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Nicotiana rustica L’nin Bazı Önemli Metabolik Enzimleri Üzerindeki İnhibisyon Etkisi, LC-MS / MS Analizi, Antioksidan Özellikleri

Year 2021, Volume: 24 Issue: 5, 930 - 938, 31.10.2021

Adem Necip , Mesut Işık , Abdussamat Güzel , Kasım Takım , Feyza Kaygısız

https://doi.org/10.18016/ksutarimdoga.vi.856514
Cited By: 9

Abstract

Nitrik oksit, hidrokarbonlar, aldehidler, fenollar, kinon ve semikinon radikalleri gibi pek çok kimyasal maddeyi bünyesinde barındıran ve doğrudan ya da dolaylı olarak oksijen kaynaklı serbest radikal oluşumuna yol açan tütün keşfedilmesinden günümüze kadar geçen zaman içinde yaygın olarak kullanılmaktadır. Bu yüzden dolayı Nicotiana rustica L.’nin fenolik içeriğinin, antioksidan/oksidan özelliklerinin bilinmesi ve önemli metabolik enzim olan Paraoksonaz (PON 1) ve Asetilkolinesteraz (AChE) üzerine etki çalışmaları önem arzetmektedir. Çalışmada Nicotiana rustica L.’nin su ve methanol ektresinin, PON 1 ve AChE enzim aktivitesi üzerine etkisine bakılmış. Nicotiana rustica Linn‘in su ektresi ceviz ile karıştırılmış maraş otu, (MPWW) ve methanol ektresi meşe ile karıştırılmış maraş otu (MPNR), ceviz ile karıştırılmış maraş otu (MPWW) ve bakır kazanlarında nemlendirilmiş maraş otu (MPCC) AChE üzerine inhibisyon etkisi (IC50 değerleri 0.104-0.203 mg ml -1 aralığında) gösterirken su ektresi MPCC ve methanol ektresi MPNR, MPWW ve MPCC ise PON 1 üzerine inhibisyon etkisi göstermiştir (IC50 değerleri 0.013-0. 25 mg ml -1 ). En yüksek radikal giderme aktivitesini MPNR su ektresi % 26 oranında DPPH radikal giderme aktivitesi gösterirken, MPCC su ektresi % 13 oranında ABTS radikal giderme aktivitesi göstermiştir.

