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Tıbbi Açıdan Önemli Enzimlere Karşı İnhibisyon Yeteneğinin Invitro ve Insilico Çalışmalarla Değerlendirilmesi: Endemik Centaurea cadmea subsp. pontica Bitkisinin Fenolik İçeriği

Year 2024, Volume: 27 Issue: 1, 14 - 25, 28.02.2024

Dursun Kısa , Ahmet Çelik , Rizvan İmamoğlu

https://doi.org/10.18016/ksutarimdoga.vi.1294720
Cited By: 1

Abstract

Centaurea türleri geleneksel şifalı bitki olarak büyük bir potansiyele sahiptir. Küre Dağı'nın kayalık yamaç yarıklarından toplanan C. cadmea subsp. pontica Türkiye florasına endemiktir. Bu çalışmada, bitkinin farmakolojik önemini ortaya koymak için çeşitli tıbbi enzimleri inhibe etme pontansiyeli, moleküler yerleştirme çalışmaları ile desteklenerek araştırılmıştır. Çalışılan enzimler için yarı maksimum inhibitör konsantrasyon (IC50) sonuçları 0.50-86.97 µg mLˉˡ arasında belirlendi. Bitki ekstraktı diyabet ve kolesterol ile bağlantılı olan HMG_CoA R, α-amilaz ve α -glukosidaz enzimlerine karşı etki gösterdi. C. cadmea subsp. pontica özütünde dokuz fenolik bileşik tanımlandı ve en fazla bulunan fenolik bileşiklerin enzimlerle etkileşimleri moleküler yerleştirme çalışmaları ile incelenmiştir. Sonuç olarak, mevcut çalışmadan elde edilen bulgular, bu endemik bitkinin sağlıklı yaşam kalitesinin geliştirilmesine yönelik yeni bileşenlerin formüle edilmesi için etkili bir bitki olarak yararlı olabileceğini göstermektedir.

Keywords

Centaurea cadmea Enzim inhibisyonu Moleküler kenetlenme Fenolik içerik

Supporting Institution

Scientific Research Projects Unit of Bartın University

Project Number

2021-FEN-A-004

Thanks

The present study was financially supported with a research grant coded 2021-FEN-A-004 by the Scientific Research Projects Unit of Bartın University, Türkiye. We are very grateful to Prof. Dr. Zafer Kaya, who identified the plant and passed away from this world.

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Assessment of Inhibitory Ability Against Medicinally Important Enzymes with Invitro and In Silico Studies: Phenolic Content of Endemic Centaurea cadmea subsp. pontica

Year 2024, Volume: 27 Issue: 1, 14 - 25, 28.02.2024

Dursun Kısa , Ahmet Çelik , Rizvan İmamoğlu

https://doi.org/10.18016/ksutarimdoga.vi.1294720
Cited By: 1

Abstract

Centaurea species has great potential as a traditional medicinal herb and C. cadmea subsp. pontica collected from rocky slope crevices of Küre Mountain is endemic to the flora of Türkiye. In the present work, to reveal the plant's pharmacological importance, its potency to inhibit various medicinal enzymes was investigated, supported by molecular docking studies. The half-maximal inhibitory concentration (IC50) results for studied enzymes were quantified between 0.50-86.97 µg mLˉˡ, and the extract was efficient against HMG_CoA R, α-glucosidase, and α-amylase enzymes linked to diabetes and cholesterol. Nine phenolic compounds were identified in the C. cadmea subsp. pontica extract and the interactions of the most abundant phenolic compounds with the enzymes were examined with molecular docking studies. In conclusion, findings amassed from the present study inclined to support the opinion that C. cadmea subsp. pontica may be beneficial as an effective herb for formulating novel health-promoting ingredients.

