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Ratlarda Toluenle İndüklenen Oksidatif Hasara Karşı p-Kumarik Asitin Antioksidan Etkisi

Year 2021, Volume: 24 Issue: 3, 473 - 478, 30.06.2021

Zeki Erol Selinay Başak Erdemli Köse , Simge Garlı Fatma Kocasarı

https://doi.org/10.18016/ksutarimdoga.vi.765193
Cited By: 5

Abstract

TBu araştırmada, fenolik asidin bir türevi olan p-CA'nın toluen kaynaklı oksidatif hasara karşı koruyucu etkisinin araştırılması amaçlanmıştır. Çalışmada, her grupta 8 olmak üzere toplam 32 Sprague-Dawley erkek sıçan kullanıldı. Kontrol, toluen, p-CA ve toluen+p-CA olarak toplam 4 grup oluşturuldu. Kontrol grubu, toluen grubu ve p-CA grubundaki hayvanlara 21 gün boyunca sırasıyla %0.9 NaCl, 0.9 mg kg-1 c.a toluen ve 100 mg kg-1 c.a p-CA verildi. Toluen+p-CA grubundaki hayvanlara 3 gün boyunca p-CA verildi ve 4. günden itibaren toluen ve p-CA 25 güne kadar günlük olarak birlikte uygulandı. 25. günde çalışma sonlandırıldı ve kan örnekleri alındı. Eritrositlerde katalaz (CAT) ve glutatyon peroksidaz (GSH-Px) aktiviteleri ile malondialdehit (MDA) ve glutatyon (GSH) seviyeleri; plazma örneklerinde süperoksit dismutaz (SOD) aktivitesi belirlendi. Bu çalışmada, toluen grubunun kan örneklerinde CAT ve SOD aktiviteleri ve MDA düzeyi anlamlı (p <0.05) olarak arttığı; GSH düzeyi ve GSH-Px aktivitesinin anlamlı (p <0.05) olarak azaldığı tespit edildi. Toluen+p-CA grubunda, toluen grubuna göre GSH düzeyi ve GSH-Px aktivitesinde anlamlı (p <0.05) artış; MDA düzeyi ile ve SOD ve CAT aktivitelerinde anlamlı (p <0.05) azalma saptandı. Toluenin kan dokusunda oksidatif strese ve lipit peroksidasyonuna neden olduğu ve bu oksidatif hasara karşı p-CA'nın koruyucu bir etkiye sahip olduğu belirlenmiştir.

