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Research Article
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Evaluation of Some Biochemical Parameters In Saanen Goats Naturally Infected With Mycoplasma agalactiae

Year 2024, Volume: 27 Issue: 5, 1021 - 1025, 17.09.2024

Sezai Arslan

https://doi.org/10.18016/ksutarimdoga.vi.1435506

Abstract

Mycoplasma agalactiae in sheeps and goats causes significant economic losses worldwide. The disease can cause mastitis, arthritis, ophthalmitis and less commonly abortion. This study aimed to reveal what kind of changes the disease causes in routine biochemical parameters and PCT and CRP levels in naturally infected goats. The material of the study consisted of fifteen naturally infected with Mycoplasma agalactiae and nine healthy (control group) female goats in a private commercial enterprise. M. agalactiae was diagnosed by a growth inhibition test in milk and blood serum. Serum biochemical analysis was performed by autoanalyzer. In the statistical study conducted between the control and infected groups, a significant decrease was found in albumin levels and A/G ratio in the infected group, and a significant increase in globulin, chlorine and potassium levels. No significance could be determined in levels of ALT, AST, D.BIL, T.BIL, BUN, Creatinine, Urea, Glucose, Na, P, CRP and PCT. As a result, it was revealed that PCT is not an important biomarker in goats with Mycoplasma agalactiae.