Keywords

Centaurea cadmea Enzyme inhibition Molecular docking Phenolic component

Supporting Institution

Bartın University

Project Number

2021-FEN-A-004

References

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  • Aktumsek, A., Zengin, G., Guler, G. O., Cakmak, Y. S. & Duran, A. (2013). Antioxidant potentials and anticholinesterase activities of methanolic and aqueous extracts of three endemic Centaurea L. species. Food Chem Toxicol, 55, 290-296. doi: 10.1016/j.fct.2013.01.018.
  • Albayrak, S., Atasagun, B. & Aksoy, A. (2017). Comparison of phenolic components and biological activities of two Centaurea sp. obtained by three extraction techniques. Asian Pac J Trop Med. 10(6), 599-606. doi: 10.1016/j.apjtm.2017.06.010.
  • Alper., M. & Güneş, H. (2019). The Anticancer and Anti-inflammatory Effects of Centaurea solstitialis Extract on Human Cancer Cell Lines. Turk J Pharm Sci, 16(3), 273-281. doi: 10.4274/ tjps.galenos.2018.27146.
  • Alper, M., Özay, C., Güneş, H. & Mammadov, R. (2021). Assessment of Antioxidant and Cytotoxic Activities and Identification of Phenolic Compounds of Centaurea solstitialis and Urospermum picroides from Turkey. Brazilian Arch Biol Technol, 64, 1-12. doi: 10.1590/1678-4324-2021190530.
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  • Astari, K. A., Baykan, Erel, Ş., Aydin Köse F, Köksal Ç. & Karaalp C. (2014). Cytotoxic and Antibacterial Activities of Centaurea cadmea Boiss. Turkish J Pharm Sci, 11, 101-106.
  • Bancheva, S., Badalamenti, N. & Bruna, M. (2023). The essential oil composition of the endemic plant species Centaurea vandasii and chemotaxonomy of section Phalolepis (Asteraceae). Natural Product Research, 37(7), 1122-1129. https://doi.org/10.1080/ 14786419.2021.1992627.
  • Baskaran G, Salvamani S, Ahmad, S. A., Shaharuddin, N. A., Pattiram, P. D. & Shukor, M. Y. (2015). HMG-CoA reductase inhibitory activity and phytocomponent investigation of Basella alba leaf extract as a treatment for hypercholesterolemia. Drug Des Devel Ther, 9, 509-517. doi: 10.2147/DDDT.S75056.
  • Baydoun, S., Chalak, L., Dalleh, H. & Arnold, N. (2015). Ethnopharmacological survey of medicinal plants used in traditional medicine by the communities of Mount Hermon, Lebanon. J Ethnopharmacol, 173, 139-156. doi: 10.1016/ j.jep.2015.06.052.
  • Boğa, M., Alkan, H., Ertaş, A., Oral, E.V., Yılmaz, M.A., Yeşil, Y., Gören, A.C., Temel, H. & Kolak, U. (2016). Phytochemical profile and some biological activities of three centaurea species from Turkey. Trop J Pharm Res. 15, 1865-1875. doi: 10.4314/ tjpr.v15i9.8.
  • Ćurković-Perica, M., Likić, S. & Rusak, G. (2014). Phenolic compounds in centaurea rupestris tissues and their antiphytoviral activity. Croat Chem Acta, 87, 79-84. doi: 10.5562/cca2272.
  • Dalar, A., Uzun, Y., Mukemre, M., Turker, M. & Konczak, I. (2015). Centaurea karduchorum Boiss. from Eastern Anatolia: Phenolic composition, antioxidant and enzyme inhibitory activities. J Herb Med. 5, 211-216. doi: 10.1016/j.hermed. 2015.09.006.
  • Duman, H., Uzunhisarcıklı, M.E. & Bahadır, Y.N. (2021). A new species of Centaurea (Asteraceae) from northern Turkey. Nordic Journal of Botany, 39(10), 1-8. doi: 10.1111/njb.03244
  • Dutta, T., Anand, U., Saha, S. C., Mane, A.B., Prasanth, D. A., Kandimalla, R., Proćków, J. & Dey, A. (2021). Advancing urban ethnopharmacology: A modern concept of sustainability, conservation and cross-cultural adaptations of medicinal plant lore in the urban environment. Conserv Physiol, 9, 1–20. doi: 10.1093/conphys/coab073.
  • Eberhardt, J., Santos-Martins, D., Tillack, A. F. & Forli, S. (2021). AutoDock Vina 1.2.0: New Docking Methods, Expanded Force Field, and Python Bindings. Chem. Inf. Model. 61(8), 3891-3898.