Keywords

Toluen Oksidatif stres p-Kumarik asit Sıçan

Project Number

1919BO11501737

References

  • Abdel-Wahab MH, El-Mahdy MA, Abd-Ellah MF, Helal GK, Khalifa F, Hamada FMA 2003. Influence of p-coumaric acid on doxorubicin-induced oxidative stress in rat’s heart. Pharmacological Research, 48(5): 461-465.
  • Aebi H 1984. Catalase in vitro. Methods Enzymology, 105: 121-126.
  • Afravy M, Angali K, Khodadadi A, Ahmadizadeh M 2017. The protective effect of Buffalo’s milk against toluene induced-nephrotoxicity in rats. Journal of Nephropathology, 6(3): 174-179.
  • Agency of Toxic Substances and Disease Registry (ATSDR) Toxicological profile for Toluene (2000). Available from: URL: http://www.atsdr.cdc.gov/ toxprofiles/tp56.pdf. (Access Date: September 2016)
  • Balster RL, Cruz SL, Howard MO, Dell CA, Cottler LB 2009. Classification of abused inhalants. Addiction, 104(6): 878-882.
  • Benignus VA, Muller KE, Barton CN, Bittikofer JA 1981. Toluene levels in blood and brain of rats during and after respiratory exposure. Toxicology and Applied Pharmacology, 61(3):326-334.
  • Bento-Silva A, Koistinen VM, Mena P, Bronze MR, Hanhineva K, Sahlstrøm S, Aura A M 2020. Factors affecting intake, metabolism and health benefits of phenolic acids: do we understand individual variability? European Journal of Nutrition, 59(4): 1275-1293.
  • Boo YC 2019. p-Coumaric acid as an active ingredient in cosmetics: A review focusing on its antimelanogenic effects. Antioxidants, 8(8): 275. doi:10.3390/antiox8080275.
  • Božić TP, Stevanović J, Kovačević M, Jović S, Lukić S, Petakov M, Borozan S, Mijaćević Z, Kneževićh M, Bulajić S 2003. Toluene mediated oxidative stress and granulo-monocytopoiesis. Acta Veterinaria (Beograd), 53(4): 201-210.
  • Chen C 2016. Sinapic acid and its derivatives as medicine in oxidative stress-induced diseases and aging. Oxidative Medicine and Cellular Longevity, 2016:3571614. doi: 10.1155/2016/3571614.
  • Cruz SL, Rivera-Garcia MT, Woodward JJ 2014. Review of toluene actions: Clinical evidence, animal studies, and molecular targets. Journal of Drug and Alcohol Research, 3: 235840. doi:10.4303/jdar/ 235840.
  • Dundaroz MR, Turkbay T, Akay C, Sarici SU, Aydin A, Denli M, Gokcay E 2003. Antioxidant enzymes and lipid peroxidation in adolescents with inhalant abuse. Turkish Journal of Pediatrics, 45(1): 43-45.
  • Ekinci-Akdemir FN, Albayrak M, Çalik M, Bayir Y, Gülçin I 2017a. The protective effects of p-coumaric acid on acute liver and kidney damages induced by cisplatin. Biomedicines, 5 (2): 18. doi:10.3390/bio medicines5020018.
  • Ekinci-Akdemir FN, Gülçin I, Gürsul C, Alwasel SH, Bayir Y 2017b. Effect of p-coumaric acid against oxidative stress induced by cisplatin in brain tissue of rats. The Journal of Animal & Plant Sciences, 27(5): 1560-1564.
  • Godarzia SM, Gorji AV, Gholizadehc B, Mardd SA, Mansouri E 2020. Antioxidant effect of p-coumaric acid on interleukin 1-β and tumor necrosis factor-α in rats with renal ischemic reperfusion. Nefrologia, 40(3): 311-319.
  • Halifeoglu I, Canatan H, Ustundag B, Ilhan N, Inanc F 2000. Effect of thinner inhalation on lipid peroxidation and some antioxidant enzymes of people working with paint thinner. Cell Biochemistry and Function, 18: 263-267.
  • Huang X, You Y, Yang Xi, Ni B, Chu X, Zhang R, You H 2020. p-Coumaric acid attenuates IL-1β-induced inflammatory responses and cellular senescence in rat chondrocytes. Inflammation, 43(2): 619-628.
  • Karabulut I, Dicle Balkanci Z, Pehlivanoglu B, Erdem A, Fadillioglu E 2009. Effect of toluene on erythrocyte membrane stability under in vivo and in vitro conditions with assessment of oxidant/antioxidant status. Toxicology and Industrial Health, 25(8): 545-550.
  • Kheiry M, Dianat M, Badavi M, Mard SA, Bayati V 2019. p-Coumaric acid attenuates lipopolysaccharide-induced lung ınflammation in rats by scavenging ROS production: an in vivo and in vitro study. Inflammation, 42: 1939-1950.
