity of Herbal Products. Journal of Agricultural and Food Chemistry 52(1): 21-25.
  • Özgökçe F, Özçelik H 2004. Ethnobotanical Aspects of Some Taxa in East Anatolia (Turkey). Economic Botany 58(4): 697-704.
  • Öztürk H, Kolak U, Meric C 2011. Antioxidant, Anticholinesterase and Antibacterial Activities of Jurinea consanguinea DC. Records of Natural Products 5(1): 43-51.
  • Pan L, Chai H, Kinghom AD 2010. The Continuing Search for Antitumor Agents from Higher Plants. Phytochemistry Letters 3(1): 1-8.
  • Polat R, Çakılcıoğlu U, Satıl F 2013. Traditional Uses of Medicinal Plants in Solhan (Bingöl-Turkey). Journal of Ethnopharmacology 148(3): 951-963.
  • Shah NA, Khan MR, Naz K, Khan MA 2014. Antioxidant Potential, DNA Protection, and HPLC-DAD Analysis of Neglected Medicinal Jurinea dolomiaea Roots. BioMed Research International 1-10.
  • Singh P, Singh R, Sati N, Sati OP, Kumar N 2016. A Review of Genus: Jurinea. International Journal of Life-Sciences Scientific Research 2: 23-30.
  • Singh R 2015. Medicinal Plants: A Review, Journal of Plant Sciences 3(1-1): 50-55.
  • Taherkhani M 2015. Total Phenolic Content, Antioxidant Activity and In vitro Cytotoxicity of the Essential Oil of Jurinea leptoloba DC. Journal of Medicinal Plants and By-products 2: 171-178.
  • Taherkhani M, Rustaiyan A 2016. Investigation of In vitro Cytotoxic, Mutagenic and Anti-mutagenic Effects of Shirazolide Extracted from Jurinea leptoloba. Natural Product Research Formerly. Natural Product Letters 30(23): 2743-2746.
  • Turkish Plants Data Service (TÜBİVES), Jurinea brevicaulis. http://www.tubives.com/ 11.07.2020. Wenzel U, Kuntz S, Brendel M D, Daniel H 2000. Dietary Flavone is A Potent Apoptosis Inducer in Human Colon Carcinoma Cells. Cancer Research 60(14): 3823-3831.
  • Yalçın AS, Yılmaz AM, Altundağ EM, Koçtürk S 2017. Kurkumin, Kuersetin ve Çay Kateşinlerinin Anti-Kanser Etkileri. Marmara Pharmaceutical Journal 21: 19-29.
  • Yin F, Giuliano AE, Van Herle AJ 1999. Growth Inhibitory Effects of Flavonoids in Human Thyroid Cancer Cell Lines. Thyroid 9(4): 369-376.
  • Yokuş B, Çakır DU 2012. Kanser Biyokimyası. Dicle Üniversitesi Veteriner Fakültesi Dergisi 1(2): 7-18

Jurinea brevicaulis'in Biyolojik Aktivitesi; Sitotoksisite ve Antioksidan Aktivitesi

Year 2021, Volume: 24 Issue: 2, 278 - 284, 30.04.2021

Mahmoud Abudayyak , Şeyda Kanbolat Şeyma Batur Reyyan Ergene Rezzan Aliyazıcıoğlu

https://doi.org/10.18016/ksutarimdoga.vi.772989
Cited By: 2

Abstract

Jurinea brevicaulis is a perennial herbaceous plant belonging to the Asteraceae family. J. brevicaulis is an endemic genus and grows Erzincan and Gümüşhane provinces in Turkey. Jurinea species are known to have anticancer, antibacterial, antifungal and antioxidant effects. In this article, it is aimed to evaluate the antioxidant capacity and cytotoxic effects of J. brevicaulis. Results indicate that, TPC values were between 41.7 - 537.5 GAE µg g-1, FRAP values were between 109.52 - 1076.2 µM Trolox equivalent g-1, CUPRAC values were between 231.4 - 3083.3 µM Trolox equivalent g-1, IC50 values in DPPH determination were between 0.0102 - 3.4174 mg mL-1. The extracts caused cell death in a concentration-dependent manner in, IC50 values were calculated to be between 3.67-10.2 µg mL-1. In conclusion, the cytotoxic effects in cancerous cells and the high antioxidant capacity indicates that J. brevicaulis could be an important herb in developing new drugs.