Keywords

Mycoplasma agalactiae PCT CRP Goat Biochemical

References

  • Akkose, M. (2020). Evaluation of a bovine rapid visual PAG ELISA test and transabdominal ultrasonography for early pregnancy diagnosis in awassi sheep. KSU Journal of Agriculture and Nature 23 (5), 1366-1372. https://doi.org/10.18016/ ksutarimdoga.vi.668707.
  • Al-Nawas, B., & Shah P. (1997). Procalcitonin in acute malaria. European Journal of Medical Research, 2 (5), 206-208.
  • Anderson, D.E., Hull, B.L., & Pugh, D.G. (2002). Diseases of the Mammary Gland. In: D.G. Pugh (Ed.), Sheep and goat medicine. 1st edition, Elsevier, Philadelphia, 355.
  • Arslan, S., Altuğ N., Muz, M.N., Yüksek, N., Başbuğan, Y., & Orunç, K.O. (2018). Diagnostic and prognostic value of procalcitonin (PCT), C reactive protein (CRP), nitric oxide (NO) levels, and adenosine deaminase (ADA) activity in sheep with natural babesiosis before and after treatment. Turkish Journal of Veterinary & Animal Sciences, 42, 512–520. https://doi.org/ 10.3906/vet-1805-35.
  • Assicot, M., Gendrel, D., Carsin, H., Raymond, J., Guilbaud, J., & Bohuon, C. (1993). High serum procalcitonin concentrations in patients with sepsis and infection. Lancet., 341: 515–518. doi:10.1016/0140-6736(93)90277-n.
  • Bergonier, D., Berthelot, X., & Poumarat, F. (1997). Contagious agalactia of small ruminants: current knowledge concerning epidemiology, diagnosis and control. Revue Scientifique et Technique, 16 (3), 848-873. doi: 10.20506/rst.16.3.1062.
  • Black, S., Kushner, I., & Samols, D. (2004). C-reactive Protein. Journal of Biological Chemistry, 279, 48487-48490. doi: 10.1074/jbc.R400025200.
  • Bock, J.L. ( 2011). Cardiac Injury, Atherosclerosis, And Thrombotic Disease. In: R.A McPherson, M.R. Pincus, (Eds.), Henry’s Clinical Diagnosis And Management By Laboratory Methods. 22nd ed., Elsevier, Philadelphia, 254 -255.
  • Cleland, D.A., & Eranki, A.P. (2023). Procalcitonin. Apr 23. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan.
  • Corrales, J.C., Esnal, A., De la Fe, C., Sánchez, A., Assunçao, P., Poveda, JB., & Contreras, A. (2007). Contagious agalactia in small ruminants. Small Ruminant Research, 68 (1-2), 154-166. https://doi.org/10.1016/j.smallrumres.2006.09.01.
  • Durnaś, B., Wątek, M., Wollny, T., Niemirowicz, K., Marzec, M., Bucki, R., & Góźdź S. (2016). Utility of blood procalcitonin concentration in the management of cancer patients with infections. Onco Targets and Therapy, 22 (9), 469-475. doi: 10.2147/OTT.S95600.
  • Hausfater, P., Juillien, G., Madonna-Py, B., Haroche, J., Bernard, M., & Riou B. (2007). Serum procalcitonin measurement as a diagnostic and prognostic marker in febrile adult patients presenting to the emergency department. Critical Care, 11 (3), 1-9. doi: 10.1186/cc5926.
  • Jaÿ, M., & Tardy, F. (2019). Contagious Agalactia In Sheep And Goats: Current Perspectives. Veterinary medicine (Auckland, N.Z.), 27 (10), 229-247. doi: 10.2147/VMRR.S201847.
  • Kang, Y.A., Kwon, S.Y., Yoon, H.I., Lee, J.H., & Lee, C.T. (2009). Role of C-reactive protein and procalcitonin in the differentiation of tuberculosis from bacterial community-acquired pneumonia. The Korean Journal of Internal Medicine, 24 (4), 337-342. doi: 10.3904/kjim.2009.24.4.337.
  • Kaygısız, A., & Sönmez, E. (2018). Süt emme döneminde uygulanan farklı besleme yöntemlerinin siyah alaca buzağıların gelişim performansı ve bazı kan parametreleri üzerine etkisi. KSÜ Tarım ve Doğa Dergisi 21(5), 757-764. doi:10.18016/ksudobil.336717.
  • Kizil, O., & Ozdemir, H. (2006). Clinical, haematological and biochemical studies in goats naturally infected with Mycoplasma agalactiae. Bulletin of the Veterinary Institute in Pulawy, 50, 325-328.
  • Kumar, A., Rahal A., Chakraborty, S., Verma, A.K., & Dhama, K. (2014). Mycoplasma agalactiae, an Etiological Agent of Contagious Agalactia in Small Ruminants: A Review. Veterinary Medicine International, 286752, 1-13. doi: 10.1155/2014/286752.