  • Ellman, G. L., Courtney, K. D., Andres, V. & Featherstone, R. M. (1961). A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol, 7, 88-95. doi:10.1016/0006-2952(61)90145-9.
  • Elmastaş, M., Demir, A., Genç, N., Dölek, Ü. & Güneş, M. (2017). Changes in flavonoid and phenolic acid contents in some Rosa species during ripening. Food Chem, 235, 154-159. doi: 10.1016/j.foodchem. 2017.05.004.
  • Sönmez, P. & Çakıloğlu, U. (2020). Screening of Antimicrobial Effect against Microorganisms Threatening to Human Health of the Endemic Plant; Centaurea saligna (C. Koch) Wagenitz from Turkey. Türk Doğa ve Fen Derg, 9, 23-27 . doi: 10.46810/tdfd.732234.
  • Gonçalves, S. & Romano, A. (2017). Inhibitory Properties of Phenolic Compounds Against Enzymes Linked with Human Diseases. In: Soto-Hernández M (ed) Phenolic Compounds Biological Activity. IntechOpen, p 228.
  • Gonçalves, S. & Romano, A. (2018). Production of Plant Secondary Metabolites by Using Biotechnological Tools. In: Vijayakumar R (ed) Secondary Metabolites Sources and Applications. IntechOpen, p 138.
  • Grafakou, N. E., Djeddi, S., Tarek, H. & Skaltsa, H. (2018). Secondary metabolites from the aerial parts of Centaurea papposa (Coss.) Greuter. Biochemical Systematics and Ecology, 76, 15-22. https://doi.org/ 10.1016/j.bse.2017.11.005.
  • Guerrero, L., Castillo, J., Quiñones, M., Garcia-Vallvé, S., Arola, L., Pujadas, G. & Muguerza, B. (2012.) Inhibition of Angiotensin-Converting Enzyme Activity by Flavonoids: Structure-Activity Relationship Studies. PLoS One, 7, 1-11. doi: 10.1371/journal.pone.0049493.
  • Holdgate, G. A., Ward, W. H. J. & McTaggart, F. (2003). Molecular mechanism for inhibition of 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase by rosuvastatin. Biochem Soc Trans, 31, 528-531. doi: 10.1042/BST0310528.
  • Hou, W. C., Chen, H. J. & Lin, Y. H. (2003). Antioxidant peptides with angiotensin converting enzyme inhibitory activities and applications for angiotensin converting enzyme purification. J Agric Food Chem, 51, 1706-1709. doi: 10.1021/jf0260242.
  • Ikram, M., Rehman, S., Subhan, F., Akhtar, M. N, & Sinnokrot, M. O. (2017). Synthesis, characterization, thermal degradation and urease inhibitory studies of the new hydrazide based Schiff base ligand 2-(2-hydroxyphenyl)-3-{[(E)-(2-hydroxyphenyl)methylidene]amino}-2,3-dihydroquinazolin-4(1H)-one. Open Chem, 15, 308-319. doi: 10.1515/chem-2017-0035.
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Details

Primary Language English
Subjects Structural Biology
Journal Section RESEARCH ARTICLE
Authors

Dursun Kısa 0000-0002-7681-2385

Ahmet Çelik 0000-0001-9802-4868

Rizvan İmamoğlu 0000-0002-6306-4760

Project Number 2021-FEN-A-004
Early Pub Date October 13, 2023
Publication Date February 28, 2024
Submission Date May 9, 2023
Acceptance Date July 28, 2023
Published in Issue Year 2024 Volume: 27 Issue: 1

Cite

APA Kısa, D., Çelik, A., & İmamoğlu, R. (2024). Assessment of Inhibitory Ability Against Medicinally Important Enzymes with Invitro and In Silico Studies: Phenolic Content of Endemic Centaurea cadmea subsp. pontica. Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi, 27(1), 14-25. https://doi.org/10.18016/ksutarimdoga.vi.1294720

Cited By

Centaurea lycaonica Boiss. & Heldr. Bitkisinin İnsan Servikal Kanser Hücre Hattında Sitotoksisitesinin MTT Testi ve xCELLigence Sistemi ile Değerlendirilmesi
Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi
https://doi.org/10.18016/ksutarimdoga.vi.1496499
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