Keywords

Jurinea brevicaulis Antioxidant Capacity Cytotoxicity

Supporting Institution

TÜBİTAK (2209A)

Project Number

1919B011800561

References

  • Abudayyak M, Özdemir Nath E, Özhan G 2015. Toxic Potentials of Ten Herbs Commonly Used Aphrodisiac Effect in Turkey. Turkish Journal of Medical Sciences 44(3): 496-506.
  • Acıbuca V, Bostan Budak D 2018. Dünya’da ve Türkiye’de Tıbbi ve Aromatik Bitkilerin Yeri ve Önemi. Çukurova Journal of Agricultural and Food Science 33(1): 37-44.
  • Alley MC, Scudiero DA, Monks A, Hursey ML, Czerwinski MJ, Fine DL, Abbott BJ, Mayo JG, Shoemaker RH, Boyd MR 1988. Feasibility of Drug Screening with Panels of Human Tumor Cell Lines Using a Microculture Tetrazolium Assay. Cancer Research 48: 589-601.
  • Apak R, Güçlü K, Özyürek M, Karademir SE, Erçağ E 2006. The Cupric Ion Reducing Antioxidant Capacity and Polyphenolic Content of Some Herbal Teas. International Journal Food Science Nutrition 57(5-6): 292-304.
  • Ayad R, Çakmak YS, Özüsağlam MA, Medjroubi K, Akkal S 2017. In vitro Antioxidant and Antimicrobial Activities of Aerial Parts of Algerian Jurinea humilis DC (Asteraceae). Tropical Journal of Pharmaceutical Research 16(12): 2903-2909.
  • Chahar MK, Sharma N, Dobhal MP, Joshi YC 2011. Flavonoids: A Versatile Source of Anticancer Drugs. Pharmacognosy Reviews 5(9): 1-12.
  • Chan K 2003. Some Aspects of Toxic Contaminants in Herbal Medicines. Chemosphere 52(9): 1361-1371.
  • Davis P 1975. Flora of Turkey and the East Aegean Islands, Volume 5 Edinburgh: Edinburgh University Press, 978-0-8522-42803. 890 pages.
  • Doğan A, Tuzlacı E 2015. Tunceli’nin Bazı Yöresel Bitki Adları. Eurasscience Journal 3(2): 23-33.
  • Doğan B, Duran A, Martin E, Hakkı EE 2011. Karyotype Analyses of the Species of the Genus Jurinea Cass. (Compositae) in Turkey. African Journal of Biotechnology 10(5): 722-729.
  • Doğan B, Duran A, Hakkı EE 2007. Phylogenetic Analysis of Jurinea (Asteraceae) Species from Turkey Based on ISSR Amplification. Annales Botanici Fennici 44: 353-358.
  • Dwivedi SD, Wagay SA 2014. Antimicrobial Activity of Leaf Extracts of Jurinea dolomiaea Plant Against Clinical and Phytopathogenic Bacteria. Chemical and Process Engineering Research 24: 9-13.
  • Faydaoğlu E, Sürücüoğlu MS 2011. Geçmisten Günümüze Tıbbi ve Aromatik Bitkilerin Kullanılması ve Ekonomik Önemi. Kastamonu Üniversitesi Orman Fakültesi Dergisi 11(1): 52-67.
  • Gemici Y, Tam K, Yıldırım H, Gemici M 2008. Helichrysum yurterianum (Asteraceae, Inuleae), A New Species from NE Anatolia, Turkey. Annales Botanici Fennici, 45(3): 223-228.
  • Gupta RK, Patel AK, Shah N, Choudhary AK, Jha UK, Yadav UC, Gupta PK, Pakuwal U 2014. Oxidative Stress and Antioxidants in Disease and Cancer: A Review. Asian Pacific Journal of Cancer Prevention 15(11): 4405-4409.
  • Jiménez N, Carrillo-Hormazaa L, Pujol A, Álzate F, Osorioa E, Lara-Guzmana O 2015. Antioxidant Capacity and Phenolic Content of Commonly Used Anti-Inflammatory Medicinal Plants in Colombia. Industrial Crops and Products 70: 272-279.
  • Kiliç O, Bağcı E 2013. An Ethnobotanical Survey of Some Medicinal Plants in Keban (Elazığ-Turkey). Journal of Medicinal Plants Research 7(23): 1675-1684.
  • Korkmaz M, Kandemir A, Karacan S 2014. A Surway on Determining the Plant of Taxa Zetrin Spice Ussed in Kemaliye District (Erzincan, Turkey). Bothalia 44(3): 101-108.
  • Lau CBS, Ho CY, Kim CF, Leunge KN, Fung KP, Tse TF, Chow MSS 2004. Cytotoxic Activities of Coriolus versicolor (Yunzhi) Extract on Human Leukemia and Lymphoma Cells by Induction of Apoptosis. Life Science Journal 75(7): 797-808.