Keywords

Maraş Otu Fenolik Antioksidan Enzim inhibisyon Paraoksonaz

Project Number

1906

References

  • Al-Lahham S, Sbieh R, Jaradat N, Almasri M, Mosa A, Hamayel A, Hammad F. 2020. Antioxidant, antimicrobial and cytotoxic properties of four different extracts derived from the roots of Nicotiana tabacum L. European Journal of Integrative Medicine, 33: 101039.
  • Apak R, Güçlü K, Özyürek M, Karademir, SE. 2004. Novel Total Antioxidant Capacity İndex for Dietary Polyphenols and Vitamins C and E, Using Their Cupric İon Reducing Capability in The Presence of Neocuproine: CUPRAC Method. Journal of Agricultural and Food Chemistry, 52 (26): 7970–7981.
  • Aral M, Ekerbicer HC, Celik M, Ciragil P, Gul M 2006. Comparison Of Effects of Smoking and Smokeless Tobacco “Maras Powder” Use on Humoral İmmune System Parameters. Mediators Inflamm 3: 85019.
  • Atlan N, Sepici Dinçel A, Koca C. 2006. Diabetes Mellitus ve Oksidatif Stres. Türk Biyokimya Dergisi 31: 51-6.
  • Aviram M, Rosenblat M. 2004. Paraoxonases 1, 2, And 3, Oxidative Stress, and Macrophage Foam Cell Formation During Atherosclerosis Development. Free Radic Biol Med 37:1304–16.
  • Benowitz NL. 1988. Nicotine and Smokeless Tobacco. CA Cancer J Clin 38:244-7.
  • Blois, M. S. 1958. Antioxidant Determinations by The Use of A Stable Free Radical. Nature 181: 1199–1200.
  • Çalıkoğlu M, Ünlü A, Bilgin R. 2002. Stabil Astımlı Hastalarda Lipid Peroksidasyonu ve Antioksidan Enzim Aktiviteleri. Solunum 4: 458-62.
  • Chang LW. Yen WJ, Huang SC, Duh PD 2002. Antioxidant Activity of Sesame Coat. Food Chemistry 78(3): 347–354.
  • Chen C, Loo G 1995. Cigarette Smoke Extract İnhibits Oxidative Modification of Low Density Lipoprotein. Atherosclerosis 112: 177–185.
  • Church DF, Pryor WA. 1985. Free-Radical Chemistry of Cigarette Smoke and Its Toxicological İmplications. Environ Health Perspect 64:111-26.
  • Davis DL, Neilson MT 1999. Tobacco: Production, Chemistry and Technology. Blackwell Science Ltd, Oxford, 467 S.
  • Davis PH. 1982. Flora of Turkey. Edinburgh University Press, Edinburgh, 572 S.
  • Demir Y, Işık M, Gülçin İ, Beydemir Ş. 2017. Phenolic Compounds Inhibit the Aldose Reductase Enzyme from The Sheep Kidney. Journal of Biochemical and Molecular Toxicology, 31(9): E21936.
  • Diplock AT. 1997. Will The ‘Good Fairies’ Please Prove To Us That Vitamin E Lessens Human Degenerative Disease? Free Radical Research, 27(5): 511–532.
  • Duh PD, Tu YY, Yen GC. 1999. Antioxidant Activity of Water Extract of Harng Jyur (Chrysanthemum Morifolium Ramat). LWT-Food Science And Technology, 32(5): 269–277.
  • Ellman GL, Courtney KD, Andres V, Featherstone RM. 1961. A New and Rapid Colorimetric Determination of Acetylcholinesterase Activity. Biochem Pharmacol 7: 88-95.
  • Elmastaş M, Gülçin I, Beydemir Ş, Küfrevioǧlu ÖI, Aboul-Enein HY. 2006. A Study on The in Vitro Antioxidant Activity of Juniper (Juniperus Communis L.) Fruit Extracts. Analytical Letters, 39: 47–65.
  • Erenmemişoğlu A, Tekol Y, Kartal M, Kurucu S. 1991. The Use of A Smokeless Tobacco in Our Country “Maraşotu” Second International Symposium of Pharmaceutical Sciences. Ankara-Turkey, June, 11- 14.
  • Erenmemisoğlu E. 1999. Turkish Smokeless Tobacco “Maraş Powder”. Preventive Medicine, 28:616-617.
  • Fan P, Hay AE, Marston A, Hostettmann K. 2008. Acetylcholinesterase-inhibitory activity of linarin from Buddleja davidii, structure-activity relationships of related flavonoids, and chemical investigation of Buddleja nitida. Pharmaceutical biology, 46(9): 596-601.