  • Mates JM, Segura JA, Alonso FJ, Marquez J 2008. Intracellular redox status and oxidative stress: implications for cell proliferation, apoptosis, and carcinogenesis. Archives of Toxicology, 82(5): 273-299.
  • Meydan S, Nacar A, Ozturk HO, Tas U, Kose E, Zararsiz I, Yilmaz N, Kus I 2016. The protective effects of caffeic acid phenethyl ester against toluene-induced nephrotoxicity in rats. Toxicology and Industrial Health, 32(1): 15-21.
  • Moro AM, Brucker N, Charão M, Bulcão R, Freitas F, Baierle M, Nascimento S, Valentini J, Cassini C, Salvador M, Linden R, Thiesen F, Buffon A, Moresco R, Garcia SC 2012. Evaluation of genotoxicity and oxidative damage in painters exposed to low levels of toluene. Mutation Research, 746(1): 42-48.
  • Muti AD, Pârvu AE, Muti LA, Moldovan R, Muresan A 2016. Vitamin E effect in a rat model of toluene diisocyanate-induced asthma. Clujul Medical, 89(4): 499-505.
  • OSHA, US 2013. Globally harmonized system of classification and labelling of chemicals (GHS). United Nations Economic Commission for Europe (UNECE) 224, 2013. https://www.osha.gov/dsg/ hazcom/ghsguideoct05.pdf Access Date: 15.06.2020.
  • Paglia DE, Valentine WN 1967. Studies on the quantitative and qualitative characterisation of erythrocyte glutathione peroxidase. Journal of Laboratory and Clinical Medicine 70: 158-169.
  • Patocková J, Marhol P, Tůmová E, Krsiak M, Rokyta R, Stípek S, Crkovská J, Anděl M 2003. Oxidative stress in the brain tissue of laboratory mice with acute post insulin hypoglycemia. Physiological Research, 52(1): 131-135.
  • Rafiee Z, Moaiedi MZ, Gorji AV, Mansouri E 2020. p-Coumaric acid mitigates doxorubicin-induced nephrotoxicity through suppression of oxidative stress, inflammation and apoptosis. Archives of Medical Research, 51(1): 32-40.
  • Roy AJ, Prince PSM 2013. Preventive effects of p-coumaric acid on lysosomal dysfunction and myocardial infarct size inexperimentally induced myocardial infarction. European Journal of Pharmacology, 699(1-3): 33-39.
  • Sabitha R, Nishi K, Gunasekaran VP, Annamalai G, Agilan B, Ganeshan M 2019. p-Coumaric acid ameliorates ethanol-induced kidney injury by inhibiting inflammatory cytokine production and NF-κB signaling in rats. Asian Pacific Journal of Tropical Biomedicine, 9(5): 188-195.
  • Sedlak J, Lindsay RH 1968. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman’s reagent. Analytical Biochemistry 25: 192-205.
  • Shen Y, Song X, Li L, Sun J, Jaiswal Y, Huang J, Liu C, Yang W, Williams L, Zhang H, Guan Y 2019. Protective effects of p-coumaric acid against oxidant and hyperlipidemia-an in vitro and in vivo evaluation. Biomedicine & Pharmacotherapy, 111: 579-587.
  • Stajković SS, Borozan SZ, Gađanski-Omerović G 2009. The effect of toluene on oxidative processes in rat blood. Journal of the Serbian Chemical Society, 74(1): 15-25.
  • Tamie N, Rui-Sheng W 1994. Induction of cytochrome P450 by toluene. The International Journal of Biochemistry, 26(12): 1333-1340.
  • Tas U, Ogeturk M, Meydan S, Kus I, Kuloglu T, Ilhan N, Kose E, Sarsilmaz M 2011. Hepatotoxic activity of toluene inhalation and protective role of melatonin. Toxicology and Industrial Health, 27(5): 465-473.
  • Urfalioglu A, Yazar FM, Bilal B, Tolun FI, Oksuz H, Boran OF, Oksuz G 2017. The effect of p-coumaric acid and ellagic acid on the liver and lungs in a rat model of sepsis. Asian Biomedicine, 11(3): 217-225.
  • Valko M, Leibfritz D, Moncol J, Cronin M, Mazur M, Telser J 2007. Free radicals and antioxidants in normal physiological functions and human disease. The International Journal of Biochemistry and Cell Biology, 39: 44-84.
  • Yoshioka T, Kawada K, Shimada T, Mori M 1979. Lipid peroxidation in maternal and cord blood and protective mechanism against activated oxygen toxicity in the blood. American Journal of Obstetrics & Gynecology 135: 372-376.