  • Kusiluka, L., & Kambarage, D. (1996). Diseases of small ruminants in sub-Saharan Africa: A Handbook. 1st. edition, VETAID, Scotland, 64.
  • Matur, E., Dokuzeylül, B., Özcan, M., Çetinkaya, H., Arslan, M., Or, E., Erhan, S., & Çötelioğlu Ü (2023). Can procalcitonin be used as a clinical biomarker during dogs’ bacterial, viral and parasitic infections? Japanese Journal of Veterinary Research, 69 (1), 5-17. https://doi.org/ 10.14943/jjvr.69.1.5.
  • Maudsley, S., Baltz, M.L., Munn, E.A., Buttress, N., Herbert, J., Feinstein, A., & Pepys, MB. (1987). Isolation and characterisation of goat C-reactive protein. Biochimica et Biophysica Acta. 924 (1), 75-80. doi: 10.1016/0304-4165(87)90072-9.
  • McPherson, R.A. (2011). Specific Proteins. Henry’s Clinical Diagnosis And Management By Laboratory Methods, In: R.A. McPherson, M.R. Pincus (Eds.), Henry’s Clinical Diagnosis And Management By Laboratory Methods. 22th edition, Elsevier, Philadelphia, 269-270.
  • Mondal, D., Pramanik, A.K., & Basak, D.K. (2004). Clinico-haematology and pathology of caprine mycoplasmal pneumonia in rain-fed tropics of West Bengal. Small Ruminant Research, 51 (3), 285-295. https://doi.org/10.1016/S0921-4488(02) 00177-3.
  • Moulin, F., Raymond, J., Lorrot, M., Marc, E., Coste, J., Iniguez, JL., Kalifa, G., Bohuon, C., & Gendrel, D. (2001). Procalcitonin in children admitted to hospital with community-acquired pneumonia. Archives of Disease in Childhood, 84 (4), 332-336. doi: 10.1136/adc.84.4.332.
  • Noomi, B.S., Hadi, K.A., Hiba, Y.K., Azeez, A.A., Jaafar, N.A., & Al-refaai, H.A.N. (2018). Investigating M. agalactiae and studying its effects on some haematological and biochemical parameters in sheep and goats infected with mastitis. Basrah Journal of Veterinary Research, 17 (3), 761-769.
  • Pathak, A., & Agrawal, A. (2019). Evolution of C-Reactive Protein. Frontiers in Immunology, 10: 1-12. doi: 10.3389/fimmu.
  • Pincus, M.R., & Abraham, N.Z Jr. (2011). Interpreting Laboratory Results. In: R.A. McPherson, M.R. Pincus (Eds.), Henry’s Clinical Diagnosis And Management By Laboratory Methods. 22nd edition, Elsevier, Philadelphia, 96.
  • Plummer, P.J., & Plummer, C. (2012). Diseases of the Mammary Gland. In: D.G. Pugh, A.N. Baird (Eds.), Sheep and goat medicine. 2nd edition. Elsevier, Missouri, 460-461.
  • Rosendal, S. (1981). Experimental infection of goats, sheep and calves with the large colony type of Mycoplasma mycoides subsp. mycoides. Veterinary Pathology, 18 (1), 71-81. doi: 10.1177/ 030098588101800108.
  • Saleem, A. (2019). Serum Procalcitonin in Lower Respiratory Tract Infections in Adult Patients. British Journal of Medical Practitioners, 12 (2), 1-3.
  • Self, W.H., Balk, R.A., Grijalva, C.G., Williams, D.J., Zhu, Y., Anderson, E.J., Waterer, G.W., Courtney, D.M., Bramley, A.M., Trabue, C., Fakhran, S., Blaschke, A.J., Jain, S., Edwards, K.M., & Wunderink, R.G. (2017). Procalcitonin as a Marker of Etiology in Adults Hospitalized With Community-Acquired Pneumonia. Clinical Infectious Diseases 65 (2), 183-190. doi: 10.1093/ cid/cix317.
  • Shah, S.S.A., Sadique, U., Hassan, Z.U., Ahmad, S., Khan, H., Shah, M.K., Israr, M., & Rahman, H.U. (2017). Clinico-pathological profile and frequency of Mycoplasma mycoides subsp. Capri infection in goats in the northern zone of Khyber-Pakhtunkhwa, Pakistan. Veterinaria, 66 (2), 72-77.
  • Smith, M.C., & Sherman, D.M. (2009). Goat Medicine, 2nd ed., Singapore: Wiley-Blackwell, 662.
  • TCGTHB (Türkiye Cumhuriyeti Gıda Tarım Hayvancılık Bakanlığı) (2014). Teşhiste Metot Birliği, Bakteriyoloji, Cilt 1.155-185 sy.
  • Uzzan, B., Izri, A., Durand, R., Deniau, M., Bouchaud, O., & Perret, G.Y. (2006). Serum procalcitonin in uncomplicated falciparum malaria: a preliminary study. Travel Medicine and Infectious Disease, 4 (2), 77-80. doi 10.1016/j.tmaid.2005.04.003.