  • Feng Y, Yang S, Du X, Zhang X, Sun X, Zha M, et al. 2009. Ellagic Acid Promotes Aβ42 Fibrillization and Inhibits Aβ42-Induced Neurotoxicity, Biochem Biophys Res Commun, 390:1250-1254.
  • Gülçin I. 2012. Antioxidant Activity of Food Constituents: An Overview. Archives of Toxicology, 86(3): 345–391.
  • Gulcin I, Buyukokuroglu ME, Oktay M, Kufrevioglu O I. 2002. On The İn Vitro Antioxidative Properties of Melatonin. Journal of Pineal Research, 33(3): 167–171.
  • Mouhamed DH, Ezzaher A, Araoud M, Neffati F, Douki W, Najjar MF. 2010. Paraoxonase 1 (PON1) Activity and Lipid Parameters in Tunisian Smokers. Ann Biol Clin (Paris) 68:143–7.
  • Han Y, Dorajoo R, Ke T, Ayala B, Chang X, Khor CC, ... Heng CK. 2015. Interaction Effects Between Paraoxonase 1 Variants and Cigarette Smoking on Risk of Coronary Heart Disease İn A Singaporean Chinese Population. Atherosclerosis. 240(1):40–45.
  • Huen K, Richter R, Furlong C, Eskenazi B, Holland N. 2009. Validation Of PON1 Enzyme Activity Assays for Longitudinal Studies. Clin Chim Acta 402:67–74.
  • Isik B, Ceylan A, Isik R. 2007. Oxidative Stress in Smokers And Nonsmokers. Inhal Toxicol 9:767–769.
  • Işık M. 2020. Salvia officinalis L. Etanol Ekstraktının Antikolinerjik ve Antioksidan Aktivitesi ve LC-MS/MS Analizi. International Journal of Life Sciences and Biotechnology, 3(1): 51-61.
  • Işık M. 2019. The Binding Mechanisms and Inhibitory Effect of Intravenous Anesthetics on Ache In Vitro And In Vivo: Kinetic Analysis and Molecular Docking. Neurochemical Research, 44(9): 2147-2155.
  • Işık M, Beydemir Ş, Demir Y, Durgun M, Türkeş C, Nasır, A., ... Akkuş M. 2019. Benzenesulfonamide Derivatives Containing Imine and Amine Groups: Inhibition on Human Paraoxonase and Molecular Docking Studies. International Journal of Biological Macromolecules.
  • Işık M, Beydemir Ş, Yılmaz A, Naldan ME, Aslan H. E, Gülçin İ. 2017. Oxidative Stress and Mrna Expression of Acetylcholinesterase in The Leukocytes of Ischemic Patients. Biomedicine & Pharmacotherapy, 87: 561-567.
  • Işık M, Demir Y, Kırıcı M, Demir R, Şimşek F, Beydemir Ş. 2015. Changes in The Antioxidant System in Adult Epilepsy Patients Receiving Anti-Epileptic Drugs. Archives of Physiology and Biochemistry, 121(3): 97-102.
  • Jha AB, Panchal SS, Shah A. 2018. Ellagic Acid: Insights into Its Neuroprotective And Cognitive Enhancement Effects In Sporadic Alzheimer's Disease. Pharmacology Biochemistry and Behavior, 175: 33-46.
  • Kakinuma Y, Furihata M, Akiyama T, Arikawa M, Handa T, Katare RG, Sato T. 2010. Donepezil, An Acetylcholinesterase Inhibitor Against Alzheimer's Dementia, Promotes Angiogenesis in An Ischemic Hindlimb Model. Journal of Molecular and Cellular Cardiology, 48(4): 680-693.
  • Kamisaki Y, Wada K, Nakamoto K, Kishimoto Y, Ashida K, Itoh T 1997. Inhibition By Cigarette Smoke of Lipid Peroxidation İnduced Neurotransmitter Release. Life Sci 60: 229–233.
  • Kurtul N, Cil MY, Pacaci SD. 2005. Serum Total Sialic Acid Levels in Smokers And Users of Smokeless Tobacco in Form of Oral Powder (Maraş Powder). J Biomed Sci 12:559–63.
  • Kurtul N, Çil MY, Paçacı SF. 2005. Serum Total Sialic Acid Levels in Smokers And Users of Smokeless Tobacco in Form of Oral Powder (Maras Powder). J Biomed Sci, 12:559-63.
  • Kurtul N, Gökpınar E. 2012. Salivary Lipid Peroxidation and Total Sialic Acid Levels in Smokers and Smokeless Tobacco Users As Mara¸S Powder. Mediat Inflamm 2012:619293.