The Antioxidant Effect of p-Coumaric Acid Against Toluene-Induced Oxidative Stress in Rats

Year 2021, Volume: 24 Issue: 3, 473 - 478, 30.06.2021

Zeki Erol Selinay Başak Erdemli Köse , Simge Garlı Fatma Kocasarı

https://doi.org/10.18016/ksutarimdoga.vi.765193
Cited By: 5

Abstract

This research aimed to investigate the protective effect of p-CA, a derivative of phenolic acid, against toluene-induced oxidative damage. A total of 32 Sprague-Dawley male rats, 8 in each group, were used. A total of 4 groups were formed as control, toluene, p-CA and toluene+p-CA. Animals in the control group, toluene group and p-CA group were given 0.9 % NaCl, 0.9 mg kg-1 b.w toluene and 100 mg kg-1 b.w p-CA orally for 21 days, respectively. The animals in toluene+p-CA group were received p-CA for 3 days and from day 4, toluene and p-CA were applied together daily until day 25. On the 25th day, the study was terminated, and blood samples were collected. Catalase (CAT) and glutathione peroxidase (GSH-Px) activities and malondialdehyde (MDA) and glutathione (GSH) levels in the erythrocytes and superoxide dismutase (SOD) activity in plasma samples were determined. In this study, CAT and SOD activities and MDA level significantly (p <0.05) increased, GSH level and GSH-Px activity significantly (p <0.05) decreased in the blood samples of toluene group compared to the control group. In toluene+p-CA group, significant (p <0.05) increases in GSH level and GSH-Px activity and significant (p <0.05) decreases in MDA level and SOD and CAT activities were detected compared to the toluene group. It has been determined that toluene caused oxidative stress and lipid peroxidation in blood tissue and against this oxidative damage, p-CA had a protective effect.

Keywords

Toluene Oxidative stress p-Coumaric acid Rat

Supporting Institution

TUBİTAK

Project Number

1919BO11501737

Thanks

Authors thank TUBITAK for supporting this project.