Mycoplasma agalactiae ile Doğal İnfekte Sanen Keçilerinde Bazı Biyokimyasal Parametrelerin Değerlendirilmesi

Year 2024, Volume: 27 Issue: 5, 1021 - 1025, 17.09.2024

Sezai Arslan

https://doi.org/10.18016/ksutarimdoga.vi.1435506

Abstract

Koyun ve keçilerde Mycoplasma agalactiae, dünya çapında önemli ekonomik kayıplara neden olmaktadır. Hastalık, mastitis, artrit, oftalmitis ve daha az yaygın olarak abort yapabilir. Bu çalışmanın amacı, doğal olarak enfekte olan keçilerde hastalığın rutin biyokimyasal parametreleri ile PCT ve CRP seviyelerinde meydana gelen değişiklikleri ortaya koymaktır. Çalışmanın materyalini, özel bir ticari işletmede doğal olarak Mycoplasma agalactiae ile enfekte olmuş 15 ile 9 adet sağlıklı (kontrol grubu) dişi keçi oluşturmaktadır. M. agalactiae, süt ve kan serumunda Growth Inhibition Test ile teşhis edildi. Serum biyokimyasal analizi otomatik analizör ile yapıldı. Kontrol ve enfekte gruplar arasında yapılan istatistiksel çalışmada, enfekte gruplarda albümin seviyelerinde ve A/G oranında önemli bir azalma, globulin, klorin ve potasyum seviyelerinde ise önemli bir artış tespit edildi. ALT, AST, D.BIL, T.BIL, BUN, kreatinin, üre, glukoz, Na, P, CRP ve PCT seviyelerinde anlamlılık belirlenemedi. Sonuç olarak, Mycoplasma agalactiae enfeksiyonlu keçilerde PCT’nin önemli bir biyobelirteç olmadığı ortaya konuldu.