  • Kurtul N, Söylemez S, Çelik M. 2014. Plasma Paraoxonase and Arylesterase Activities in Smokers and Smokeless Tobacco Users As Maraş Powder. Inhalation Toxicology, 26(4): 235-239.
  • Lapenna D, Degioia S, Mezzetti A, Ciofani G, Consoli A, Marzio L, Cuccurullo F 1995. Cigarette Smoke, Ferritin, And Lipid Peroxidation. Am J Respir Crit Care Med 151: 431–435.
  • Mackness MI, Abbott C, Arrol S, Durrington PN. 1993. The Role of High-Density Lipoprotein and Lipid-Soluble Antioxidant Vitamins in Inhibiting Low-Density Lipoprotein Oxidation. Biochem J 294: 829–34.
  • Mackness MI, Mackness B, Durrington PN. 2002. Paraoxonase and Coronary Heart Disease. Atheroscler Suppl 3:49–55.
  • Meir, S, Kanner J, Akiri B, Philosoph-Hadas S. 1995. Determination and Involvement of Aqueous Reducing Compounds in Oxidative Defense Systems of Various Senescing Leaves. Journal of Agricultural and Food Chemistry, 43(7): 1813–1819.
  • Nair J, Pakhale SS, Bhide SV. 1989. Carcinogenic Tobacco Specific Nitrosamines in Indian Tobacco Products. Food Chem Toxicol 27:751–3.
  • Neagu E, Paun G, Albu C, Radu GL. 2015. Assessment of Acetylcholinesterase and Tyrosinase Inhibitory and Antioxidant Activity of Alchemilla Vulgaris and Filipendula Ulmaria Extracts. Journal of The Taiwan Institute of Chemical Engineers, 52: 1-6.
  • Necip A, Işık M. 2019. Bioactivities of Hypericum Perforatum L and Equisetum Arvense L Fractions Obtained With Different Solvents. Int J Life Sci Biotech, 2: 221-30.
  • Nilsson R. 1998. A Qualitative and Quantitative Risk Assessment of Snuff Dipping. Reg Toxicol Pharmacol 28:1–16.
  • Oyaizu, M. 1986. Studies on Products of Browning Reaction. Antioxidative Activities of Products Of Browning Reaction Prepared From Glucosamine. The Japanese Journal of Nutrition and Dietetics, 44(6): 307–315.
  • Ozkul Y, Donmez H, Erenmemisoglu A, Demirtas H, Imamoglu N. 1997. Induction of Micronuclei By Smokeless Tobacco on Buccal Mucosa Cells of Habitual Users. Mutagenesis, 12: 285-7.
  • Perry G, Raina AK, Nunomura A, Wataya T, Sayre L M, Smith MA. 2000. How İmportant İs Oxidative Damage? Lessons From Alzheimer’s Disease. Free Radical Biology & Medicine, 28(5): 831–834.
  • Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C. 1999. Antioxidant Activity Applying an İmproved ABTS Radical Cation Decolorization Assay. Free Radical Biology And Medicine, 26(9): 1231–1237.
  • Senti M, Tomas M, Anglada R, et al. 2003. Interrelationship of Smoking, Paraoxonase Activity, and Leisure Time Physical Activity: A Population Based Study. Eur J Intern Med 14:178–84.
  • Seyoum A, Asres K, El-Fiky FK. 2006. Structure–Radical Scavenging Activity Relationships of Flavonoids. Phytochemistry, 67(18): 2058–2070.
  • Soare JR, Dinis TCP, Cunha AP, Almeida L. 1997. Antioxidant Activities of Some Extracts of Thymus Zygis. Free Radical Research, 26(5): 469–478.
  • Türkeş C, Söyüt H, Beydemir Ş. 2014. Effect of Calcium Channel Blockers on Paraoxonase-1 (PON1) Activity and Oxidative Stress. Pharmacological Reports, 66(1): 74-80.
  • Weitberg AB, Corvese D. 1999. The Effect of Epigallocatechin Galleate and Sarcophytol A on DNA Strand Breakage İnduced By Tobaccospecific Nitrosamines and Stimulated Human Phagocytes. JECCR 18:433–7.
  • Wolf G. 2005. The Discovery of The Antioxidant Function of Vitamin E: The Contribution of Henry A. Mattill. The Journal of Nutrition, 135(3): 363–366.