References

  • Abdel-Wahab MH, El-Mahdy MA, Abd-Ellah MF, Helal GK, Khalifa F, Hamada FMA 2003. Influence of p-coumaric acid on doxorubicin-induced oxidative stress in rat’s heart. Pharmacological Research, 48(5): 461-465.
  • Aebi H 1984. Catalase in vitro. Methods Enzymology, 105: 121-126.
  • Afravy M, Angali K, Khodadadi A, Ahmadizadeh M 2017. The protective effect of Buffalo’s milk against toluene induced-nephrotoxicity in rats. Journal of Nephropathology, 6(3): 174-179.
  • Agency of Toxic Substances and Disease Registry (ATSDR) Toxicological profile for Toluene (2000). Available from: URL: http://www.atsdr.cdc.gov/ toxprofiles/tp56.pdf. (Access Date: September 2016)
  • Balster RL, Cruz SL, Howard MO, Dell CA, Cottler LB 2009. Classification of abused inhalants. Addiction, 104(6): 878-882.
  • Benignus VA, Muller KE, Barton CN, Bittikofer JA 1981. Toluene levels in blood and brain of rats during and after respiratory exposure. Toxicology and Applied Pharmacology, 61(3):326-334.
  • Bento-Silva A, Koistinen VM, Mena P, Bronze MR, Hanhineva K, Sahlstrøm S, Aura A M 2020. Factors affecting intake, metabolism and health benefits of phenolic acids: do we understand individual variability? European Journal of Nutrition, 59(4): 1275-1293.
  • Boo YC 2019. p-Coumaric acid as an active ingredient in cosmetics: A review focusing on its antimelanogenic effects. Antioxidants, 8(8): 275. doi:10.3390/antiox8080275.
  • Božić TP, Stevanović J, Kovačević M, Jović S, Lukić S, Petakov M, Borozan S, Mijaćević Z, Kneževićh M, Bulajić S 2003. Toluene mediated oxidative stress and granulo-monocytopoiesis. Acta Veterinaria (Beograd), 53(4): 201-210.
  • Chen C 2016. Sinapic acid and its derivatives as medicine in oxidative stress-induced diseases and aging. Oxidative Medicine and Cellular Longevity, 2016:3571614. doi: 10.1155/2016/3571614.
  • Cruz SL, Rivera-Garcia MT, Woodward JJ 2014. Review of toluene actions: Clinical evidence, animal studies, and molecular targets. Journal of Drug and Alcohol Research, 3: 235840. doi:10.4303/jdar/ 235840.
  • Dundaroz MR, Turkbay T, Akay C, Sarici SU, Aydin A, Denli M, Gokcay E 2003. Antioxidant enzymes and lipid peroxidation in adolescents with inhalant abuse. Turkish Journal of Pediatrics, 45(1): 43-45.
  • Ekinci-Akdemir FN, Albayrak M, Çalik M, Bayir Y, Gülçin I 2017a. The protective effects of p-coumaric acid on acute liver and kidney damages induced by cisplatin. Biomedicines, 5 (2): 18. doi:10.3390/bio medicines5020018.
  • Ekinci-Akdemir FN, Gülçin I, Gürsul C, Alwasel SH, Bayir Y 2017b. Effect of p-coumaric acid against oxidative stress induced by cisplatin in brain tissue of rats. The Journal of Animal & Plant Sciences, 27(5): 1560-1564.
  • Godarzia SM, Gorji AV, Gholizadehc B, Mardd SA, Mansouri E 2020. Antioxidant effect of p-coumaric acid on interleukin 1-β and tumor necrosis factor-α in rats with renal ischemic reperfusion. Nefrologia, 40(3): 311-319.
  • Halifeoglu I, Canatan H, Ustundag B, Ilhan N, Inanc F 2000. Effect of thinner inhalation on lipid peroxidation and some antioxidant enzymes of people working with paint thinner. Cell Biochemistry and Function, 18: 263-267.
  • Huang X, You Y, Yang Xi, Ni B, Chu X, Zhang R, You H 2020. p-Coumaric acid attenuates IL-1β-induced inflammatory responses and cellular senescence in rat chondrocytes. Inflammation, 43(2): 619-628.
  • Karabulut I, Dicle Balkanci Z, Pehlivanoglu B, Erdem A, Fadillioglu E 2009. Effect of toluene on erythrocyte membrane stability under in vivo and in vitro conditions with assessment of oxidant/antioxidant status. Toxicology and Industrial Health, 25(8): 545-550.
  • Kheiry M, Dianat M, Badavi M, Mard SA, Bayati V 2019. p-Coumaric acid attenuates lipopolysaccharide-induced lung ınflammation in rats by scavenging ROS production: an in vivo and in vitro study. Inflammation, 42: 1939-1950.
  • Mates JM, Segura JA, Alonso FJ, Marquez J 2008. Intracellular redox status and oxidative stress: implications for cell proliferation, apoptosis, and carcinogenesis. Archives of Toxicology, 82(5): 273-299.
  • Meydan S, Nacar A, Ozturk HO, Tas U, Kose E, Zararsiz I, Yilmaz N, Kus I 2016. The protective effects of caffeic acid phenethyl ester against toluene-induced nephrotoxicity in rats. Toxicology and Industrial Health, 32(1): 15-21.