Keywords

Mycoplasma agalactiae Biyokimyasal PCT CRP Keçi

References

  • Akkose, M. (2020). Evaluation of a bovine rapid visual PAG ELISA test and transabdominal ultrasonography for early pregnancy diagnosis in awassi sheep. KSU Journal of Agriculture and Nature 23 (5), 1366-1372. https://doi.org/10.18016/ ksutarimdoga.vi.668707.
  • Al-Nawas, B., & Shah P. (1997). Procalcitonin in acute malaria. European Journal of Medical Research, 2 (5), 206-208.
  • Anderson, D.E., Hull, B.L., & Pugh, D.G. (2002). Diseases of the Mammary Gland. In: D.G. Pugh (Ed.), Sheep and goat medicine. 1st edition, Elsevier, Philadelphia, 355.
  • Arslan, S., Altuğ N., Muz, M.N., Yüksek, N., Başbuğan, Y., & Orunç, K.O. (2018). Diagnostic and prognostic value of procalcitonin (PCT), C reactive protein (CRP), nitric oxide (NO) levels, and adenosine deaminase (ADA) activity in sheep with natural babesiosis before and after treatment. Turkish Journal of Veterinary & Animal Sciences, 42, 512–520. https://doi.org/ 10.3906/vet-1805-35.
  • Assicot, M., Gendrel, D., Carsin, H., Raymond, J., Guilbaud, J., & Bohuon, C. (1993). High serum procalcitonin concentrations in patients with sepsis and infection. Lancet., 341: 515–518. doi:10.1016/0140-6736(93)90277-n.
  • Bergonier, D., Berthelot, X., & Poumarat, F. (1997). Contagious agalactia of small ruminants: current knowledge concerning epidemiology, diagnosis and control. Revue Scientifique et Technique, 16 (3), 848-873. doi: 10.20506/rst.16.3.1062.
  • Black, S., Kushner, I., & Samols, D. (2004). C-reactive Protein. Journal of Biological Chemistry, 279, 48487-48490. doi: 10.1074/jbc.R400025200.
  • Bock, J.L. ( 2011). Cardiac Injury, Atherosclerosis, And Thrombotic Disease. In: R.A McPherson, M.R. Pincus, (Eds.), Henry’s Clinical Diagnosis And Management By Laboratory Methods. 22nd ed., Elsevier, Philadelphia, 254 -255.
  • Cleland, D.A., & Eranki, A.P. (2023). Procalcitonin. Apr 23. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan.
  • Corrales, J.C., Esnal, A., De la Fe, C., Sánchez, A., Assunçao, P., Poveda, JB., & Contreras, A. (2007). Contagious agalactia in small ruminants. Small Ruminant Research, 68 (1-2), 154-166. https://doi.org/10.1016/j.smallrumres.2006.09.01.
  • Durnaś, B., Wątek, M., Wollny, T., Niemirowicz, K., Marzec, M., Bucki, R., & Góźdź S. (2016). Utility of blood procalcitonin concentration in the management of cancer patients with infections. Onco Targets and Therapy, 22 (9), 469-475. doi: 10.2147/OTT.S95600.
  • Hausfater, P., Juillien, G., Madonna-Py, B., Haroche, J., Bernard, M., & Riou B. (2007). Serum procalcitonin measurement as a diagnostic and prognostic marker in febrile adult patients presenting to the emergency department. Critical Care, 11 (3), 1-9. doi: 10.1186/cc5926.
  • Jaÿ, M., & Tardy, F. (2019). Contagious Agalactia In Sheep And Goats: Current Perspectives. Veterinary medicine (Auckland, N.Z.), 27 (10), 229-247. doi: 10.2147/VMRR.S201847.
  • Kang, Y.A., Kwon, S.Y., Yoon, H.I., Lee, J.H., & Lee, C.T. (2009). Role of C-reactive protein and procalcitonin in the differentiation of tuberculosis from bacterial community-acquired pneumonia. The Korean Journal of Internal Medicine, 24 (4), 337-342. doi: 10.3904/kjim.2009.24.4.337.
  • Kaygısız, A., & Sönmez, E. (2018). Süt emme döneminde uygulanan farklı besleme yöntemlerinin siyah alaca buzağıların gelişim performansı ve bazı kan parametreleri üzerine etkisi. KSÜ Tarım ve Doğa Dergisi 21(5), 757-764. doi:10.18016/ksudobil.336717.
  • Kizil, O., & Ozdemir, H. (2006). Clinical, haematological and biochemical studies in goats naturally infected with Mycoplasma agalactiae. Bulletin of the Veterinary Institute in Pulawy, 50, 325-328.
  • Kumar, A., Rahal A., Chakraborty, S., Verma, A.K., & Dhama, K. (2014). Mycoplasma agalactiae, an Etiological Agent of Contagious Agalactia in Small Ruminants: A Review. Veterinary Medicine International, 286752, 1-13. doi: 10.1155/2014/286752.
  • Kusiluka, L., & Kambarage, D. (1996). Diseases of small ruminants in sub-Saharan Africa: A Handbook. 1st. edition, VETAID, Scotland, 64.