LC-MS/MS Analysis, Antioxidant Properties and Inhibition Effect on Some Important Metabolic Enzymes of Nicotiana rustica L

Year 2021, Volume: 24 Issue: 5, 930 - 938, 31.10.2021

Adem Necip , Mesut Işık , Abdussamat Güzel , Kasım Takım , Feyza Kaygısız

https://doi.org/10.18016/ksutarimdoga.vi.856514
Cited By: 9

Abstract

Being widely used since its discovery, tobacco contains many chemical substances including nitric oxide, hydrocarbons, aldehydes, phenols, quinone and semiquinone radicals, and causes the formation of oxygen-induced free radicals directly or indirectly. Therefore, it is important to know the oxidant/antioxidant properties, phenolic content of Nicotiana rustica Linn., and the effect studies on Paraoxonase (PON 1) and Acetylcholinesterase (AChE) which are important metabolic enzymes. In the study, the effect of extracts (water and methanol) of Nicotiana rustica Linn on PON 1 and AChE enzyme activity was examined. Water extract of Nicotiana rustica Linn Maras Powder with walnut, (MPWW) and methanol extract Maras Powder with Nicotiana rustica, (MPNR), Maras Powder with walnut, (MPWW) and Maras Powder with copper cauldron, (MPCC) had an inhibitory effect on AChE (IC50 values in the range of 0.104-0.203 mg ml-1). Also water extract MPCC and methanol extract MPNR, MPWW and MPCC showed an inhibition effect on PON 1 (IC50 values 0.013-0.225 mg ml -1). MPNR water extract showed the highest activity with 26% DPPH radical scavenging activity. MPCC water extract showed a 13% ABTS radical scavenging activity.

Keywords

Maras Grass Phenolic Antioxidant Enzyme inhibition Paraoxonase

Supporting Institution

Harran Unıversty

Project Number

1906

Thanks

This study was supported by the Scientific Research and Project Coordination Unit of Harran University. We would like to thank Harran University for its contribution.