  • Maiti B, Nagori BP, Singh R, Kumar P 2011, Upadhyay N. Recent Trends in Herbal Drugs: A Review. The International Journal of Drug Research and Technology 1(1): 17-25.
  • Molyneux P 2004. The Use of the Stable Free Radical Diphenylpicrylhydrazyl (DPPH) for Estimating Antioxidant Activity. Songklanakarin Journal of Science and Technology 26(2): 211-219.
  • Zaporozhets OA, Krushynska OA, Lipkovska NA, Barvinchenko VN 2004. A New Test Method for the Evaluation of Total Antioxidant Activity of Herbal Products. Journal of Agricultural and Food Chemistry 52(1): 21-25.
  • Özgökçe F, Özçelik H 2004. Ethnobotanical Aspects of Some Taxa in East Anatolia (Turkey). Economic Botany 58(4): 697-704.
  • Öztürk H, Kolak U, Meric C 2011. Antioxidant, Anticholinesterase and Antibacterial Activities of Jurinea consanguinea DC. Records of Natural Products 5(1): 43-51.
  • Pan L, Chai H, Kinghom AD 2010. The Continuing Search for Antitumor Agents from Higher Plants. Phytochemistry Letters 3(1): 1-8.
  • Polat R, Çakılcıoğlu U, Satıl F 2013. Traditional Uses of Medicinal Plants in Solhan (Bingöl-Turkey). Journal of Ethnopharmacology 148(3): 951-963.
  • Shah NA, Khan MR, Naz K, Khan MA 2014. Antioxidant Potential, DNA Protection, and HPLC-DAD Analysis of Neglected Medicinal Jurinea dolomiaea Roots. BioMed Research International 1-10.
  • Singh P, Singh R, Sati N, Sati OP, Kumar N 2016. A Review of Genus: Jurinea. International Journal of Life-Sciences Scientific Research 2: 23-30.
  • Singh R 2015. Medicinal Plants: A Review, Journal of Plant Sciences 3(1-1): 50-55.
  • Taherkhani M 2015. Total Phenolic Content, Antioxidant Activity and In vitro Cytotoxicity of the Essential Oil of Jurinea leptoloba DC. Journal of Medicinal Plants and By-products 2: 171-178.
  • Taherkhani M, Rustaiyan A 2016. Investigation of In vitro Cytotoxic, Mutagenic and Anti-mutagenic Effects of Shirazolide Extracted from Jurinea leptoloba. Natural Product Research Formerly. Natural Product Letters 30(23): 2743-2746.
  • Turkish Plants Data Service (TÜBİVES), Jurinea brevicaulis. http://www.tubives.com/ 11.07.2020. Wenzel U, Kuntz S, Brendel M D, Daniel H 2000. Dietary Flavone is A Potent Apoptosis Inducer in Human Colon Carcinoma Cells. Cancer Research 60(14): 3823-3831.
  • Yalçın AS, Yılmaz AM, Altundağ EM, Koçtürk S 2017. Kurkumin, Kuersetin ve Çay Kateşinlerinin Anti-Kanser Etkileri. Marmara Pharmaceutical Journal 21: 19-29.
  • Yin F, Giuliano AE, Van Herle AJ 1999. Growth Inhibitory Effects of Flavonoids in Human Thyroid Cancer Cell Lines. Thyroid 9(4): 369-376.
  • Yokuş B, Çakır DU 2012. Kanser Biyokimyası. Dicle Üniversitesi Veteriner Fakültesi Dergisi 1(2): 7-18
There are 35 citations in total.

Details

Primary Language English
Subjects Structural Biology
Journal Section RESEARCH ARTICLE
Authors

Mahmoud Abudayyak 0000-0003-2286-4777

Şeyda Kanbolat 0000-0001-7261-7067

Şeyma Batur 0000-0003-0934-0223

Reyyan Ergene 0000-0003-4985-9812

Rezzan Aliyazıcıoğlu 0000-0003-2913-2528

Project Number 1919B011800561
Publication Date April 30, 2021
Submission Date July 24, 2020
Acceptance Date September 7, 2020
Published in Issue Year 2021 Volume: 24 Issue: 2

Cite

APA Abudayyak, M., Kanbolat, Ş., Batur, Ş., … Ergene, R. (2021). Jurinea brevicaulis’in Biyolojik Aktivitesi; Sitotoksisite ve Antioksidan Aktivitesi. Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi, 24(2), 278-284. https://doi.org/10.18016/ksutarimdoga.vi.772989

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