  • Moro AM, Brucker N, Charão M, Bulcão R, Freitas F, Baierle M, Nascimento S, Valentini J, Cassini C, Salvador M, Linden R, Thiesen F, Buffon A, Moresco R, Garcia SC 2012. Evaluation of genotoxicity and oxidative damage in painters exposed to low levels of toluene. Mutation Research, 746(1): 42-48.
  • Muti AD, Pârvu AE, Muti LA, Moldovan R, Muresan A 2016. Vitamin E effect in a rat model of toluene diisocyanate-induced asthma. Clujul Medical, 89(4): 499-505.
  • OSHA, US 2013. Globally harmonized system of classification and labelling of chemicals (GHS). United Nations Economic Commission for Europe (UNECE) 224, 2013. https://www.osha.gov/dsg/ hazcom/ghsguideoct05.pdf Access Date: 15.06.2020.
  • Paglia DE, Valentine WN 1967. Studies on the quantitative and qualitative characterisation of erythrocyte glutathione peroxidase. Journal of Laboratory and Clinical Medicine 70: 158-169.
  • Patocková J, Marhol P, Tůmová E, Krsiak M, Rokyta R, Stípek S, Crkovská J, Anděl M 2003. Oxidative stress in the brain tissue of laboratory mice with acute post insulin hypoglycemia. Physiological Research, 52(1): 131-135.
  • Rafiee Z, Moaiedi MZ, Gorji AV, Mansouri E 2020. p-Coumaric acid mitigates doxorubicin-induced nephrotoxicity through suppression of oxidative stress, inflammation and apoptosis. Archives of Medical Research, 51(1): 32-40.
  • Roy AJ, Prince PSM 2013. Preventive effects of p-coumaric acid on lysosomal dysfunction and myocardial infarct size inexperimentally induced myocardial infarction. European Journal of Pharmacology, 699(1-3): 33-39.
  • Sabitha R, Nishi K, Gunasekaran VP, Annamalai G, Agilan B, Ganeshan M 2019. p-Coumaric acid ameliorates ethanol-induced kidney injury by inhibiting inflammatory cytokine production and NF-κB signaling in rats. Asian Pacific Journal of Tropical Biomedicine, 9(5): 188-195.
  • Sedlak J, Lindsay RH 1968. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman’s reagent. Analytical Biochemistry 25: 192-205.
  • Shen Y, Song X, Li L, Sun J, Jaiswal Y, Huang J, Liu C, Yang W, Williams L, Zhang H, Guan Y 2019. Protective effects of p-coumaric acid against oxidant and hyperlipidemia-an in vitro and in vivo evaluation. Biomedicine & Pharmacotherapy, 111: 579-587.
  • Stajković SS, Borozan SZ, Gađanski-Omerović G 2009. The effect of toluene on oxidative processes in rat blood. Journal of the Serbian Chemical Society, 74(1): 15-25.
  • Tamie N, Rui-Sheng W 1994. Induction of cytochrome P450 by toluene. The International Journal of Biochemistry, 26(12): 1333-1340.
  • Tas U, Ogeturk M, Meydan S, Kus I, Kuloglu T, Ilhan N, Kose E, Sarsilmaz M 2011. Hepatotoxic activity of toluene inhalation and protective role of melatonin. Toxicology and Industrial Health, 27(5): 465-473.
  • Urfalioglu A, Yazar FM, Bilal B, Tolun FI, Oksuz H, Boran OF, Oksuz G 2017. The effect of p-coumaric acid and ellagic acid on the liver and lungs in a rat model of sepsis. Asian Biomedicine, 11(3): 217-225.
  • Valko M, Leibfritz D, Moncol J, Cronin M, Mazur M, Telser J 2007. Free radicals and antioxidants in normal physiological functions and human disease. The International Journal of Biochemistry and Cell Biology, 39: 44-84.
  • Yoshioka T, Kawada K, Shimada T, Mori M 1979. Lipid peroxidation in maternal and cord blood and protective mechanism against activated oxygen toxicity in the blood. American Journal of Obstetrics & Gynecology 135: 372-376.
There are 37 citations in total.

Details

Primary Language English
Subjects Structural Biology
Journal Section RESEARCH ARTICLE
Authors

Zeki Erol 0000-0002-1563-0043

Selinay Başak Erdemli Köse 0000-0001-8986-585X

Simge Garlı 0000-0002-9818-5212

Fatma Kocasarı 0000-0002-6123-4762

Project Number 1919BO11501737
Publication Date June 30, 2021
Submission Date July 6, 2020
Acceptance Date September 16, 2020
Published in Issue Year 2021 Volume: 24 Issue: 3

Cite

APA Erol, Z., Erdemli Köse, S. B., Garlı, S., Kocasarı, F. (2021). The Antioxidant Effect of p-Coumaric Acid Against Toluene-Induced Oxidative Stress in Rats. Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi, 24(3), 473-478. https://doi.org/10.18016/ksutarimdoga.vi.765193

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