References

  • Al-Lahham S, Sbieh R, Jaradat N, Almasri M, Mosa A, Hamayel A, Hammad F. 2020. Antioxidant, antimicrobial and cytotoxic properties of four different extracts derived from the roots of Nicotiana tabacum L. European Journal of Integrative Medicine, 33: 101039.
  • Apak R, Güçlü K, Özyürek M, Karademir, SE. 2004. Novel Total Antioxidant Capacity İndex for Dietary Polyphenols and Vitamins C and E, Using Their Cupric İon Reducing Capability in The Presence of Neocuproine: CUPRAC Method. Journal of Agricultural and Food Chemistry, 52 (26): 7970–7981.
  • Aral M, Ekerbicer HC, Celik M, Ciragil P, Gul M 2006. Comparison Of Effects of Smoking and Smokeless Tobacco “Maras Powder” Use on Humoral İmmune System Parameters. Mediators Inflamm 3: 85019.
  • Atlan N, Sepici Dinçel A, Koca C. 2006. Diabetes Mellitus ve Oksidatif Stres. Türk Biyokimya Dergisi 31: 51-6.
  • Aviram M, Rosenblat M. 2004. Paraoxonases 1, 2, And 3, Oxidative Stress, and Macrophage Foam Cell Formation During Atherosclerosis Development. Free Radic Biol Med 37:1304–16.
  • Benowitz NL. 1988. Nicotine and Smokeless Tobacco. CA Cancer J Clin 38:244-7.
  • Blois, M. S. 1958. Antioxidant Determinations by The Use of A Stable Free Radical. Nature 181: 1199–1200.
  • Çalıkoğlu M, Ünlü A, Bilgin R. 2002. Stabil Astımlı Hastalarda Lipid Peroksidasyonu ve Antioksidan Enzim Aktiviteleri. Solunum 4: 458-62.
  • Chang LW. Yen WJ, Huang SC, Duh PD 2002. Antioxidant Activity of Sesame Coat. Food Chemistry 78(3): 347–354.
  • Chen C, Loo G 1995. Cigarette Smoke Extract İnhibits Oxidative Modification of Low Density Lipoprotein. Atherosclerosis 112: 177–185.
  • Church DF, Pryor WA. 1985. Free-Radical Chemistry of Cigarette Smoke and Its Toxicological İmplications. Environ Health Perspect 64:111-26.
  • Davis DL, Neilson MT 1999. Tobacco: Production, Chemistry and Technology. Blackwell Science Ltd, Oxford, 467 S.
  • Davis PH. 1982. Flora of Turkey. Edinburgh University Press, Edinburgh, 572 S.
  • Demir Y, Işık M, Gülçin İ, Beydemir Ş. 2017. Phenolic Compounds Inhibit the Aldose Reductase Enzyme from The Sheep Kidney. Journal of Biochemical and Molecular Toxicology, 31(9): E21936.
  • Diplock AT. 1997. Will The ‘Good Fairies’ Please Prove To Us That Vitamin E Lessens Human Degenerative Disease? Free Radical Research, 27(5): 511–532.
  • Duh PD, Tu YY, Yen GC. 1999. Antioxidant Activity of Water Extract of Harng Jyur (Chrysanthemum Morifolium Ramat). LWT-Food Science And Technology, 32(5): 269–277.
  • Ellman GL, Courtney KD, Andres V, Featherstone RM. 1961. A New and Rapid Colorimetric Determination of Acetylcholinesterase Activity. Biochem Pharmacol 7: 88-95.
  • Elmastaş M, Gülçin I, Beydemir Ş, Küfrevioǧlu ÖI, Aboul-Enein HY. 2006. A Study on The in Vitro Antioxidant Activity of Juniper (Juniperus Communis L.) Fruit Extracts. Analytical Letters, 39: 47–65.
  • Erenmemişoğlu A, Tekol Y, Kartal M, Kurucu S. 1991. The Use of A Smokeless Tobacco in Our Country “Maraşotu” Second International Symposium of Pharmaceutical Sciences. Ankara-Turkey, June, 11- 14.
  • Erenmemisoğlu E. 1999. Turkish Smokeless Tobacco “Maraş Powder”. Preventive Medicine, 28:616-617.
  • Fan P, Hay AE, Marston A, Hostettmann K. 2008. Acetylcholinesterase-inhibitory activity of linarin from Buddleja davidii, structure-activity relationships of related flavonoids, and chemical investigation of Buddleja nitida. Pharmaceutical biology, 46(9): 596-601.
  • Feng Y, Yang S, Du X, Zhang X, Sun X, Zha M, et al. 2009. Ellagic Acid Promotes Aβ42 Fibrillization and Inhibits Aβ42-Induced Neurotoxicity, Biochem Biophys Res Commun, 390:1250-1254.