  • Matur, E., Dokuzeylül, B., Özcan, M., Çetinkaya, H., Arslan, M., Or, E., Erhan, S., & Çötelioğlu Ü (2023). Can procalcitonin be used as a clinical biomarker during dogs’ bacterial, viral and parasitic infections? Japanese Journal of Veterinary Research, 69 (1), 5-17. https://doi.org/ 10.14943/jjvr.69.1.5.
  • Maudsley, S., Baltz, M.L., Munn, E.A., Buttress, N., Herbert, J., Feinstein, A., & Pepys, MB. (1987). Isolation and characterisation of goat C-reactive protein. Biochimica et Biophysica Acta. 924 (1), 75-80. doi: 10.1016/0304-4165(87)90072-9.
  • McPherson, R.A. (2011). Specific Proteins. Henry’s Clinical Diagnosis And Management By Laboratory Methods, In: R.A. McPherson, M.R. Pincus (Eds.), Henry’s Clinical Diagnosis And Management By Laboratory Methods. 22th edition, Elsevier, Philadelphia, 269-270.
  • Mondal, D., Pramanik, A.K., & Basak, D.K. (2004). Clinico-haematology and pathology of caprine mycoplasmal pneumonia in rain-fed tropics of West Bengal. Small Ruminant Research, 51 (3), 285-295. https://doi.org/10.1016/S0921-4488(02) 00177-3.
  • Moulin, F., Raymond, J., Lorrot, M., Marc, E., Coste, J., Iniguez, JL., Kalifa, G., Bohuon, C., & Gendrel, D. (2001). Procalcitonin in children admitted to hospital with community-acquired pneumonia. Archives of Disease in Childhood, 84 (4), 332-336. doi: 10.1136/adc.84.4.332.
  • Noomi, B.S., Hadi, K.A., Hiba, Y.K., Azeez, A.A., Jaafar, N.A., & Al-refaai, H.A.N. (2018). Investigating M. agalactiae and studying its effects on some haematological and biochemical parameters in sheep and goats infected with mastitis. Basrah Journal of Veterinary Research, 17 (3), 761-769.
  • Pathak, A., & Agrawal, A. (2019). Evolution of C-Reactive Protein. Frontiers in Immunology, 10: 1-12. doi: 10.3389/fimmu.
  • Pincus, M.R., & Abraham, N.Z Jr. (2011). Interpreting Laboratory Results. In: R.A. McPherson, M.R. Pincus (Eds.), Henry’s Clinical Diagnosis And Management By Laboratory Methods. 22nd edition, Elsevier, Philadelphia, 96.
  • Plummer, P.J., & Plummer, C. (2012). Diseases of the Mammary Gland. In: D.G. Pugh, A.N. Baird (Eds.), Sheep and goat medicine. 2nd edition. Elsevier, Missouri, 460-461.
  • Rosendal, S. (1981). Experimental infection of goats, sheep and calves with the large colony type of Mycoplasma mycoides subsp. mycoides. Veterinary Pathology, 18 (1), 71-81. doi: 10.1177/ 030098588101800108.
  • Saleem, A. (2019). Serum Procalcitonin in Lower Respiratory Tract Infections in Adult Patients. British Journal of Medical Practitioners, 12 (2), 1-3.
  • Self, W.H., Balk, R.A., Grijalva, C.G., Williams, D.J., Zhu, Y., Anderson, E.J., Waterer, G.W., Courtney, D.M., Bramley, A.M., Trabue, C., Fakhran, S., Blaschke, A.J., Jain, S., Edwards, K.M., & Wunderink, R.G. (2017). Procalcitonin as a Marker of Etiology in Adults Hospitalized With Community-Acquired Pneumonia. Clinical Infectious Diseases 65 (2), 183-190. doi: 10.1093/ cid/cix317.
  • Shah, S.S.A., Sadique, U., Hassan, Z.U., Ahmad, S., Khan, H., Shah, M.K., Israr, M., & Rahman, H.U. (2017). Clinico-pathological profile and frequency of Mycoplasma mycoides subsp. Capri infection in goats in the northern zone of Khyber-Pakhtunkhwa, Pakistan. Veterinaria, 66 (2), 72-77.
  • Smith, M.C., & Sherman, D.M. (2009). Goat Medicine, 2nd ed., Singapore: Wiley-Blackwell, 662.
  • TCGTHB (Türkiye Cumhuriyeti Gıda Tarım Hayvancılık Bakanlığı) (2014). Teşhiste Metot Birliği, Bakteriyoloji, Cilt 1.155-185 sy.
  • Uzzan, B., Izri, A., Durand, R., Deniau, M., Bouchaud, O., & Perret, G.Y. (2006). Serum procalcitonin in uncomplicated falciparum malaria: a preliminary study. Travel Medicine and Infectious Disease, 4 (2), 77-80. doi 10.1016/j.tmaid.2005.04.003.
There are 34 citations in total.

Details

Primary Language English
Subjects Veterinary Sciences (Other)
Journal Section RESEARCH ARTICLE
Authors

Sezai Arslan 0000-0001-9537-6024

Early Pub Date July 2, 2024
Publication Date September 17, 2024
Submission Date February 12, 2024
Acceptance Date April 3, 2024
Published in Issue Year 2024 Volume: 27 Issue: 5

Cite

APA Arslan, S. (2024). Evaluation of Some Biochemical Parameters In Saanen Goats Naturally Infected With Mycoplasma agalactiae. Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi, 27(5), 1021-1025. https://doi.org/10.18016/ksutarimdoga.vi.1435506
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