  • Gülçin I. 2012. Antioxidant Activity of Food Constituents: An Overview. Archives of Toxicology, 86(3): 345–391.
  • Gulcin I, Buyukokuroglu ME, Oktay M, Kufrevioglu O I. 2002. On The İn Vitro Antioxidative Properties of Melatonin. Journal of Pineal Research, 33(3): 167–171.
  • Mouhamed DH, Ezzaher A, Araoud M, Neffati F, Douki W, Najjar MF. 2010. Paraoxonase 1 (PON1) Activity and Lipid Parameters in Tunisian Smokers. Ann Biol Clin (Paris) 68:143–7.
  • Han Y, Dorajoo R, Ke T, Ayala B, Chang X, Khor CC, ... Heng CK. 2015. Interaction Effects Between Paraoxonase 1 Variants and Cigarette Smoking on Risk of Coronary Heart Disease İn A Singaporean Chinese Population. Atherosclerosis. 240(1):40–45.
  • Huen K, Richter R, Furlong C, Eskenazi B, Holland N. 2009. Validation Of PON1 Enzyme Activity Assays for Longitudinal Studies. Clin Chim Acta 402:67–74.
  • Isik B, Ceylan A, Isik R. 2007. Oxidative Stress in Smokers And Nonsmokers. Inhal Toxicol 9:767–769.
  • Işık M. 2020. Salvia officinalis L. Etanol Ekstraktının Antikolinerjik ve Antioksidan Aktivitesi ve LC-MS/MS Analizi. International Journal of Life Sciences and Biotechnology, 3(1): 51-61.
  • Işık M. 2019. The Binding Mechanisms and Inhibitory Effect of Intravenous Anesthetics on Ache In Vitro And In Vivo: Kinetic Analysis and Molecular Docking. Neurochemical Research, 44(9): 2147-2155.
  • Işık M, Beydemir Ş, Demir Y, Durgun M, Türkeş C, Nasır, A., ... Akkuş M. 2019. Benzenesulfonamide Derivatives Containing Imine and Amine Groups: Inhibition on Human Paraoxonase and Molecular Docking Studies. International Journal of Biological Macromolecules.
  • Işık M, Beydemir Ş, Yılmaz A, Naldan ME, Aslan H. E, Gülçin İ. 2017. Oxidative Stress and Mrna Expression of Acetylcholinesterase in The Leukocytes of Ischemic Patients. Biomedicine & Pharmacotherapy, 87: 561-567.
  • Işık M, Demir Y, Kırıcı M, Demir R, Şimşek F, Beydemir Ş. 2015. Changes in The Antioxidant System in Adult Epilepsy Patients Receiving Anti-Epileptic Drugs. Archives of Physiology and Biochemistry, 121(3): 97-102.
  • Jha AB, Panchal SS, Shah A. 2018. Ellagic Acid: Insights into Its Neuroprotective And Cognitive Enhancement Effects In Sporadic Alzheimer's Disease. Pharmacology Biochemistry and Behavior, 175: 33-46.
  • Kakinuma Y, Furihata M, Akiyama T, Arikawa M, Handa T, Katare RG, Sato T. 2010. Donepezil, An Acetylcholinesterase Inhibitor Against Alzheimer's Dementia, Promotes Angiogenesis in An Ischemic Hindlimb Model. Journal of Molecular and Cellular Cardiology, 48(4): 680-693.
  • Kamisaki Y, Wada K, Nakamoto K, Kishimoto Y, Ashida K, Itoh T 1997. Inhibition By Cigarette Smoke of Lipid Peroxidation İnduced Neurotransmitter Release. Life Sci 60: 229–233.
  • Kurtul N, Cil MY, Pacaci SD. 2005. Serum Total Sialic Acid Levels in Smokers And Users of Smokeless Tobacco in Form of Oral Powder (Maraş Powder). J Biomed Sci 12:559–63.
  • Kurtul N, Çil MY, Paçacı SF. 2005. Serum Total Sialic Acid Levels in Smokers And Users of Smokeless Tobacco in Form of Oral Powder (Maras Powder). J Biomed Sci, 12:559-63.
  • Kurtul N, Gökpınar E. 2012. Salivary Lipid Peroxidation and Total Sialic Acid Levels in Smokers and Smokeless Tobacco Users As Mara¸S Powder. Mediat Inflamm 2012:619293.
  • Kurtul N, Söylemez S, Çelik M. 2014. Plasma Paraoxonase and Arylesterase Activities in Smokers and Smokeless Tobacco Users As Maraş Powder. Inhalation Toxicology, 26(4): 235-239.
  • Lapenna D, Degioia S, Mezzetti A, Ciofani G, Consoli A, Marzio L, Cuccurullo F 1995. Cigarette Smoke, Ferritin, And Lipid Peroxidation. Am J Respir Crit Care Med 151: 431–435.
  • Mackness MI, Abbott C, Arrol S, Durrington PN. 1993. The Role of High-Density Lipoprotein and Lipid-Soluble Antioxidant Vitamins in Inhibiting Low-Density Lipoprotein Oxidation. Biochem J 294: 829–34.
  • Mackness MI, Mackness B, Durrington PN. 2002. Paraoxonase and Coronary Heart Disease. Atheroscler Suppl 3:49–55.
  • Meir, S, Kanner J, Akiri B, Philosoph-Hadas S. 1995. Determination and Involvement of Aqueous Reducing Compounds in Oxidative Defense Systems of Various Senescing Leaves. Journal of Agricultural and Food Chemistry, 43(7): 1813–1819.
  • Nair J, Pakhale SS, Bhide SV. 1989. Carcinogenic Tobacco Specific Nitrosamines in Indian Tobacco Products. Food Chem Toxicol 27:751–3.
  • Neagu E, Paun G, Albu C, Radu GL. 2015. Assessment of Acetylcholinesterase and Tyrosinase Inhibitory and Antioxidant Activity of Alchemilla Vulgaris and Filipendula Ulmaria Extracts. Journal of The Taiwan Institute of Chemical Engineers, 52: 1-6.
  • Necip A, Işık M. 2019. Bioactivities of Hypericum Perforatum L and Equisetum Arvense L Fractions Obtained With Different Solvents. Int J Life Sci Biotech, 2: 221-30.
  • Nilsson R. 1998. A Qualitative and Quantitative Risk Assessment of Snuff Dipping. Reg Toxicol Pharmacol 28:1–16.
  • Oyaizu, M. 1986. Studies on Products of Browning Reaction. Antioxidative Activities of Products Of Browning Reaction Prepared From Glucosamine. The Japanese Journal of Nutrition and Dietetics, 44(6): 307–315.
  • Ozkul Y, Donmez H, Erenmemisoglu A, Demirtas H, Imamoglu N. 1997. Induction of Micronuclei By Smokeless Tobacco on Buccal Mucosa Cells of Habitual Users. Mutagenesis, 12: 285-7.
  • Perry G, Raina AK, Nunomura A, Wataya T, Sayre L M, Smith MA. 2000. How İmportant İs Oxidative Damage? Lessons From Alzheimer’s Disease. Free Radical Biology & Medicine, 28(5): 831–834.
  • Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C. 1999. Antioxidant Activity Applying an İmproved ABTS Radical Cation Decolorization Assay. Free Radical Biology And Medicine, 26(9): 1231–1237.
  • Senti M, Tomas M, Anglada R, et al. 2003. Interrelationship of Smoking, Paraoxonase Activity, and Leisure Time Physical Activity: A Population Based Study. Eur J Intern Med 14:178–84.
  • Seyoum A, Asres K, El-Fiky FK. 2006. Structure–Radical Scavenging Activity Relationships of Flavonoids. Phytochemistry, 67(18): 2058–2070.
  • Soare JR, Dinis TCP, Cunha AP, Almeida L. 1997. Antioxidant Activities of Some Extracts of Thymus Zygis. Free Radical Research, 26(5): 469–478.
  • Türkeş C, Söyüt H, Beydemir Ş. 2014. Effect of Calcium Channel Blockers on Paraoxonase-1 (PON1) Activity and Oxidative Stress. Pharmacological Reports, 66(1): 74-80.
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There are 58 citations in total.

Details

Primary Language English
Subjects Structural Biology
Journal Section RESEARCH ARTICLE
Authors

Adem Necip 0000-0002-2092-7829

Mesut Işık 0000-0002-4677-8104

Abdussamat Güzel 0000-0001-7810-4510

Kasım Takım 0000-0003-4631-1982

Feyza Kaygısız 0000-0002-2899-2289

Project Number 1906
Publication Date October 31, 2021
Submission Date January 8, 2021
Acceptance Date February 18, 2021
Published in Issue Year 2021 Volume: 24 Issue: 5

Cite

APA Necip, A., Işık, M., Güzel, A., … Takım, K. (2021). LC-MS/MS Analysis, Antioxidant Properties and Inhibition Effect on Some Important Metabolic Enzymes of Nicotiana rustica L. Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi, 24(5), 930-938. https://doi.org/10.18016/ksutarimdoga.vi.856514

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